Exploratory Analytic Cases (EACs): EAC Report and Upcoming Analysis
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Mike Menzel↗
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EAC: A program for the error analysis of STAGS results for plates
A computer code is now available for estimating the error in results from the STAGS finite element code for a shell unit consisting of a rectangular orthotropic plate. This memorandum contains basic information about the computer code EAC (Error Analysis and Correction) and describes the connection between the input data for the STAGS shell units and the input data necessary to run the error analysis code. The STAGS code returns a set of nodal displacements and a discrete set of stress resultants; the EAC code returns a continuous solution for displacements and stress resultants. The continuous solution is defined by a set of generalized coordinates computed in EAC. The theory and the assumptions that determine the continuous solution are also outlined in this memorandum. An example of application of the code is presented and instructions on its usage on the Cyber and the VAX machines have been provided.
Sistla, Rajaram↗
Experimental Methods for the Performance Test of Environment-Assisted Cracking (EAC) in Nuclear Industry and Examples through NSUF
Environmentally assisted cracking (EAC) is a critical failure mode in nuclear reactor environments, where materials are exposed to high temperatures, radiation, and corrosive media. Specific EAC studies in nuclear environments include stress corrosion cracking in primary water chemistry, irradiation-assisted stress corrosion cracking (IASCC) under neutron exposure, and hydrogen induced cracking (HIC) in reactor pressure vessels. The experimental methodologies of EAC include slow strain rate testing (SSRT), constant load, and cyclic loading techniques, conducted in autoclaves designed to simulate the reactor’s operational environments. This paper highlights several experimental case studies, especially on IASCC, conducted within the Nuclear Science User Facilities (NSUF).
36 - MATERIALS SCIENCE↗
Exploratory Analytic Cases (EACs) Presentation
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CML3↗
Response to 2015 EAC Report
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2015 EAC Report↗
A NASA Case Study - Are EVM Estimate at Completion (EAC) Reliable?
No abstract available
Kerby, Jerald↗
What Constitutes Optimal Management of T1N0 Esophageal Adenocarcinoma?
Purpose and Design: Esophageal adenocarcinoma (EAC) develops as a consequence of gastroesophageal reflux disease and Barrett’s esophagus (BE). While combination therapy with chemotherapy or concurrent chemoradiotherapy followed by esophagectomy improves survival in more advanced tumors, the optimal treatment strategy for early-stage EAC is undefined. Endoscopic eradication therapy, consisting of endoscopic resection and mucosal ablation, has revolutionized therapy for superficial (T1a) EAC in BE and allows for esophageal preservation in appropriate patients at low risk for lymph node metastasis (LNM). This review critically examines the literature regarding evaluation, treatment, and outcomes in patients with T1 EAC. Methods: The literature was queried via the PubMed database to include articles published between 1990 and 2017. Search terms were generated from the key statements “Endoscopic eradication therapy results in equivalent overall survival when compared to esophagectomy for clinical T1aN0 EAC” and “Esophagectomy provides better overall survival than endoscopic eradication therapy for cT1b EAC”. Abstracts were reviewed and included according to predefined selection and exclusion criteria, and were then assessed according to the GRADE system. Results and Conclusions: In patients with T1aN0 EAC, overall survival with endoscopic eradication therapy is equal to esophagectomy. Given the substantial risk of LNM in patients with submucosal (T1b) EAC, esophagectomy remains the standard of care for surgical candidates. In the case of inoperability or low-risk lesions, endoscopic resection may be considered adequate therapy. Chemotherapy and radiation can be offered as primary therapy for non-surgical candidates with lesions not amenable to endoscopic therapy, but does not have a clear role in the adjuvant setting after either endoscopic or surgical resection.
62 RADIOLOGY AND NUCLEAR MEDICINE↗
CCN1 sensitizes esophageal cancer cells to TRAIL-mediated apoptosis
Highlights: • EAC cells express all three decoy receptors of TRAIL. • CCN1 is barely detectable in EAC cells. • CCN1 inhibits expression of TRAIL decoy receptors in EAC cells. • CCN1 induces apoptosis in EAC cells. • TRAIL mediates CCN1-induced EAC cell apoptosis. TRAIL is one of the best anti-cancer molecules in our body. It kills a variety of cancer cells that are resistant to conventional chemotherapy, without causing much negative impact on normal cells, because its death receptors are almost exclusively found on cancer cells. However, some cancer cells are not sensitive to TRAIL treatment, even though they express its death receptors. A second molecule is needed to help TRAIL to complete its mission. Finding such molecules now becomes a top priority in cancer research. Our study shows that CCN1 is such a molecule. CCN1 was highly expressed in the esophageal epithelium of the patients suffering from gastroesophageal reflux disease, but faded away as the situation worsened towards adenocarcinoma. Treating the tumor cells with CCN1 resulted in apoptosis, while the same treatment to the normal cells only nourished cell growth. It was TRAIL that mediated this process. Apparently, CCN1 altered the expression profile of TRAIL and its receptors in tumor cells, namely, activating TRAIL and its death receptors and shutting down its decoy receptors. CCN1 and TRAIL worked as a team to put the cancer cells to death, as elimination of either one failed apoptosis.
60 APPLIED LIFE SCIENCES↗
Hydrogen interactions in aluminum-lithium alloys
A program is described which seeks to develop an understanding of the effects of dissolved and trapped hydrogen on the mechanical properties of selected Al-Li-Cu-X alloys. A proposal is made to distinguish hydrogen (H2) induced EAC from aqueous dissolution controlled EAC, to correlate H2 induced EAC with mobile and trapped concentrations, and to identify significant trap sites and hydride phases (if any) through use of model alloys and phases. A literature review shows three experimental factors which have impeded progress in the area of H2 EAC for this class of alloys. These are as listed: (1) inter-subgranular fracture in Al-Li alloys when tested in the S-T orientation in air or vacuum make it difficult to readily detect H2 induced fracture based on straight forward changes in fractography; (2) the inherently low H2 diffusivity and solubility in Al alloys is further compounded by a native oxide which acts as a H2 permeation barrier; and (3) H2 effects are masked by dissolution assisted processes when mechanical testing is performed in aqueous solutions.
Smith, S. W.↗
On the Loading Rate Dependence of Environment-assisted Cracking in Sensitized AA5456-H116 Exposed to Marine Environments
The influence of the applied loading rate (dK/dt) on the environment-assisted cracking (EAC) behavior of sensitized AA5456-H116 in 0.6 M NaCl at applied potentials ranging from −800 to −900 mV_SCE is assessed via a rising-K testing framework. The applied potential strongly affects the dK/dt-dependence of EAC with results suggesting a minimal influence for potentials more positive than −830 mVSCE and a stronger dK/dt-dependence for potentials more negative than −830 mV_SCE. Crack growth rates measured using rising versus static K testing are compared, which demonstrates that rising K methods consistently yield conservative EAC metrics with increased efficiency.
Al-Mg↗
Intermediate frequency atmospheric disturbances: A dynamical bridge connecting western U.S. extreme precipitation with East Asian cold surges: Atmospheric Rivers and IF disturbances
In this study, an atmospheric river (AR) detection algorithm is developed to investigate the downstream modulation of the eastern North Pacific ARs by another weather extreme, known as the East Asian cold surge (EACS), in both reanalysis data and high-resolution global model simulations. It is shown that following the peak of an EACS, atmospheric disturbances of intermediate frequency (IF; 10–30 day period) are excited downstream. This leads to the formation of a persistent cyclonic circulation anomaly over the eastern North Pacific that dramatically enhances the AR occurrence probability and the surface precipitation over the western U.S. between 30°N and 50°N. A diagnosis of the local geopotential height tendency further confirms the essential role of IF disturbances in establishing the observed persistent anomaly. This downstream modulation effect is then examined in the two simulations of the National Center for Atmospheric Research Community Climate System Model version 4 with different horizontal resolutions (T85 and T341) for the same period (1979–2005). The connection between EACS and AR is much better captured by the T341 version of the model, mainly due to a better representation of the scale interaction and the characteristics of IF atmospheric disturbances in the higher-resolution model. The findings here suggest that faithful representations of scale interaction in a global model are critical for modeling and predicting the occurrences of hydrological extremes in the western U.S. and for understanding their potential future changes.
54 ENVIRONMENTAL SCIENCES↗
TU-AB-BRC-03: Accurate Tissue Characterization for Monte Carlo Dose Calculation Using Dual-and Multi-Energy CT Data
Purpose: To develop a general method for human tissue characterization with dual-and multi-energy CT and evaluate its performance in determining elemental compositions and the associated proton stopping power relative to water (SPR) and photon mass absorption coefficients (EAC). Methods: Principal component analysis is used to extract an optimal basis of virtual materials from a reference dataset of tissues. These principal components (PC) are used to perform two-material decomposition using simulated DECT data. The elemental mass fraction and the electron density in each tissue is retrieved by measuring the fraction of each PC. A stoichiometric calibration method is adapted to the technique to make it suitable for clinical use. The present approach is compared with two others: parametrization and three-material decomposition using the water-lipid-protein (WLP) triplet. Results: Monte Carlo simulations using TOPAS for four reference tissues shows that characterizing them with only two PC is enough to get a submillimetric precision on proton range prediction. Based on the simulated DECT data of 43 references tissues, the proposed method is in agreement with theoretical values of protons SPR and low-kV EAC with a RMS error of 0.11% and 0.35%, respectively. In comparison, parametrization and WLP respectively yield RMS errors of 0.13% and 0.29% on SPR, and 2.72% and 2.19% on EAC. Furthermore, the proposed approach shows potential applications for spectral CT. Using five PC and five energy bins reduces the SPR RMS error to 0.03%. Conclusion: The proposed method shows good performance in determining elemental compositions from DECT data and physical quantities relevant to radiotherapy dose calculation and generally shows better accuracy and unbiased results compared to reference methods. The proposed method is particularly suitable for Monte Carlo calculations and shows promise in using more than two energies to characterize human tissue with CT.
60 APPLIED LIFE SCIENCES↗
Tissue scale agent-based simulation of premalignant progressions in Barrett’s esophagus
Barrett’s esophagus (BE) is a benign condition of the distal esophagus that initiates a multistage pathway to esophageal adenocarcinoma (EAC). Short of frequent intrusive (and costly) surveillance, effective screening for neoplasia in BE populations is yet to be established since progressors are rare and virtually undetectable without routine biopsies, which often sample only a small portion of the BE tissue. As a result, reliable estimation of the true prevalence of dysplasia in a BE population and evidence-based optimization of screening for at-risk individuals is challenging. Data-driven microsimulations, i.e., model-generated instances of disease history in a predefined virtual population, have found utility in the EAC screening literature as low-overhead alternatives to real-world hypothesis testing of optimal interventions for dysplasia. Despite the successes, computational limitations, paucity of knowledge and data on Barrett’s dysplasia, and the complexities of disease progression as a multiscale multiphysics process have hindered the treatment of disease progression in BE as a spatial process. Agent-based modeling of nucleation and proliferation processes in dysplasia warrants exploration in this context as an approximation that operates at a trade-off between computational tractability and precise representation of the composition and physics of the substrate (tissue). In this study, we describe spatially resolved simulations of premalignant progression toward EAC in a coarse-grained model of Barrett’s tissue that resolves the metaplastic tissue at a length scale of 0.42 mm (~3300 crypts/mm 2 ). Finally, the model is calibrated to reproduce historical high-grade dysplasia prevalence when model-generated patients are screened using the Seattle protocol.
59 BASIC BIOLOGICAL SCIENCES↗
Should Multidisciplinary Treatment Differ for Esophageal Adenocarcinoma Versus Esophageal Squamous Cell Cancer?
Current treatment of locally advanced esophageal cancers (ECs) centres on a multimodal approach regardless of histology. While surgery remains the mainstay of curative intent therapy, its implementation alone results in suboptimal outcomes, which have improved significantly with the increased utilization of induction regimens comprising of concurrent chemoradiation (CRT) or chemotherapy alone followed by surgery. Due in large part to the positive results of the CROSS trial, neoadjuvant CRT has become the predominant standard applied in the West. However, the bulk of the data published to date suggests that a more nuanced approach to the management of locally advanced EC is required with respect to the application of radiation, which related to the differential sensitivity of esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (SCC) to radiation. While the latter demonstrates excellent radiosensitivity, which has translated into improved survival outcomes, the same cannot be said for patients with EAC who may be subject to greater toxicity without any benefit. Herein, the differential effectiveness of CRT in patients with EAC versus SCC is highlighted, with a focus on the randomized evidence to date.
62 RADIOLOGY AND NUCLEAR MEDICINE↗
Gas-Electric Interdependence
Presentation to February 2024 DOE Electricity Advisory Committee (EAC) Meeting regarding interrelationship between gas and electric. The EAC is a Federal Advisory Committee Act (FACA) committee. The purpose of the EAC is to provide advice to the U.S. Department of Energy in implementing the Energy Policy Act of 2005, executing the Energy Independence and Security Act of 2007, and modernizing the nation's electricity delivery infrastructure.
Brewer, John↗
Program Analyzes Errors In STAGS
EAC computer program designed for analysis of errors in results of STAGS computer program (COSMIC Program HQN-10967). Requires input data for geometry of plate, properties of material, and set of boundary conditions. These input data come from STAGS code. (The specific link between input and output data from STAGS and input data for EAC is POSTP, postprocessor program in STAGS processors.) EAC computes continuous solution from discrete results of STAGS in order to estimate error of results of STAGS. Written in FORTRAN 77.
Thurston, Gaylen A.↗
Enabling the On-Line Intrinsic Evolution of Analog Controllers
The intrinsic evolution of analog controllers to provide closed-loop control of the speed of a DC motor has been previously demonstrated at NASA Marshall Space Flight Center. A side fleet of the evolutionary process is that during evolution there are necessarily poor configurations to be evaluated that could cause damage to the plant. This paper concern the development and implementation of a safe Evolvable Analog Controller (EAC) architecture able to evolve controllers on-line even in the presence of these poor configurations. The EAC concept is discussed and experimental results are presented that show the feasibility of the approach This EAC architecture represents the first in a series of steps required to make deployment of an evolvable controller a reality.
Gwaltney, David A.↗
Enabling the On-line Intrinsic Evolution of Analog Controllers
The intrinsic evolution of analog controllers to provide closed-loop control of the speed of a DC motor has been previously demonstrated at NASA Marshall Space Flight Center. A side effect of the evolutionary process is that during evolution there are necessarily poor configurations to be evaluated that could cause damage to the plant, This paper concerns the development and implementation of a safe Evolvable Analog Controller (EAC) architecture able to evolve controllers on-line even in the presence of these poor configurations, The EAC concept is discussed and experimental results are presented that show the feasibility of the approach This EAC architecture represents the first in a series of steps required to make deployment of an evolvable controller a reality.
Gwaltney, David A.↗