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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,639 records · Page 91
All sourcesNASA NTRSDOE OSTI
DOE OSTI2017

Molecular mechanisms of 3,3′4,4′,5-pentachlorobiphenyl-induced epithelial-mesenchymal transition in human hepatocellular carcinoma cells

Polychlorinated biphenyls (PCBs) are classic persistent organic pollutants (POPs). Many studies have found a positive association between the progression of hepatocellular carcinoma (HCC) and PCBs exposure. However, the influence of PCBs on epithelial-mesenchymal transition (EMT) of HCC remains to be unclear. In this study, we explored the effect of PCB126 on EMT in HCC cells and its underlying mechanisms. The data showed that PCB126, exposing both Bel-7402 and SMMC-7721 cells for 48 h, promoted EMT that was demonstrated by E-cadherin repression, up-regulation of N-cadherin and vimentin, and morphological alteration. We found that signal transducer and activator of transcription 3 (STAT3)/Snail1 signaling was activated after PCB126 exposure, and the addition of STAT3 inhibitor WP1066 blocked PCB126-induced down-regulation of E-cadherin as well as up-regulation of N-cadherin and vimentin. Moreover, PCB126 exposure increased pyruvate kinase M2 (PKM2) expression and its nuclear translocation, whereas treatment with PKM2 shRNA suppressed the activation of STAT3/Snail1 signaling and the alternation of EMT-related molecules (E-cadherin, N-cadherin and vimentin). Furthermore, this study indicated estrogen receptor (ER) and aryl hydrocarbon receptor (AhR) were involved in PCB126-induced effects on PKM2, STAT3/Snail1 signaling and EMT by according treatment using ER inhibitor ICI and AhR shRNA. Notably, PCB126-increased reactive oxygen species (ROS) production via AhR is associated with activation of PKM2/STAT3/Snail1 cascades and contributes to EMT. Taken together, these results indicated that PCB126 promotes EMT process of HCC cells via PKM2/STAT3/Snail1 signaling which is mediated by ER and AhR. - Highlights: • PCB126 promotes epithelial-mesenchymal transition of HCC cells. • PCB126 regulates EMT through the activation of STAT3/Snail1 signaling. • PKM2 is responsible for PCB126-induced activation of STAT3/Snail1 signaling. • AhR-induced ROS generation regulates PKM2/STAT3/Snail1 signaling. • PCB126-induced EMT is mediated by ER and AhR.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2019

Incomplete tumor capsule on preoperative imaging reveals microvascular invasion in hepatocellular carcinoma: a systematic review and meta-analysis

Purpose: Microvascular invasion (MVI), which is difficult to diagnose before surgery, is a major factor affecting postoperative recurrence in patients with hepatocellular carcinoma (HCC). The relationship between the radiological tumor capsule and MVI is controversial. This study aimed to evaluate the association between the tumor capsule and MVI. Methods: We searched Medline (by PubMed) and Embase (by OvidSP). Two review authors independently screened titles and abstracts, selected studies about MVI prediction with radiologic tumor capsule and studies with enough data for extracted, assessed the methodological quality and collected data. Summary results were presented as the diagnostic odds ratio (DOR), sensitivity, specificity, and 95% confidence interval. Results: Fifteen studies with 2038 patients were included; fourteen studies, including 1331 patients, with no significant heterogeneity indicated no relationship between absent tumor capsule and MVI [DOR = 0.90 (0.64, 1.26)]. Six studies, including 541 patients, with no significant heterogeneity showed incomplete capsule could be used to predict MVI of HCC preoperatively [DOR = 1.85 (1.13, 3.04)]. The overall sensitivity and specificity estimate were 0.50 (0.37, 0.64) and 0.64 (0.53, 0.74), respectively. Eight studies, including 1349 patients, with highly significant heterogeneity revealed that complete capsule could be a protective factor for MVI [DOR = 1.97 (1.01, 3.86)]. Conclusions: For MVI of HCC, incomplete tumor capsule is a risk factor, while a complete tumor capsule might be a protective factor. However, absent capsule doesn’t show significant relationship with MVI. This might be due to combination of the risk and protective effects of present capsule in MVI.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
NASA NTRS2001

On the Numerical Study of Heavy Rainfall in Taiwan

Heavy rainfall events are frequently observed over the western side of the CMR (central mountain range), which runs through Taiwan in a north-south orientation, in a southwesterly flow regime and over the northeastern side of the CMR in a northeasterly flow regime. Previous studies have revealed the mechanisms by which the heavy rainfall events are formed. Some of them have examined characteristics of the heavy rainfall via numerical simulations. In this paper, some of the previous numerical studies on heavy rainfall events around Taiwan during the Mei-Yu season (May and June), summer (non-typhoon cases) and autumn will be reviewed. Associated mechanisms proposed from observational studies will be reviewed first, and then characteristics of numerically simulated heavy rainfall events will be presented. The formation mechanisms of heavy rainfall from simulated results and from observational analysis are then compared and discussed. Based on these previous modeling studies, we will also discuss what are the major observations and modeling processes which will be needed for understanding the heavy precipitation in the future.

Tao, Wei-Kuo↗
NASA NTRS1989

A CO and far-infrared study of the S254-S258 region

The molecular cloud associated with compact radio and bright optical H II regions is studied from observations of (C-12)O, (C-13)O, HCN J = 1-0 emission. The far-infrared and millimeter molecular line emission from the S254-S258 molecular cloud is analyzed, using co-added survey data from IRAS, to investigate the coupling between the dust and gas components and the internal energetics associated with molecular clouds. The dust component is analyzed by fitting model intensities, derived from a dust mass column density temperature relation, to the observed far-infrared emission. Such modeling is shown to provide a more complete description of the cold dust component which comprises most of the dust mass than can be determined from the standard single temperature analysis. Local heating of the dust component by newborn massive stars associated with the H II regions of the cloud is inferred from the spatial distribution of temperatures of grains which make the largest contributions to the observed 60 and 100 micron emission.

Heyer, Mark H.↗
DOE OSTI2016

Toward an Understanding of the Environmental and Public Health Impacts of Unconventional Natural Gas Development: A Categorical Assessment of the Peer-Reviewed Scientific Literature, 2009-2015

The body of science evaluating the potential impacts of unconventional natural gas development (UNGD) has grown significantly in recent years, although many data gaps remain. Still, a broad empirical understanding of the impacts is beginning to emerge amidst a swell of research. The present categorical assessment provides an overview of the peer reviewed scientific literature from 2009–2015 as it relates to the potential impacts of UNGD on public health, water quality, and air quality. We have categorized all available original research during this time period in an attempt to understand the weight and direction of the scientific literature. Our results indicate that at least 685 papers have been published in peer-reviewed scientific journals that are relevant to assessing the impacts of UNGD. 84% of public health studies contain findings that indicate public health hazards, elevated risks, or adverse health outcomes; 69% of water quality studies contain findings that indicate potential, positive association, or actual incidence of water contamination; and 87% of air quality studies contain findings that indicate elevated air pollutant emissions and/or atmospheric concentrations. This paper demonstrates that the weight of the findings in the scientific literature indicates hazards and elevated risks to human health as well as possible adverse health outcomes associated with UNGD. There are limitations to this type of assessment and it is only intended to provide a snapshot of the scientific knowledge based on the available literature. However, this work can be used to identify themes that lie in or across studies, to prioritize future research, and to provide an empirical foundation for policy decisions.

03 NATURAL GAS↗
NASA NTRS1979

Dynamics of severe storms through the study of thermospheric-tropospheric coupling

Atmospheric acoustic-gravity waves associated with severe local thunderstorms, tornadoes, and hurricanes can be studied through the coupling between the thermosphere and the troposphere. Reverse group ray tracing computations of acoustic-gravity waves, observed by an ionospheric Doppler sounder array, show that the wave sources are in the neighborhood of storm systems and the waves are excited prior to the storms. It is suggested that the overshooting and ensuing collapse of convective turrets may be responsible for generating the acoustic-gravity waves observed. The results of this study also show that the study of wave-wave resonant interactions may be a potential tool for investigating the dynamical behavior of severe storm systems using ionospheric observations of atmospheric acoustic-gravity waves associated with severe storms.

Hung, R. J.↗
DOE OSTI2015

Impact on Patient Safety and Satisfaction of Implementation of an Outpatient Clinic in Interventional Radiology (IPSIPOLI-Study): A Quasi-Experimental Prospective Study

PurposeInterventional radiology (IR) procedures are associated with high rates of preparation and planning errors. In many centers, pre-procedural consultation and screening of patients is performed by referring physicians. Interventional radiologists have better knowledge about procedure details and risks, but often only get acquainted with the patient in the procedure room. We hypothesized that patient safety (PS) and patient satisfaction (PSAT) in elective IR procedures would improve by implementation of a pre-procedural visit to an outpatient IR clinic.Material and MethodsIRB approval was obtained and informed consent was waived. PS and PSAT were measured in patients undergoing elective IR procedures before (control group; n = 110) and after (experimental group; n = 110) implementation of an outpatient IR clinic. PS was measured as the number of process deviations. PSAT was assessed using a questionnaire measuring Likert scores of three dimensions: interpersonal care aspects, information/communication, and patient participation. Differences in PS and PSAT between the two groups were compared using an independent t test.ResultsThe average number of process deviations per patient was 0.39 in the control group compared to 0.06 in the experimental group (p < 0.001). In 9.1 % patients in the control group, no legal informed consent was obtained compared to 0 % in the experimental group. The mean overall Likert score was significantly higher in the experimental group compared to the control group: 2.68 (SD 0.314) versus 2.48 (SD 0.381) (p < 0.001).ConclusionPS and PSAT improve significantly if patients receive consultation and screening in an IR outpatient clinic prior to elective IR procedures.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2020

Chemical changes in thirdhand smoke associated with remediation using an ozone generator

Ozonation is a common remediation approach to eliminate odors from mold, tobacco and fire damage in buildings. Little information exists to: 1) assess its effectiveness; 2) provide guidance on operation conditions; and 3) identify potential risks associated with the presence of indoor ozone and ozonation byproducts. The goal of this study is to evaluate chemical changes in thirdhand smoke (THS) aerosols induced by high levels of ozone, in comparison with THS aerosols aged under similar conditions in the absence of ozone. Samples representing different stages of smoke aging in the absence of ozone, including freshly emitted secondhand smoke (SHS) and THS, were collected inside an 18-m 3 room-sized chamber over a period of 42 h after six cigarettes were consumed. The experiments involved collection and analysis of gas phase species including volatile organic compounds (VOCs), volatile carbonyls, semivolatile organic compounds (SVOCs), and particulate matter. VOC analysis was carried out by gas chromatography/mass spectrometry with a thermal desorption inlet (TD-GC/MS), and volatile carbonyls were analyzed by on-line derivatization with dinitrophenylhydrazine (DNPH), followed by liquid chromatography with UV/VIS detection. SVOCs were extracted from XAD-coated denuders and Teflon-coated fiberglass filters in the absence of ozone. In those extracts, tobacco-specific nitrosamines (TSNAs) and other SVOCs were analyzed by gas chromatography with positive chemical ionization-triple quadrupole mass spectrometric detection (GC/PCI-QQQ-MS), and polycyclic aromatic hydrocarbons (PAHs) were quantified by gas chromatography with ion trap mass spectrometric detection (GC/IT-MS) in selected ion monitoring mode. Particulate matter concentration was determined gravimetrically. In a second experiment, a 300 mg h -1 commercial ozone generator was operated during 1 h, one day after smoke was generated, to evaluate the remediation of THS by ozonation. VOCs and volatile carbonyls were analyzed before and after ozonation. Extracts from fabrics that were exposed in the chamber before and after ozonation as surrogates for indoor furnishings were analyzed by GC/IT-MS, and aerosol size distribution was studied with a scanning mobility particle sizer. Ozone concentration was measured with a photometric detector. An estimated 175 mg ozone reacted with THS after 1 h of treatment, corresponding to 58% of the total O 3 released during that period. Fabric-bound nicotine was depleted after ozonation, and the surface concentration of PAHs adsorbed to fabric specimens decreased by an order of magnitude due to reaction with ozone, reaching pre-smoking levels. These results suggest that ozonation has the potential to remove harmful THS chemicals from indoor surfaces. However, gas phase concentrations of volatile carbonyls, including formaldehyde, acetaldehyde and acetone were higher immediately after ozonation. Ultrafine particles (UFP, in most cases with size <60 nm) were a major ozonation byproduct. UFP number concentrations peaked shortly after ozonation ended, and remained at higher-than background levels for several hours. Based on these results, minimum re-entry times after ozone treatment were predicted for different indoor scenarios. Clearly defining re-entry times can serve as a practical measure to prevent acute exposures to ozone and harmful ozonation byproducts after treatment. This study evaluated potential benefits and risks associated with THS remediation using ozone, providing insights into this technology.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2013

Psychosocial Modeling of Insider Threat Risk Based on Behavioral and Word Use Analysis

In many insider crimes, managers and other coworkers observed that the offenders had exhibited signs of stress, disgruntlement, or other issues, but no alarms were raised. Barriers to using such psychosocial indicators include the inability to recognize the signs and the failure to record the behaviors so that they can be assessed. A psychosocial model was developed to assess an employee’s behavior associated with an increased risk of insider abuse. The model is based on case studies and research literature on factors/correlates associated with precursor behavioral manifestations of individuals committing insider crimes. A complementary Personality Factor modeling approach was developed based on analysis to derive relevant personality characteristics from word use. Several implementations of the psychosocial model were evaluated by comparing their agreement with judgments of human resources and management professionals; the personality factor modeling approach was examined using email samples. If implemented in an operational setting, these models should be part of a set of management tools for employee assessment to identify employees who pose a greater insider threat.

behavioral modeling↗
DOE OSTI2019

Verification of Feasibility Studies at High-Technology Enterprises

Innovation and investment in the development of high-technology enterprises must be preceded by thorough feasibility studies. The potential errors in the associated management decisions may be categorized. In the light of such potential errors, feasibility studies must be verified by qualified and impartial experts, with a final verdict regarding the presence or absence of significant errors and perhaps recommendations for improvement. In the present work, the most common approaches to expert verification are categorized, and proposals are made regarding the development and synergetic combination of such methods.

42 ENGINEERING↗
DOE OSTI2022

Different feeding patterns affect meat quality of Tibetan pigs associated with intestinal microbiota alterations

This study aimed to investigate the effects of different feeding patterns on meat quality, gut microbiota and its metabolites of Tibetan pigs. Tibetan pigs with similar body weight were fed the high energy diets ( HEP , 20 pigs) and the regular diets ( RFP , 20 pigs), and free-ranging Tibetan pigs ( FRP , 20 pigs) were selected as the reference. After 6 weeks of experiment, meat quality indexes of semitendinosus muscle ( SM ) and cecal microbiota were measured. The results of meat quality demonstrated that the shear force of pig SM in FRP group was higher than that in HEP and RFP groups ( p < 0.001); the pH-value of SM in HEP pigs was higher at 45 min ( p < 0.05) and lower at 24 h ( p < 0.01) after slaughter than that in FRP and RFP groups; the SM lightness ( L* value) of FRP pigs increased compared with RFP and HEP groups ( p < 0.001), while the SM redness ( a* value) of FRP pigs was higher than that of RFP group ( p < 0.05). The free fatty acid ( FA ) profile exhibited that the total FAs and unsaturated FAs of pig SM in HEP and RFP groups were higher than those in FRP group ( p < 0.05); the RFP pigs had more reasonable FA composition with higher n-3 polyunsaturated FAs ( PUFAs ) and lower n-6/n-3 PUFA ratio than HEP pigs ( p < 0.05). Based on that, we observed that Tibetan pigs fed high energy diets (HEP) had lower microbial α-diversity in cecum ( p < 0.05), and distinct feeding patterns exhibited a different microbial cluster. Simultaneously, the short-chain FA levels in cecum of FRP and RFP pigs were higher compared with HEP pigs ( p < 0.05). A total of 11 genera related to muscle lipid metabolism or meat quality, including Alistipes , Anaerovibrio , Acetitomaculun , etc., were identified under different feeding patterns ( p < 0.05). Spearman correlation analysis demonstrated that alterations of free FAs in SM were affected by the genera Prevotellaceae_NK3B31_group , Prevotellaceae UCG-003 and Christensenellaceae_R-7_group ( p < 0.05). Taken together, distinct feeding patterns affected meat quality of Tibetan pigs related to gut microbiota alterations.

Zhu, Yanbin↗
NASA NTRS1975

STOL aircraft transient ground effects. Part 2: Experimental techniques feasibility study

Procedures for simulating transient effects associated with STOL aircraft landings and takeoffs were examined and a basis was developed for selection of an experimental approach based on consideration of simulation requirements, experimental techniques, facilities, and costs. The results are generally applicable to STOL aircraft employing any of the following powered lift systems: externally blown flap, upper surface blown flap, augmentor wing, or internally ducted jet flap. Scaling relationships were developed to apply the simulation requirements to model test situations. Procedures for the derivation of aerodynamic forces from the measured data were discussed. Various means of expressing the aerodynamic data in forms convenient for use in performance or stability and control applications were described. Five different experimental techniques were presented that depend on two different types of experimental facilities, wind tunnels and test tracks, and involving different types of model motion, and factors pertinent to selection were summarized.

Crowder, J. P.↗
NASA NTRS1978

Some heat transfer and hydrodynamic problems associated with superconducting cables (SPTL)

To study some effects of thermogravitation on (CIIK-SPTL) systems, a heated tube experiment was set up at Krzhizhanovsky Power Engineering Institute Moscow, U.S.S.R. Heat transfer data were taken with fluid helium flowing through a 2.85 m, 19 mm diameter uniformly heated horizontal tube. Temperatures were measured on the top and bottom of the tube at six axial locations with three other circumferential measurements made at (X/L) =57. Typical temperature profiles show significant variations both axially and circumferentially. The data are grouped using reduced Nusselt number (NuR) and the bulk expansion parameter for each axial location. The average data for 0.26 less than or equal to X/L less than or equal to 0.76 follow a power law relation with the average expansion parameter. System instabilities are noted and discussed. Future work including heat transfer in coaxial cylinders is discussed.

Hendricks, R. C.↗
NASA NTRS1983

Shuttle derived vehicle analysis solid booster unmanned launch vehicle concept definition study, volume 2

The technical effort associated with the selection and definition of the recommended SRB-X concept is documented. Included are discussions concerning the trades leading to the selected concept, the analysis that established the concept's basic subsystem characteristics, selected configuration description and performance capabilities, launch site operations and facility needs, development schedule, cost characteristics, risk assessment, and a cursory comparison with other launch systems.

Source record↗
NASA NTRS1984

Supersonic jet shock noise reduction

Shock-cell noise is identified to be a potentially significant problem for advanced supersonic aircraft at takeoff. Therefore NASA conducted fundamental studies of the phenomena involved and model-scale experiments aimed at developing means of noise reduction. The results of a series of studies conducted to determine means by which supersonic jet shock noise can be reduced to acceptable levels for advanced supersonic cruise aircraft are reviewed. Theoretical studies were conducted on the shock associated noise of supersonic jets from convergent-divergent (C-D) nozzles. Laboratory studies were conducted on the influence of narrowband shock screech on broadband noise and on means of screech reduction. The usefulness of C-D nozzle passages was investigated at model scale for single-stream and dual-stream nozzles. The effect of off-design pressure ratio was determined under static and simulated flight conditions for jet temperatures up to 960 K. Annular and coannular flow passages with center plugs and multi-element suppressor nozzles were evaluated, and the effect of plug tip geometry was established. In addition to the far-field acoustic data, mean and turbulent velocity distributions were measured with a laser velocimeter, and shadowgraph images of the flow field were obtained.

Stone, J. R.↗
NASA NTRS1985

Coronal propagation of flare associated electrons and protons

A statistical study of characteristic times and intensities of 36 solar particle events observed between 1977 and 1979 by the Kiel Cosmic Ray Experiment on board HELIOS-1 and -2 has been carried out. For approx. 0.5 MeV electrons we order the times of maximum and the absolute intensities with respect to angular distance from the parent flare. Discussion of coronal parameters in terms of Reid's model leads to typical time constants for coronal diffusion and escape.

Schellert, G.↗