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At least 1,711 records · Page 95

Lasers for Surgery and Photodynamic Therapy Final Report CRADA No. TC-0437-93

This proposed project is designed to apply the combined resources and expertise of the Lawrence Livermore National Laboratory (LLNL) and the Wellman Laboratories of Photomedicine (WL) to develop several new diode laser systems for use in photodynamic therapy (PDT) and to develop diode-pumped solid state infrared lasers for surgery. The use oflaser light-activated photosensitive dyes in the treatment and diagnosis of disease is developing rapidly. Current PDT relies on the use of large, expensive, and inefficient argon-ion laser pumped dye lasers as sources. The recent advances in the technology of diode lasers emitted in the 620-700 nm region offers an opportunity to make source technology for PDT more reliable, compact, and efficient. This project will develop visible diode lasers and control system for photodynamic therapy, and infrared diode pumped solid-state lasers for applications to surgery. Testing and evaluation of the laser systems will be performed at WL using cells, tissue in vitro, animal models, and ultimately human subjects in clinical trials. Once clinical testing is complete, commercialization will be pursued through WL ties to the medical laser industry. Several efforts within this proposed program are of interest to a number of other potential ti.NL funding sources. In particular, several of the diode pumped solid-state devices share some commonalty with work being proposed in conjunction with the Beckman Laser Institute and Medical Clinic. A further example is the commonalty with LLNL existing and proposed efforts in coupling high average power diode arrays into fiber optic delivery systems.

42 ENGINEERING↗

HED Hydrodynamics in the Common Modeling Framework

Within the Common Modeling Framework (CMF), the HED Hydrodynamics Project has implemented a common methodology, or "Authority", for modeling high energy density (HED) experiments by extending development of the Eulerian Applications Project code Authority, "EAPA," to include relevant physics models, customization tools and templates, and in situ and post-processing capabilities. Additionally, several models for small-scale HED experiments were successfully added to the CMF and simulations reproduce the results of preexisting, benchmarked input decks. We expect use of the CMF to improve our effectiveness in developing predictive capabilities for experiments ranging from small-scale planar single-interface, single-shock to multi-interface, multi-shock configurations and up through multi-shell inertial confinement fusion (ICF) implosions. Additionally, this will strengthen our ability to design future targeted experiments. Using the CMF infrastructure and Authorities for HED modeling has three key impacts. First, it enables a version-controlled, pedigreed and archived base model for each experiment with tools that allow easy setup, execution and analysis of simulations to assess and/or expose sensitivities to various parameters. Second, having a common base set of inputs and physics definitions helps identify systematic differences between models in the codes and experimental data to support code validation, and build confidence in our predictive capabilities. Finally, designed to work in concert with multiple programs and projects including PEM, IC, OES, V&V and DSW, the CMF supports improved collaboration and integration through shared model definitions, data, simulations and results, enhancing the workflow required to underwrite the knowledge base and capabilities ultimately required for stockpile stewardship

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Hydropower Cyber-Physical Configurations

The U.S. Department of Energy’s Water Power Technologies Office funded Pacific Northwest National Laboratory, Argonne National Laboratory, and the National Renewable Energy Laboratory to develop a typology to characterize the variety and pervasiveness of cyber-physical configurations across the nation’s hydropower fleet. Outreach to owners and operators returned configurations for 275 hydropower plants or approximately 12% of the fleet. Components (OT and IT), systems, and connections among systems differed among plants according to function, age, position in the river cascade, and many other factors. Seven cyber-physical configuration types labeled A through I, included from 2 to dozens of plants. They were differentiated by how pervasive data and control connections were among cyber-physical components and how frequently control signals paired with data signals in a feedback loop. The flow of data and control within each type implies what cybersecurity vulnerabilities may exist, and what mitigation actions may be most effective. A self-assessment approach allows plant operators to identify the configuration type similar to their plant and link to the lessons learned and best practices information. The cyber-physical typology reinforces the idea that hydropower facilities vary widely, but it also identifies groups that highlight similarities in how their cyber-physical components interact. This helps address fleetwide cybersecurity needs by identifying a reasonable number of configuration types that share risks, vulnerabilities, and potential mitigations.

13 HYDRO ENERGY↗

Twinac: A Universal Framework for Virtual Accelerator Controls

We propose a universal framework for a system of virtual accelerator controls (Twinac), a standard toolkit for research institutions to design, maintain, and use a real-time, end-to-end "digital twin" of their particle accelerator facility. This virtual counterpart will mirror any physical accelerator to provide (1) predictive maintenance; (2) surveillance of hidden environmental factors, such as seasonal temperature variations, which could impact performance of power supplies, magnets, and other instruments; and (3) a capability to model novel ways to operate the accelerator without risking equipment damage. Twinac is envisioned as accelerator facility agnostic, allowing institutions to share and reuse myriad simulation approaches (analytics-based, A.I.-driven, or combinations of the like) across facilities. The Twinac system lays the groundwork for a collaborative network of institutions to maintain and update this shared virtual accelerator technology.

Miceli, Tia M. [Fermilab] (ORCID:0000000265577789)↗

A parallel-pipelined architecture for a multi carrier demodulator

Analog devices have been used for processing the information on board the satellites. Presently, digital devices are being used because they are economical and flexible as compared to their analog counterparts. Several schemes of digital transmission can be used depending on the data rate requirement of the user. An economical scheme of transmission for small earth stations uses single channel per carrier/frequency division multiple access (SCPC/FDMA) on the uplink and time division multiplexing (TDM) on the downlink. This is a typical communication service offered to low data rate users in commercial mass market. These channels usually pertain to either voice or data transmission. An efficient digital demodulator architecture is provided for a large number of law data rate users. A demodulator primarily consists of carrier, clock, and data recovery modules. This design uses principles of parallel processing, pipelining, and time sharing schemes to process large numbers of voice or data channels. It maintains the optimum throughput which is derived from the designed architecture and from the use of high speed components. The design is optimized for reduced power and area requirements. This is essential for satellite applications. The design is also flexible in processing a group of a varying number of channels. The algorithms that are used are verified by the use of a computer aided software engineering (CASE) tool called the Block Oriented System Simulator. The data flow, control circuitry, and interface of the hardware design is simulated in C language. Also, a multiprocessor approach is provided to map, model, and simulate the demodulation algorithms mainly from a speed view point. A hypercude based architecture implementation is provided for such a scheme of operation. The hypercube structure and the demodulation models on hypercubes are simulated in Ada.

Kwatra, S. C.↗

A Coordinated Initialization Process for the Distributed Space Exploration Simulation (DSES)

This document describes the federate initialization process that was developed at the NASA Johnson Space Center with the HIIA Transfer Vehicle Flight Controller Trainer (HTV FCT) simulations and refined in the Distributed Space Exploration Simulation (DSES). These simulations use the High Level Architecture (HLA) IEEE 1516 to provide the communication and coordination between the distributed parts of the simulation. The purpose of the paper is to describe a generic initialization sequence that can be used to create a federate that can: 1. Properly initialize all HLA objects, object instances, interactions, and time management 2. Check for the presence of all federates 3. Coordinate startup with other federates 4. Robustly initialize and share initial object instance data with other federates.

Phillips, Robert↗

Why are Lead Iodide‐Based Perovskite Precursor Inks Yellow?

A challenge faced by metal halide perovskite (MHP) photovoltaics is scaling up solution deposition processes to realize rapid and inexpensive manufacturing. The challenge lies in completely understanding and controlling solution speciation, nucleation, and self-assembly of iodoplumbate complexes during solvent evaporation as the liquid transforms into gels and solids. An accurate description of solution species, at all points in the transformation, is a prerequisite to design robust and reliable processes. Here, in this study, the common assumption that initial monoplumbate solution species typically invoked (e.g., [PbI 6 ] 4− ) are certainly not the origin of optical absorbance at >400 nm wavelengths is disproved, as are many large particles of common “intermediate” iodoplumbate phases with face- or edge-sharing connectivity. Instead, a new perspective is offered, involving (partially) corner-sharing iodo(poly)plumbates (>1 Pb 2+ per complex) that experience highly dynamic chemical environments. It is outlined how the MHP field would benefit by elucidating these phenomena. Future work is required to determine the size and kinetic behavior of polyplumbate species, and contextualize these findings in relation to broader trends in materials chemistry beyond MHPs. Ultimately, a complete explanation for the solution speciation, optical absorbance signatures, and the color of MHP precursor inks remains an open challenge to the community.

14 SOLAR ENERGY↗

Impact of Chiral Symmetry Breaking on Spin-Texture and Lone Pair Expression in Chiral Crystals of Hybrid Antimony and Bismuth Halides

Chiral organic building blocks can be incorporated into hybrid organic-inorganic metal-halide crystalline semiconductors so as to control and impact the interconversion between light, charge, and spin. Here, we report a series of hybrid antimony and bismuth halide materials of the general formula MBA 4 B 2 X 10 (B = Sb 3+ , Bi 3+ ; X = Br - , I - ) and study how chiral symmetry breaking imposed by the templating organic chiral methylbenzylammonium (MBA) cations induces symmetry breaking within the inorganic sublattice and leads to a unique spin-texture. The chiral MBA cations introduce two structural modifications to the metal-halide sublattice that consists of isolated edge-sharing dimers of B 2 X 10 octahedra: (1) the dimers have a chiral spatial arrangement with respect to one another and (2) there is an asymmetric distortion of the two subunits within the individual dimers with a higher distortion caused by strong stereochemical activity of the Sb 5s 2 lone pair electrons. The structural distortions and chiral arrangement result in circular dichroism (CD) at the band edge of the inorganic framework with dissymmetry factors in the range of 10 -4 . Chiral spin-splitting of the inorganic states, caused by breaking of the inversion symmetry and large spin-orbit coupling, is studied via density functional theory (DFT), and a multiband effective mass theory was developed that links the DFT-derived spin-splitting of helical character (i.e., spin expectation value not perpendicular to the crystal momentum) to the observed CD. Furthermore, we also find broad red photoluminescence from the MBA 4 Sb 2 Br 10 compounds, which we attribute to self-trapped excitonic emission driven by the large distortion due to the lone pair expression.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

A Non-canonical RNA Silencing Pathway Promotes mRNA Degradation in Basal Fungi

The increasing knowledge on the functional relevance of endogenous small RNAs (esRNAs) as riboregulators has stimulated the identification and characterization of these molecules in numerous eukaryotes. In the basal fungus Mucor circinelloides, an emerging opportunistic human pathogen, esRNAs that regulate the expression of many protein coding genes have been described. These esRNAs share common machinery for their biogenesis consisting of an RNase III endonuclease Dicer, a single Argonaute protein and two RNA-dependent RNA polymerases. We show in this study that, besides participating in this canonical dicer-dependent RNA interference (RNAi) pathway, the rdrp genes are involved in a novel dicer-independent degradation process of endogenous mRNAs. The analysis of esRNAs accumulated in wild type and silencing mutants demonstrates that this new rdrp-dependent dicer-independent regulatory pathway, which does not produce sRNA molecules of discrete sizes, controls the expression of target genes promoting the specific degradation of mRNAs by a previously unknown RNase. This pathway mainly regulates conserved genes involved in metabolism and cellular processes and signaling, such as those required for heme biosynthesis, and controls responses to specific environmental signals. Searching the Mucor genome for candidate RNases to participate in this pathway, and functional analysis of the corresponding knockout mutants, identified a new protein, R3B2. This RNase III-like protein presents unique domain architecture, it is specifically found in basal fungi and, besides its relevant role in the rdrp-dependent dicer-independent pathway, it is also involved in the canonical dicer-dependent RNAi pathway, highlighting its crucial role in the biogenesis and function of regulatory esRNAs. The involvement of RdRPs in RNA degradation could represent the first evolutionary step towards the development of an RNAi mechanism and constitutes a genetic link between mRNA degradation and post-transcriptional gene silencing.

59 BASIC BIOLOGICAL SCIENCES↗

How Do Climate Change Experiments Alter Plot-Scale Climate?

To understand and forecast biological responses to climate change, scientists frequently use field experiments that alter temperature and precipitation. Climate manipulations can manifest in complex ways, however, challenging interpretations of biological responses. We reviewed publications to compile a database of daily plot-scale climate data from 15 active-warming experiments. We find that the common practices of analysing treatments as mean or categorical changes (e.g. warmed vs.unwarmed) masks important variation in treatment effects over space and time. Our synthesis showed that measured mean warming, in plots with the same target warming within a study, differed by up to 1.6° Celsius degrees (63% of target), on average, across six studies with blocked designs. Variation was high across sites and designs: for example, plots differed by 1.1°Celsius degrees (47% of target) on average, for infrared studies with feedback control (n = 3) vs. by 2.2° Celsius degrees (80% of target) on average for infrared with constant wattage designs (n = 2). Warming treatments produce non-temperature effects as well, such as soil drying. The combination of these direct and indirect effects is complex and can have important biological consequences. With a case study of plant phenology across five experiments in our database, we show how accounting for drier soils with warming tripled the estimated sensitivity of budburst to temperature. We provide recommendations for future analyses, experimental design,and data sharing to improve our mechanistic understanding from climate change experiments, and thus their utility to accurately forecast species' responses.

warming experiment↗

Phase Discovery and Selected Synthesis of Subvalent Niobium Tellurides Using a Polytelluride Flux Strategy

Transition metal subchalcogenides involve electron-rich metals and can facilitate an in-depth understanding of the relationships among quantum properties such as superconductivity, charge density wave, and topological band structures. However, effective experimental routes toward synthesizing transition metal subchalcogenides are still lacking, hindering the development of new quantum materials. Herein, we propose a eutectic polytelluride flux strategy as an excellent solution to address phase discovery and crystal growth in transition metal subtelluride systems. We report new phases easily and selectively synthesized using a eutectic “K 3 Te 4 ” polytelluride flux upon adjusting the ratio of Nb metal to flux in the starting materials (K/Nb/Te = 3:x:4). Using a high Nb content in the solvent (x = 2 and 1), crystals of KNb 3 Te 3 O 0.38 and K 0.9 Nb 3 Te 4 are obtained. Both subtellurides exhibit diverse Nb clusters, including face-sharing and edge-sharing Nb 6 octahedral columns and zig-zag Nb chains. Reducing the Nb content to x = 0.33 leads to the formation of a layered compound, K 1.06 NbTe 2 . This compound comprises a NbTe 6 trigonal prism with K intercalated between the layers. Single crystals of known binary Nb tellurides can also be grown using another eutectic flux “KTe 3 . 2 ”, and the obtained NbTe 2 exhibits a new polymorphism with extra trimerization along the b-axis in the Nb–Nb bonded double zig-zag cluster. Finally, precise control over the structural dimensionality and oxidation state, combined with the facile crystal growth process, makes our synthetic strategy an efficient route to explore quantum materials in transition metal subchalcogenides.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Design optimization for Richtmyer–Meshkov instability suppression at shock-compressed material interfaces

We report the Richtmyer–Meshkov instability (RMI) is a phenomenon that occurs at the interface of two substances of different densities due to an impulsive acceleration, such as a shock wave passing through this interface. Under these conditions, the instability can be seen as interface perturbations begin to grow into narrow jets or spikes of one substance that propagate into the other. In some cases, this interface may involve an elastic–plastic material, which can play a significant role in the development and behavior of the RMI. The ability to effectively control RMI jetting and spike growth is one major limiting factor in technological challenges, such as inertial confinement fusion, that involve using high-pressure shock waves to implode a fuel target. The propagation of RMI growth can lead to increased asymmetry in this implosion process and significantly reduce the obtained energy yield. We use hydrodynamics simulations of impactor shock-compression experiments and methods based in design optimization to suppress RMI spike growth by altering the geometry and other properties of a shock-compressed elastic–plastic material target that shares an interface with atmospheric air. These hydrodynamics simulations use an arbitrary Lagrangian–Eulerian method with a high-order finite element approach. Our results demonstrate that RMI suppression can be achieved by intentionally creating a separate upstream interface instability to counteract the growth of long narrow RMI spikes at an interface with initial perturbations.

36 MATERIALS SCIENCE↗

Node-red Software Architecture For Soec System Control

The software workflows that have been developed are open-source and therefore can be accessed and utilized by researchers and students all around the world for free of cost. The software is flexible and easily modifiable to suit the needs for testing bench-scale to system-level setups, and is not limited to just hydrogen generation facilities. The web-interface of the code allows for easy remote access and management, which is especially useful for distributed systems. This is more challenging with traditional PLCs, which often require direct connections or specialized software, making remote troubleshooting more cumbersome. Additionally, since the underlying interface is open-source, with an active community contributing to its development, regular updates, new features, and a wealth of community support and shared solutions will keep improving the overall architecture without excessive fees for upgrades.

Shigrekar, Amey [Idaho National Laboratory (INL), ↗

The Power and Energy Storage Systems Toolbox–PSTess (V1.0)

This document describes the Power and Energy Storage Systems Toolbox for MATLAB, abbreviated as PSTess. This computing package is a fork of the Power Systems Toolbox (PST). PST was originally developed at Rensselaer Polytechnic Institute (RPI) and later upgraded by Dr. Graham Rogers at Cherry Tree Scientific Software. While PSTess shares a common lineage with PST Version 3.0, it is a substantially different application. This document supplements the main PST manual by describing the features and models that are unique to PSTess. As the name implies, the main distinguishing characteristic of PSTess is its ability to model inverter-based energy storage systems (ESS). The model that enables this is called ess.m , and it serves the dual role of representing ESS operational constraints and the generator/converter interface. As in the WECC REGC_A model, the generator/converter interface is modeled as a controllable current source with the ability to modulate both real and reactive current. The model ess.m permits four-quadrant modulation, which allows it to represent a wide variety of inverter-based resources beyond energy storage when paired with an appropriate supplemental control model. Examples include utility-scale photovoltaic (PV) power plants, Type 4 wind plants, and static synchronous compensators (STATCOM). This capability is especially useful for modeling hybrid plants that combine energy storage with renewable resources or FACTS devices.

97 MATHEMATICS AND COMPUTING↗

S&MA Internship to Support Orion and the European Service Module

As a University Space Research Association (USRA) intern for NASA Johnson Space Center (JSC) during the summer 2016 work term, I worked on three main projects for the Space Exploration Division (NC) of the Safety and Mission Assurance (S&MA) Directorate. I worked on all three projects concurrently. One of the projects involved facilitating the status and closure of technical actions that were created during European Service Module (ESM) safety reviews by the MPCV Safety & Engineering Review Panel (MSERP). The two main duties included accurately collecting and summarizing qualitative data, and communicating that information to the European Space Agency (ESA) and Airbus (ESA's prime contractor) in a clear, succinct and precise manner. This project also required that I create a report on the challenges and opportunities of international S&MA. With its heavy emphasis on soft skills, this project taught me how to communicate better, by showing me how to present and share information in an easy-to-read and understandable format, and by showing me how to cooperate with and culturally respect international partners on a technical project. The second project involved working with the Orion Thermal Protection System (TPS) Process Failure Modes and Effects Analysis (PFMEA) Working Group to create the first full version of the Orion TPS PFMEA. The Orion TPS PFMEA Working Group met twice a week to analyze the Avcoat block installation process for failure modes, the failure modes effects, and how such failure modes could be controlled. I was in charge of implementing changes that were discussed in meeting, but were not implemented real time. Another major task included creating a significant portion of the content alongside another team member outside the two weekly meetings. This project caused me to become knowledgeable about TPS, heatshields, space-rated manufacturing, and non-destructive evaluation (NDE). The project also helped me to become better at working with a small team and helped improved my technical communication skills. My main duty for the third project was creating a Safety Verification Tracking Log (SVTL) for the Orbital Maneuvering System Engine (OMS-E), and contacting subject matter experts to close Hazard Report (HR) control verifications. This project also required me to support other OMS-E safety process tasks, like monitoring OMS-E vibration testing for Quality Assurance (QA) purposes. This project helped me become even more proficient in Excel. Throughout the project, I gained knowledge about the OMS-E system and improved my understanding of pressure systems and propellant systems. In terms of education goals, this work term has affirmed my desire to take a few more space-related courses, like orbital mechanics, so that I can have a better understanding of human spaceflight and the industry surrounding it. However, the work term did not persuade me to pursue a master's degree. In terms of career goals, this work term has helped me clarify the direction I would like to head in the future. The perspective of three summer terms working for NASA in S&MA has allowed me to observe that most S&MA employees joined S&MA after working in other NASA directorates, such as Engineering or Flight Operations. It is my belief that it would be advantageous for both NASA and I for me to broaden my knowledge base and technical skill set by completing hands-on technical work on human spaceflight projects, and for me to integrate my safety experience directly into technical work in other directorates. The other significant advantage to this proposed situation is that if I were to eventually return to S&MA, I would be returning with a substantial set of hands-on technical experience and knowledge, which would be a significant resource for S&MA tasks and projects.

Hutcheson, Connor↗

Exploring Management of Arrival Spacing Using Route Extensions with Terminal Spacing Tools

Airports with shared runway operations between arrivals and departures can experience severe departure gridlock and delays during a heavy arrival push due to insufficient gaps in the arrival stream for aircraft to depart. The problem is accentuated in situations when a large gap in the arrival spacing has to be created at the last minute due to wake vortex separation requirements. At LaGuardia airport, wake vortex separation problems arise when a heavy jet, such as a B757, departing on Runway 31 needs additional spacing between arrivals on Runway 22. A standard solution for controllers in many airports in situations such as this is to extend the downwind leg of arrival aircraft to create extra space between the arrivals. The question addressed in this paper is how such route extensions would work with terminal scheduling operations, namely (1) the automated Terminal Sequencing and Spacing (TSS) tools and (2) a new scheduling tool which increases the availability of gaps for departure aircraft (Departure Sensitive Arrival Spacing or DSAS). In a simulated LaGuardia airport (LGA) Terminal Radar Approach Control (TRACON) airspace, two new RNAV arrival routes were created along with extensions to these routes. The arrival route from the south had a downwind leg extension near the airport in the final sector. The arrival route from the north had an extension in a feeder sector further from the airport. An exploratory one-hour run with the route extensions was compared to an hour run without the extensions. Topics included in the paper are 1) how the route extensions were developed, 2) a procedure outlining how the aircraft could be scheduled to the extensions and who would do it, and 3) the results of the exploratory run compared to the original run without the extensions. The results indicated that the extended downwind leg route helped to create a B757 departure gap in the middle of a packed arrival stream, resulting in a reduction of 11 minutes in average wait time for the B757s, but at a cost of increased controller self-reported workload from low to moderate.

time based flow management↗

The Human Challenges of Remotely Piloted Aircraft Systems

Remotely Piloted Aircraft (RPA) range from small electric quadcopters that are flown close to the ground within visual range of the operator, to larger systems capable of extended flight in airspace shared with conventional aircraft. Before RPA can operate routinely and safely in civilian airspace, we need to understand the unique human factors associated with these aircraft. RPA pilots participated in focus groups where they were asked to recall critical incidents that either presented a threat to safety, or highlighted a case where the pilot contributed to system resilience or mission success. Ninety incidents were gathered from focus-groups. Human factor issues included the impact of reduced sensory cues, traffic separation in the absence of an out-the-window view, control latencies, vigilance during monotonous and ultra-long endurance flights, control station design considerations, transfer of control between control stations, the management of lost link procedures, and decision-making during emergencies. Some of these concerns have received significant attention in the literature, or are analogous to human factors of manned aircraft. Although many of the reported incidents were related to pilot error, the participants also provided examples of the positive contribution that humans make to the operation of highly-automated systems.

Hobbs, Alan↗

Lithium ion battery

A multi-core lithium ion battery includes a sealed enclosure and a support member disposed within the sealed enclosure. The sealed enclosure may further include at least two support members housed within individual compartments, separated by shared wall(s). The support member(s) includes a plurality of cavities and a plurality of lithium ion core members which are disposed within the plurality of cavities. The battery may further include a plurality of cavity liners, each of which is positioned between a corresponding one of the lithium ion core members and a surface of a corresponding one of the cavities. The hermetically sealed enclosure may be formed using a clamshell configuration. Structures may be included in proximity to or in contact with the lithium ion core members to control gas/fluid flow therefrom.

25 ENERGY STORAGE↗