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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,693 records · Page 94
All sourcesNASA NTRSDOE OSTI
NASA NTRS1994

Influence of antiorthostatic suspension on resistance to murine Listeria monocytogenes infection

The present study was designed to evaluate the influence of antiorthostatic suspension, a ground-based modeling system employed to simulate certain aspects of weightlessness that occur during space flight, on the capacity of mice to resist infection with the facultative intracellular bacterial pathogen Listeria monocytogenes. Female BDF1 mice were suspended by the tail in the orthostatic or antiorthostatic position and were infected with a sublethal dose of virulent L. monocytogenes at various times during the suspension. It was found that suspension did not influence the kinetics of bacterial growth in vivo if the infection was started concurrently with the suspension. However, mice that were antiorthostatically suspended 2, 4, or 7 days before the onset of infection exhibited an enhanced capacity to eliminate the challenge infection. Suspending mice on day 2 of the infection did not alter the kinetics of bacterial growth. Finally, the enhancement of resistance to the primary Listeria infection was accompanied by failure of the mice to generate long-term protective immunological memory to the challenge organism. Collectively, these results indicate that the stress of antiorthostatic suspension can influence the capacity of mice to resist bacterial infection.

NASA Discipline Regulatory Physiology↗
DOE OSTI2019

Prominent Influence of Socioeconomic and Governance Factors on the Food-Energy-Water Nexus in sub-Saharan Africa

Food, energy, and water (FEW) are primary resources required for human populations and ecosystems. Availability of the raw resources is essential, but equally important are the services that deliver resources to human populations, such as adequate access to safe drinking water, electricity, and sufficient food. Any failures in either resource availability or FEW resources-related services will have an impact on human health. The ability of countries to intervene and overcome the challenges in the FEW domain depends on governance, education, and economic capacities. We distinguish between FEW resources, FEW services, and FEW health outcomes to develop an analysis framework for evaluating interrelationships among these critical resources. The framework is applied using a data-driven approach for sub-Saharan African countries, a region with notable FEW insecurity challenges. The data-driven approach using a cross-validated stepwise regression analysis indicates that limited governance and socioeconomic capacity in sub-Saharan African countries, rather than lack of the primary resources, more significantly impact access to FEW services and associated health outcomes. The proposed framework helps develop a cohesive approach for evaluating FEW metrics and could be applied to other regions of the world to continue improving our understanding of the FEW nexus.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2024

Crack‐Free Single‐Crystalline LiNiO 2 for High Energy Density All‐Solid‐State Batteries

Abstract Single‐crystalline layered oxide (LiNi 1‐ x ‐ y Mn x Co y O 2 ) cathodes have been found to exhibit exceptional electrochemical properties when coupled with various inorganic solid electrolytes (ISEs) in all‐solid‐state batteries (ASSBs). Their advantages stem from the robust morphological integrity with the absence of grain boundaries and the high electrochemical oxidative stability. Here, ASSBs featuring single‐crystalline LiNiO 2 (LNO) with the highest Ni content are reported, offering a high theoretical specific capacity of 275 mAh g ‐1 alongside a high average discharge voltage (3.7 V vs Li + /Li). Through a careful investigation, it is demonstrated that micron‐sized single‐crystalline LNO (µSC‐LNO) composite cathodes with a halide ISE exhibit a high initial discharge capacity of 205 mAh g ‐1 with an outstanding cycle performance over 200 cycles in room‐temperature ASSBs. The significance of engineering parameters is emphasized, such as particle size and specific density, in promoting a homogeneous and fast Li + transport within the composite cathodes. Furthermore, the formation of undesirable interphase between the halide ISE in the cathode and sulfide ISE separator is elucidated, which may be a critical factor impeding long‐term cyclability of ASSBs. This work provides insights into the design of composite cathodes for high‐energy‐density ASSBs.

Chemistry↗
DOE OSTI2018

Ergonomic Safety and Health Activities to Support Commercial Nuclear Power Plant Control Room Modernization in the United States

Affordable, abundant, and reliable electricity generation is essential to fueling a nation’s robust and globally competitive economy. In the United States (U.S.), commercial nuclear power plants (NPPs) account for approximately 19% of reliable and cost-competitive baseload electricity generation. Other technologies that reduce reliance on fossil fuels and provide baseload electricity cost-competitively at a national scale are still under development. Thus, without suitable replacements for nuclear power, the generating capacity of nuclear energy in the U.S. must be continued through the safe and efficient operation of commercial NPPs. The U.S. De-partment of Energy’s (DOE) Light Water Reactor Sustainability (LWRS) research and development (R&D) program provides the technical bases for the long-term, safe, and economical operation of NPPs. One area in the LWRS program is the Plant Modernization pathway, which includes human factors R&D, human factors engineering (HFE), and ergonomics to enable the modernization of the instrumentation and control (I&C) technologies in NPP main control rooms (MCRs). DOE researchers, including ergonomics specialists at Idaho National Laboratory (INL) have collaborated with nu-merous commercial NPP utilities over the last few years on control room modernization. This paper summarizes recent ergonomics safety and health R&D and HFE performed in collaboration with a U.S. commercial utility to modernize their NPP MCRs.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2023

Scaling CFB risers: Beyond the data using microstructure similarity

Scaling circulating fluidized bed risers has been a point of contention for nearly a century. There have been numerous attempts to define various methodologies. These have all fallen short of providing a robust approach, primarily due to a lack of maintaining microstructure dynamics – a key factor in maintaining interphase heat and mass transfer. Recent work by the author put forward an approach based upon preserving dynamic similarity at different scales by ensuring that the microstructure remained similar by maintaining statistical and chaotic parameters across the scale. That work relied on a dimensionless regime map in which the x-axis was defined by the ratio of the solids flux to the saturation carrying capacity. This latter property was only good within the range of the data, and it became evident that extrapolation beyond the limits of the data could induce unrealistic conditions. Therefore, literature was reviewed to develop a better correlation for the saturation carrying capacity. In doing so, a critical riser diameter concept was developed and applied to the correlations for both Geldart Group A and B materials. The critical diameter for Geldart Group A and B materials is 0.2 m and 0.3 m, respectively. Here the paper then gives three examples on how to use the scaling approach to maintain dynamic similarity across the scales.

02 PETROLEUM↗
DOE OSTI2012

Toll-like receptors 2 and 4 mediate the capacity of mesenchymal stromal cells to support the proliferation and differentiation of CD34{sup +} cells

Bone marrow derived-mesenchymal stromal cells (BM-MSCs) are multipotent, nonhematopoietic progenitors in a hematopoietic microenvironment and indispensable for regulating hematopoiesis. Several studies have reported that toll-like receptors (TLRs) are expressed in mesenchymal stromal cells (MSCs) to modulate their biological functions. In this study, we investigated the possible role(s) of TLRs in mediating the hematopoiesis-supporting role of human BM-MSCs. Human BM-MSCs were analyzed for mRNA expression of TLR1-10 by reverse transcription-polymerase chain reaction. TLR1-6, but not TLR7-10 were expressed by BM-MSCs. The protein expression of TLR2 and TLR4 was also confirmed by flow cytometry. We further explored the role of TLR2 and TLR4 in mediating the capacity of BM-MSCs to support the proliferation and differentiation of CD34{sup +} hematopoietic stem/progenitor cells obtained from cord blood. BM-MSCs increased proliferation of CD34{sup +} cells and promoted the differentiation towards the myeloid lineage 7 or 14 days after co-culture, as well as colony formation by those cells and the production of interleukin 1 (IL-1), IL-8, IL-11, stem cell factor (SCF), granulocyte colony-stimulating factor (CSF), macrophage CSF and granulocyte-macrophage CSF, if MSCs had been stimulated with TLR2 agonist (PAM{sub 3}CSK{sub 4}) or TLR4 agonist (LPS). Interestingly, although these effects were elevated in a different degree, a synergistic effect was not observed in BM-MSCs co-stimulated with PAM{sub 3}CSK{sub 4} and LPS. Together, our findings suggest that TLR2 and TLR4 signaling may indirectly regulate hematopoiesis by modulating BM-MSCs' functions. The increased hematopoietic proliferation and differentiation could be mediated, at least in part, by augmented hematopoiesis-related cytokine production of BM-MSCs.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

Revealing functional insights into ER proteostasis through proteomics and interactomics

The endoplasmic reticulum (ER), responsible for processing approximately one-third of the human proteome including most secreted and membrane proteins, plays a pivotal role in protein homeostasis (proteostasis). Dysregulation of ER proteostasis has been implicated in a number of disease states. As such, continued efforts are directed at elucidating mechanisms of ER protein quality control which are mediated by transient and dynamic protein-protein interactions with molecular chaperones, co-chaperones, protein folding and trafficking factors that take place in and around the ER. Technological advances in mass spectrometry have played a pivotal role in characterizing and understanding these protein-protein interactions that dictate protein quality control mechanisms. Here, we highlight the recent progress from mass spectrometry-based investigation of ER protein quality control in revealing the topological arrangement of the proteostasis network, stress response mechanisms that adjust the ER proteostasis capacity, and disease specific changes in proteostasis network engagement. We close by providing a brief outlook on underexplored areas of ER proteostasis where mass spectrometry is a tool uniquely primed to further expand our understanding of the regulation and coordination of protein quality control processes in diverse diseases.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2023

Large-scale genomic analyses with machine learning uncover predictive patterns associated with fungal phytopathogenic lifestyles and traits

Abstract Invasive plant pathogenic fungi have a global impact, with devastating economic and environmental effects on crops and forests. Biosurveillance, a critical component of threat mitigation, requires risk prediction based on fungal lifestyles and traits. Recent studies have revealed distinct genomic patterns associated with specific groups of plant pathogenic fungi. We sought to establish whether these phytopathogenic genomic patterns hold across diverse taxonomic and ecological groups from the Ascomycota and Basidiomycota, and furthermore, if those patterns can be used in a predictive capacity for biosurveillance. Using a supervised machine learning approach that integrates phylogenetic and genomic data, we analyzed 387 fungal genomes to test a proof-of-concept for the use of genomic signatures in predicting fungal phytopathogenic lifestyles and traits during biosurveillance activities. Our machine learning feature sets were derived from genome annotation data of carbohydrate-active enzymes (CAZymes), peptidases, secondary metabolite clusters (SMCs), transporters, and transcription factors. We found that machine learning could successfully predict fungal lifestyles and traits across taxonomic groups, with the best predictive performance coming from feature sets comprising CAZyme, peptidase, and SMC data. While phylogeny was an important component in most predictions, the inclusion of genomic data improved prediction performance for every lifestyle and trait tested. Plant pathogenicity was one of the best-predicted traits, showing the promise of predictive genomics for biosurveillance applications. Furthermore, our machine learning approach revealed expansions in the number of genes from specific CAZyme and peptidase families in the genomes of plant pathogens compared to non-phytopathogenic genomes (saprotrophs, endo- and ectomycorrhizal fungi). Such genomic feature profiles give insight into the evolution of fungal phytopathogenicity and could be useful to predict the risks of unknown fungi in future biosurveillance activities.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2017

Light Water Reactor Sustainability Program: Integrated Program Plan

Nuclear power has safely, reliably, and economically contributed almost 20% of electrical generation in the United States over the past two decades. It remains the single largest contributor (more than 60%) of non-greenhouse-gas-emitting electric power generation in the United States. Domestic demand for electrical energy is expected to grow by about 24% from 2013 to 2040 . At the same time, most of the currently operating nuclear power plants will begin reaching the end of their initial 20-year extension to their original 40-year operating license, for a total of 60 years of operation (the oldest commercial plants in the United States reached their 40th anniversary in 2009). Figure E-1 shows projected nuclear energy contribution to the domestic generating capacity for 40- and 60-year license periods. If current operating nuclear power plants do not operate beyond 60 years (and new nuclear plants are not built quickly enough to replace them), the total fraction of generated electrical energy from nuclear power will rapidly decline. That decline will be accelerated if plants are shut down before 60 years of operation. Decisions on extended operation ultimately rely on economic factors; however, economics can often be improved through technical advancements. The U.S. Department of Energy Office of Nuclear Energy’s 2010 Research and Development Roadmap (2010 Nuclear Energy Roadmap) organizes its activities around four objectives that ensure nuclear energy remains a compelling and viable energy option for the United States. The four objectives are as follows: 1. Develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors; 2. Develop improvements in the affordability of new reactors to enable nuclear energy to help meet the Administration’s energy security and climate change goals; 3. Develop sustainable nuclear fuel cycles; and 4. Understand and minimize the risks of nuclear proliferation and terrorism. The Light Water Reactor Sustainability (LWRS) Program is the primary programmatic activity that addresses Objective 1. This document summarizes the LWRS Program’s plans. For the LWRS Program, sustainability is defined as the ability to maintain safe and economic operation of the existing fleet of nuclear power plants for a longer-than-initially-licensed lifetime. It has two facets with respect to long-term operations: (1) manage the aging of plant systems, structures, and components so that nuclear power plant lifetimes can be extended and the plants can continue to operate safely, efficiently, and economically; and (2) provide science-based solutions to the industry to implement technology to exceed the performance of the current labor-intensive business model.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗
DOE OSTI2015

Light Water Reactor Sustainability Program Integrated Program Plan

Nuclear power has safely, reliably, and economically contributed almost 20% of electrical generation in the United States over the past two decades. It remains the single largest contributor (more than 60%) of non-greenhouse-gas-emitting electric power generation in the United States. Domestic demand for electrical energy is expected to grow by about 24% from 2013 to 2040 . At the same time, most of the currently operating nuclear power plants will begin reaching the end of their initial 20-year extension to their original 40-year operating license, for a total of 60 years of operation (the oldest commercial plants in the United States reached their 40th anniversary in 2009). Figure E-1 shows projected nuclear energy contribution to the domestic generating capacity for 40- and 60-year license periods. If current operating nuclear power plants do not operate beyond 60 years (and new nuclear plants are not built quickly enough to replace them), the total fraction of generated electrical energy from nuclear power will rapidly decline. That decline will be accelerated if plants are shut down before 60 years of operation. Decisions on extended operation ultimately rely on economic factors; however, economics can often be improved through technical advancements. The U.S. Department of Energy Office of Nuclear Energy’s 2010 Research and Development Roadmap (2010 Nuclear Energy Roadmap) organizes its activities around four objectives that ensure nuclear energy remains a compelling and viable energy option for the United States. The four objectives are as follows: 1. Develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors. 2. Develop improvements in the affordability of new reactors to enable nuclear energy to help meet the Administration’s energy security and climate change goals. 3. Develop sustainable nuclear fuel cycles. 4. Understand and minimize the risks of nuclear proliferation and terrorism. The Light Water Reactor Sustainability (LWRS) Program is the primary programmatic activity that addresses Objective 1. This document summarizes the LWRS Program’s plans. For the LWRS Program, sustainability is defined as the ability to maintain safe and economic operation of the existing fleet of nuclear power plants for a longer-than-initially-licensed lifetime. It has two facets with respect to long-term operations: (1) manage the aging of plant systems, structures, and components so that nuclear power plant lifetimes can be extended and the plants can continue to operate safely, efficiently, and economically; and (2) provide science-based solutions to the industry to implement technology to exceed the performance of the current labor-intensive business model.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗
NASA NTRS1993

Weasel works SA-150: Design study of a 100 to 150 passenger transport aircraft

As the year 2000 rapidly approaches, the airlines are faced with an extremely competitive and environmentally restrictive marketplace. In order to survive, commercial air carriers will need to find new ways to lower their direct operating costs, increase load factors and comply with tightening federal and international constraints. The SA-150 has been designed to meet these demands by focusing on the areas of aerodynamic efficiency, an improved level of passenger comfort, and a limited application of advanced technology. The SA-150 has been optimized for a 500 nmi. mission to help the airlines meet the challenges of the short haul, quick turnaround flight. With a maximum capacity of 124 passengers, and full baggage, the SA-150 is also capable of covering a range of 1500 nmi. This additional range capability will provide the airlines with flexibility when scheduling their routes. The aircraft features a 'V' tail, fly-by-wire system and is powered by two turbofans mounted under a twelve aspect ratio wing. The SA-150 will have an initial production run of 800 units and have a purchase price of $37.7 million in 1993 dollars.

Alkema, Kevin↗
NASA NTRS2000

KDD Services at the Goddard Earth Sciences Distributed Active Archive Center

NASA's Goddard Earth Sciences Distributed Active Archive Center (GES DAAC) processes, stores and distributes earth science data from a variety of remote sensing satellites. End users of the data range from instrument scientists to global change and climate researchers to federal agencies and foreign governments. Many of these users apply data mining techniques to large volumes of data (up to 1 TB) received from the GES DAAC. However, rapid advances in processing power are enabling increases in data processing that are outpacing tape drive performance and network capacity. As a result, the proportion of data that can be distributed to users continues to decrease. As mitigation, we are migrating more data mining and mining preparation activities into the data center in order to reduce the data volume that needs to be distributed and to offer the users a more useful and manageable product. This migration of activities faces a number of technical and human-factor challenges. As data reduction and mining algorithms are normally quite specific to the user's research needs, the user's algorithm must be integrated virtually unchanged into the archive environment. Also, the archive itself is busy with everyday data archive and distribution activities and cannot be dedicated to, or even impacted by, the mining activities. Therefore, we schedule KDD 'campaigns' (similar to reprocessing campaigns), during which we schedule a wholesale retrieval of specific data products, offering users the opportunity to extract information from the data being retrieved during the campaign.

Lynnes, Christopher↗
DOE OSTI2023

Maintaining Microstructure – The Path to Successful Technology Maturation in Fluidized Systems

Scaling circulating fluidized bed risers has been a point of contention for nearly a century. There have been numerous attempts to define various methodologies. These have all fallen short of providing a robust approach, primarily due to a lack of maintaining microstructure dynamics – a key factor in maintain interphase heat and mass transfer. Recent work by the author put forward an approach based up maintaining dynamic similarity at different scales by ensuring that the microstructure remained similar by maintaining statistical and chaotic parameters across the scale. That work relied on a dimensionless regime map in which the x-axis was defined by the ratio of the solids flux to the saturation carrying capacity. This latter property was only good within the range of the data and it became evident that extrapolation beyond the limits of the data could induce unrealistic conditions. Therefore, literature was reviewed to develop a better correlation for the saturation carrying capacity. In doing so, a critical diameter concept was developed and applied to the correlations for both Geldart Group A and B materials. The critical diameter for Geldart Group A and B materials is 0.2 m and 0.3 m, respectively. The paper then gives examples on how to use the scaling approach to maintain dynamic similarity across the scales.<br>

Breault, Ronald↗
DOE OSTI2016

Light Water Reactor Sustainability Program: Integrated Program Plan

Nuclear power has safely, reliably, and economically contributed almost 20% of electrical generation in the United States over the past two decades. It remains the single largest contributor (more than 60%) of non-greenhouse-gas-emitting electric power generation in the United States. Domestic demand for electrical energy is expected to grow by about 24% from 2013 to 2040 . At the same time, most of the currently operating nuclear power plants will begin reaching the end of their initial 20-year extension to their original 40-year operating license, for a total of 60 years of operation (the oldest commercial plants in the United States reached their 40th anniversary in 2009). Figure E-1 shows projected nuclear energy contribution to the domestic generating capacity for 40- and 60-year license periods. If current operating nuclear power plants do not operate beyond 60 years (and new nuclear plants are not built quickly enough to replace them), the total fraction of generated electrical energy from nuclear power will rapidly decline. That decline will be accelerated if plants are shut down before 60 years of operation. Decisions on extended operation ultimately rely on economic factors; however, economics can often be improved through technical advancements. The U.S. Department of Energy Office of Nuclear Energy's 2010 Research and Development Roadmap (2010 Nuclear Energy Roadmap) organizes its activities around four objectives that ensure nuclear energy remains a compelling and viable energy option for the United States. The four objectives are as follows: 1. Develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors; 2. Develop improvements in the affordability of new reactors to enable nuclear energy to help meet the Administration's energy security and climate change goals; 3. Develop sustainable nuclear fuel cycles; and 4. Understand and minimize the risks of nuclear proliferation and terrorism. The Light Water Reactor Sustainability (LWRS) Program is the primary programmatic activity that addresses Objective 1. This document summarizes the LWRS Program's plans. For the LWRS Program, sustainability is defined as the ability to maintain safe and economic operation of the existing fleet of nuclear power plants for a longer-than-initially-licensed lifetime. It has two facets with respect to long-term operations: (1) manage the aging of plant systems, structures, and components so that nuclear power plant lifetimes can be extended and the plants can continue to operate safely, efficiently, and economically; and (2) provide science-based solutions to the industry to implement technology to exceed the performance of the current labor-intensive business model.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗
DOE OSTI2024

Cost-Benefit Analysis For Indonesia Building Sector: Whole-Building Cooling Solutions

The Net Zero World (NZW) Initiative Collaborative Work Program with the Government of Indonesia (GoI) includes technical assistance and investment mobilization facilitation to accelerate deployment of energy efficiency technologies and solutions for the building sector. A February 2023 U.S.–Indonesia Joint Workshop on Decarbonizing the Building Sector yielded a NZW Indonesia Building Decarbonization Working Group (NZW IBDWG) with four sub-working groups (SWG): SWG-A National Center, SWG-B Capacity Building, SWG-C Investment and Financing, and SWG-D Pilot Projects. Technical analysis of whole-building cooling solutions for tropical climates of Indonesia was conducted by SWG-A to quantify energy savings, carbon dioxide reductions, and comfort improvements offered by 12 passive or low-energy cooling strategies: ceiling fans with and without thermostat setbacks; cool roofs; cool walls; exterior awnings; exterior shades; interior shades; insulated roofs; insulated walls; low-e windows; solar window films; and natural ventilation. Leveraging the results from SWG-A, cost-benefit analysis (CBA) was conducted by SWG-C to assess the consumer and national costs and impacts associated with these 12 cooling solutions. The evaluation involved estimating life-cycle costs (LCC), payback period (PBP), net present values (NPV), annual electricity burden change for low-income households, and reduced national annual power-sector generation demand by 2030, 2040, 2050, and 2060. This evaluation can help guide Indonesia’s Just Energy Transition Partnership (JETP) investments in policies and programs to advance research, development, deployment, and commercial adoption (RDDCA) of efficient residential building sector cooling technologies and solutions in Indonesia. Four key energy conservation measures (ECM) have been identified to reduce air-conditioning (AC) energy demand in single-family housing in Indonesia: ceiling fan with temperature setback (to 28.1 °Celcius from 25 °C); insulated walls; insulated roof; and cool roof. This study found that low-income households with AC installations in Indonesia currently face a high energy cost burden of approximately 10%. However, by implementing a ceiling fan with temperature setback, this burden could decrease to 2.5% today and further reduce to 1.3% by the year 2060. The PBP for a ceiling fan with temperature setback is one year, indicating one of the lowest LCC and best NPV. In the planned upcoming phase of CBA, a series of building cooling improvement scenarios can be further defined, incorporating more than one ECM in combination with socio-economic factors evaluated in the initial CBA phase. Additionally, the analysis of ECM effects in multifamily housing can be expanded. This broader national analysis aims to encompass a holistic and comprehensive system-level perspective, including factors such as avoided power sector infrastructure investments, domestic job creation, domestic manufacturing job creation, and gross domestic product (GDP) growth.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2020

Regional patterns in hydrologic response, a new three-component metric for hydrograph analysis and implications for ecohydrology, Northwest Volcanic Aquifer Study Area, USA

Spatial patterns of hydrologic response were examined for the Northwest Volcanic Aquifer Study Area (NVASA). The utility of established hydrograph-separation methods for assessing hydrologic response in permeable volcanic terranes was assessed and a new three-component metric for hydrograph analysis was developed. The new metric, which partitions streamflow into subcomponents defined by the timescales of hydrologic response (e.g., fast-runoff, intermediate-interflow and slow-baseflow), was used to gain a fundamental understanding of the regional hydrology, investigate sub-regional differences, influencing factors, and ecohydrological implications. The combined effects of NVASA’s physiography, climate and geology create a strongly coupled surface-groundwater system that produces copious baseflow and limited quantities of runoff and interflow. Patterns of hydrologic response are influenced by the type and rate of precipitation and permeability of the underlying geology. Under variable precipitation conditions the hydrologic response of volcanic terranes with similar permeability and subsurface-storage capacity can be significantly different. From a water management and ecohydrology perspective, understanding regional patterns of hydrologic response and sub-regional differences is fundamental. Results indicate that minimum-flow methods provide the most conservative estimate of baseflow and may be the most robust for filtering out snowmelt bias in baseflow estimates. Baseflow contributes ~75% of the perennial streamflow across the NVASA and represents a critical component of the regional water supply that provides critical cold-water habitat.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2017

Sensitivity analysis for best-estimate thermal models of vertical dry cask storage systems

Loading requirements for dry cask storage of spent nuclear fuel are driven primarily by decay heat capacity limitations, which themselves are determined through recommended limits on peak cladding temperature within the cask. This study examines the relative sensitivity of peak material temperatures within the cask to parameters that influence both the stored fuel residual decay heat as well as heat removal mechanisms. Here, these parameters include the detailed reactor operating history parameters (e.g., soluble boron concentrations and the presence of burnable poisons) as well as factors that influence heat removal, including non-dominant processes (such as conduction from the fuel basket to the canister and radiation within the canister) and ambient environmental conditions. By examining the factors that drive heat removal from the cask alongside well-understood factors that drive decay heat, it is therefore possible to make a contextual analysis of the most important parameters to evaluation of peak material temperatures within the cask.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2016

Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity

Hedgehog (Hh) pathway activation in R26-SmoM2;CAGGS-CreER mice, which carry a tamoxifen-inducible activated Smoothened allele (SmoM2), results in numerous microscopic tumor foci in mouse skeletal muscle. These tumors exhibit a highly differentiated myogenic phenotype and resemble human fetal rhabdomyomas. This study sought to apply previously established strategies to isolate lineally distinct populations of normal mouse myofiber-associated cells in order to examine cellular heterogeneity in SmoM2 tumors. We demonstrate that established SmoM2 tumors are composed of cells expressing myogenic, adipocytic and hematopoietic lineage markers and differentiation capacity. SmoM2 tumors thus recapitulate the phenotypic and functional hetereogeneity observed in normal mouse skeletal muscle. SmoM2 tumors also contain an expanded population of PAX7+ and MyoD+ satellite-like cells with extremely low clonogenic activity. Selective activation of Hh signaling in freshly isolated muscle satellite cells enhanced terminal myogenic differentiation without stimulating proliferation. Our findings support the conclusion that SmoM2 tumors represent an aberrant skeletal muscle state and demonstrate that, similar to normal muscle, myogenic tumors contain functionally distinct cell subsets, including cells lacking myogenic differentiation potential. - Highlights: • Hedgehog activation induces multifocal tumors in skeletal muscle. • These tumors recapitulate skeletal muscle phenotypic and functional heterogeneity. • They contain cells with differential myogenic and adipogenic capacity. • Hedgehog activation enhances satellite cell differentiation.

60 APPLIED LIFE SCIENCES↗