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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,675 records · Page 93
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Integrative Multi-PTM Proteomics Reveals Dynamic Global, Redox, Phosphorylation, and Acetylation Regulation in Cytokine-treated Pancreatic Beta Cells

Studying regulation of protein function at a systems level necessitates an understanding of the interplay among diverse post-translational modifications (PTMs). A variety of proteomics sample processing workflows are currently used to study specific PTMs but rarely characterize multiple types of PTMs from the same sample inputs. Method incompatibilities and laborious sample preparation steps complicate large-scale physiological investigations and can lead to variations in results. The single-pot, solid-phase-enhanced sample preparation (SP3) method for sample cleanup is compatible with different lysis buffers and amenable to automation, making it attractive for high-throughput multi-PTM profiling. Herein, we describe an integrative SP3 workflow for multiplexed quantification of protein abundance, cysteine thiol oxidation, phosphorylation, and acetylation. The broad applicability of this approach is demonstrated using cell and tissue samples, and its utility for studying interacting regulatory networks is highlighted in a time-course experiment of cytokine-treated ß-cells. We observed a swift response in global regulation of protein abundances consistent with rapid activation of JAK-STAT and NF-?B signaling pathways. Regulators of these pathways as well as proteins involved in their target processes displayed multi-PTM dynamics indicative of a complex cellular response stages: acute, adaptation, and chronic (prolonged stress). PARP14, a negative regulator of JAK-STAT, had multiple co-localized PTMs that may be involved in intraprotein regulatory crosstalk. Our workflow provides a high-throughput platform that can profile multi-PTMomes from the same sample set, which is valuable in unraveling the functional roles of PTMs and their co-regulation.

proteomics, PTM, automation, SP3, cysteine thiol o↗
DOE OSTI2017

Bayesian and variational Bayesian approaches for flows in heterogeneous random media

In this paper, we study porous media flows in heterogeneous stochastic media. We propose an efficient forward simulation technique that is tailored for variational Bayesian inversion. As a starting point, the proposed forward simulation technique decomposes the solution into the sum of separable functions (with respect to randomness and the space), where each term is calculated based on a variational approach. This is similar to Proper Generalized Decomposition (PGD). Next, we apply a multiscale technique to solve for each term (as in ) and, further, decompose the random function into 1D fields. As a result, our proposed method provides an approximation hierarchy for the solution as we increase the number of terms in the expansion and, also, increase the spatial resolution of each term. We use the hierarchical solution distributions in a variational Bayesian approximation to perform uncertainty quantification in the inverse problem. We conduct a detailed numerical study to explore the performance of the proposed uncertainty quantification technique and show the theoretical posterior concentration.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
NASA NTRS1976

Vibroacoustic test plan evaluation: Parameter variation study

Statistical decision models are shown to provide a viable method of evaluating the cost effectiveness of alternate vibroacoustic test plans and the associated test levels. The methodology developed provides a major step toward the development of a realistic tool to quantitatively tailor test programs to specific payloads. Testing is considered at the no test, component, subassembly, or system level of assembly. Component redundancy and partial loss of flight data are considered. Most and probabilistic costs are considered, and incipient failures resulting from ground tests are treated. Optimums defining both component and assembly test levels are indicated for the modified test plans considered. modeling simplifications must be considered in interpreting the results relative to a particular payload. New parameters introduced were a no test option, flight by flight failure probabilities, and a cost to design components for higher vibration requirements. Parameters varied were the shuttle payload bay internal acoustic environment, the STS launch cost, the component retest/repair cost, and the amount of redundancy in the housekeeping section of the payload reliability model.

Stahle, C. V.↗
NASA NTRS1987

Global petrologic variations on the moon - A ternary-diagram approach

An improved method for global petrologic mapping of the moon is presented, which uses a color-coded ternary diagram whose apexes are assigned the average Fe and Th/Ti ratio (normalized to chondrites) compositions of KREEP/Mg-suite rocks, mare basalts, and ferroan anorthosites. The composition of each pixel within these Apollo orbital gamma ray data bases is used to determine its position within the ternary diagram. The color corresponding to this ternary position is then placed on a classification map at that pixel's position within the orbital data bases. The resultant classification map shows spatial transitions among petrologic units, allows direct determination of the relative proportions of each end-member composition in a pixel, and provides more geologic information than can be obtained by using only the elemental data. The map units correspond remarkably well to previously delineated geologic provinces.

Davis, Philip A.↗
NASA NTRS2011

Scatterometer-Calibrated Stability Verification Method

The requirement for scatterometer-combined transmit-receive gain variation knowledge is typically addressed by sampling a portion of the transmit signal, attenuating it with a known-stable attenuation, and coupling it into the receiver chain. This way, the gain variations of the transmit and receive chains are represented by this loop-back calibration signal, and can be subtracted from the received remote radar echo. Certain challenges are presented by this process, such as transmit and receive components that are outside of this loop-back path and are not included in this calibration, as well as the impracticality for measuring the transmit and receive chains stability and post fabrication separately, without the resulting measurement errors from the test set up exceeding the requirement for the flight instrument. To cover the RF stability design challenge, the portions of the scatterometer that are not calibrated by the loop-back, (e.g., attenuators, switches, diplexers, couplers, and coaxial cables) are tightly thermally controlled, and have been characterized over temperature to contribute less than 0.05 dB of calibration error over worst-case thermal variation. To address the verification challenge, including the components that are not calibrated by the loop-back, a stable fiber optic delay line (FODL) was used to delay the transmitted pulse, and to route it into the receiver. In this way, the internal loopback signal amplitude variations can be compared to the full transmit/receive external path, while the flight hardware is in the worst-case thermal environment. The practical delay for implementing the FODL is 100 s. The scatterometer pulse width is 1 ms so a test mode was incorporated early in the design phase to scale the 1 ms pulse at 100-Hz pulse repetition interval (PRI), by a factor of 18, to be a 55 s pulse with 556 s PRI. This scaling maintains the duty cycle, thus maintaining a representative thermal state for the RF components. The FODL consists of an RF-modulated fiber-optic transmitter, 20 km SMF- 28 standard single-mode fiber, and a photodetector. Thermoelectric cooling and insulating packaging are used to achieve high thermal stability of the FODL components. The chassis was insulated with 1-in. (.2.5-cm) thermal isolation foam. Nylon rods support the Micarta plate, onto which are mounted four 5-km fiber spool boxes. A copper plate heat sink was mounted on top of the fiber boxes (with thermal grease layer) and screwed onto the thermoelectric cooler plate. Another thermal isolation layer in the middle separates the fiberoptics chamber from the RF electronics components, which are also mounted on a copper plate that is screwed onto another thermoelectric cooler. The scatterometer subsystem fs overall stability was successfully verified to be calibratable to within 0.1 dB error in thermal vacuum (TVAC) testing with the fiber-optic delay line, while the scatterometer temperature was ramped from 10 to 30 C, which is a much larger temperature range than the worst-case expected seasonal variations.

McWatters, Dalia A.↗
NASA NTRS1973

A study of the diurnal variation in the thermosphere as derived by satellite drag

An analysis was performed on 29,574 densities derived from the drag of 10 satellites to determine simultaneously the parameters of the solar-activity effect in the thermosphere on the one hand, and the amplitude and shape of the diurnal-variation curve on the other. This paper reports on the study of the diurnal variation only. Although a considerable amount of smoothing is inherent in the drag method, it seemed useful to see whether any change could be detected in the shape of the diurnal-variation curve with height, latitude and solar activity. None was detected; the curve remains remarkably stable, symmetric, with a maximum at 14 hr 20 min L.S.T. and a minimum at 2 hr 20 min L.S.T. A systematic variation of the temperature range with height is observed when static models are used to derive it.

Jacchia, L. G.↗
NASA NTRS1996

A Green's function method for high charge and energy ion transport

A heavy-ion transport code using Green's function methods is developed. The low-order perturbation terms exhibiting the greatest energy variation are used as dominant energy-dependent terms, and the higher order collision terms are evaluated using nonperturbative methods. The recently revised NUCFRG database is used to evaluate the solution for comparison with experimental data for 625A MeV 20Ne and 517A MeV 40Ar ion beams. Improved agreements with the attenuation characteristics for neon ions are found, and reasonable agreement is obtained for the transport of argon ions in water.

Energy Transfer↗
DOE OSTI2021

A Nonstationary and Non-Gaussian Moving Average Model for Solar Irradiance

Historically, power has flowed from large power plants to customers. Increasing penetration of distributed energy resources such as solar power from rooftop photovoltaic has made the distribution network a two-way-street with power being generated at the customer level. The incorporation of renewables introduces additional uncertainty and variability into the power grid. Distribution network operation studies are being adapted to include renewables; however, such studies require high quality solar irradiance data that adequately reflect realistic meteorological variability. Data from satellite-based products are spatially complete, but temporally coarse, whereas solar irradiances exhibit high frequency variation at very fine timescales. We propose a new stochastic method for temporally downscaling global horizontal irradiance (GHI) to 1 min resolution, but we do not consider the spatial aspect due to limited availability of the in situ irradiance measurements. Solar irradiance's first and second-order structures vary diurnally and seasonally, and our model adapts to such nonstationarity. Empirical irradiance data exhibits highly non-Gaussian behavior; we develop a nonstationary and non-Gaussian moving average model that is shown to capture realistic solar variability at multiple timescales. We also propose a new estimation scheme based on Cholesky factors of empirical autocovariance matrices, bypassing difficult and inaccessible likelihood-based approaches. The model is demonstrated for a case study of three locations that are located in diverse climates through the United States. The model is compared against competitors from the literature and is shown to provide better uncertainty and variability quantification on testing data.

Cholesky factor↗
NASA NTRS1986

A second-order accurate kinetic-theory-based method for inviscid compressible flows

An upwind method for the numerical solution of the Euler equations is presented. This method, called the kinetic numerical method (KNM), is based on the fact that the Euler equations are moments of the Boltzmann equation of the kinetic theory of gases when the distribution function is Maxwellian. The KNM consists of two phases, the convection phase and the collision phase. The method is unconditionally stable and explicit. It is highly vectorizable and can be easily made total variation diminishing for the distribution function by a suitable choice of the interpolation strategy. The method is applied to a one-dimensional shock-propagation problem and to a two-dimensional shock-reflection problem.

Deshpande, Suresh M.↗
DOE OSTI2018

Near-infrared and blue cooperative Yb3+ luminescence in Lu3Sc2Ga3O12 nano-garnets

Highlights: • Lu{sub 3}Sc{sub 2}Ga{sub 3}O{sub 12} nano-garnets doped with Yb{sup 3+} ions were synthesized by sol-gel method. • Concentration dependent structural and luminescence properties were investigated. • Variation of blue cooperative luminescence as a function of laser pump power has been studied. • Mechanism of blue cooperative luminescence of Yb{sup 3+} ions in these nano-garnets has been described. - Abstract: Nanocrystalline Lu{sub 3}Sc{sub 2}Ga{sub 3}O{sub 12} garnet powders doped with different concentrations of trivalent ytterbium (Yb{sup 3+}) ions have been prepared by sol-gel method. These garnet nano-powders have been characterized for their structural and luminescence properties using X-ray diffraction, diffuse reflectance and luminescence spectra. Near-infrared and blue cooperative upconversion luminescence spectra and decay curves of Yb{sup 3+} ions in these nano-garnets have been measured as a function of the optically active ion concentration. Quenching of near-infrared and cooperative luminescence intensity beyond 5.0 mol% of Yb{sup 3+} ion concentration have been observed. Variation of blue cooperative luminescence intensity with pump power has also been discussed.

77 NANOSCIENCE AND NANOTECHNOLOGY↗
NASA NTRS2004

Method and Apparatus for Determining Changes in Intracranial Pressure Utilizing Measurement of the Circumferential Expansion or Contraction of a Patient's Skull

A method and apparatus for measuring changes in intracranial pressure (ICP) utilizing the variation of the surface wave propagation parameters of the patient's skull to determine the change in ICP. In one embodiment, the method comprises the steps of transmitting an ultrasonic bulk compressional wave onto the surface of the skull at a predetermined angle with respect to the skull so as to produce a surface wave, receiving the surface wave at an angle with respect tn the skull which is substantially the same as the predetermined angle and at a location that is a predetermined distance from where the ultrasonic bulk compressional wave was transmitted upon the skull, determining the retardation or advancement in phase of the received surface wave with respect to a reference phase, and processing the determined retardation or advancement in phase to determine circumferential expansion or contraction of the skull and utilizing the determined circumferential change to determine the change in intracranial pressure.

William T Yost↗
NASA NTRS1971

A neutral particle wake method for measuring the atmospheric temperature from a satellite

A method is described that permits a satellite-borne neutral mass spectrometer to perform measurements of the atmospheric temperature. The method employs the spectrometer to examine the partial pressure variations that occur as the wake of a small rectangular baffle is swept across the entrance orifice of the spectrometer. For a given baffle size and mounting distance from the orifice the depth of the resulting pressure minimum depends only upon the thermal velocity, or temperature, of the observed species. A check upon the validity of the method is obtained by measuring the wake characteristics of more than one species and/or by employing each of several baffle sizes.

Brace, L. H.↗
NASA NTRS2021

Experimental and Computational Investigation of Flow Boiling in Microgravity

This study explores use of Computational Fluid Dynamics (CFD) to predict near-saturated flow boiling of FC-72 in microgravity. The computational method employs transient analysis to predict detailed interfacial behavior and heat transfer characteristics along a rectangular channel heated along two opposite walls. Predicted results are validated against experimental temperature measurements and high-speed video images captured during a series of parabolic aircraft maneuvers for three sets of operating conditions which include variations of both mass velocity and wall heat flux. The computational method is based on the multi-phase volume of fluid (VOF) model, which is combined with appropriate phase change and turbulence models, and accounts for both shear-lift force on bubbles and conjugate heat transfer along the heating walls. A key advantage of the CFD method is ability to capture details that are very difficult to measure experimentally, including detailed spatial variations of bubble shape, void fraction, mixture fluid temperature, liquid velocity, and vapor velocity, results for which are presented for each of the three test cases. Different flow regimes predicted along the heated length exhibit a number of dominant mechanisms including bubble nucleation, bubble growth, coalescence, vapor blankets, interfacial waviness, and residual liquid sub-layer, all of which agree well with experiment. Vapor velocity is shown to increase appreciably along the heated length because of increased void fraction, while liquid velocity experiences large fluctuations. Non-equilibrium effects are accentuated with increasing mass velocity, contributing minor deviations of fluid temperature from simulations compared to those predicted by the analytical method. Predicted wall temperature is fairly uniform in the middle of the heated length but increases in the entrance region, due to sensible heat transfer in the subcooled liquid, and decreases toward the exit, mostly because of flow acceleration resulting from increased void fraction.

two-phase cooling; flow boiling; CFD; microgravity↗
NASA NTRS1982

Data use investigation for the magnetic field satellite (MAGSAT) mission: Geomagnetic field forecasting and fluid dynamics of the core

MAGSAT data were used to construct a variety of spherical harmonic models of the main geomagnetic field emanating from Earth's liquid core at poch 1980. These models were used to: (1) accurately determine the radius of Earth's core by a magnetic method, (2) calculate estimates, of the long-term ange of variation of geomagnetic Gauss coefficients; (3) establish a preferred truncation level for current spherical harmonic models of the main geomagnetic field from the core; (4) evaluate a method for taking account of electrical conduction in the mantle when the magnetic field is downward continued to the core-mantle boundary; and (5) establish that upwelling and downwelling of fluid motion at the top of the core is probably detectable, observationally. A fluid dynamics forecast model was not produced because of insufficient data.

Benton, E. R.↗
NASA NTRS1985

Nonparametric solutions to the variational principle of ideal magnetohydrodynamics

In an effort to gain a better understanding of MHD equilibria in three dimensions, the lower dimensional cases are studied. The solution of the three-dimensional problem is based on the classical variational principle of ideal magnetohydrodynamics. The crucial assumption for the numerical method is the existence of a nested set of toroidal flux surfaces, which is then used as a coordinate. This paper studies the nonparametric solutions to this variational problem in those cases when the direct solution is known to have islands. A form of the variational principle for the slab geometry is described; the one-dimensional problem is analyzed; and asymptotic expansions and numerical solutions to the two-dimensional problem are discussed. An example is presented which shows that the assumption of nested flux surfaces need not rule out the occurrence of islands.

Betancourt, O. L.↗
NASA NTRS1987

The detection of global convection on the sun by an analysis of line shift data of the John M. Wilcox Solar Observatory at Stanford University

An analysis of the absorption line shift data of the John M. Wilcox Solar Observatory at Stanford University has yielded signatures of the existence of global convection on the sun. These include persistent periodic time variations in the east-west component of the velocity fields defined by fitting a slope to the line shift data in a certain longitude window at a specified latitude and longitude by the least squares method. The amplitude of the velocity fields estimated from these variations is of the order of 100 m/s. The results of the analysis also suggest that several modes of global convection coexist in the solar convection zone. Details of the analysis are given.

Yoshimura, Hirokazu↗
DOE OSTI2023

Comparative study of adaptive variational quantum eigensolvers for multi-orbital impurity models

Hybrid quantum-classical embedding methods for correlated materials simulations provide a path towards potential quantum advantage. However, the required quantum resources arising from the multi-band nature of d and f electron materials remain largely unexplored. Here we compare the performance of different variational quantum eigensolvers in ground state preparation for interacting multi-orbital embedding impurity models, which is the computationally most demanding step in quantum embedding theories. Focusing on adaptive algorithms and models with 8 spin-orbitals, we show that state preparation with fidelities better than 99.9% can be achieved using about 2 14 shots per measurement circuit. When including gate noise, we observe that parameter optimizations can still be performed if the two-qubit gate error lies below 10 -3 , which is slightly smaller than current hardware levels. Finally, we measure the ground state energy on IBM and Quantinuum hardware using a converged adaptive ansatz and obtain a relative error of 0.7%.

42 ENGINEERING↗