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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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Recent developments in deuterated scintillators for neutron measurements at low-energy accelerators

Deuterated ( 2 H-based) organic scintillators, unlike conventional 1 H-based scintillators can generate pulse-shape gated neutron energy spectra 1 to 30 MeV without need for time-of-flight (ToF). They are especially appropriate for measurements at high-intensity, low-energy accelerators where a pulsed beam is not available. Even when the latter is available, the loss in effective beam intensity combined with the need for suitable long-path ToF measurements can be very inefficient. In contrast, as we demonstrate, arrays of d- benzene scintillators (NE230, BC537, EJ315) and recently xylene-d10 (EJ301D) together with related digital signal processing (DSP) can provide highly efficient neutron energy measurements w/o n-ToF. Lastly, we also report the recent synthesis and initial testing of crystalline d-stilbene as a neutron detector.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

The spatially resolved transcriptome signatures of glomeruli in chronic kidney disease

Here, we used digital spatial profiling (DSP) to describe the glomerular transcriptomic signatures that may characterize the complex molecular mechanisms underlying progressive kidney disease in Alport syndrome, focal segmental glomerulosclerosis, and membranous nephropathy. Our results revealed significant transcriptional heterogeneity among diseased glomeruli, and this analysis showed that histologically similar glomeruli manifested different transcriptional profiles. Using glomerular pathology scores to establish an axis of progression, we identified molecular pathways with progressively decreased expression in response to increasing pathology scores, including signal recognition particle–dependent cotranslational protein targeting to membrane and selenocysteine synthesis pathways. We also identified a distinct signature of upregulated and downregulated genes common to all the diseases investigated when compared with nondiseased tissue from nephrectomies. These analyses using DSP at the single-glomerulus level could help to increase insight into the pathophysiology of kidney disease and possibly the identification of biomarkers of disease progression in glomerulopathies.

60 APPLIED LIFE SCIENCES↗