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At least 19 records

Exposure of the Bone Marrow Microenvironment to Simulated Solar and Galactic Cosmic Radiation Induces Biological Bystander Effects on Human Hematopoiesis

The stem cell compartment of the hematopoietic system constitutes one of the most radiosensitive tissues of the body and leukemias represent one of the most frequent radiogenic cancers with short latency periods. As such, leukemias may pose a particular threat to astronauts during prolonged space missions. Control of hematopoiesis is tightly governed by a specialized bone marrow (BM) microenvironment/niche. As such, any environmental insult that damages cells of this niche would be expected to produce pronounced effects on the types and functionality of hematopoietic/immune cells generated. We recently reported that direct exposure of human HSC to simulated SEP and GCR radiation dramatically altered the differentiative potential of these cells, and that simulated GCR exposures can directly induce DNA damage and mutations within human HSC, which led to leukemic transformation when these cells repopulated murine recipients. In the present study, we performed the first in depth examination to define changes that occur in mesenchymal stem cells (MSC) present in the human BM niche following exposure to accelerated protons and iron ions, and assess the impact these changes have upon human hematopoiesis. Here, our data thus provides compelling evidence that simulated SEP/GCR exposures can also contribute to defective hematopoiesis/immunity through so-called “biological bystander effects” by damaging the stromal cells that comprise the human marrow microenvironment, thereby altering their ability to support normal hematopoiesis.

59 BASIC BIOLOGICAL SCIENCES↗

Evaluating Use of the NASA Nowcastof Atmospheric Ionizing Radiation for Aviation Safety (NAIRAS) System for Verifying/Validating AMS Cosmic Background Radiation Measurements, RSLA-006-20, Year 1

This presentation will be presented at FY 2020 SDRD Annual (Webex) Meeting scheduled for September 23–24, 2020. Evaluating Use of the NASA Nowcastof Atmospheric Ionizing Radiation for Aviation Safety (NAIRAS) System for Verifying/Validating AMS Cosmic Background Radiation Measurements, RSLA-006-20, Year 1

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

LiteBIRD: A Satellite for the Studies of B-Mode Polarization and Inflation from Cosmic Background Radiation Detection

LiteBIRD is a candidate satellite for a strategic large mission of JAXA. With its expected launch in the middle of the 2020s with a H 3 rocket, LiteBIRD plans to map the polarization of the cosmic microwave background radiation over the full sky with unprecedented precision. The full success of LiteBIRD is to achieve δr<0.001, where δr is the total error on the tensor-to-scalar ratio r. The required angular coverage corresponds to 2 ≤ ℓ ≤ 00 , where ℓ is the multipole moment. This allows us to test well-motivated cosmic inflation models. Full-sky surveys for 3 years at a Lagrangian point L2 will be carried out for 15 frequency bands between 34 and 448 GHz with two telescopes to achieve the total sensitivity of 2.5 μ K arcmin with a typical angular resolution of 0.5° at 150 GHz. Each telescope is equipped with a half-wave plate system for polarization signal modulation and a focal plane filled with polarization-sensitive TES bolometers. A cryogenic system provides a 100 mK base temperature for the focal planes and 2 K and 5 K stages for optical components.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

The Astroparticle Detectors Array—An Educational Project in Cosmic Ray Physics

ADA, short for Astroparticle Detectors Array, is an educational project aiming to detect cosmic radiation and possibly high-energy particles known as ultra-high-energy cosmic rays (UHECRs) or even to spot a supernova event. Its working process is the same as that used in professional cosmic ray observatories: it consists of simple detectors spread over the entire Italian territory and beyond. The detectors are hosted among high schools, associations, and private astronomical observatories. ADA has been operating since 2013 and was brought about with the intention of promoting astroparticle physics to any given level of outreach. Furthermore, ADA is becoming an interesting tool not only for teachers but also for independent and keen scientists. Over the years, we have discovered the importance of having a long series of data for studying the relation between and among cosmic rays, weather, and space weather and to investigate the main cause of oscillations in cosmic ray data. In this paper, we show what we find to be the most compelling results, such as the beautiful symmetry of the behavior between muons and the atmospheric temperature and, likewise, the evident anti-correlation between the intensity of the muons at ground level compared with solar activity.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Effects of Six Sequential Charged Particle Beams on Behavioral and Cognitive Performance in B6D2F1 Female and Male Mice

The radiation environment astronauts are exposed to in deep space includes galactic cosmic radiation (GCR) with different proportions of all naturally occurring ions. To assist NASA with assessment of risk to the brain following exposure to a mixture of ions broadly representative of the GCR, we assessed the behavioral and cognitive performance of female and male C57BL/6J × DBA2/J F1 (B6D2F1) mice two months following rapidly delivered, sequential 6 beam irradiation with protons (1 GeV, LET = 0.24 keV, 50%), 4 He ions (250 MeV/n, LET = 1.6 keV/μm, 20%), 16 O ions (250 MeV/n, LET = 25 keV/μm 7.5%), 28 Si ions (263 MeV/n, LET = 78 keV/μm, 7.5%), 48Ti ions (1 GeV/n, LET = 107 keV/μm, 7.5%), and 56 Fe ions (1 GeV/n, LET = 151 keV/μm, 7.5%) at 0, 25, 50, or 200 cGy) at 4–6 months of age. When the activity over 3 days of open field habituation was analyzed in female mice, those irradiated with 50 cGy moved less and spent less time in the center than sham-irradiated mice. Sham-irradiated female mice and those irradiated with 25 cGy showed object recognition. However, female mice exposed to 50 or 200 cGy did not show object recognition. When fear memory was assessed in passive avoidance tests, sham-irradiated mice and mice irradiated with 25 cGy showed memory retention while mice exposed to 50 or 200 cGy did not. The effects of radiation passive avoidance memory retention were not sex-dependent. There was no effect of radiation on depressive-like behavior in the forced swim test. There was a trend toward an effect of radiation on BDNF levels in the cortex of males, but not for females, with higher levels in male mice irradiated with 50 cGy than sham-irradiated. Finally, sequential 6-ion irradiation impacted the composition of the gut microbiome in a sex-dependent fashion. Taxa were uncovered whose relative abundance in the gut was associated with the radiation dose received. Thus, exposure to sequential six-beam irradiation significantly affects behavioral and cognitive performance and the gut microbiome.

60 APPLIED LIFE SCIENCES↗

Connecting primordial gravitational waves and dark energy

Cosmic acceleration manifested in the early universe as inflation, generating primordial gravitational waves detectable in the cosmic microwave background (CMB) radiation. Cosmic acceleration is occurring again at present as dark energy, detectable in cosmic distance and structure surveys. We explore the intriguing idea of connecting the two occurrences through quintessential inflation by an α-attractor potential without a cosmological constant. For this model we demonstrate robustness of the connection 1 + w 0 ≈ 4/(3N 2 r) between the present day dark energy equation of state parameter w 0 and the primordial tensor to scalar ratio r for a wide range of initial conditions. Analytic and numerical solutions produce current thawing behavior, resulting in a tight relation w a ≈ -1.53(1 + w 0 )≈ -0.2 (4 × 10 -3 /r). Upcoming CMB and galaxy redshift surveys can test this consistency condition. In conclusion, within this model, lack of detection of a dark energy deviation from Λ predicts a higher r, and lack of detection of r predicts greater dark energy dynamics.

79 ASTRONOMY AND ASTROPHYSICS↗

Origin of Gamma-Ray Families Accompanied by Halos and Detected in Experiments with X-Ray Emulsion Chambers

The phenomenon of gamma-ray families featuring halos that is observed in an experiment with x-ray emulsion chambers (XREC) in the Pamir experiment and in other XREC experiments is explained. The experimental properties of halos are analyzed via a comparison with the results of their simulation. It is shown that gamma-ray families featuring halos are predominantly produced (more than 96% of them) by protons and heliumnuclei. This makes it possible to employ the experimental properties of halos to estimate the fraction of protons and helium nuclei in the mass composition of primary cosmic radiation.

79 ASTRONOMY AND ASTROPHYSICS↗

Combined Effects of Three High-Energy Charged Particle Beams Important for Space Flight on Brain, Behavioral and Cognitive Endpoints in B6D2F1 Female and Male Mice

The radiation environment in deep space includes the galactic cosmic radiation with different proportions of all naturally occurring ions from protons to uranium. Most experimental animal studies for assessing the biological effects of charged particles have involved acute dose delivery for single ions and/or fractionated exposure protocols. Here, we assessed the behavioral and cognitive performance of female and male C 57 BL/6J × DBA2/J F1 (B6D2F1) mice 2 months following rapidly delivered, sequential irradiation with protons (1 GeV, 60%), 16 O (250 MeV/n, 20%), and 28 Si (263 MeV/n, 20%) at 0, 25, 50, or 200 cGy at 4-6 months of age. Cortical BDNF, CD68, and MAP-2 levels were analyzed 3 months after irradiation or sham irradiation. During the dark period, male mice irradiated with 50 cGy showed higher activity levels in the home cage than sham-irradiated mice. Mice irradiated with 50 cGy also showed increased depressive behavior in the forced swim test. When cognitive performance was assessed, sham-irradiated mice of both sexes and mice irradiated with 25 cGy showed normal responses to object recognition and novel object exploration. However, object recognition was impaired in female and male mice irradiated with 50 or 200 cGy. For cortical levels of the neurotrophic factor BDNF and the marker of microglial activation CD68, there were sex × radiation interactions. In females, but not males, there were increased CD68 levels following irradiation. In males, but not females, there were reduced BDNF levels following irradiation. A significant positive correlation between BDNF and CD68 levels was observed, suggesting a role for activated microglia in the alterations in BDNF levels. Finally, sequential beam irradiation impacted the diversity and composition of the gut microbiome. These included dose-dependent impacts and alterations to the relative abundance of several gut genera, such as Butyricicoccus and Lachnospiraceae . Thus, exposure to rapidly delivered sequential proton, 16 O ion, and 28 Si ion irradiation significantly affects behavioral and cognitive performance, cortical levels of CD68 and BDNF in a sex-dependent fashion, and the gut microbiome.

59 BASIC BIOLOGICAL SCIENCES↗

Fundamental Phenomena and Applications of Swift Heavy Ion Irradiations

This review concentrates on the specific properties and characteristics of damage structures generated with high-energy ions in the electronic energy loss regime. Irradiation experiments with so-called swift heavy ions (SHIs) find applications in many different fields, with examples presented in ion-track nanotechnology, radiation hardness analysis of functional materials, and laboratory tests of cosmic radiation. The basics of the SHI-solid interaction are described with special attention to processes in the electronic subsystem. The broad spectrum of damage phenomena is exemplified for various materials and material classes, along with a description of typical characterization techniques. This review also presents state-of-the-art modeling efforts that try to account for the complexity of the coupled processes of the electronic and atomic subsystems. Lastly, a brief discussion at the end of this review on SHI phenomena induced by fission fragments in nuclear materials will highlight the relevance of energetic ion irradiation in nuclear technology applications.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Measurement of the cosmic ray proton spectrum from 40 GeV to 100 TeV with the DAMPE satellite

The precise measurement of the spectrum of protons, the most abundant component of the cosmic radiation, is essential to understand the source and acceleration of cosmic rays in the Milky Way. This work reports the measurement of the cosmic ray proton fluxes with kinetic energies from 40 GeV to 100 TeV, with 2 1 / 2 years of data recorded by the DArk Matter Particle Explorer (DAMPE). This is the first time that an experiment directly measures the cosmic ray protons up to ~100 TeV with high statistics. The measured spectrum validates the spectral hardening at ~300 GeV found by previous experiments and reveals a softening at ~13.6 TeV, with the spectral index changing from ~2.60 to ~2.85. Our result implies the existence of a new spectral feature of cosmic rays at energies lower than the so-called knee and sheds new light on the origin of Galactic cosmic rays.

79 ASTRONOMY AND ASTROPHYSICS↗

Electromagnetic Radiation Effects on MgO-Based Magnetic Tunnel Junctions: A Review

Magnetic tunnel junctions (MTJs) have been widely utilized in sensitive sensors, magnetic memory, and logic gates due to their tunneling magnetoresistance. Moreover, these MTJ devices have promising potential for renewable energy generation and storage. Compared with Si-based devices, MTJs are more tolerant to electromagnetic radiation. In this review, we summarize the functionalities of MgO-based MTJ devices under different electromagnetic irradiation environments, with a focus on gamma-ray radiation. We explore the effects of these radiation exposures on the MgO tunnel barriers, magnetic layers, and interfaces to understand the origin of their tolerance. This review enhances our knowledge of the radiation tolerance of MgO-based MTJs, improves the design of these MgO-based MTJ devices with better tolerances, and provides information to minimize the risks of irradiation under various irradiation environments. This review starts with an introduction to MTJs and irradiation backgrounds, followed by the fundamental properties of MTJ materials, such as the MgO barrier and magnetic layers. Then, we review and discuss the MTJ materials and devices’ radiation tolerances under different irradiation environments, including high-energy cosmic radiation, gamma-ray radiation, and lower-energy electromagnetic radiation (X-ray, UV–vis, infrared, microwave, and radiofrequency electromagnetic radiation). In conclusion, we summarize the radiation effects based on the published literature, which might benefit material design and protection.

42 ENGINEERING↗

Radiography of Dry Cask Storage for Used Nuclear Fuel

Since the U.S. currently only approves of storing used nuclear fuel in pools or dry casks, the demand for dry cask storage is on the rise due to the continuous operation of currently existing nuclear plants which are reaching or have reached the capacity of their used fuel pools. With the rising demand comes additional pressure to ensure the integrity of dry cask systems. Visual inspection is costly and man-power intensive, so alternative nondestructive testing techniques are desired to insure the continued safe and effective storage of fuel. Several approaches being investigated by the University of Florida and the larger multi-university Department of Energy (DOE) Nuclear Energy University Program (NEUP) Integrated Research Project (IRP) are gamma or neutron radiography, both transmission based and interior source emission. Additionally muon radiography is discussed. This work leverages the well-established techniques in medical image reconstruction and applies them to a significantly larger scale with additional considerations due to the dense nuclear materials which serves as effective shields for radiation. Emission source radiography relies on the radiation that is emitted from the used fuel. The main advantage of this technique is the passive nature of the measurement. The fuel is already emitting radiation and only detectors are needed. Transmission radiography uses an external source of radiation to penetrate the side of the cask. Challenges include selecting the external source spectrum to avoid overlap with the spectrum emitted from the fuel, and ensuring the radiation dose limits do not exceed those mandated by the Nuclear Regulatory Commission (NRC). Benefits of this technique include better understanding of the source location allowing for clear image reconstruction, and isolation of the signal from surrounding radiation sources. Muon radiography takes advantage of the natural background flux coming from the interaction of the atmosphere with cosmic radiation. The technique is particularly effective at interrogating large dense objects as the highly energetic muons have smaller cross sections than most typical sources and energies used in nuclear engineering. The various techniques are discussed individually then the conclusion compares them. Finally, future work is identified.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Effects of Desiccation and Freezing on Microbial Ionizing Radiation Survivability: Considerations for Mars Sample Return

Increasingly, national space agencies are expanding their goals to include Mars exploration with sample return. To better protect Earth and its biosphere from potential extraterrestrial sources of contamination, as set forth in the Outer Space Treaty of 1967, international efforts to develop planetary protection measures strive to understand the danger of cross-contamination processes in Mars sample return missions. We aim to better understand the impact of the martian surface on microbial dormancy and survivability. Radiation resistance of microbes is a key parameter in considering survivability of microbes over geologic times on the frigid, arid surface of Mars that is bombarded by solar and galactic cosmic radiation. We tested the influence of desiccation and freezing on the ionizing radiation survival of six model microorganisms: vegetative cells of two bacteria (Deinococcus radiodurans, Escherichia coli) and a strain of budding yeast (Saccharomyces cerevisiae); and vegetative cells and endospores of three Bacillus bacteria (B. subtilis, B. megaterium, B. thuringiensis). Desiccation and freezing greatly increased radiation survival of vegetative polyploid microorganisms when applied separately, and when combined, desiccation and freezing increased radiation survival even more so. Thus, the radiation survival threshold of polyploid D. radiodurans cells can be extended from the already high value of 25 kGy in liquid culture to an astonishing 140 kGy when the cells are both desiccated and frozen. However, such synergistic radioprotective effects of desiccation and freezing were not observed in monogenomic or digenomic Bacillus cells and endospores, which are generally sterilized by 12 kGy. This difference is associated with a critical requirement for survivability under radiation, that is, repair of genome damage caused by radiation. Deinococcus radiodurans and S. cerevisiae accumulate similarly high levels of the Mn antioxidants that are required for extreme radiation resistance, as do endospores, though they greatly exceed spores in radioresistance because they contain multiple identical genome copies, which in D. radiodurans are joined by persistent Holliday junctions. We estimate ionizing radiation survival limits of polyploid DNA-based life-forms to be hundreds of millions of years of background radiation while buried in the martian subsurface. Our findings imply that forward contamination of Mars will essentially be permanent, and backward contamination is a possibility if life ever existed on Mars.

59 BASIC BIOLOGICAL SCIENCES↗

Radiological Impact of 2020 Operations at the Savannah River Site

This report presents environmental dose assessment methods and the estimated potential doses to the public from 2020 Savannah River Site (SRS) atmospheric and liquid radioactive releases. It also documents potential doses from special-case exposure scenarios, such as the consumption of wildlife and/or goat milk. Unless noted, the generic term “dose,” as used in this report, includes both the committed effective dose (50-year committed dose) from internal deposition of radionuclides and the effective dose attributable to sources external to the body. Using the effective dose allows doses from different types of radiation and to different parts of the body to be expressed on the same basis. Humans, plants, and animals potentially receive radiation doses from natural and man-made occurrences. The average annual “background” dose for all people living in the United States is 625 mrem. This includes an average background dose of 311 mrem from naturally occurring radionuclides (found in our bodies and in the earth) and from cosmic radiation. Man-made sources include medical procedures (300 mrem), consumer products (13 mrem), and industrial and occupational exposures (less than 1 mrem).

54 ENVIRONMENTAL SCIENCES↗

Radiation portal monitor data file format for comprehensive background radiation monitoring

Radiation portal monitors (RPMs) are widely used at border security checkpoints to detect the presence of radioactive materials in people, vehicles, and cargo. Typically, RPM detection systems consist of two pillars equipped with gamma and neutron detectors. To improve detection efficiency, RPMs employ techniques such as a limited energy window, dynamic alarm thresholds, and lead shielding. However, without continuous monitoring of background radiation, signal interpretation can be compromised, because environmental factors and mechanical failures can cause fluctuations. Here, we introduce a daily file format that logs gamma background and neutron background radiation levels continuously over a 24 h period; this format is different from traditional formats that record data only when the RPM is active or occupied. The approach enables RPM operators and analysts to (1) identify and diagnose malfunctioning components, (2) adjust system settings to account for dynamic environmental factors, and (3) use the recorded data to characterize outer space phenomena. Continuous background reporting is essential for identifying issues such as faulty connections, voltage divider failures, and errors in background updates. Continuous background reporting also enables the detection of external influences, including nearby X-ray scanners, temperature fluctuations, rainfall, cosmic radiation, and lunar phase changes. These data files are designed to be easily evaluated and parsed using common tools, and a quick review by an expert is often sufficient for problem diagnosis. We anticipate that continuous background radiation monitoring and these new strategies will significantly improve the accuracy and reliability of RPM systems, reducing the rate of false alarms and enhancing overall system performance.

Background radiation monitoring↗