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Results for “Collateral Circulation”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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5 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS2003

Computational Hemodynamic Simulation of Human Circulatory System under Altered Gravity

A computational hemodynamics approach is presented to simulate the blood flow through the human circulatory system under altered gravity conditions. Numerical techniques relevant to hemodynamics issues are introduced to non-Newtonian modeling for flow characteristics governed by red blood cells, distensible wall motion due to the heart pulse, and capillary bed modeling for outflow boundary conditions. Gravitational body force terms are added to the Navier-Stokes equations to study the effects of gravity on internal flows. Six-type gravity benchmark problems are originally presented to provide the fundamental understanding of gravitational effects on the human circulatory system. For code validation, computed results are compared with steady and unsteady experimental data for non-Newtonian flows in a carotid bifurcation model and a curved circular tube, respectively. This computational approach is then applied to the blood circulation in the human brain as a target problem. A three-dimensional, idealized Circle of Willis configuration is developed with minor arteries truncated based on anatomical data. Demonstrated is not only the mechanism of the collateral circulation but also the effects of gravity on the distensible wall motion and resultant flow patterns.

Kim. Chang Sung↗
NASA NTRS1988

Serotonin, atherosclerosis, and collateral vessel spasm

Studies on animal models demonstrate that platelet products contribute to vascular spasm in ischemic syndromes and that this is reversible with administration of ketanserin and thromboxane synthesis inhibitors. Laboratory animals (dogs, rabbits, and rats) that had femoral artery ligations exhibited supersensitivity to serotonin within days in their collateral blood vessels. This supersensitivity lasted at least 6 months. The response to serotonin was reversed by ketanserin, but not by 5HT-1 antagonists. Supersensitivity does not extend to norepinephrine, and alpha blockers do not influence the response to serotonin. It appears that platelet activation by endothelial injury contributes to ischemia through blood vessel occlusion and vascular spasm. When platelet activation occurs in vivo, blood vessel occlusion and vascular spasm are reversible in part by using ketanserin or agents that block thromboxane synthesis or its action. Combining both classes of agents reverses spasm completely. These findings support existing evidence that platelet products contribute to vascular disease, and provide an approach to improved management with currently available pharmacologic agents.

Review, Tutorial↗
NASA NTRS1998

Contribution of the vertebral artery to cerebral circulation in the rat snake Elaphe obsoleta

Blood supplying the brain in vertebrates is carried primarily by the carotid vasculature. In most mammals, cerebral blood flow is supplemented by the vertebral arteries, which anastomose with the carotids at the base of the brain. In other tetrapods, cerebral blood is generally believed to be supplied exclusively by the carotid vasculature, and the vertebral arteries are usually described as disappearing into the dorsal musculature between the heart and head. There have been several reports of a vertebral artery connection with the cephalic vasculature in snakes. We measured regional blood flows using fluorescently labeled microspheres and demonstrated that the vertebral artery contributes a small but significant fraction of cerebral blood flow (approximately 13% of total) in the rat snake Elaphe obsoleta. Vascular casts of the anterior vessels revealed that the vertebral artery connection is indirect, through multiple anastomoses with the inferior spinal artery, which connects with the carotid vasculature near the base of the skull. Using digital subtraction angiography, fluoroscopy, and direct observations of flow in isolated vessels, we confirmed that blood in the inferior spinal artery flows craniad from a point anterior to the vertebral artery connections. Such collateral blood supply could potentially contribute to the maintenance of cerebral circulation during circumstances when craniad blood flow is compromised, e.g., during the gravitational stress of climbing.

NASA Center ARC↗
NASA NTRS1998

Joint NASA/EPA AVIRIS Analysis in the Chesapeake Bay Region: Plans and Initial Results

NASA's Ames Research Center is performing an AVIRIS demonstration project in conjunction with the U. S. Environmental Protection Agency (Region 3). NASA and EPA scientists have jointly defined a Study Area in eastern Virginia to include portions of the Chesapeake Bay, southern Delmarva Peninsula, and the mouths of the York and James Rivers. Several environmental issues have been identified for study. These include, by priority: 1) water constituent analysis in the Chesapeake Bay, 2) mapping of submerged aquatic vegetation in the Bay, 3) detection of vegetation stress related to Superfund sites at the Yorktown Naval Weapons Station, and 4) wetland species analysis in the York River vicinity. In support of this project, three lines of AVIRIS data were collected during the Wallops Island deployment on 17 August 1997. The remote sensing payload included AVIRIS, MODIS Airborne Simulator and an RC-10 color infrared film camera. The AVIRIS data were delivered to Ames from the JPL AVIRIS Data Facility, on 29 September 1997. Quicklook images indicate nominal data acquisition, and at the current time an atmospheric correction is being applied. Water constituent analysis of the Bay is our highest priority based on EPA interest and available collateral data, both from the surface and from other remote sensing instruments. Constituents of interest include suspended sediments, chlorophyll-a and accessory pigments, Analysis steps will include: verification of data quality, location of study sites in imagery, incorporation of relevant field data from EPA and other Chesapeake Bay cooperators, processing of imagery to show phenomenon of interest, verification of results with cooperators. By 1st quarter CY98 we plan to circulate initial results to NASA and EPA management for review. In the longer term we will finalize documentation, prepare results for publication, and complete any needed technology transfer to EPA remote sensing personnel.

Johnson, Lee↗