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DOE OSTI2023

Abbreviated Technical Report: Experimentally Interrogating Detonation Chemistry on Sub-Nanosecond to Nanosecond Timescales

Direct experimental measurement of chemical reactions during high explosive detonation remains challenging. Theory and modeling have long preceded experiment in the fundamental physical and chemical kinetic properties of detonation, and experimentation at the relevant timescales are needed to both validate models and provide fundamental understanding of detonation. In this LDRD-ER project, two approaches, x-ray diffraction and core-level x-ray Raman, were developed and used to further experimental capabilities to address this gap. We further developed dynamic x-ray diffraction to directly detect nanodiamond formation during detonation, providing experimental data towards resolving longstanding controversy in the scientific literature, and although the full kinetics have not yet been fully mapped, diamond diffraction appears on the same timescales as detonation soot formation. In the second research thrust, we have developed core-level x-ray Raman for use with high explosives. This technique provides information analogous to x-ray absorption spectroscopy and electron energy loss spectroscopy, but uses inelastic scattering of hard x-rays that can interrogate chemistry around light elements much deeper into the material. The low cross section and requisite high solid angle collection have hindered its use for ultra-fast spectroscopy. We developed and tested a high-q spectrometer which will substantially increase cross section and signal-to-noise, showing this method will also not dramatically alter, compared to x-ray absorption, the most discriminating spectral features of C, N, and O from various high explosives and expected detonation products. We have also used x-ray Raman combined with OCEAN electronic structure calculations to explore dynamic photodegradation mechanisms in PETN and CL-20 explosives. This provides a pathway towards implementing capability to dynamically explore chemistry at an x-ray free electron laser.

36 MATERIALS SCIENCE↗

NASA NTRS1995

Calibration and postlaunch performance of the Meteor 3/TOMS instrument

Prelaunch and postlaunch calibration results for the Meteor 3/total ozone mapping spectrometer (TOMS) instrument are presented here. Ozone amounts are retrieved from measurements of Earth albedo in the 312- to 380-nm range. The accuracy of albedo measurements is primarily tied to knowledge of the reflective properties of diffusers used in the calibrations and to the instrument's wavelength selection. These and other important prelaunch calibrations are presented. Their estimated accuracies are within the bounds necessary to determine column ozone to better than 1%. However, postlaunch validation results indicate some prelaunch calibration uncertainties may be larger than originally estimated. Instrument calibrations have been maintained postlaunch to within a corresponding 1% error in retrieved ozone. Onboard calibrations, including wavelength monitoring and a three-diffuser solar measurement system, are described and specific results are presented. Other issues, such as the effects of orbital precession on calibration and recent chopper wheel malfunctions, are also discussed.

Jaross, G.↗

NASA NTRS2013

Testing of the Trim Tab Parametric Model in NASA Langley's Unitary Plan Wind Tunnel

In support of NASA's Entry, Descent, and Landing technology development efforts, testing of Langley's Trim Tab Parametric Models was conducted in Test Section 2 of NASA Langley's Unitary Plan Wind Tunnel. The objectives of these tests were to generate quantitative aerodynamic data and qualitative surface pressure data for experimental and computational validation and aerodynamic database development. Six component force-and-moment data were measured on 38 unique, blunt body trim tab configurations at Mach numbers of 2.5, 3.5, and 4.5, angles of attack from -4deg to +20deg, and angles of sideslip from 0deg to +8deg. Configuration parameters investigated in this study were forebody shape, tab area, tab cant angle, and tab aspect ratio. Pressure Sensitive Paint was used to provide qualitative surface pressure mapping for a subset of these flow and configuration variables. Over the range of parameters tested, the effects of varying tab area and tab cant angle were found to be much more significant than varying tab aspect ratio relative to key aerodynamic performance requirements. Qualitative surface pressure data supported the integrated aerodynamic data and provided information to aid in future analyses of localized phenomena for trim tab configurations.

Murphy, Kelly J.↗

NASA NTRS2017

Application of IRTAM to Support ISS Program Safety

The International Space Station (ISS) orbits near the F-peak of the ionosphere (approximately 400 km altitude). Generally, satellites orbiting at this altitude would have a floating potential (FP) of approximately -1 V due to the electron temperature (Te). However, the ISS has 8 large negatively grounded 160 V solar array wings (SAW) that collect a significant electron current from the ionosphere. This current drives the ISS FP much more negative during insolation and is highly dependent on the electron density (Ne). Also, due to the size of the ISS, magnetic inductance caused by the geomagnetic field produces a delta potential up to 40 V across the truss, possibly producing positive potentials. During Extravehicular Activity (EVA) the negative FP can lead to an arcing hazard when it exceeds -45.5 V, and the positive FP can produce a DC current high enough to stimulate the astronaut's muscles and also cause a hazard. Data collected from the Floating Potential Monitoring Unit (FPMU) have shown that the probability of either of these hazards occurring during times with quiet to moderately disturbed geomagnetic activity is low enough to no longer be considered a risk. However, a study of the ionosphere Ne during severe geomagnetic storm activity has shown that the Ne can be enhanced by a factor of 6 in the ISS orbit. As a result, the ISS Safety Review Panel (SRP) requires that ionospheric conditions be monitored using the FPMU in conjunction with the ISS Plasma Interaction Model (PIM) to determine if a severe geomagnetic storm could result in a plasma environment that could produce a hazard. A 'Real-Time' plasma hazard assessment process was developed to support ISS Program real-time decision making providing constraint relief information for EVAs planning and operations. This process incorporates 'real time' ionospheric conditions, ISS solar arrays' orientation, ISS flight attitude, and where the EVA will be performed on the ISS. This assessment requires real time data that is presently provided by the FPMU including ISS floating potential, along with ionospheric Ne and Te, in order to determine the present environment. Once the present environment conditions are known to be either above, below, or near the current IRI values, the IRI is used to forecast what the environment could become in the event of a severe geomagnetic storm. If the FPMU should fail, the Space Environments team needs another source of data which is utilized to support a short-term forecast for EVAs. The IRI Real-Time Assimilative Mapping (IRTAM) model is an ionospheric model that uses real time measurements from approximately 70 digisondes to produce foF2 and hmF2 global maps in 15 minute cadence. The Boeing Space Environments team has used the IRI coefficients produced in IRTAM to calculate the Ne along the ISS orbital track. The results of the IRTAM model have been compared to FPMU measurements and show excellent agreement (figure 1). IRTAM has been identified as a potential FPMU back-up system will be used as a backup for the FPMU to support the ISS Program following completion of an FPMU/IRTAM validation campaign.

Hartman, William A.↗

NASA NTRS2023

Estimating the concentration of total suspended solids in inland and coastal waters from Sentinel-2 MSI: A semi-analytical approach

Inland and coastal waters provide key ecosystem services and are closely linked to human well-being. In this study, we propose a semi-analytical method, which can be applied to Sentinel-2 MultiSpectral Instrument (MSI) images to retrieve high spatial-resolution total suspended solids (TSS) concentration in a broad spectrum of aquatic ecosystems ranging from clear to extremely turbid waters. The presented approach has four main steps. First, the remote sensing reflectance ( R rs ) at a band lacking in MSI (620 nm) is estimated through an empirical relationship from R rs at 665 nm. Second, waters are classified into four types (clear, moderately turbid, highly turbid, and extremely turbid). Third, semi-analytical algorithms are used to estimate the particulate backscattering coefficient ( b bp ) at a reference band depending on the water types. Last, TSS is estimated from bbp at the reference band. Validation and comparison of the proposed method with three existing methods are performed using a simulated dataset ( N = 1000), an in situ dataset collected from global inland and coastal waters ( N = 1265) and satellite matchups ( N = 40). Results indicate that the proposed method can improve TSS estimation and provide accurate retrievals of TSS from all three datasets, with a median absolute percentage error (MAPE) of 14.88 %, 31.50 % and 41.69 % respectively. We also present comparisons of TSS mapping between the Sentinel-3 Ocean and Land Colour Instrument (OLCI) and MSI in Lake Kasumigaura, Japan and the Tagus Estuary, Portugal. Results clearly demonstrate the advantages of using MSI for TSS monitoring in small water bodies such as rivers, river mouths and other nearshore waters. MSI can provide more detailed and realistic TSS estimates than OLCI in these water bodies. The proposed TSS estimation method was applied to MSI images to produce TSS time-series in Lake Kasumigaura, which showed good agreements with in situ and OLCI-derived TSS time-series.

Sentinel-2↗

NASA NTRSDate not supplied

Unsteady Aerodynamic Modeling of Atmospheric Entry Vehicles in Subsonic and Incompressible flow: A Frequency Response Approach

The determination of time-varying lift force and pitch moment generated by a purely pitching Earth-entry capsule is investigated. Experiments were conducted in the 12-foot Low-Speed Tunnel at NASA Langley Research Center, testing a range of oscillation frequencies at a zero-mean angle of attack with a pitching amplitude of 10 degrees. In light of these measurements, a closed-form set of analytically derived equations for lift and moment was used to develop a semi-empirical formulation, incorporating empirically determined values from the experimental runs. The equations are grounded in potential flow theory, Theodorsen's classical theory of unsteady aerodynamics, and the Joukowski theorem of conformal mapping. The unsteady aerodynamics generated by the oscillating body are then modeled by constructing frequency response functions, with quasi-steady forces and moments serving as inputs and unsteady forces and moments as outputs. The experimentally determined gain and phase variations characterize the unsteady nature of the flow and the system's response and flow time-lag to input flow parameters for a blunt-body entry vehicle. The final semi-empirical model is validated with a set of parameters beyond the initial test matrix.

Entry Systems Modeling↗

NASA NTRSDate not supplied

Unsteady Aerodynamic Modeling of Atmospheric Entry Vehicles in Subsonic and Incompressible Flow: A Frequency Response Approach

Entry Systems Modeling↗

DOE OSTI2014

SU-E-T-479: Development and Validation of Analytical Models Predicting Secondary Neutron Radiation in Proton Therapy Applications

Purpose: Test and validation of analytical models predicting leakage neutron exposure in passively scattered proton therapy. Methods: Taking inspiration from the literature, this work attempts to build an analytical model predicting neutron ambient dose equivalents, H*(10), within the local 75 MeV ocular proton therapy facility. MC simulations were first used to model H*(10) in the beam axis plane while considering a closed final collimator and pristine Bragg peak delivery. Next, MC-based analytical model was tested against simulation results and experimental measurements. The model was also expended in the vertical direction to enable a full 3D mapping of H*(10) inside the treatment room. Finally, the work focused on upgrading the literature model to clinically relevant configurations considering modulated beams, open collimators, patient-induced neutron fluctuations, etc. Results: The MC-based analytical model efficiently reproduced simulated H*(10) values with a maximum difference below 10%. In addition, it succeeded in predicting measured H*(10) values with differences <40%. The highest differences were registered at the closest and farthest positions from isocenter where the analytical model failed to faithfully reproduce the high neutron fluence and energy variations. The differences remains however acceptable taking into account the high measurement/simulation uncertainties and the end use of this model, i.e. radiation protection. Moreover, the model was successfully (differences < 20% on simulations and < 45% on measurements) extended to predict neutrons in the vertical direction with respect to the beam line as patients are in the upright seated position during ocular treatments. Accounting for the impact of beam modulation, collimation and the present of a patient in the beam path is far more challenging and conversion coefficients are currently being defined to predict stray neutrons in clinically representative treatment configurations. Conclusion: Analytical models predicting secondary neutrons in proton therapy represent a promising solution that substitute for time-consuming MC calculations.

60 APPLIED LIFE SCIENCES↗

NASA NTRSDate not supplied

Preliminary Results Using Galvanic Vestibular Reduction as a Non-Pharmaceutical Tool for Motion Sickness Mitigation

Introduction: Alterations in vestibular sensory processing following G-transitions lead to motion sickness and spatial disorientation upon return to Earth’s gravity. The use of non-pharmaceutical mitigation for motion sickness has several potential advantages over drug treatment options. The purpose of this study was to validate a non-pharmaceutical tool using galvanic vestibular reduction (GVR) to mitigate G-transitional induced motion sickness and spatial disorientation. Methods: Using a repeated measures counter-balanced design, motion sickness and perception are obtained during Coriolis cross-coupling stimuli on a rotating chair across three GVR treatment interventions: throughout stimulus testing (prevention), following symptom onset (rescue), and placebo control. Subjects perform up to 10 sets of pitch head movements during constant rotation. For each set, head movement is cued every 10 seconds, alternating between pitch forward (chin resting to chest) and pitch backward (head upright) for a total of 7 forward and backward movements. During each head movement, subjects are asked to use a joystick to record the magnitude of their perceived rotation along all three axes. During the 2-minute pause between sets, motion sickness symptom scoring was obtained using the Pensacola Diagnostic Index and subject discomfort (0-20) ratings. Performance on a sensorimotor and cognitive test battery is measured during a fourth session to map changes in GVR level with functional performance. Results: Fifteen of 30 subjects have completed testing to date. Preliminary findings suggest GVR may be more effective in reducing symptoms in subjects who self-report less susceptibility on a pre-test motion sickness susceptibility questionnaire. Based on the joystick measures, GVR significantly reduces both the magnitude (mean 22% - 34%) and duration (mean 42% - 49%) of perceived roll and pitch sensation with head movements during constant rotation. It is important to note that comparable levels of GVR (up to 2.5mA) does not impair performance on a functional test battery including mobility and balance tasks. Discussion: Our preliminary findings suggest GVR may be useful in reducing disorienting roll and pitch illusions associated with Coriolis cross-coupling stimuli. While transfer to post-flight treatment will need to be validated, the potential advantages of our non-pharmaceutical countermeasure approach would be to provide rapid therapeutic effect while allowing continuous titration of GVR amplitude during recovery to maintain operational performance.

Gaurav Pradhan↗

DOE OSTI2021

First coupled GENE–XGC microturbulence simulations

Covering the core and the edge region of a tokamak, respectively, the two gyrokinetic turbulence codes Gyrokinetic Electromagnetic Numerical Experiment (GENE) and X-point Gyrokinetic Code (XGC) have been successfully coupled by exchanging three-dimensional charge density data needed to solve the gyrokinetic Poisson equation over the entire spatial domain. Certain challenges for the coupling procedure arise from the fact that the two codes employ completely different numerical methods. This includes, in particular, the necessity to introduce mapping procedures for the transfer of data between the unstructured triangular mesh of XGC and the logically rectangular grid (in a combination of real and Fourier space) used by GENE. Constraints on the coupling scheme are also imposed by the use of different time integrators. First, coupled simulations are presented. We have considered collisionless ion temperature gradient turbulence, in both circular and fully shaped plasmas. Coupled simulations successfully reproduce both GENE and XGC reference results, confirming the validity of the code coupling approach toward a whole device model. Here, many lessons learned in the present context, in particular, the need for a coupling procedure as flexible as possible, should be valuable to our and other efforts to couple different kinds of codes in pursuit of a more comprehensive description of complex real-world systems and will drive our further developments of a whole device model for fusion plasmas.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

DOE OSTI2025

Low- n stability and plasma response to RMP in various STEP scenarios

The low-n (n is the toroidal mode number) magnetohydrodynamic (MHD) stability and plasma response are numerically investigated for various scenarios designed for STEP, that are relevant for the H-mode pedestal analysis. Control of the edge-localized modes (ELMs) with externally applied resonant magnetic perturbations (RMPs) is considered. Optimization of the ELM control coil current configuration, based on the computed plasma MHD response and well-established figures of merit validated on present-day experiments, finds reasonable robustness of a fixed coil phasing (for a given n-number) to control ELMs in all five STEP plasmas considered. Based on certain semi-empirical criteria, the required coil current to achieve ELM suppression is estimated to be about 10–20 kAt with the n = 1 or 2 RMP configuration and about 100–200 kAt for the n = 4 RMP. Systematic linear stability calculations are used to map out stability windows for the low-n kink-peeling modes, in terms of the ideal-wall location and variation of the edge safety factor q 95 with respect to the target design. The kink-peeling stability boundary is found to be generally sensitive to the q 95 variation, which has implications for achieving the quiescent H-mode regime in STEP. Full toroidal quasilinear initial-value simulations for these STEP plasmas find that generation of the edge-harmonic oscillations (EHOs) depends sensitively on the plasma scenario, the initial linear stability of the kink-peeling modes, the initial plasma toroidal flow and q 95 . In general, it is easier (more robust) to access the EHO-regime for two of the cases considered with smaller plasma volume and higher on-axis safety factor. Finally, quasilinear simulations find robust density pumpout due to applied RMPs in these STEP plasmas, but the effect on the plasma toroidal flow varies among different cases.

EHO↗

DOE OSTI2025

Correspondence between Color Glass Condensate and High-Twist Formalism

The color glass condensate (CGC) effective theory and the collinear factorization at high twist (HT) are two well-known frameworks describing perturbative QCD multiple scatterings in nuclear media. It has long been recognized that these two formalisms have their own domain of validity in different kinematic regions. Taking direct photon production in proton-nucleus collisions as an example, we clarify for the first time the relation between CGC and HT at the level of a physical observable. We show that the CGC formalism beyond shock-wave approximation, and with the Landau-Pomeranchuk-Migdal interference effect is consistent with the HT formalism in the transition region where they overlap. Such a unified picture paves the way for mapping out the phase diagram of parton density in nuclear medium from dilute to dense region.

Parton distribution functions↗

DOE OSTI2010

Universal calculation formula and calibration method in Fourier transform profilometry

We propose a universal calculation formula of Fourier transform profilometry and give a strict theoretical analysis about the phase-height mapping relation. As the request on the experimental setup of the universal calculation formula is unconfined, the projector and the camera can be located arbitrarily to get better fringe information, which makes the operation flexible. The phase-height calibration method under the universal condition is proposed, which can avoid measuring the system parameters directly. It makes the system easy to manipulate and improves the measurement velocity. A computer simulation and experiment are conducted to verify its validity. The calculation formula and calibration method have been applied to measure an object of 22.00 mm maximal height. The relative error of the measurement result is only 0.59%. The experimental results prove that the three-dimensional shape of tested objects can be reconstructed exactly by using the calculation formula and calibration method, and the system has better universality.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

DOE OSTI2018

Final Technical Report: Application of in situ Neutron Diffraction to Understand the Mechanism of Phase Transitions

In this research, phase transitions in the bulk electrodes for Li-ion batteries were investigated using neutron diffraction (ND) as well as neutron imaging techniques. The objectives of this research is to design of a novel in situ electrochemical cell to obtain Rietveld refinable neutron diffraction experiments using small volume electrodes of various laboratory/research-scale electrodes intended for Li-ion batteries. This cell is also to be used to investigate the complexity of phase transitions in Li(Mg) alloy electrodes, either by diffraction or by neutron imaging, which occur under electrochemical lithiation and delithiation, and to determine aspects of phase transition that enable/limit energy storage capacity. Additional objective is to investigate the phase transitions in electrodes made of etched micro-columns of silicon and investigate the effect of particle/column size on phase transitions and nonequilibrium structures. An in situ electrochemical cell was designed successfully and was used to study the phase transitions under in-situ neutron diffraction in both the electrodes (anode/cathode) simultaneously in graphite/LiCoO 2 and in graphite/LiMn 2 O 4 cells each with two cells. The diffraction patterns fully validated the working of the in situ cell. Additional experimental were performed using the Si micro-columnar electrodes. The results revealed new lithiation phenomena, as evidenced by mosaicity formation in silicon electrode. These experiments were performed in Vulcan diffractometer at SNS, Oak Ridge National Laboratory. In parallel, the spatial distribution of Li during lithiation and delithiation processes in Li-battery electrodes were investigated. For this purpose, neutron tomographic imaging technique has been used for 3D mapping of Li distribution in bulk Li(Mg) alloy electrodes. It was possible to observe the phase boundary of Li(Mg) alloy indicating phase transition from Li-rich BCC β-phase to Li-lean α-phase. These experiments have been performed at CG-1D Neutron Imaging Prototype Station at SNS.

25 ENERGY STORAGE↗

DOE OSTI2020

Improved Performance of Cu(InGa)(SeS) 2 PV Modules Using the Reaction of Metal Precursors. Final Report

This project “Improved Performance of Cu(InGa)(SeS) 2 PV Modules using the Reaction of Metal Precursors” was a partnership led by the Institute of Energy Conversion (IEC) at the University of Delaware with Columbia University and the Molecular Foundry at the Lawrence Berkeley National Laboratory. The aim was to develop pathways to improve Cu(InGa)(SeS) 2 (CIGSS) thin film photovoltaic modules using processes compatible with low manufacturing cost. The CIGSS approach investigated was a two-step process including deposition of metal precursor films following by reaction in hydride gases utilizing IEC’s novel reactor. The process was similar to that under commercial development by the project’s industry partner Stion. When Stion went out of business mid-project the focus changed to a rapid thermal process considered more commercially viable. Approaches to improve the performance of solar cells using the reacted films focused on two material innovations. First, the overall Ga content was increased to increase the operating voltage, which is desirable for scale-up to commercial modules. Second, the processing and performance advantages arising from Ag alloying were investigated. Advanced characterization guided process and material development including control of relative composition gradients. Research on the formation of Cu-Ga-In metal precursors utilized sputtering deposition which is normally used in commercial applications. The work resulted in processes for deposition of precursor stacks with increased relative Ga content and effects of deposition parameters on morphology and phase composition were established. It was shown that the metal precursor films have comparable phase composition and morphology so subsequent reaction follows from the same starting point. The addition of Ag to the metal precursors gave more uniform morphology and improved adhesion of reacted films which enable higher reaction temperature for faster processing. A novel outcome was the discovery of a previously undocumented material phase in sputter-deposited and evaporated Ag-Cu-In-Ga thin films. Hydride gas reaction processes including time-temperature-concentration profiles were developed for different precursor compositions. This enables control of composition profiles to engineer through-film gradients for solar cell optimization with characterization and simulations used to correlate measured film composition profiles to measurements of devices. In particular, the gradient of sulfur at the front of the CIGSS film was found to be critical. The simulations guided process development leading to improved reproducibility of devices improved performance with higher Ga content and higher voltage. With Ag-alloyed precursors, the reaction pathways leading were determined. A significant finding was that Ag-alloying increases the reaction rate to completely convert precursor films to the final chalcopyrite which could enable reduced reaction time to benefit manufacturability. To maintain potential commercial viability, the process under investigation was refocused to a rapid thermal process that could potentially be incorporated into an in-line process for manufacturing. Precursors with different composition were capped with an extra selenium layer and reacted in hydrogen sulfide 5-15 minutes, compared to typically 2 hours in the previous multi-step batch process. Critical RTP parameters were identified to control the reaction. Further optimization would be needed for high efficiency solar cells but pathways to high quality devices with further optimization and improved heating uniformity were developed. The project also developed new optoelectronic characterization approaches with a focus on development and application of spatial- and time-resolved photoluminescence and a custom mapping photoluminescence microscope built. It was shown how critical electronic transport properties strongly depend on the chemical composition of the material and that a wide range of samples show inhomogeneity on a length scale larger than the grains in the films. Additionally, two-photon excitation capability was developed to distinguish bulk vs surface losses. The project advances the state-of-the -art for precursor reaction processes in several ways that could impact manufacturing. This includes validation of approaches to increase voltage and establishment of model-guided control to form optimal composition profiles. The application of process control approaches with knowledge of phase formation and reaction pathways can be critically valuable in designing a large-scale process.

14 SOLAR ENERGY↗

DOE OSTI2021

Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication

All tumors have DNA mutations, and a predictive understanding of those mutations could inform clinical treatments. However, 40% of the mutations are variants of unknown significance (VUS), with the challenge being to objectively predict whether a VUS is pathogenic and supports the tumor or whether it is benign. To objectively decode VUS, we mapped cancer sequence data and evolutionary trace (ET) scores onto crystallography and cryo-electron microscopy structures with variant impacts quantitated by evolutionary action (EA) measures. As tumors depend on helicases and nucleases to deal with transcription/replication stress, we targeted helicase–nuclease–RPA complexes: (1) XPB-XPD (within TFIIH), XPF-ERCC1, XPG, and RPA for transcription and nucleotide excision repair pathways and (2) BLM, EXO5, and RPA plus DNA2 for stalled replication fork restart. As validation, EA scoring predicts severe effects for most disease mutations, but disease mutants with low ET scores not only are likely destabilizing but also disrupt sophisticated allosteric mechanisms. For sites of disease mutations and VUS predicted to be severe, we found strong co-localization to ordered regions. Rare discrepancies highlighted the different survival requirements between disease and tumor mutations, as well as the value of examining proteins within complexes. In a genome-wide analysis of 33 cancer types, we found correlation between the number of mutations in each tumor and which pathways or functional processes in which the mutations occur, revealing different mutagenic routes to tumorigenesis. We also found upregulation of ancient genes including BLM, which supports a non-random and concerted cancer process: reversion to a unicellular, proliferation-uncontrolled, status by breaking multicellular constraints on cell division. Together, these genes and global analyses challenge the binary “driver” and “passenger” mutation paradigm, support a gradient impact as revealed by EA scoring from moderate to severe at a single gene level, and indicate reduced regulation as well as activity. The objective quantitative assessment of VUS scoring and gene overexpression in the context of functional interactions and pathways provides insights for biology, oncology, and precision medicine.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1993

Computational strategies in the dynamic simulation of constrained flexible MBS

This research focuses on the computational dynamics of flexible constrained multibody systems. At first a recursive mapping formulation of the kinematical expressions in a minimum dimension as well as the matrix representation of the equations of motion are presented. The method employs Kane's equation, FEM, and concepts of continuum mechanics. The generalized active forces are extended to include the effects of high temperature conditions, such as creep, thermal stress, and elastic-plastic deformation. The time variant constraint relations for rolling/contact conditions between two flexible bodies are also studied. The constraints for validation of MBS simulation of gear meshing contact using a modified Timoshenko beam theory are also presented. The last part deals with minimization of vibration/deformation of the elastic beam in multibody systems making use of time variant boundary conditions. The above methodologies and computational procedures developed are being implemented in a program called DYAMUS.

Amirouche, F. M. L.↗

NASA NTRS2009

A Blended Global Snow Product using Visible, Passive Microwave and Scatterometer Satellite Data

A joint U.S. Air Force/NASA blended, global snow product that utilizes Earth Observation System (EOS) Moderate Resolution Imaging Spectroradiometer (MODIS), Advanced Microwave Scanning Radiometer for EOS (AMSR-E) and QuikSCAT (Quick Scatterometer) (QSCAT) data has been developed. Existing snow products derived from these sensors have been blended into a single, global, daily, user-friendly product by employing a newly-developed Air Force Weather Agency (AFWA)/National Aeronautics and Space Administration (NASA) Snow Algorithm (ANSA). This initial blended-snow product uses minimal modeling to expeditiously yield improved snow products, which include snow cover extent, fractional snow cover, snow water equivalent (SWE), onset of snowmelt, and identification of actively melting snow cover. The blended snow products are currently 25-km resolution. These products are validated with data from the lower Great Lakes region of the U.S., from Colorado during the Cold Lands Processes Experiment (CLPX), and from Finland. The AMSR-E product is especially useful in detecting snow through clouds; however, passive microwave data miss snow in those regions where the snow cover is thin, along the margins of the continental snowline, and on the lee side of the Rocky Mountains, for instance. In these regions, the MODIS product can map shallow snow cover under cloud-free conditions. The confidence for mapping snow cover extent is greater with the MODIS product than with the microwave product when cloud-free MODIS observations are available. Therefore, the MODIS product is used as the default for detecting snow cover. The passive microwave product is used as the default only in those areas where MODIS data are not applicable due to the presence of clouds and darkness. The AMSR-E snow product is used in association with the difference between ascending and descending satellite passes or Diurnal Amplitude Variations (DAV) to detect the onset of melt, and a QSCAT product will be used to map areas of snow that are actively melting.

Foster, James L.↗