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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 19 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2016

Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression

The transcriptional cofactor Che-1 is an RNA polymerase II (Pol II) which is involved in tumorigenesis, such as breast cancer and multiple myeloma. Che-1 can also regulate mutant p53 expression, which plays roles in many types of cancer. In this study, we aimed to investigate the effects and specific mechanism of Che-1 in the regulation of osteosarcoma (OS) cell growth. We found that Che-1 is highly expressed in several kinds of OS cells compared with osteoblast hFOB1.19 cells. MTT and flow cytometry assays showed that Che-1 depletion by siRNA markedly suppressed MG-63 and U2OS cell proliferation and promoted apoptosis. The chromatin immunoprecipitation (ChIP) assay verified the presence of Che-1 on the p53 promoter in MG-63 and U2OS cells carrying mutant p53. Further studies showed that Che-1 depletion inhibited mutant p53 expression. Notably, our study showed that the loss of Che-1 inhibits proliferation and promotes apoptosis in MG-63 cells by decreasing the level of mutant p53. Therefore, these findings open the possibility that silencing of Che-1 will have therapeutic benefit in OS. - Highlights: • Che-1 is highly expressed in several kinds of OS cells. • Che-1 depletion suppressed MG-63 and U2OS cell growth. • Che-1 is existed in the p53 promoter in MG-63 and U2OS cells. • Che-1 depletion inhibited mutant p53 expression. • Che-1 depletion inhibits cell growth by decreasing the level of mutant p53.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Communication: The formation of CHe{sup 2+} by radiative association

The detection of ArH{sup +} has revived the interest in the search for noble gas containing species. Despite helium being the second most abundant element in the universe (He/H ∼ 1/10), it has never been observed in any other form than that of a neutral/ionized atom in the interstellar medium. Because He is the “most noble” gas, its non-observation as part of neutral molecular systems is understandable. It is more surprising for charged species, especially HeH{sup +} whose spectral signatures are well documented in the laboratory. The purpose of this work was to find a simple positive ion containing He, and likely to be observed as an alternative to undetected HeH{sup +}. Among the HeX{sup 2+} diatomics formed with first row atoms, we focused on X = C because of both its relative abundance and the magnitude of its ionization potentials with respect to He. The formation of CHe{sup 2+} by radiative association is the center of this study. The question was addressed by means of numerical simulations using high level ab initio calculations of the CHe{sup 2+} potential surface, followed by a quantum chemical determination of the rate coefficients for the corresponding radiative association in the range of 10 to 1000K. The radiative association path shows a potential well deep enough to accommodate 20 vibrational levels, and no barrier to oppose the reaction. The rate coefficient varies from ∼4.5 × 10{sup −20} cm{sup 3}s{sup −1} to ∼2.5 × 10{sup −22} cm{sup 3}s{sup −1} for the temperatures considered. The present study suggests that the existence of this species has to be searched for mainly in highly irradiated regions.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2017

FY18 CHE GC Overview

Explore the source record for details and available documents.

Parker, Gary Robert Jr.↗
DOE OSTI2019

Surface-modified cyanide-based transition metal compounds

A system, method, and articles of manufacture for a surface-modified transition metal cyanide coordination compound (TMCCC) composition, an improved electrode including the composition, and a manufacturing method for the composition which may include multiple chelation species (Che_x). The composition, compound, device, and uses thereof according to A.sub.xMn.sub.(y-k)M.sup.j.sub.k[Mn.sup.m(CN).sub.(6-p-q)(NC).sub.p(Che_I- ).sup.r.sub.q].sub.z. CHE_GROUP (Vac).sub.(1-z).nH.sub.2O, wherein CHE_GROUP includes one or more chelation materials selected from the group consisting of (Che_I).sup.r.sub.w, (Che_II).sup.s.sub.v, and combinations thereof, and wherein 0<j.ltoreq.4, 0.ltoreq.k.ltoreq.0.1, 0.ltoreq.(p+q).ltoreq.6, 0<x.ltoreq.4, 0<y.ltoreq.1, 0<z.ltoreq.1, 0<w.ltoreq.0.2; -3.ltoreq.r.ltoreq.3; 0<v.ltoreq.0.2; -3.ltoreq.s.ltoreq.3; and 0.ltoreq.n.ltoreq.6; wherein x+2(y-k)+jk+(m+(r+1)q-6)z+wr+vs=0.

Motallebi, Shahrokh↗
DOE OSTI2020

Surface-modified cyanide-based transition metal compounds

A system, method, and articles of manufacture for a surface-modified transition metal cyanide coordination compound (TMCCC) composition, an improved electrode including the composition, and a manufacturing method for the composition which may include multiple chelation species (Che_x). The composition, compound, device, and uses thereof according to AxMn(y-k)Mjk[Mnm(CN)(6-p-q)(NC)p(Che_I)rq]z. CHE_GROUP (Vac)(1-z).nH2O, wherein CHE_GROUP includes one or more chelation materials selected from the group consisting of (Che_I)rw, (Che_II)sv, and combinations thereof, and wherein 0 < j≤4, 0≤k≤0.1, 0≤(p+q)≤6, 0 < x≤4, 0 < y≤1, 0 < z≤1, 0 < w≤0.2; −3≤r≤3; 0 < v≤0.2; −3≤s≤3; and 0≤n≤6; wherein x+2(y−k)+jk+(m+(r+1)q−6)z+wr+vs=0.

36 MATERIALS SCIENCE↗
DOE OSTI2018

Interaction of Chelerythrine with Keyhole Limpet Hemocyanin: a Fluorescence Spectroscopy and Molecular Docking Study

The quenching mechanism between chelerythrine (CHE) and keyhole limpet hemocyanin (KLH) was investigated using fluorescence spectroscopy and molecular docking. The experiments were conducted at three different temperatures (293, 298, and 303 K). The results revealed that the intrinsic fluorescence of KLH was strongly quenched by CHE through a static quenching mechanism. The thermodynamic parameters (ΔG, ΔH, and ΔS) of the interaction were calculated, indicating that the interaction between CHE and KLH was spontaneous and that van der Waals forces and hydrogen bond formation played major roles in the binding process. The intrinsic fluorescence of the tyrosine and tryptophan residues in KLH was studied by synchronous fluorescence, which suggested that CHE changed the conformation of KLH. Finally, molecular docking was used to obtain detailed information on the binding sites and binding affinities between CHE and KLH.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2019

Limited genetic diversity across pathogen populations responsible for the global emergence of boxwood blight identified using SSR s

Boxwood blight is an emerging disease of ornamental as well as native boxwood. The disease became widely established in Europe at the beginning of the 21st century, prior to its more recent discovery in North America and Asia. Two sister‐species of fungi cause the disease, Calonectria pseudonaviculata (Cps) and C. henricotiae (Che). Prior efforts to quantify intraspecific genetic polymorphisms of Cps and Che have yielded little information, limiting the ability to understand the evolution and migration of these pathogens. This study describes the development and implementation of simple sequence repeat ( SSR ) markers to analyse genetic diversity from a global collection of Cps and Che isolates, representing major blight outbreaks since the disease was first identified in the UK in the late 1990s. Analysis of the Cps CB 002 genome sequence identified 180 single copy SSR loci using stringent search criteria, 11 of which were polymorphic and used to screen a global sample of 306 isolates. Fourteen multilocus genotypes of Cps and two multilocus genotypes of Che were identified. Twelve of the 14 Cps genotypes differed from each other by a single allele. The most common Cps genotype was found on all continents where boxwood blight is confirmed. Based on measurement of linkage disequilibrium, Cps showed no evidence of sexual recombination. Further in silico analysis identified 1594 SSR s using relaxed SSR definition criteria. Comparison of these SSR ‐containing loci with Cps and Che genome sequences representing three different genotypes demonstrated that single nucleotide polymorphisms might serve as informative genetic markers for future studies.

LeBlanc, N.↗
DOE OSTI2024

Exploring Multidimensional Spatial-Temporal Hydropower Operational Flexibilities by Modeling and Optimizing Water-Constrained Cascading Hydroelectric Systems

Because of unique characteristics such as clean and cost-competitive electricity as well as fast-ramping and storage abilities, the power industry continues to evolve its operation strategies for cascading hydroelectric (CHE) systems for providing enhanced values to the grid, especially under the deeper renewable resource integration. However, existing operation practices of CHEs predate the integration of renewables, which could prohibit the effective utilization of their inherent flexibilities in delivering maximum financial benefits and providing valuable grid services to the power system and electricity market operations. Indeed, modeling and optimizing these resource-limited while flexible CHE assets with uncertainties and imperfect information across multiple spatial-temporal dimensions present significant challenges. To facilitate CHE facility operators in effectively coordinating water usage and hydropower plant operations across multiple timescales, this project aims to fill the existing gaps by developing a suite of accurate water inflow (WI) forecast models as well as enhanced CHE modeling and optimization approaches with proper consideration of their unique characteristics, which would help explore their multidimensional spatial-temporal operational flexibility potentials. The developed approaches could better align reservoir operation strategies with variability and uncertainty of future water availability. They can also promote more effective utilization of multidimensional spatial-temporal hydropower operational flexibility potentials by designing long-term evacuation plans of reservoirs and short-term operation of CHEs, along with their coordination with other types of renewables. The project leverages various resources to facilitate the research and development activities, including actual characteristics data of CHE systems and a library of current and future cases of Portland General Electric (PGE). These realistic data enable the project team to study how to maximize the value of CHEs under current and future portfolios and evaluate opportunities to improve operation practices.

13 HYDRO ENERGY↗
DOE OSTI2020

Surface-modified cyanide-based transition metal compounds

A system, method, and articles of manufacture for a surface-modified transition metal cyanide coordination compound (TMCCC) composition, an improved electrode including the composition, and a manufacturing method for the composition which may include multiple chelation species (Che_x). The composition, compound, device, and uses thereof according to AxMn(y-k)Mjk[Mnm(CN)(6-p-q)(NC)p(Che_I)rq]z.CHE_GROUP (Vac)(1-z).nH2O, wherein CHE_GROUP includes one or more chelation materials selected from the group consisting of (Che_I)rw, (Che_II)sv, and combinations thereof, and wherein 0 < j≤4, 0≤k≤0.1, 0≤(p+q)≤6, 0 < x≤4, 0 < y≤1, 0 < z≤1, 0 < w≤0.2; −3≤r≤3; 0 < v≤0.2; −3≤s≤3; and 0≤n≤6; wherein x+2(y−k)+jk+(m+(r+1)q−6)z+wr+vs=0.

36 MATERIALS SCIENCE↗