Search NASA⌕ Search

SEARCH · Search NASA

Results for “BOX MODELS”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,747 records · Page 97
All sourcesNASA NTRSDOE OSTI
DOE OSTI2017

The structure and statistics of interstellar turbulence

We explore the structure and statistics of multiphase, magnetized ISM turbulence in the local Milky Way by means of driven periodic box numerical MHD simulations. Using the higher order-accurate piecewise-parabolic method on a local stencil (PPML), we carry out a small parameter survey varying the mean magnetic field strength and density while fixing the rms velocity to observed values. We quantify numerous characteristics of the transient and steady-state turbulence, including its thermodynamics and phase structure, kinetic and magnetic energy power spectra, structure functions, and distribution functions of density, column density, pressure, and magnetic field strength. The simulations reproduce many observables of the local ISM, including molecular clouds, such as the ratio of turbulent to mean magnetic field at 100 pc scale, the mass and volume fractions of thermally stable Hi, the lognormal distribution of column densities, the mass-weighted distribution of thermal pressure, and the linewidth-size relationship for molecular clouds. Our models predict the shape of magnetic field probability density functions (PDFs), which are strongly non-Gaussian, and the relative alignment of magnetic field and density structures. Finally, our models show how the observed low rates of star formation per free-fall time are controlled by the multiphase thermodynamics and large-scale turbulence.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2014

Dosimetry in Thermal Neutron Irradiation Facility at BMRR

Radiation dosimetry for Neutron Capture Therapy (NCT) has been performed since 1959 at Thermal Neutron Irradiation Facility (TNIF) of the three-megawatt light-water cooled Brookhaven Medical Research Reactor (BMRR). In the early 1990s when more effective drug carriers were developed for NCT, in which the eye melanoma and brain tumors in rats were irradiated in situ, extensive clinical trials of small animals began using a focused thermal neutron beam. To improve the dosimetry at irradiation facility, a series of innovative designs and major modifications made to enhance the beam intensity and to ease the experimental sampling at BMRR were performed; including (1) in-core fuel addition to increase source strength and balance flux of neutrons towards two ports, (2) out of core moderator remodeling, done by replacing thicker D 2 O tanks at graphite-shutter interfacial areas, to expedite neutron thermalization, (3) beam shutter upgrade to reduce strayed neutrons and gamma dose, (4) beam collimator redesign to optimize the beam flux versus dose for animal treatment, (5) beam port shielding installation around the shutter opening area (lithium-6 enriched polyester-resin in boxes, attached with polyethylene plates) to reduce prompt gamma and fast neutron doses, (6) sample holder repositioning to optimize angle versus distance for a single organ or whole body irradiation, and (7) holder wall buildup with neutron reflector materials to increase dose and dose rate from scattered thermal neutrons. During the facility upgrade, reactor dosimetry was conducted using thermoluminescent dosimeters TLD for gamma dose estimate, using ion chambers to confirm fast neutron and gamma dose rate, and by the activation of gold-foils with and without cadmium-covers, for fast and thermal neutron flux determination. Based on the combined effect from the size and depth of tumor cells and the location and geometry of dosimeters, the measured flux from cadmium-difference method was 4 - 7 % lower than the statistical mean derived from the Monte-Carlo modeling (5% uncertainty). The dose rate measured by ion chambers was 6 - 10 % lower than the output tallies (7% uncertainty). The detailed dosimetry that was performed at the TNIF for the NCT will be described.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
NASA NTRS1977

Specialized physiological studies in support of manned space flight

Breath-by-breath measurements of pulmonary capillary O2 transfer and ventilation with a box-balloon spirometer and mass spectrometer were made on 3 subjects before, during and after 10 min of lower body negative pressure (LBNP) at -20, -40 and -60 Torr with arterial samples at -60 Torr. Deficits in blood O2 stores (O2B) were noted during LBNP with repayment of O2B during recovery being related to the intensity of LBNP stress. Concurrent calf volume, measured with a Hg strain gauge, decreased towards baseline well before the peak rise in pulmonary capillary O2 transfer after the release of LBNP which signified that O2B changes were related to blood volume shifts. The return of O2-depleted pooled blood to the central circulation during the first min. of recovery caused significant stress-related hyperpnea which peaked near 30 sec. and returned to near baseline after the first min. Three-compartment lung model analyses indicated an increase in the ventilated unperfused lung fraction from 0.09 to 0.17 with the effective compartment decreasing from 0.83 to 0.77. It appears that the 30% increase in ventilation equivalent was primarily the result of less effective lung perfusion during the LBNP.

Source record↗
NASA NTRS2001

Geoscience Laser Altimeter System (GLAS) Instrument: Flight Loop Heat Pipe (LHP) Acceptance Thermal Vacuum Test

Two loop heat pipes (LHPs) are to be used for tight thermal control of the Geoscience Laser Altimeter System (GLAS) instrument, planned for flight in late 2001. The LHPs are charged with Propylene as a working fluid. One LHP will be used to transport 110 W from a laser to a radiator, the other will transport 160 W from electronic boxes to a separate radiator. The application includes a large amount of thermal mass in each LHP system and low initial startup powers. The initial design had some non-ideal flight design compromises, resulted in a less than ideal charge level for this design concept with a symmetrical secondary wick. This less than ideal charge was identified as the source of inadequate performance of the flight LHPs during the flight thermal vacuum test in October of 2000. We modified the compensation chamber design, re-built and charged the LHPs for a final LHP acceptance thermal vacuum test. This test performed March of 2001 was 100% successful. This is the last testing to be performed on the LHPs prior to instrument thermal vacuum test. This sensitivity to charge level was shown through varying the charge on a Development Model Loop Heat Pipe (DM LHP) and evaluating performance at various fill levels. At lower fills similar to the original charge in the flight units, the same poor performance was observed. When the flight units were re-designed and filled to the levels similar to the initial successful DM LHP test, the flight units also successfully fulfilled all requirements. This final flight Acceptance test assessed performance with respect to startup, low power operation, conductance, and control heater power, and steady state control. The results of the testing showed that both LHPs operated within specification. Startup on one of the LHPs was better than the other LHP because of the starter heater placement and a difference in evaporator design. These differences resulted in a variation in the achieved superheat prior to startup. The LHP with the lower superheat was sensitive to the thermal environment around the compensation chamber, while the LHP with the higher superheat (similar in design to DM LHP) was not. In response to the test results the placement of the starter heater will be optimized for the flight instrument testing for higher achieved superheat. This presentation discusses startup behavior, overall conductance of a radiator system, low power operation, high power operation, temperature control stability, and control heater power requirements as measured during this acceptance thermal vacuum test. A brief summary of 'lessons learned' will be included.

Baker, Charles↗
NASA NTRS2004

Improving the Simulation of Sea Ice Lead Conditions and Turbulent Fluxes Using RGPS Products and Merged RADARSAT, AVHRR and MODIS Data

The importance of sea ice leads in the ice-ocean-atmosphere system lies in the fact that each of the boxes in the 'surface processes' interface in this diagram is closely linked to lead conditions. For example, heat, moisture and salt exchange between the Ocean and atmosphere within the ice pack occur nearly entirely through leads. The shear, divergence and convergence associated with lead formation and closure alter surface and basal roughness and topography, which in turn affects momentum transfer in the atmosphere and ocean boundary layers, and modifies the accumulation of snow on the ice surface, which then affects heat conduction and summertime albedo. In addition to providing openings for loss of heat and moisture fluxes to the atmosphere, leads absorb solar energy, which is used to melt ice and is transmitting to the underlying ocean. Given that leads dominate the ice-ocean interface in this manner, then it stands to reason that focusing on lead treatments within models can identify performance limitations of models and yield routes for significant improvements.

Maslanik, James A.↗
DOE OSTI2019

Burn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma

Singular traumatic insults, such as bone fracture, typically initiate an appropriate immune response necessary to restore the host to pre-insult homeostasis with limited damage to self. However, multiple concurrent insults, such as a combination of fracture, blunt force trauma, and burns (polytrauma), are clinically perceived to result in abnormal immune response leading to inadequate healing and resolution. To investigate this phenomenon, we created a model rat model of polytrauma. To investigate relationship between polytrauma and delayed healing, we created a novel model of polytrauma in a rat which encompassed a 3-mm osteotomy, blunt chest trauma, and full-thickness scald burn. Healing outcomes were determined at 5 weeks where the degree of bone formation at the osteotomy site of polytrauma animals was compared to osteotomy only animals (OST). We observed significant differences in the bone volume fraction between polytrauma and OST animals indicating that polytrauma negatively effects wound healing. Polytrauma animals also displayed a significant decrease in their ability to return to pre-injury weight compared to osteotomy animals. Polytrauma animals also exhibited significantly altered gene expression in osteogenic pathways as well as the innate and adaptive immune response. Perturbed inflammation was observed in the polytrauma group compared to the osteotomy group as evidenced by significantly altered white blood cell (WBC) profiles and significantly elevated plasma high-mobility group box 1 protein (HMGB1) at 6 and 24 h post-trauma. Conversely, polytrauma animals exhibited significantly lower concentrations of plasma TNF-alpha (TNF-α) and interleukin 6 (IL-6) at 72 h post-injury compared to OST. Following polytrauma with burn injury, the local and systemic immune response is divergent from the immune response following a less severe singular injury (osteotomy). This altered immune response that follows was associated with a reduced capacity for wound healing.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2013

Closeout of CRADA JSA 2012S004: Chapter 5, Integrated Control System, of the document of the ESS Conceptual Design Report, publicly available at https://europeanspallationsource.se/accelerator-documents

The integrated control system (ICS) is responsible for the whole ESS machine and facility: accelerator, target, neutron scattering instruments and conventional facilities. This unified approach keeps the costs of development, maintenance and support relatively low. ESS has selected a standardised, field-proven controls framework, the Experimental Physics and Industrial Control System (EPICS), which was originally developed jointly by Argonne and Los Alamos National Laboratories. Complementing this selection are best practices and experience from similar facilities regarding platform standardisation, control system development and device integration and commissioning. The components of ICS include the control system core, the control boxes, the BLED database management system, and the human machine interface. The control system core is a set of systems and tools that make it possible for the control system to provide required data, information and services to engineers, operators, physicists and the facility itself. The core components are the timing system that makes possible clock synchronisation across the facility, the machine protection system (MPS) and the personnel protection system (PPS) that prevent damage to the machine and personnel, and a set of control system services. Control boxes are servers that control a collection of equipment (for example a radio frequency cavity). The integrated control system will include many control boxes that can be assigned to one supplier, such as an internal team, a collaborating institute or a commercial vendor. This approach facilitates a clear division of responsibilities and makes integration much easier. A control box is composed of a standardised hardware platform, components, development tools and services. On the top level, it interfaces with the core control system components (timing, MPS, PPS) and with the human-machine interface. At the bottom, it interfaces with the equipment and parts of the facility through a set of analog and digital signals, real-time control loops and other communication buses. The ICS central data management system is named BLED (beam line element databases). BLED is a set of databases, tools and services that is used to store, manage and access data. It holds vital control system configuration and physics-related (lattice) information about the accelerator, target and instruments. It facilitates control system configuration by bringing together direct input-output controller (IOC) con guration and real-time data from proton and neutron beam line models. BLED also simplifies development and speeds up the code-test-debug cycle. The set of tools that access BLED will be tailored to the needs of different categories of users, such as ESS staff physicists, engineers, and operators; external partner laboratories; and visiting experimental instrument users. The human-machine interface is vital to providing a high-quality experience to ICS users. It encompasses a wide array of devices and software tools, from control room screens to engineer terminal windows; from beam physics data tools to post-mortem data analysis tools. It serves users with a wide range of skills from widely varied backgrounds. The Controls Group is developing a set of user profiles to accommodate this diverse range of use-cases and users.

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗
DOE OSTI2019

Evaluation of Aluminum-clad Spent Nuclear Fuel during Drying and Dry Storage

The DOE SNF Working Group ASNF Subgroup and the U.S. Nuclear Waste Technical Review Board have identified knowledge gaps regarding the management of aluminum-clad spent nuclear fuel (ASNF).[1, 2] The objectives of this research are to observe, sample and analyze the nature of aluminum surface corrosion and corrosion layer chemistry relevant to the ASNF performance over the duration of the dry storage segment of the fuel life cycle. The primary goal is to build an understanding of ASNF behavior, from reactor service and wet storage through drying and dry storage, with parallel testing of surrogate materials. The premise is that residual water affiliated with the aluminum oxide from corrosion during reactor service and wet storage, continues to influence ASNF performance during dry storage, and that even after successful drying the surface conditions of ASNF have yet to be satisfactorily characterized. The initial scope collected and analyzed specimens from irradiated non-fuel components of aluminum-clad Advanced Test Reactor (ATR) fuel elements that are routinely removed at the end of reactor service life. Techniques have been developed for remote material sampling from ATR elements from vented dry storage at the Irradiated Fuel Storage Facility (IFSF). These techniques involve 1) nipping off a small corner of the aluminum near where the end box had been removed and 2) scraping the exterior (non-fueled) plate surface to collect an oxide sample. This second effort targets ATR elements expected to have seen the longest residence in storage, both in the CPP-603 pool (with poor water quality) and in dry storage at IFSF, within the fuel handling scheduled to consolidate ATR at IFSF and receive the remaining inventory at CPP-666. Follow on work has been proposed to nip corners and collect scrapings immediately following ATR fuel drying, before placement in dry storage. Sample analysis will use multiple techniques to understand the chemical composition and morphology of the surface oxides. A simultaneous effort is progressing to develop surrogate materials to enable rigorous controlled experiments. Consistently produced, these surrogate materials can then be used to demonstrate limitations inherent to remote sampling and to validate performance models under relevant constraints. The combined efforts will substantiate ASNF performance and fuel management decisions regarding drying and packaging over a more complete range of life cycle conditions. [1] DOE Spent Nuclear Fuel Working Group, Aluminum-Clad Spent Nuclear Fuel: Technical Considerations and Challenges for Extended (>50 Years) Dry Storage, DOE/ID RPT#: 1575, prepared by Aluminum-Clad SNF Sub Working Group, June 2017. [2] U.S. Nuclear Waste Technical Review Board, Management and Disposal of U.S. Department of Energy Spent Nuclear Fuel, A Report to the United States Congress and the Secretary of Energy, December 2017, p. 143.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2016

MicroRNA-mediated Th2 bias in methimazole-induced acute liver injury in mice

MicroRNA (miRNA) is a class of small non-coding RNAs containing approximately 20 nucleotides that negatively regulate target gene expression. Little is known about the role of individual miRNAs and their targets in immune- and inflammation-related responses in drug-induced liver injury. In the present study, involvement of miRNAs in the T helper (Th) 2-type immune response was investigated using a methimazole (MTZ)-induced liver injury mouse model. Co-administration of L-buthionine-S,R-sulfoximine and MTZ induced acute hepatocellular necrosis and elevated plasma levels of alanine aminotransferase (ALT) from 4 h onward in female Balb/c mice. The hepatic mRNA expression of Th2 promotive factors was significantly increased concomitantly with plasma ALT levels. In contrast, the hepatic mRNA expression of Th2 suppressive factors was significantly decreased during the early phase of liver injury. Comprehensive profiling of hepatic miRNA expression was analyzed before the onset of MTZ-induced liver injury. Using in silico prediction of miRNAs that possibly regulate Th2-related genes and subsequent quantification, we identified up-regulation of expression of miR-29b-1-5p and miR-449a-5p. Among targets of these miRNAs, down-regulation of Th2 suppressive transcription factors, such as SRY-related HMG-box 4 (SOX4) and lymphoid enhancer factor-1 (LEF1), were observed from the early phase of liver injury. In conclusion, negative regulation of the expression of SOX4 by miR-29b-1-5p and that of LEF1 by miR-449a-5p is suggested to play an important role in the development of Th2 bias in MTZ-induced liver injury. - Highlights: • Methimazole induced hepatic Th2 bias in the pathogenesis of liver injury in mice. • Rapid down-regulation of SOX4 and LEF1 may initiate and/or maintain hepatic Th2 bias. • Negative regulation of SOX4 by miR-29b-1-5p and LEF1 by miR-449a-5p was suggested.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

Modeling Liquid Water by Climbing up Jacob’s Ladder in Density Functional Theory Facilitated by Using Deep Neural Network Potentials

Within the framework of Kohn–Sham density functional theory (DFT), the ability to provide good predictions of water properties by employing a strongly constrained and appropriately normed (SCAN) functional has been extensively demonstrated in recent years. Here, we further advance the modeling of water by building a more accurate model on the fourth rung of Jacob’s ladder with the hybrid functional, SCAN0. In particular, we carry out both classical and Feynman path-integral molecular dynamics calculations of water with the SCAN0 functional and the isobaric–isothermal ensemble. To generate the equilibrated structure of water, a deep neural network potential is trained from the atomic potential energy surface based on ab initio data obtained from SCAN0 DFT calculations. For the electronic properties of water, a separate deep neural network potential is trained by using the Deep Wannier method based on the maximally localized Wannier functions of the equilibrated trajectory at the SCAN0 level. The structural, dynamic, and electric properties of water were analyzed. The hydrogen-bond structures, density, infrared spectra, diffusion coefficients, and dielectric constants of water, in the electronic ground state, are computed by using a large simulation box and long simulation time. For the properties involving electronic excitations, we apply the GW approximation within many-body perturbation theory to calculate the quasiparticle density of states and bandgap of water. Compared to the SCAN functional, mixing exact exchange mitigates the self-interaction error in the meta-generalized-gradient approximation and further softens liquid water toward the experimental direction. For most of the water properties, the SCAN0 functional shows a systematic improvement over the SCAN functional. However, some important discrepancies remain. The H-bond network predicted by the SCAN0 functional is still slightly overstructured compared to the experimental results.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2023

LA100 Equity Strategies. Chapter 3: Community-Guided Energy Equity Strategies

The LA100 Equity Strategies project synthesizes community guidance with robust research, modeling, and analysis to identify strategy options that can increase equitable outcomes in Los Angeles' clean energy transition. Grounded in the analysis of past and ongoing energy inequities and engagement with underserved communities, the project presents community-guided strategies that aim to operationalize recognition and procedural justice. Chapters 1 and 2 target the problem space - the causal factors, impact areas, and values affecting LA's energy justice landscape. This chapter threads those themes through to begin focusing on the solution space. We examine community-identified problems and solutions through the lens of recognition and procedural justice, presenting analysis and strategies that form the basis for more equitable outcomes in LA's energy transition. In our listening sessions, underserved Angelenos highlighted the need to transition away from the status quo one participant described as "transactional extraction of information to check the box. To say yes, we engaged." She asked the LA Department of Water and Power (LADWP) to approach her community with respect and transparency, stating, "We consider you all to be experts in your community, and we'd like to authentically engage with you in the decision-making process. So, I do think there needs to be some intentional actions for that rapport building and that trust building." The community-informed analysis and strategies described in this chapter, which are foundational to the LA100 Equity Strategies project, rise to the challenge of engaging authentically to build rapport, establish relationships of respect, and meaningfully involve Angelenos in the decision-making process. LADWP is already making concerted efforts to redress a disproportionate distribution of investments in physical infrastructure and energy efficient technologies in Los Angeles. This chapter concentrates on the challenge to further rectify past and ongoing inequities in the social, cultural, and institutional scaffolding of Los Angeles. We examine community-guided strategies to tackle this challenge, informed by community input on how all Angelenos can equitably access green jobs and affordable, safe, and resilient energy services, technologies, and programs. These actionable strategies can help move energy equity programs from plans to applied practices, supporting LADWP in launching a just and equitable clean energy transition.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2025

Interactive Rotated Object Detection for Novel Class Detection in Remotely Sensed Imagery

In this paper we propose IRTR-DETR an Interactive and Real-Time Rotated DEtection TRansformer that extends IRTDETR to predict rotated bounding boxes. IRTR-DETR maintains the Human-In-The-Loop (HIL) workflow of IRTDETR but introduces rotation-aware heads for improved detection of objects with arbitrary orientations. Similarly to IRTDETR IRTR-DETR can be trained with a small labeled sample set in an interactive setting but we show that it can also be pretrained on related but not identical data--such as a building damage dataset--before being applied to tasks like identifying buildings under construction. We demonstrate the efficacy of our approach on the publicly available Tiny-DOTA and xBD dataset as well as two study-cases on proprietary datasets of greenhouses and houses under construction ("waffle homes"). Detecting greenhouses is highly relevant in the context of damage assessment while "waffle homes" aid understanding typical floorplans and building codes in different areas both thereby supporting population modeling emergency response and policy planning. Our method outperforms the state of the art in interactive rotated object detection on the Tiny-DOTA dataset by 5.7 percent and improves upon the non interactive RTDETR by 7.85 to 19.39 percent (depending on the number of provided samples) while maintaining its real-time efficiency.

Burges, Marvin [ORNL] (ORCID:0000000312690769)↗
DOE OSTI2015

Ectopic AP4 expression induces cellular senescence via activation of p53 in long-term confluent retinal pigment epithelial cells

When cells are grown to confluence, cell–cell contact inhibition occurs and drives the cells to enter reversible quiescence rather than senescence. Confluent retinal pigment epithelial (RPE) cells exhibiting contact inhibition was used as a model in this study to examine the role of overexpression of transcription factor AP4, a highly expressed transcription factor in many types of cancer, in these cells during long-term culture. We generated stable inducible RPE cell clones expressing AP4 or AP4 without the DNA binding domain (DN-AP4) and observed that, when cultured for 24 days, RPE cells with a high level of AP4 exhibit a large, flattened morphology and even cease proliferating; these changes were not observed in DN-AP4-expressing cells or non-induced cells. In addition, AP4-expressing cells exhibited senescence-associated β-galactosidase activity and the senescence-associated secretory phenotype. We demonstrated that the induced cellular senescence was mediated by enhanced p53 expression and that AP4 regulates the p53 gene by binding directly to two of the three E-boxes present on the promoter of the p53 gene. Moreover, we showed that serum is essential for AP4 in inducing p53-associated cellular senescence. Collectively, we showed that overexpression of AP4 mediates cellular senescence involving in activation of p53 in long-term post-confluent RPE cells.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1994

From Antarctica to space: Use of telepresence and virtual reality in control of remote vehicles

In the Fall of 1993, NASA Ames deployed a modified Phantom S2 Remotely-Operated underwater Vehicle (ROV) into an ice-covered sea environment near McMurdo Science Station, Antarctica. This deployment was part of the antarctic Space Analog Program, a joint program between NASA and the National Science Foundation to demonstrate technologies relevant for space exploration in realistic field setting in the Antarctic. The goal of the mission was to operationally test the use of telepresence and virtual reality technology in the operator interface to a remote vehicle, while performing a benthic ecology study. The vehicle was operated both locally, from above a dive hole in the ice through which it was launched, and remotely over a satellite communications link from a control room at NASA's Ames Research Center. Local control of the vehicle was accomplished using the standard Phantom control box containing joysticks and switches, with the operator viewing stereo video camera images on a stereo display monitor. Remote control of the vehicle over the satellite link was accomplished using the Virtual Environment Vehicle Interface (VEVI) control software developed at NASA Ames. The remote operator interface included either a stereo display monitor similar to that used locally or a stereo head-mounted head-tracked display. The compressed video signal from the vehicle was transmitted to NASA Ames over a 768 Kbps satellite channel. Another channel was used to provide a bi-directional Internet link to the vehicle control computer through which the command and telemetry signals traveled, along with a bi-directional telephone service. In addition to the live stereo video from the satellite link, the operator could view a computer-generated graphic representation of the underwater terrain, modeled from the vehicle's sensors. The virtual environment contained an animate graphic model of the vehicle which reflected the state of the actual vehicle, along with ancillary information such as the vehicle track, science markers, and locations of video snapshots. The actual vehicle was driven either from within the virtual environment or through a telepresence interface. All vehicle functions could be controlled remotely over the satellite link.

Stoker, Carol↗
NASA NTRS1994

Interactive visualization of Earth and Space Science computations

Computers have become essential tools for scientists simulating and observing nature. Simulations are formulated as mathematical models but are implemented as computer algorithms to simulate complex events. Observations are also analyzed and understood in terms of mathematical models, but the number of these observations usually dictates that we automate analyses with computer algorithms. In spite of their essential role, computers are also barriers to scientific understanding. Unlike hand calculations, automated computations are invisible and, because of the enormous numbers of individual operations in automated computations, the relation between an algorithm's input and output is often not intuitive. This problem is illustrated by the behavior of meteorologists responsible for forecasting weather. Even in this age of computers, many meteorologists manually plot weather observations on maps, then draw isolines of temperature, pressure, and other fields by hand (special pads of maps are printed for just this purpose). Similarly, radiologists use computers to collect medical data but are notoriously reluctant to apply image-processing algorithms to that data. To these scientists with life-and-death responsibilities, computer algorithms are black boxes that increase rather than reduce risk. The barrier between scientists and their computations can be bridged by techniques that make the internal workings of algorithms visible and that allow scientists to experiment with their computations. Here we describe two interactive systems developed at the University of Wisconsin-Madison Space Science and Engineering Center (SSEC) that provide these capabilities to Earth and space scientists.

Hibbard, William L.↗
DOE OSTI2026

Leveraging machine learning to enhance aerosol classification using Single-Particle Mass Spectrometry

Advancing automated classification of atmospheric aerosols from Single-Particle Mass Spectrometry (SPMS) data remains challenging due to overlapping ion signatures, compositional diversity, and limited labeled data. This study evaluates supervised and semi-supervised learning frameworks to enhance aerosol identification by jointly leveraging labeled and unlabeled spectra. Four models were compared: a supervised Support Vector Machine (SVM), a self-training SVM, a stacked autoencoder classifier, and a stacked autoencoder trained using a temporal-ensembling Mean Teacher approach. All models achieved high and stable accuracies (90.0 %–91.1 %), surpassing previous results on the same dataset (87 %) and matching the performance of state-of-the-art deep learning methods. Despite small global metric differences (≤ 1 %), semi-supervised variants yielded up to 5 %–10 % improvements for compositionally rare particle types – such as soot (0.77 % of spectra, F1-score: 0.93–0.97) and hazelnut pollen (0.98 % of spectra, F1-score: 0.97–1.00) – equating to roughly ∼ 187 additional correctly classified spectra. These gains are scientifically significant, as such rare particles exert disproportionate influence on radiative absorption and ice nucleation processes; their improved detection reduces modeled uncertainties in aerosol absorption optical depth and mixed-phase cloud ice nucleation rates. The models' residual misclassifications (≈ 9 %) largely arise from true spectral overlap among chemically adjacent species (e.g., Na- vs. K-feldspar, coated vs. uncoated feldspars), reflecting physical compositional continuity rather than algorithmic error. Collectively, these findings demonstrate that leveraging unlabeled data to learn robust spectral representations and refine classification enhances both fidelity and interpretability, bridging data-driven analysis with aerosol–climate process understanding.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2018

Pax2 is essential for proliferation and osteogenic differentiation of mouse mesenchymal stem cells via Runx2

Highlights: • Knock-down of Pax2 inhibits the osteogenesis of mouse MSCs in vitro and in vivo. • Pax2 promotes the proliferation of mouse MSCs. • Pax2 enhances transcriptional activity of Runx2 and activates MAPK pathways. • Pax2 promotes the osteogenesis of mouse MSCs and may serve as a target for future clinical treatment. Mesenchymal stem cells (MSCs) have been widely studied in the field of regenerative medicine with the potential to solve osteoporosis. Paired box 2 (Pax2), as a transcription factor, is the master regulator of embryogenesis and oncogenesis. However, the function of Pax2 in osteogenesis is unknown. Here, we reported for the first time that the expression of Pax2 gradually increased during osteogenic differentiation of mouse MSCs, and osteoprogenitor cells. However, detected in osteoblastic cells of mouse tibia, the expression of Pax2 in the embryonic stage was higher than that in adulthood. In C3H/10/T1/2 cells and compact bone-derived mouse MSCs (mMSCs), Pax2 knock-down inhibited the proliferation of these cells, down-regulated the expression of osteogenic marker genes, as well as repressed the ALP activity and mineralization. In addition, Pax2 enhanced the transcriptional activity of Runx2, and activated the MAPK pathway genes (ERK, JNK and p38). Furthermore, knock-down of Pax2 repressed the mMSCs-mediated bone regeneration in an ectopic bone formation model. In conclusion, Pax2 promotes osteogenesis of mouse MSCs, suggesting that Pax2 has a role in the pathophysiology of bone related diseases, and has potential application in bone tissue regeneration.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2009

Objectives and Progress on Ground Vibration Testing for the Ares Launch Vehicles

NASA has conducted dynamic tests on each of its major launch vehicles during the past 45 years. Each test has provided invaluable data to correlate and correct analytical models used to predict structural responses to differing dynamics for these vehicles. With both Saturn V and Space Shuttle, hardware changes were also required to the flight vehicles to ensure crew and vehicle safety. The Ares I IVGVT will undoubtedly provide similar valuable test data to support successful flights of the Constellation Program. The IVGVT will provide test determined natural frequencies, mode shapes and damping for the Ares I. This data will be used to support controls analysis by providing this test data to reduce uncertainty in the models. The value of this testing has been proven by past launch vehicle successes and failures. Performing dynamic testing on the Ares vehicles will provide confidence that the launch vehicles will be safe and successful in their missions. In addition, IVGVT will provide the following benefits for the Ares rockets: a) IVGVT data along with Ares development flights like Ares I-X, Ares I-Y, Ares I-X Prime, and Orion-1 or others will reduce the risk to the Orion-2 crew. IVGVT will permit anchoring the various analytical and operational models used in so many different aspects of Ares operations. b) IVGVT data will permit better understanding of the structural and GN&C margins of the spacecraft and may permit mass savings or expanded day-of-launch opportunities or fewer constraints to launch. c) Undoubtedly IVGVT will uncover some of the "unknown unknowns" so often seen in developing, launching, and flying new spacecraft vehicles and data from IVGVT may help prevent a loss of vehicle or crew. d) IVGVT also will be the first time Ares I flight-like hardware is transported, handled, rotated, mated, stacked, and integrated. e) Furthermore, handling and stacking the IVGVT launch vehicle stacks will be an opportunity to understand certain aspects of vehicle operability much better (for example, handling procedures, touch-labor time to accomplish tasks, access at interfaces, access to stage mating bolts, access to avionics boxes, access to the Interstage, GSE functionality, and many other important aspects of Ares I operability). All of these results will provide for better vehicle safety and better stewardship of national resources as NASA begins its next phase of human space exploration.

Tuma, Margaret L.↗