SEARCH · Search NASA

Results for “Utility Regulation”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

SourceResearch connectionFrom yearThrough year

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,765 records · Page 98

All sources NASA NTRS DOE OSTI

NASA NTRS1979

LANDSAT supports data needs for EPA 208 planning

Excerpts from federal legislation and regulations mandating areawide waster treatment management as a means of restoring and maintaining the integrity of the nation's water are presented along with requirements for grants to the states for water quality planning, management, and implementation. Experiences using LANDSAT to identify nonpoint sources of water pollution as well as land/use/land cover features in South Dakota, Kentucky, Georgia, New Jersey, and Texas are described. Present activities suggest that this type of remote sensing is an efficient, effective tool for areawide water quality planning. Interaction with cognizant federal, state, and local government personnel involved in EPA section 208 planning activities can guide the development of new capabilities and enhance their utility and prospect for use.

Source record↗

NASA NTRS1994

Tactile display device using an electrorheological fluid

A tactile display device utilizes an electrorheological fluid to activate a plurality of tactile dots. A voltage is selectively produced uniformly across an electrorheological fluid flowing between a common ground electrode and a plurality of conductive dot electrodes, thereby producing an increase in the fluid's viscosity to the extent that fluid flow between the two electrodes is restricted. The flow restriction produces a build-up of electrorheological fluid in a corresponding dot actuator chamber. The resulting pressure increase in the chamber displaces an elastic diaphragm fixed to a display surface to form a lump which can be perceived by the reader as one dot in a Braille character cell. A flow regulation system provides a continually pressurized flow system and provides for free flow of the electrorheological fluid through the plurality of dot actuator chambers when they are not activated. The device is adaptable to printed circuit techniques and can simultaneously display tactile dots representative of a full page of Braille characters stored on a medium such as a tape cassette or to display tactile dots representative of non-Braille data appearing on a computer monitor or contained on another data storage medium. In an alternate embodiment, the elastic diaphragm drives a plurality of spring-loaded pins provided with positive stops to maintain consistent displacements of the pins in both their actuated and nonactuated positions.

Garner, H. Douglas↗

NASA NTRS1996

Mechanisms of Bone Mineralization and Effects of Mechanical Loading

The data suggest that PTH and PKC inhibit nodule formation, and that alternative energy sources are utilized by osteoblasts in the process of mineralization. The conditions and techniques to grow, fix, photograph, and measure bone mineralization in vitro were defined. The results are presently in preliminary form and require further assessment as follows; quantitate the surface area of nodules + treatments via computer-aided image analysis; use PTH + inhibitors of signaling pathways to determine the mechanism of nodule formation; determine how protein kinase C is involved as a promotor of nodule formation; cell proliferation vs. cell death affected by modulation of signal transduction (i.e., PTH, enzyme inhibitors and activators); identify mRNA induced or decreased in response to PTH and signaling modulators that encode proteins that regulate cell morphology, proliferation, and nodule formation. Therefore, several follow-up studies between the laboratories at NASA-Ames Research Center and my laboratory at the University of Illinois have been initiated.

Babich, Michael↗

NASA NTRS1996

Method and device for producing a tactile display using an electrorheological fluid

Garner, H. Douglas↗

DOE OSTI2016

Implementation Guide for the Revised Branch Technical Position on Concentration Averaging and Encapsulation - 16021

As a result of the research begun in 2007 to better understand the bases of the Branch Technical Position (BTP) on 'Concentration Averaging and Encapsulation' and 10 CFR 61 'Licensing Requirements for Land Disposal of Radioactive Waste', EPRI identified three regulatory initiatives that could be pursued to enhance disposal options for the industry. These initiatives directly follow the NRC strategic assessment. The first was to revise the BTP to allow broader blending of compatible waste types. The second was to examine how 10 CFR 61.58 'Alternative requirements for waste classification and characteristics' could be used to allow for an alternative disposal criterion based on site-specific hydro-geological characteristics and end land use scenarios. And, the third is to develop a technical basis for risk informed disposal regulations in anticipation of a 10CFR 61 rulemaking. By the summer of 2015 these initiatives had been broadly addressed and resulted in the NRC issuing Revision 1 to the BTP in February of 2015. Revision 1 of the BTP (BTP 2015) is a significant re-write of the draft issued in May 2012 and a significant improvement over the 1995 BTP (BTP 1995). The NRC has altered many of the positions in the interest of clarification. The development of an Implementation Guide for applying BTP 2015 to industry-specific waste streams that is vetted and supported by a EPRI sponsored working group consisting of industry participants (including utilities, disposal sites, NRC and Agreement State representatives and industry experts) will ensure compliant and consistent application during waste generation, packaging, processing and disposal activities. The Implementation Guide will provide for a comparison to previous BTP guidance and provide clarification and common understanding of the key concepts contained within the revised BTP. These include averaging constraints, hot spots, waste streams, waste types, discrete items, blending, solidification, encapsulation and alternative approaches. EPRI plans to publish the BTP Implementation Guide in the second quarter of 2016 and it will be available to the public. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

DOE OSTI2026

Cryo-electron microscopy structure of a zinc uptake ABC transporter

Zn2+ is an essential micronutrient required for many biological processes. Microorganisms employ high-affinity Zn2+ ABC transporters to take up zinc from the environment when it is scarce, yet the mechanism of zinc uptake and its regulation remain poorly understood. Here, we report the cryo-electron microscopy structure of the Zn2+ ABC transporter complex ZnuB-ZnuC from Escherichia coli. It contains two ZnuB transport and two ZnuC regulatory subunits. The ZnuB homodimer is in an outward-facing, closed conformation with a large hydrophilic cavity at the dimer interface. Each ZnuC subunit contains an N-terminal nucleotide-binding domain and a C-terminal zinc-sensing domain (ZSD). Zn2+ binding to the ZSD locks the transporter in a closed state, whereas under low-Zn2+ conditions, the disorder of ZSD permits ATP-driven zinc uptake. Zn2+ ABC transporters are ubiquitously utilized by pathogenic bacteria to compete with hosts for Zn2+. These findings reveal potential therapeutic targets for disrupting Zn2+ homeostasis in antibiotic-resistant pathogens.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS2022

The Atmosphere-Space Transition Region Explorer (ASTRE) – A Low Perigee Satellite to Investigate the Coupling of the Earth’s Upper Atmosphere and Magnetosphere

The Atmosphere-Space Transition Region Explorer (ASTRE) is a mission concept designed to carry out an unprecedented study of the interaction between the Earth’s atmosphere and the ionized gases of space within the atmosphere-space transition region. By gathering direct measurements of the coupling of ion and neutral gases in this region, ASTRE provides the critical missing link in our knowledge of the transfer, dissipation, and regulation of energy and momentum between the sun and the upper atmosphere. ASTRE provides the first detailed, systematic investigation of this important unexplored region, vastly improves and constrains models of the upper atmosphere, and fills a critical gap in our understanding of how the coupled lower ionosphere/upper atmosphere “works” as a system. To achieve its science objectives, ASTRE gathers accurate measurements of plasma and neutral gases, electric and magnetic fields, and energetic particles using well-proven, in situ instruments with excellent flight heritage. Furthermore, as described herein, all the instruments have been designed to perform well in the low perigee environment, including altitudes of 150 km and lower. ASTRE utilizes a three-axis stabilized satellite that uses on-board propulsion to carry out systematic, low perigee measurements at high latitudes. The satellite design incorporates a “form follows function” approach with a cylindrical shape and conductive body-mounted solar arrays to minimize drag and perturbations to the space environment. Atomic-oxygen resistant materials are utilized and a passive thermal design with heat pipes and radiator panels minimizes the impact of aero-heating. ASTRE launches into a 250 km × 1500 km elliptical insertion orbit with an inclination of 83°. Perigee precesses from its highest northern latitude to its highest southern latitude every ~60 days. Hydrazine propulsion provides over 2000 orbits with perigee below 200 km, with a significant fraction as low as 150 km, during high latitude, two-week campaigns when perigee precesses to either the northern or southern high latitude region. At mid and low latitudes, the perigee is near 225 km. Because very conservative assumptions were made with respect to the orbital analysis and drag, including continuous 3-sigma “worst-case” solar flux and atmospheric density, when additional propellant is included (accommodated in the current design) and some of the stringent assumptions are relaxed, the ASTRE mission described herein may be expected to include repeated excursions to altitudes of ~130 km or even lower. This paper presents an overview of the ASTRE mission, its science motivation, and objectives. It includes a discussion of the science-driven requirements and traceability, followed by a “proof-of concept” implementation that includes notional instruments and a straightforward spacecraft design. Three key points are demonstrated: 1) There is a critical knowledge gap in the high latitude, atmosphere-space transition region below 250 km; 2) The instrument and measurement techniques needed to obtain the ASTRE measurements are well-proven and function well in the low-altitude environment; and 3) A mature spacecraft design, flight dynamics analysis, and concept of operations have been developed that demonstrate that the ASTRE mission can be achieved in a straightforward manner using current technologies.

Ionosphere↗

NASA NTRSDate not supplied

Modeling Measurement Error in Dose-Response Models of Community Annoyance to Low-Noise Supersonic Flight

The primary research goal of the forthcoming NASA Quesst mission community test campaign is to collect representative community response data in support of the development of supersonic overflight noise certification standards. Beginning in 2026, NASA will fly the novel X-59 demonstrator aircraft over select communities in United States in order to demonstrate the possibility of low-noise supersonic flight over land and to collect objective measurements and subjective data on the perceptual experience of this new noise source. It is believed that a regression of a binary perceptual response (‘highly annoyed’ or ‘not’) on estimated noise levels (doses, measured in decibels) will provide a useful dose-response relationship for regulators. However, as these estimated doses will be subject to measurement error, naïve estimators of regression coefficients are inconsistent and slopes may be subject to attenuation bias. In this presentation, I contrast functional modeling of measurement error via simulation extrapolation (SIMEX) with structural Bayesian measurement error models. These methods are applied to available data collected during two NASA risk reduction studies in California in 2011 and Texas in 2018. I’ll conclude noting that in the presence of nonnegligible measurement errors, probabilities of annoyance may be overpredicted for low noise levels and underpredicted for high noise levels, therefore, methods of correcting for measurement error will be necessary to improve the utility of the dose-response relationship for policy-making purposes.

simulation↗

DOE OSTI2015

An Approach for Assessing Development and Deployment Risks in the DOE Fuel Cycle Options Evaluation and Screening Study

Abstract One of the key objectives of the U.S. Department of Energy (DOE) Nuclear Energy R&D Roadmap is the development of sustainable nuclear fuel cycles that can improve natural resource utilization and provide solutions to the management of nuclear wastes. Recently, an evaluation and screening (E&S) of fuel cycle systems has been conducted to identify those options that provide the best opportunities for obtaining such improvements and also to identify the required research and development activities that can support the development of advanced fuel cycle options. In order to evaluate and screen the E&S study included nine criteria including Development and Deployment Risk (D&DR). More specifically, this criterion was represented by the following metrics: Development time, development cost, deployment cost from prototypic validation to first-of-a-kind commercial, compatibility with the existing infrastructure, existence of regulations for the fuel cycle and familiarity with licensing, and existence of market incentives and/or barriers to commercial implementation of fuel cycle processes. Given the comprehensive nature of the study, a systematic approach was needed to determine metric data for the D&DR criterion, and is presented here. As would be expected, the Evaluation Group representing the once-through use of uranium in thermal reactors is always the highest ranked fuel cycle Evaluation Group for this D&DR criterion. Evaluation Groups that consist of once-through fuel cycles that use existing reactor types are consistently ranked very high. The highest ranked limited and continuous recycle fuel cycle Evaluation Groups are those that recycle Pu in thermal reactors. The lowest ranked fuel cycles are predominately continuous recycle single stage and multi-stage fuel cycles that involve TRU and/or U-233 recycle.

Gehin, Jess C↗

DOE OSTI2025

Hidden diversity: Transcriptomic and photosynthetic variation among common ‘wild type’ Chlamydomonas strains

The unicellular green alga Chlamydomonas reinhardtii is a widely studied reference organism, particularly in photosynthesis research. It employs photoprotective mechanisms, such as state transitions (ST) and non-photochemical quenching (NPQ), to cope with rapid light changes. Most widely used strains share a recent common ancestor yet differ by up to ~50 000 nuclear variants—genetic diversity that is often overlooked. Even among ‘wild type’ strains, we document significant phenotypic differences, such as pigment accumulation, and nutrient utilization. To elucidate the basis for this variation, we compared transcriptomes and physiological traits of seven commonly used laboratory strains, including the reference strain and the CLiP mutant library parental strain. Despite identical growth conditions, ~40% of genes were differentially expressed between strains. Most of these differences are attributable to changes that have accrued during laboratory propagation, and adverse conditions may have driven transcriptomic drift. At the physiological level, we catalog the range of strain-dependent responses related to photosynthesis and high light (HL) acclimation. Specifically, (i) all strains develop NPQ upon HL exposure, but to various degrees, (ii) they show a substantial variation in ST capacity, and (iii) they regulate the composition of the photosynthetic apparatus differently. We find that NPQ levels do not correlate with LHCSR3 expression, suggesting an additional layer of NPQ regulation. STs are constantly activated and independent of growth light intensities. Overall, our findings highlight significant strain-to-strain differences in virtually all photosynthetic parameters, emphasizing the importance of careful strain selection in future research endeavors.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2022

Large-scale Hydrogen Storage – Risk Assessment Seattle City Light and Port of Seattle [Abstract]

This CRADA presents the strategy that Pacific Northwest National Laboratory (PNNL) and Sandia National Laboratories (SNL) will take to support Seattle City Light (SCL), and the Port of Seattle (Port) in performing a risk assessment of large-scale hydrogen storage. Risk assessment is often used to ensure that adequate measures are taken to protect workers and the public, the environment, infrastructure, and assets. A detailed risk assessment can also be used to direct funding and upgrades, to specific components and sub-systems in order to mitigate risks to the larger system. In this way risk assessments are often employed as a part of a larger risk management strategy, with the goal of minimizing the occurrence of hazards and to identify means to limit their consequences. Risk assessment is often used to engage and inform regulators, and to communicate how specific regulations are being met. However, it is important to note that the proposed work is not intended for SCL and the Port to use in order to gain regulatory acceptance for their proposed activities. The work performed as a part of this effort will be a preliminary risk assessment for early-stage component and system designs and should be considered research and development (R&D). As such, the proposed work will be performed to a quality level and design maturity consistent with R&D and is not considered appropriate for final safety analysis and regulatory compliance purposes. Previous and on-going work at SCL and the Port demonstrated the utility of deploying hydrogen systems at the Port. The deployment of hydrogen at the Port is a part of a larger vision of using hydrogen to address a range of issues for SCL and the Port. These include large-scale fueling of MD/HD vehicles, cargo-handling equipment (CHE), and harbor vessels to reduce emissions; support of adjacent LD vehicles; support of critical port operations during extreme events (i.e., resiliency); deferral of more capital- and time-intensive electrical distribution system upgrades while still supporting evolving port operations and decarbonization efforts; facilitating electrification by establishing energy storage as a grid resource, starting at strategic port locations; creation of a flexible market resource that can be used by SCL to generate revenue via arbitrage; support of planned future maritime operations that involve heavy use of hydrogen for ocean-going vessels; and future end-use applications involving natural gas pipeline hydrogen injection. Ultimately, the success of these activities is underpinned by the deployed storage capacity. Large-scale deployment of hydrogen systems will require hydrogen storage at a scale that has not been demonstrated. In addition, the ideal location for such multi-use systems is near the end user which will often necessitate deploying into urban and/or industrial areas. A detailed risk assessment using the Port as a test case is necessary to ensure the deployment of large-scale hydrogen is successful. Many technologies have been proposed for hydrogen storage; however, these technologies need to be analyzed as they apply to an actual site. The physical infrastructure and hydrogen use cases for the Port will be analyzed, and a risk assessment for compressed hydrogen, liquified hydrogen, and Liquid Organic Hydrogen Carrier (LOHC) storage will be performed. These risk assessments will be useful for understanding how each of these technologies would perform in terms of facility and public safety. The operating states of the proposed hydrogen systems at the Port will be analyzed and incorporated into the storage risk assessment. Scalability will also be analyzed to understand how future port uses would affect the overall risk assessment. Finally, using the risk assessment as a tool to inform engagement and to gain stakeholder acceptance will be explored.

08 HYDROGEN↗

NASA NTRS1988

An application of eigenspace methods to symmetric flutter suppression

An eigenspace assignment approach to the design of parameter insensitive control laws for linear multivariable systems is presented. The control design scheme utilizes constrained optimization techniques to exploit the flexibility in eigenvector assignments to reduce control system sensitivity to changes in system parameters while maintaining performance requirements; it thus provides a systematic approach for choosing values for eigensystem design variables. The methods involve use of the singular value decomposition to provide an exact description of allowable eigenvectors in terms of a minimum number of design parameters. In a design example, the methods are applied to the problem of symmetric flutter suppression in an aeroelastic vehicle. In this example the flutter mode is sensitive to changes in dynamic pressure and eigenspace methods are used to enhance the performance of a stabilizing minimum energy/linear quadratic regulator controller and associated observer. Numerical results indicate that the methods provide feedback control laws that make the stability of the nominal closed loop systems less sensitive to changes in dynamic pressure, while maintaining acceptable control power and robustness constraints.

Fennell, Robert E.↗

NASA NTRS2006

Aircraft Conceptual Design and Risk Analysis Using Physics-Based Noise Prediction

An approach was developed which allows for design studies of commercial aircraft using physics-based noise analysis methods while retaining the ability to perform the rapid trade-off and risk analysis studies needed at the conceptual design stage. A prototype integrated analysis process was created for computing the total aircraft EPNL at the Federal Aviation Regulations Part 36 certification measurement locations using physics-based methods for fan rotor-stator interaction tones and jet mixing noise. The methodology was then used in combination with design of experiments to create response surface equations (RSEs) for the engine and aircraft performance metrics, geometric constraints and take-off and landing noise levels. In addition, Monte Carlo analysis was used to assess the expected variability of the metrics under the influence of uncertainty, and to determine how the variability is affected by the choice of engine cycle. Finally, the RSEs were used to conduct a series of proof-of-concept conceptual-level design studies demonstrating the utility of the approach. The study found that a key advantage to using physics-based analysis during conceptual design lies in the ability to assess the benefits of new technologies as a function of the design to which they are applied. The greatest difficulty in implementing physics-based analysis proved to be the generation of design geometry at a sufficient level of detail for high-fidelity analysis.

Olson, Erik D.↗

DOE OSTI2023

One thousand soils for molecular understanding of belowground carbon cycling

While significant progress has been made in understanding global carbon (C) cycling, the mechanisms regulating belowground C fluxes and storage are still uncertain. New molecular technologies have the power to elucidate these processes, yet we have no widespread standardized implementation of molecular techniques. To address this gap, we introduce the Molecular Observation Network (MONet), a decadal vision from the Environmental Molecular Sciences Laboratory (EMSL), to develop a national network for understanding the molecular composition, physical structure, and hydraulic and biological properties of soil and water. These data are essential for advancing the next generation of multiscale Earth systems models. In this paper, we discuss the 1000 Soils Pilot for MONet, including a description of standardized sampling materials and protocols and a use case to highlight the utility of molecular-level and microstructural measurements for assessing the impacts of wildfire on soil. While the 1000 Soils Pilot generated a plethora of data, we focus on assessments of soil organic matter (SOM) chemistry via Fourier-transform ion cyclotron resonance-mass spectrometry and microstructural properties via X-ray computed tomography to highlight the effects of recent fire history in forested ecosystems on belowground C cycling. We observed decreases in soil respiration, microbial biomass, and potential enzyme activity in soils with high frequency burns. Additionally, the nominal oxidation state of carbon in SOM increased with burn frequency in surface soils. This results in a quantifiable shift in the molecular signature of SOM and shows that wildfire may result in oxidation of SOM and structural changes to soil pore networks that persist into deeper soils.

54 ENVIRONMENTAL SCIENCES↗

NASA NTRS2017

The Role of Nuclear Cytoskeleton in the Osteocytic Response to Simulated Weightlessness

While in space, astronauts exercise frequently to combat bone and muscle loss due to weightlessness. This loss in bone can lead to serious health problems, such as increased fracture risk. Osteocytes are known to play a vital role in bone resorption and formation. It is also theorized that osteocytes act as the mechanosensors of bone, detecting mechanical stimulus and relaying these signals to surrounding cells. Previous research suggests that, during space flight, osteocytes exhibit matrix remodeling and resorption capabilities (osteocytic osteolysis) leading to an enlargement of the lacunae and contributing to overall bone degradation. The intercellular causes of these changes has not yet been determined. LINC or Linker of Nucleoskeleton and Cytoskeleton is a protein complex that forms a connection between the nucleus and cytoskeleton. LINC serves as a way to transmit mechanical signals to the nucleus and is also involved in the regulation of Wnt signaling via KASH proteins (Nesprin -1 and Nesprin -2). Wnt signaling in osteocytes assists with bone homeostasis and perturbed Wnt signaling can lead to bone loss. This suggests that LINC may contribute to the bone diminishing effects of microgravity. Therefore, we hypothesize that the disruption of LINC or LINC components by simulated microgravity (using the hindlimb unloading model, HU) affects Wnt signaling in osteocytes affecting bone formation and leading to increased osteocyte lacunar size. To test these hypotheses, we plan to conduct an animal study using 16 week old male mice (n6group). The mice will undergo HU for up to 7 days. After the desired time point, we will utilize quantitative real-time PCR techniques to determine the changes in gene expression of seven LINC complex genes (Sun -1, Sun -2, Nesprin -1, Nesprin -2, Lamin AC, Lamin B, and Emerin) and genes related to bone formation and osteocyte signaling. To determine changes osteocytic remodeling activity we will immunostain for osteocyte markers (Dmp-1 and Sost) and osteolysis markers (TRAP, MMPs) and measure lacunar size.

Touchstone, Hallie↗

DOE OSTI2018

Electronics Upgrades to the Green is Clean Phoswich Detector Systems and Programmatic Implementation at LANL - Phase II Completion - 18403

Los Alamos National Laboratory (LANL) radiological facilities produce low-density room trash that, in many cases, is not contaminated with radioactivity. It has been estimated that 50 to 90% of low-density room trash is free of radioactive contamination and eligible for inclusion in LANL's Green is Clean (GIC) program. The GIC program is a verification program for non-regulated waste from radiation controlled areas that has been actively segregated as nonradioactive through the use of the waste generator's acceptable knowledge. The GIC program has employed two large area Phoswich gamma ray detector systems (HERCULES and ZEUS) to verify that GIC candidate low-density waste contains no radioactivity above background. The large area (127 cm{sup 2}) Phoswich detectors consist of a thin NaI front crystal (3 mm thick) that is optically coupled to a thick CsI back crystal (50 mm thick). The scintillation properties of the two crystals are different enough to allow the system's electronic components to identify the origin of any pulse. The original systems utilize Nuclear Instrumentation Module (NIM) electronics to process the detector signals. The electronics currently in use by the systems are out of date and some components are no longer manufactured. In 2015, phase I upgrades to the GIC detector systems were completed. Phase I objectives included identifying more modern commercially available electronics that could replace the NIM electronics. A pulse shape discriminator (PSD) module, the Digital Gamma Finder (DGF) Pixie-4 made by XIA LLC, that fits in a compact National Instruments{sup TM} PXI chassis was identified to replace the majority of the original NIM bin electronics - a single Pixie-4 module replaces four NIM amplifiers and four NIM pulse shape analyzers (PSAs). Another phase I objective was to show that that new PSD could separate out the NaI and CsI detector signals in a manner equivalent to or better than the NIM electronics. Proof of concept was achieved in 2015 when a prototype upgrade system on ZEUS was built and tested and gating parameter settings were determined that successfully separated the NaI and CsI signals. Phase II required establishing a LabVIEW software interface with Pixie-4 electronics in lieu of the manufacturer provided Pixie-4 software called the Pixie Viewer. In addition, phase II included 1) final optimization of the gating parameters on the prototype Pixie-4 ZEUS system, 2) finalizing Requirements, Design and Test Plan documents, 3) LabVIEW software interface quality assurance (QA) testing, 4) setting up the HERCULES system with the Pixie-4 upgrade electronics, 5) check source and background calibration of both systems, 6) absolute efficiency determination on both systems and 7) procedure revisions and implementation of both systems into routine operations. In 2017 phase II was completed including the preparation of detailed Requirements, Design and Test Plan documents. The LabVIEW interface software that communicates and controls the Pixie-4 has been completed, merged with the preexisting LabVIEW operations software and fully tested. Gating parameter optimization, configuration of HERCULES with the Pixie-4 electronics, check source and background calibrations and absolute efficiency determinations have all been performed - quantitative results are presented in the full paper. For performance validation, comparison measurements of actual GIC bags on both the HERCULES system using the old NIM Bin electronics and the ZEUS system using the upgraded Pixie-4 electronics have been done and evaluated. Finally, procedure revisions and implementation of both systems into routine operations is currently in process and planned to be complete by the end of calendar year 2017. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

DOE OSTI2016

The Response Regulator BfmR Is a Potential Drug Target for Acinetobacter baumannii

Increasing antibiotic resistance in bacteria, particularly Gram-negative bacilli, has significantly affected the ability of physicians to treat infections, with resultant increased morbidity, mortality, and health care costs. In fact, some strains of bacteria are resistant to all available antibiotics, such as Acinetobacter baumannii , which is the focus of this report. Therefore, the development of new antibiotics active against these resistant strains is urgently needed. In this study, BfmR is further validated as an intriguing target for a novel class of antibiotics. Successful inactivation of BfmR would confer the multiple benefits of a decreased ability of A. baumannii to survive in human body fluids, increased sensitivity to complement-mediated bactericidal activity and, importantly, increased sensitivity to other antibiotics. Structural studies support the potential for this “druggable” target, as they identify the potential for small-molecule binding at functionally relevant sites. Next-phase high-throughput screening studies utilizing BfmR are warranted.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2023

Stoichiometric Control and Optical Properties of BaTiO 3 Thin Films Grown by Hybrid MBE

BaTiO 3 is a technologically relevant material in the perovskite oxide class with above-room-temperature ferroelectricity and a very large electro-optical coefficient, making it highly suitable for emerging electronic and photonic devices. An easy, robust, straightforward, and scalable growth method is required to synthesize epitaxial BaTiO 3 thin films with sufficient control over the film's stoichiometry to achieve reproducible thin film properties. Here the growth of BaTiO 3 thin films by hybrid molecular beam epitaxy is reported. A self-regulated growth window is identified using complementary information obtained from reflection high energy electron diffraction, the intrinsic film lattice parameter, film surface morphology, and scanning transmission electron microscopy. Subsequent optical characterization of the BaTiO 3 films by spectroscopic ellipsometry revealed refractive index and extinction coefficient values closely resembling those of stoichiometric bulk BaTiO 3 crystals for films grown inside the growth window. Even in the absence of a lattice parameter change of BaTiO 3 thin films, degradation of optical properties is observed, accompanied by the appearance of a wide optical absorption peak in the IR spectrum, attributed to optical transitions involving defect states present. Therefore, the optical properties of BaTiO 3 can be utilized as a much finer and more straightforward probe to determine the stoichiometry level present in BaTiO 3 films.

36 MATERIALS SCIENCE↗