Search NASA⌕ Search

SEARCH · Search NASA

Results for “target identification”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9
All sourcesNASA NTRSDOE OSTI
NASA NTRS2005

Chapter 19A – Radar Cross Section

The material in this Section will provide the novice Flight Test Engineer (FTE) with a brief overview of the radar cross section (RCS) concept. Brief details of radar range descriptions, operations, target calibrations, and data reduction are included. It is noted that these range operations concentrate on the "static" test range rather than the much more sophisticated "dynamic" test range. The dynamic test range is what the FTE will probably work with. Radar reflectivity measurement has developed over the last two decades from a relatively simple endeavor involving the measurement of target RCS amplitude statistics to involving wide band, coherent systems that can measure high resolution images of targets as well as, in many cases, the polarization and phasing properties. This rapid growth in RCS technology has occurred because of the increased use of radar in today's commercial and military systems. In general, the goal for commercial systems is to enhance radar reflectivity, whereas the military goal is to reduce radar reflectivity. Also, classification and identification are important for military purposes because in adverse weather radar may be the only system that may be capable of separating enemy targets from friendly ones. This Section will discuss the fundamentals of RCS. Since the flight test techniques associated with RCS measurements are very similar to those of antenna pattern measurements, both will be presented at the same time in Section 19B Antenna Radiation Pattern Measurements.

Robert W Borek↗
NASA NTRS1981

The cool half of the H-R diagram in soft X-rays

The results of an Einstein Observatory program to map the occurrence of hot coronae (T greater than 1 million K) in the cool half of the Hertzsprung-Russell diagram are reported. F-M dwarfs, and late F through early K star giants characterized by 10,000 K chromospheric and 20,000-200,000 K FUV emission lines were studied in one region, while a second region study included red giants later than K2 III and supergiants later than G5 Ib with weaker chromospheric emission and no high temperature species. Program goals comprised determination of the C IV division as seen in soft X-rays, and identification of stellar parameters which distinguish strong from weak coronal X-ray sources. A summary of target stars, X-ray fluxes, and UV emission profiles is provided, and coronal emissions, comparisons of C IV and wind boundaries, hybrid-spectrum supergiants, the energy balance of stellar outer atmospheres, stellar rotation and coronae, and evolutionary considerations are discussed, along with lines of future research.

Ayres, T. R.↗
NASA NTRS2005

The Highest L(sub X)/L(sub opt) Sources in the ROSAT All-Sky Survey

The purpose of our program was to identify new and interesting soft X-ray sources from the Bright Source Catalog of the ROSAT All-Sky Survey. Our intent was to use XMM to observe a sample of BSC objects that had been identified as less than 10% likely to be associated with any object in the USNO-A2.0 catalog (Rutledge et al. 2000). We requested a single 5-ks pointing for each of 32 sources in this category in order to make a systematic examination of the properties of these sources. Ultimately, we hoped to identify new isolated neutron stars from within this population. Our requested observations were scheduled for execution at the end of Cycle 2, for two of our targets only (selected by sky position). A two-target sample does not allow for the statistical investigation that we originally proposed; however, based on the identification of the BSC object in the XMM data, an improved position, and reevaluation of likely off-band counterparts, it does enable a source-by-source evaluation of whether the BSC object is an isolated neutron star (INS).

Kulkarni, Shrinivas R.↗
NASA NTRS2012

Methods and Compositions Based on Culturing Microorganisms in Low Sedimental Fluid Shear Conditions

The benefits of applying a low sedimental fluid shear environment to manipulate microorganisms were examined. Microorganisms obtained from a low sedimental fluid shear culture, which exhibit modified phenotypic and molecular genetic characteristics, are useful for the development of novel and improved diagnostics, therapeutics, vaccines, and bio-industrial products. Furthermore, application of low sedimental fluid conditions to microorganisms permits identification of molecules uniquely expressed under these conditions, providing a basis for the design of new therapeutic targets.

Ott, C. Mark↗
NASA NTRS2012

Inferred Lunar Boulder Distributions at Decimeter Scales

Block size distributions of impact deposits on the Moon are diagnostic of the impact process and environmental effects, such as target lithology and weathering. Block size distributions are also important factors in trafficability, habitability, and possibly the identification of indigenous resources. Lunar block sizes have been investigated for many years for many purposes [e.g., 1-3]. An unresolved issue is the extent to which lunar block size distributions can be extrapolated to scales smaller than limits of resolution of direct measurement. This would seem to be a straightforward statistical application, but it is complicated by two issues. First, the cumulative size frequency distribution of observable boulders rolls over due to resolution limitations at the small end. Second, statistical regression provides the best fit only around the centroid of the data [4]. Confidence and prediction limits splay away from the best fit at the endpoints resulting in inferences in the boulder density at the CPR scale that can differ by many orders of magnitude [4]. These issues were originally investigated by Cintala and McBride [2] using Surveyor data. The objective of this study was to determine whether the measured block size distributions from Lunar Reconnaissance Orbiter Camera - Narrow Angle Camera (LROC-NAC) images (m-scale resolution) can be used to infer the block size distribution at length scales comparable to Mini-RF Circular Polarization Ratio (CPR) scales, nominally taken as 10 cm. This would set the stage for assessing correlations of inferred block size distributions with CPR returns [6].

Baloga, S. M.↗
NASA NTRS2013

GASPS--A Herschel Survey of Gas and Dust in Protoplanetary Disks: Summary and Initial Statistics

We describe a large-scale far-infrared line and continuum survey of protoplanetary disk through to young debris disk systems carried out using the ACS instrument on the Herschel Space Observatory. This Open Time Key program, known as GASPS (Gas Survey of Protoplanetary Systems), targeted approx. 250 young stars in narrow wavelength regions covering the [OI] fine structure line at 63 micron the brightest far-infrared line in such objects. A subset of the brightest targets were also surveyed in [OI]145 micron, [CII] at 157 μm, as well as several transitions of H2O and high-excitation CO lines at selected wavelengths between 78 and 180 micron. Additionally, GASPS included continuum photometry at 70, 100 and 160 micron, around the peak of the dust emission. The targets were SED Class II– III T Tauri stars and debris disks from seven nearby young associations, along with a comparable sample of isolated Herbig AeBe stars. The aim was to study the global gas and dust content in a wide sample of circumstellar disks, combining the results with models in a systematic way. In this overview paper we review the scientific aims, target selection and observing strategy of the program. We summarize some of the initial results, showing line identifications, listing the detections, and giving a first statistical study of line detectability. The [OI] line at 63 micron was the brightest line seen in almost all objects, by a factor of ∼10. Overall [OI] 63 micron detection rates were 49%, with 100% of HAeBe stars and 43% of T Tauri stars detected. A comparison with published disk dust masses (derived mainly from sub-mm continuum, assuming standard values of the mm mass opacity) shows a dust mass threshold for [OI] 63 μm detection of approx.10(exp -5) Solar M.. Normalizing to a distance of 140 pc, 84% of objects with dust masses ≥10 (exp -5) Solar M can be detected in this line in the present survey; 32% of those of mass 10(exp -6) – 10 (exp -5) Solar M, and only a very small number of unusual objects with lower masses can be detected. This is consistent with models with a moderate UV excess and disk flaring. For a given disk mass, [OI] detectability is lower for M stars compared with earlier spectral types. Both the continuum and line emission was, in most systems, spatially and spectrally unresolved and centered on the star, suggesting that emission in most cases was from the disk. Approximately 10 objects showed resolved emission, most likely from outflows. In the GASPS sample, [OI] detection rates in T Tauri associations in the 0.3–4 Myr age range were approx. 50%. For each association in the 5–20 Myr age range, approx. 2 stars remain detectable in [OI] 63 micron, and no systems were detected in associations with age >20 Myr. Comparing with the total number of young stars in each association, and assuming a ISM-like gas/dust ratio, this indicates that approx. 18% of stars retain a gas-rich disk of total mass approx. Jupiter- M for 1–4 Myr, 1–7% keep such disks for 5–10 Myr, but none are detected beyond 10–20 Myr. The brightest [OI] objects from GASPS were also observed in [OI]145 micron, [CII]157 micron and CO J = 18- 17, with detection rates of 20–40%. Detection of the [CII] line was not correlated with disk mass, suggesting it arises more commonly from a compact remnant envelope.

Herschel Space Observatory↗
NASA NTRS1989

Land image data processing requirements for the EOS era

Requirements are proposed for a hybrid approach to image analysis that combines the functionality of a general-purpose image processing system with the knowledge representation and manipulation capabilities associated with expert systems to improve the productivity of scientists in extracting information from remotely sensed image data. The overall functional objectives of the proposed system are to: (1) reduce the level of human interaction required on a scene-by-scene basis to perform repetitive image processing tasks; (2) allow the user to experiment with ad hoc rules and procedures for the extraction, description, and identification of the features of interest; and (3) facilitate the derivation, application, and dissemination of expert knowledge for target recognition whose scope of application is not necessarily limited to the image(s) from which it was derived.

Wharton, Stephen W.↗
NASA NTRS2016

Mapping of Spacecraft Atmosphere Monitor Signal to Major Constituent Abundances

The Spacecraft Atmosphere Monitor (S.A.M.) follows the JPL’s commitment to introduce and develop next-generation instrumentation concepts for sensing the air quality on manned space flights via continuous sampling, measuring, and reporting in 2s intervals on all gaseous pollutants. The S.A.M. will have two modes of operation: the Major Constituent Analysis (MCA) mode and the Trace Gas Analysis (TGA) mode. The MCA mode will report on molecular analytes such as CH4, H2O, N2, O2, Ar, and CO2 while the TGA mode will acquire minute amounts of volatile organic compounds. Both modes assess the composition of the ambient air with twenty full mass spectra per second giving rise to a substantial amount of data to be processed by a set of small footprint software stacks hosted by an on-board computer. Mass spectra will be accumulated as the number of counts recorded in a given mass-to-charge channel and converted into the absolute abundances of detected species using an efficient algorithm. The decomposition algorithm contains four units: peak identification, mass calibration, background and dead time correction, and an abundance analysis unit. The abundance analysis module identifies target species through their characteristic fragmentation patterns in the presence of molecular isobars, such as CO and N2. For example, in order to identify N2 analyte, the code will simultaneously monitor abundance ratios of the 14, 28 and 29 Th signals and will adapt to any instability caused by a decrease in ambient pressure or changes in humidity. This requirement becomes critical for instruments designed to monitor the near real-time quality of cabin air and promptly provide accurate feedbacks.

Nikolic, D.↗
NASA NTRS2019

Discovery and Vetting of Exoplanets. I. Benchmarking K2 Vetting Tools

We have adapted the algorithmic tools developed during the Kepler mission to vet the quality of transit-like signals for use on the K2 mission data. Using the four sets of publicly available light curves at MAST, we produced a uniformly vetted catalog of 772 transiting planet candidates from K2 as listed at the NASA Exoplanet Archive in the K2 Table of Candidates. Our analysis marks 676 of these as planet candidates and 96 as false positives. All confirmed planets pass our vetting tests. Sixty of our false positives are new identifications, effectively doubling the overall number of astrophysical signals mimicking planetary transits in K2 data. Most of the targets listed as false positives in our catalog show either prominent secondary eclipses, transit depths suggesting a stellar companion instead of a planet, or significant photocenter shifts during transit. We packaged our tools into the open-source, automated vetting pipeline Discovery and Vetting of Exoplanets (DAVE), designed to streamline follow-up efforts by reducing the time and resources wasted observing targets that are likely false positives. DAVE will also be a valuable tool for analyzing planet candidates from NASA's TESS mission, where several guest-investigator programs will provide independent light-curve sets—and likely many more from the community. We are currently testing DAVE on recently released TESS planet candidates and will present our results in a follow-up paper.

Kostov, Veselin B.↗
NASA NTRS2021

OSIRIS-REx Extended Mission Trajectory Design & Target Search

After jettisoning its Sample Return Capsule (SRC) containing regolith samples from the near-Earth asteroid (101955) Bennu to Earth in September 2023, the Origins, Spectral Interpretation, Resource Identification, and Security–Regolith Explorer (OSIRIS-REx) spacecraft will perform a divert maneuver and safely fly by Earth at an altitude of 250 km. SRC return and the divert maneuver officially mark the completion of the spacecraft’s primary mission; however, it will continue on in heliocentric orbit with a nearly fully-functional instrument suite and enough propellant for nearly 600 m/s Delta-V. The post-Earth flyby trajectory fortuitously enables an exciting extended mission opportunity: rendezvous with the near-Earth asteroid (99942)Apophis immediately following its historic Earth close approach in April 2029. In this paper, we detail the discovery, optimization, and analysis of the Apophis rendezvous trajectory for an extended OSIRIS-REx mission. We also present the technical approach for an alternate target search and corresponding results, assessing the alternate trajectories compared to the baseline Apophis rendezvous from a trajectory design standpoint.

Brian Sutter↗
NASA NTRS1997

Star Identification Without Attitude Knowledge: Testing with X-Ray Timing Experiment Data

As the budget for the scientific exploration of space shrinks, the need for more autonomous spacecraft increases. For a spacecraft with a star tracker, the ability to determinate attitude from a lost in space state autonomously requires the capability to identify the stars in the field of view of the tracker. Although there have been efforts to produce autonomous star trackers which perform this function internally, many programs cannot afford these sensors. The author previously presented a method for identifying stars without a priori attitude knowledge specifically targeted for onboard computers as it minimizes the necessary computer storage. The method has previously been tested with simulated data. This paper provides results of star identification without a priori attitude knowledge using flight data from two 8 by 8 degree charge coupled device star trackers onboard the X-Ray Timing Experiment.

Ketchum, Eleanor↗
NASA NTRS1994

Neural networks: Alternatives to conventional techniques for automatic docking

Automatic docking of orbiting spacecraft is a crucial operation involving the identification of vehicle orientation as well as complex approach dynamics. The chaser spacecraft must be able to recognize the target spacecraft within a scene and achieve accurate closing maneuvers. In a video-based system, a target scene must be captured and transformed into a pattern of pixels. Successful recognition lies in the interpretation of this pattern. Due to their powerful pattern recognition capabilities, artificial neural networks offer a potential role in interpretation and automatic docking processes. Neural networks can reduce the computational time required by existing image processing and control software. In addition, neural networks are capable of recognizing and adapting to changes in their dynamic environment, enabling enhanced performance, redundancy, and fault tolerance. Most neural networks are robust to failure, capable of continued operation with a slight degradation in performance after minor failures. This paper discusses the particular automatic docking tasks neural networks can perform as viable alternatives to conventional techniques.

Vinz, Bradley L.↗
NASA NTRS1991

Concurrent-scene/alternate-pattern analysis for robust video-based docking systems

A typical docking target employs a three-point design of retroreflective tape, one at each endpoint of the center-line, and one on the tip of the central post. Scenes, sensed via laser diode illumination, produce pictures with spots corresponding to desired reflection from the retroreflectors and other reflections. Control corrections for each axis of the vehicle can then be properly applied if the desired spots are accurately tracked. However, initial acquisition of these three spots (detection and identification problem) are non-trivial under a severe noise environment. Signal-to-noise enhancement, accomplished by subtracting the non-illuminated scene from the target scene illuminated by laser diodes, can not eliminate every false spot. Hence, minimization of docking failures due to target mistracking would suggest needed inclusion of added processing features pertaining to target locations. In this paper, we present a concurrent processing scheme for a modified docking target scene which could lead to a perfect docking system. Since the non-illuminated target scene is already available, adding another feature to the three-point design by marking two non-reflective lines, one between the two end-points and one from the tip of the central post to the center-line, would allow this line feature to be picked-up only when capturing the background scene (sensor data without laser illumination). Therefore, instead of performing the image subtraction to generate a picture with a high signal-to-noise ratio, a processed line-image based on the robust line detection technique (Hough transform) can be used to fuse with the actively sensed three-point target image to deduce the true locations of the docking target. This dual-channel confirmation scheme is necessary if a fail-safe system is to be realized from both the sensing and processing point-of-views. Detailed algorithms and preliminary results are presented.

Udomkesmalee, Suraphol↗
NASA NTRS2003

The Cytoskeleton and Force Response Mechanisms

The long term aim of this project was to define the mechanisms by which cells sense and respond to the physical forces experienced at 1g and missing in microgravity. Identification and characterization of the elements of the cells force response mechanism could provide pathways and molecules to serve as targets for pharmacological intervention to mitigate the pathologic effects of microgravity. Mechanical forces experienced by the organism can be transmitted to cells through molecules that allow cells to bind to the extracellular matrix and through other types of molecules which bind cells to each other. These molecules are coupled in large complexes of proteins to structural elements such as the actin cytoskeleton that give the cell the ability to sense, resist and respond to force. Application of small forces to tissue culture cells causes local elevation of intracellular calcium through stretch activated ion channels, increased tyrosine phosphorylation and a restructuring of the actin cytoskeleton. Using collagen coated iron oxide beads and strong magnets, we can apply different levels of force to cells in culture. We have found that force application causes the cells to polymerize actin at the site of mechanical deformation and unexpectedly, to depolymerize actin across the rest of the cell. Observations of GFP- actin expressing cells demonstrate that actin accumulates at the site of deformation within the first five minutes of force application and is maintained for many tens of minutes after force is removed. Consistent with the reinforcement of the cytoskeletal structures underlying the integrin-bead interaction, force also alters the motion of bound magnetic beads. This effect is seen following the removal of the magnetic field, and is only partially ablated by actin disruption with cytochalsin B. While actin is polymerizing locally at the site of force application, force also stimulates a global reduction in actin filament content within the cells. We have examined the roles of several actin filament disassembly factors in the global reduction of cellular actin filaments. The calcium regulated actin filament severing protein gelsolin is not necessary for the increased actin turnover, as cells derived from gelsolin null and wildtype mice still show a reduction in total actin filament content. Instead, our work suggests that the actin binding protein cofilin may be important for these changes in actin dynamics. Cofilin binds to and enhances the disassembly of actin filaments. Using immunological methods, we observe transient changes in the phosphorylation state of cofilin upon force application that suggests that cofilin may mediate actin filament turnover. Early after force application, cofilin is transiently dephosphorylated, activating its actin disassembly activity. Subsequently, we find a hyper-phosphorylation of cofilin, rendering it inactive. This reduction in cofilin activity may explain the stability of the force induced actin structuttes. In testing this hypothesis, we aimed to generate cells that express the constituitively active kinase (LIM-kinase) that phosphorylates cofilin. lnidial attempts in the cell lines used for the our previous studies proved unsuccessful. While we prepare this work for pubication, we are continuing to study other cell lines and tissue sources to determine whether they show a reduction in F-actin content after force application.

Allen, Philip Goodwin↗
NASA NTRS2015

Investigating Trojan Asteroids at the L4/L5 Sun-Earth Lagrange Points

Investigations of Earth's Trojan asteroids will have benefits for science, exploration, and resource utilization. By sending a small spacecraft to the Sun-Earth L4 or L5 Lagrange points to investigate near-Earth objects, Earth's Trojan population can be better understood. This could lead to future missions for larger precursor spacecraft as well as human missions. The presence of objects in the Sun-Earth L4 and L5 Lagrange points has long been suspected, and in 2010 NASA's Wide-field Infrared Survey Explorer (WISE) detected a 300 m object. To investigate these Earth Trojan asteroid objects, it is both essential and feasible to send spacecraft to these regions. By exploring a wide field area, a small spacecraft equipped with an IR camera could hunt for Trojan asteroids and other Earth co-orbiting objects at the L4 or L5 Lagrange points in the near-term. By surveying the region, a zeroth-order approximation of the number of objects could be obtained with some rough constraints on their diameters, which may lead to the identification of potential candidates for further study. This would serve as a precursor for additional future robotic and human exploration targets. Depending on the inclination of these potential objects, they could be used as proving areas for future missions in the sense that the delta-V's to get to these targets are relatively low as compared to other rendezvous missions. They can serve as platforms for extended operations in deep space while interacting with a natural object in microgravity. Theoretically, such low inclination Earth Trojan asteroids exist. By sending a spacecraft to L4 or L5, these likely and potentially accessible targets could be identified.

John, K. K.↗
NASA NTRSDate not supplied

Langley Automated Sensor Inter-calibration System (LASICS): Open Access Tools for Satellite Imager Inter-Calibration

Satellite imager calibration teams are tasked with maintaining stable measurement records to facilitate reliable monitoring of geophysical parameters and ensure dependable input for weather forecast models. Satellite imagers are neither uniformly calibrated nor radiometrically scaled to a common reference. Consistent inter-calibration between various earth-orbiting satellite imager pairs is a critical step in the creation of seamless earth-scene reflectance data records over time for input to higher level algorithms that retrieve earth system climate-sensitive properties. Each imager inherently by virtue of its optics (and associated properties like Spectral Response etc.) will have a unique measurement of the same earth-scene reflected signal. A key part of this is the identification and prediction of events where the imager pairs from their respective earth-orbits view the same stable terrestrial targets with nearly identical viewing and solar geometry. Langley Automated Sensor Inter-calibration System (LASICS) will provide the Earth remote sensing community with a foundation for the harmonization of these remote sensing records by the development of an intuitive, user-friendly, interactive web-based open access service that will leverage, an existing extensive and ever-growing database of earth-imager channel spectral response functions, on-demand capabilities for computation and visualization of spectral band adjustment factors using a variety of external hyper-spectral earth observation sources (e.g. SCIAMACHY, GOME-2 for VIS and IASI, AIRS for IR) and a variety of Solar Irradiance Spectra.

Arun Gopalan↗
NASA NTRSDate not supplied

Exploring rock-regolith interfaces in Jezero crater with Mars 2020 SHERLOC

The Perseverance rover successfully landed in Jezero crater, Mars in February 2021 at the Octavia E. Butler landing site and began its mission to explore and sample an ancient crater lake basin. Principal goals of the Mars 2020 mission include characterizing the geology of Mars and seeking signs of ancient microbial life via the spacecraft cameras and spectroscopic instruments onboard. The Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) instrument is a deep UV Raman spectrometer that utilizes a 248.6nm pulsed laser. Part of SHERLOC is a color camera known as the Wide Angle Topographic Sensor for Operations and eNgineering (WATSON). The SHERLOC suite provides coordinated, spectroscopic and imaging capabilities at high spatial resolution, to detect minerals and organic molecules in microtextural context. By pairing high spatial resolution (~100 μm) resonance Raman and native fluorescence spectroscopy with microscopic imaging in a novel spacecraft capability, SHERLOC enables texture-specific molecular composition measurements of rock and regolith targets on Mars. Coordinated rock-regolith observations illuminate unique insights into weathering processes and thereby to primary properties of rocks in Jezero crater. This work describes the potential of rock-regolith interfaces to preserve unique records of geological processes in Jezero crater and can powerfully supplement observations of the more general rock record on Mars. Linking observations of local rock texture with associated regolith reveals important lithologic information based on the interrelationship between differential weathering behavior and mineralogy, grain size, and cement chemistry. Preliminary observations indicate that the polygonally fractured lithotype common near the Octavia E. Butler landing site may weather by granular disintegration and/or surface creep, a relation that can be uniquely observed at the rock-regolith interface. SHERLOC -specific observations of microtextural and elemental composition transitions presented here trace rock-regolith boundaries at multiple indurated surfaces adjacent to regolith. At these locales, grain-scale based examinations suggest chemical weathering could be related to a variably distributed coating or rind on dark rock targets that may be mafic in composition. Granule deposits overlying widely distributed fine-grained material are also observable. Mineral identifications of each phase are presented, with cross-scale comparisons to the remote insights gained by the SuperCam instrument.

Emily L. Cardarelli↗
NASA NTRS2001

Extracellular calcium sensing and extracellular calcium signaling

The cloning of a G protein-coupled extracellular Ca(2+) (Ca(o)(2+))-sensing receptor (CaR) has elucidated the molecular basis for many of the previously recognized effects of Ca(o)(2+) on tissues that maintain systemic Ca(o)(2+) homeostasis, especially parathyroid chief cells and several cells in the kidney. The availability of the cloned CaR enabled the development of DNA and antibody probes for identifying the CaR's mRNA and protein, respectively, within these and other tissues. It also permitted the identification of human diseases resulting from inactivating or activating mutations of the CaR gene and the subsequent generation of mice with targeted disruption of the CaR gene. The characteristic alterations in parathyroid and renal function in these patients and in the mice with "knockout" of the CaR gene have provided valuable information on the CaR's physiological roles in these tissues participating in mineral ion homeostasis. Nevertheless, relatively little is known about how the CaR regulates other tissues involved in systemic Ca(o)(2+) homeostasis, particularly bone and intestine. Moreover, there is evidence that additional Ca(o)(2+) sensors may exist in bone cells that mediate some or even all of the known effects of Ca(o)(2+) on these cells. Even more remains to be learned about the CaR's function in the rapidly growing list of cells that express it but are uninvolved in systemic Ca(o)(2+) metabolism. Available data suggest that the receptor serves numerous roles outside of systemic mineral ion homeostasis, ranging from the regulation of hormonal secretion and the activities of various ion channels to the longer term control of gene expression, programmed cell death (apoptosis), and cellular proliferation. In some cases, the CaR on these "nonhomeostatic" cells responds to local changes in Ca(o)(2+) taking place within compartments of the extracellular fluid (ECF) that communicate with the outside environment (e.g., the gastrointestinal tract). In others, localized changes in Ca(o)(2+) within the ECF can originate from several mechanisms, including fluxes of calcium ions into or out of cellular or extracellular stores or across epithelium that absorb or secrete Ca(2+). In any event, the CaR and other receptors/sensors for Ca(o)(2+) and probably for other extracellular ions represent versatile regulators of numerous cellular functions and may serve as important therapeutic targets.

Review↗