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At least 19 records

Diffusion tensor imaging of the kidney in healthy controls and in children and young adults with autosomal recessive polycystic kidney disease

Objective: To compare diffusion tensor imaging (DTI) of the kidneys and its derived parameters in children with autosomal recessive polycystic kidney disease (ARPKD) versus healthy controls. Methods: In a prospective IRB-approved study, we evaluated the use of DTI to compare kidney parenchyma FA values in healthy controls (age-matched children with no history of renal disease) versus patients with ARPKD. A 20-direction DTI with b-values of b = 0 s/mm{sup 2} and b = 400 s/mm{sup 2} was used to acquire data in coronal direction using a fat-suppressed spin-echo echo-planar sequence. Diffusion Toolkit and TrackVis were used for analysis and segmentation. TrackVis was used to draw regions of interest (ROIs) covering the entire volume of the renal parenchyma, excluding the collecting system. Fibers were reconstructed using a deterministic fiber tracking algorithm. The FA values based on the ROI data, mean length, and volume of the tracks based on the fiber tracking data were recorded. Results: Eight healthy controls (mean age = 12.9 years ± 4.0; 1/8 males) and six ARPKD participants (mean age = 13.8 years ± 8.5; 5/6 males) were included in the study. Compared to healthy controls, patients with ARPKD had significantly lower FA values (0.33 ± 0.03 vs. 0.25 ± 0.02, p = 0.002) and mean track length (16.73 ± 3.43 vs. 11.61 ± 1.29 mm, p = 0.005). Conclusion: DTI of the kidneys shows significantly lower FA values and mean track length in children and young adults with ARPKD compared to normal subjects. DTI of the kidney offers a novel approach for characterizing renal disease based on changes in diffusion anisotropy and kidney structure.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Blocker-tolerant and high-sensitivity $Δ$\!$Σ$ correlation digitizer for radar and coherent receiver applications

In this study, a coherent subsampling digitizer for pulsed Doppler radar systems is proposed. Prior to transmission, the radar system modulates the RF pulse with a known pseudorandom binary phase shift keying (BPSK) sequence. Upon reception, the radar digitizer uses a programmable sample-and-hold circuit to multiply the received waveform by a properly time-delayed version of the known a priori BPSK sequence. This operation demodulates the desired echo signal while suppressing the spectrum of all in-band noncorrelated interferers, making them appear as noise in the frequency domain. The resulting demodulated narrowband Doppler waveform is then subsampled at the IF frequency by a delta-sigma modulator. Because the digitization bandwidth within the delta-sigma feedback loop is much less than the input bandwidth to the digitizer, the thermal noise outside of the Doppler bandwidth is effectively filtered prior to quantization, providing an increase in signal-to-noise ratio (SNR) at the digitizer's output compared with the input SNR. In this demonstration, a delta-sigma correlation digitizer is fabricated in a 0.18-μm CMOS technology. The digitizer has a power consumption of 1.12 mW with an IIP3 of 7.5 dBm. The digitizer is able to recover Doppler tones in the presence of blockers up to 40 dBm greater than the Doppler tone.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Measuring Black Hole Light Echoes with Very Long Baseline Interferometry

Light passing near a black hole can follow multiple paths from an emission source to an observer due to strong gravitational lensing. Photons following different paths take different amounts of time to reach the observer, which produces an echo signature in the image. The characteristic echo delay is determined primarily by the mass of the black hole, but it is also influenced by the black hole spin and inclination to the observer. In the Kerr geometry, echo images are demagnified, rotated, and sheared copies of the direct image and lie within a restricted region of the image. Echo images have exponentially suppressed flux, and temporal correlations within the flow make it challenging to directly detect light echoes from the total light curve. In this Letter, we propose a novel method to search for light echoes by correlating the total light curve with the interferometric signal at high spatial frequencies, which is a proxy for indirect emission. We explore the viability of our method using numerical general relativistic magnetohydrodynamic simulations of a near-face-on accretion system scaled to M87-like parameters. We demonstrate that our method can be used to directly infer the echo delay period in simulated data. An echo detection would be clear evidence that we have captured photons that have circled the black hole, and a high-fidelity echo measurement would provide an independent measure of fundamental black hole parameters. Our results suggest that detecting echoes may be achievable through interferometric observations with a modest space-based very long baseline interferometry mission.

79 ASTRONOMY AND ASTROPHYSICS↗

MR-Guided Freehand Biopsy of Liver Lesions With Fast Continuous Imaging Using a 1.0-T Open MRI Scanner: Experience in 50 Patients

The purpose of this study was to assess a new open system with a field-strength of 1.0 T for the feasibility of liver biopsy using the freehand technique with fast continuous imaging. Fifty patients with focal liver lesions measuring 5 to 30 mm in diameter were included in the study. Guidance and monitoring was performed using a 1.0-T open magnetic resonance (MR) scanner (Panorama HFO; Philips Healthcare, Best, The Netherlands). With fast continuous imaging using a T1-weighted (T1W) gradient echo (GRE) sequence after administration of gadolinium (Gd)-EOB-DTPA, the needle was placed into the lesion. An interface for interactive dynamic viewing in two perpendicular planes prevented needle deviations T2-weighted turbo spin echo (TSE) fat-suppressed sequence was added to rule out postinterventional hematoma or biloma. All lesions were visible on the interventional images. Biopsy was technically successful, and solid specimens were obtained in all cases. Forty-six patients showed a histopathologic pattern other than native liver tissue, thus confirming correct position of the needle. Time between determination of the lesion and performance of the control scan was on average 18 min. No major complications were recorded. MR guidance with the new 1-T open system must be considered an attractive alternative for liver punction. An interface for dynamic imaging of needle guidance and T1W-GRE imaging with administration of Gd-EOB-DTPA for contrast enhancement allows the pinpoint puncture of liver lesions.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Erbium quantum memory platform with long optical coherence via back-end-of-line deposition on foundry-fabricated photonics

Realizing scalable quantum interconnects necessitates the integration of solid-state quantum memories with foundry photonics processes. While prior photonic integration efforts have relied upon specialized, laboratory-scale fabrication techniques, this work demonstrates the monolithic integration of a quantum memory platform with low-loss foundry photonic circuits via back-end-of-line deposition. We deposited thin films of titanium dioxide (Ti⁢O 2 ) doped with erbium (Er) onto silicon nitride nanophotonic waveguides and studied Er optical coherence at subkelvin temperatures with photon echo techniques. Furthermore, we suppressed optical dephasing through ex-situ oxygen annealing and optimized measurement conditions, which yielded an optical coherence time of 64 μ⁢s (a 5-kHz homogeneous linewidth) and slow spectral diffusion of 27 kHz over 4 ms, results that are comparable to state-of-the-art Er nanophotonic devices. Combined with second-long electron spin lifetimes and demonstrated electrical control of Er emission, our findings establish Er:Ti⁢O 2 on foundry photonics as a manufacturable platform for ensemble and single-ion quantum memories.

Electro-optic effects↗

SU-F-I-16: Short Breast MRI with High-Resolution T2-Weighted and Dynamic Contrast Enhanced T1-Weighted Images

Purpose: To develop and demonstrate a short breast (sb) MRI protocol that acquires both T2-weighted and dynamic contrast-enhanced T1-weighted images in approximately ten minutes. Methods: The sb-MRI protocol consists of two novel pulse sequences. The first is a flexible fast spin-echo triple-echo Dixon (FTED) sequence for high-resolution fat-suppressed T2-weighted imaging, and the second is a 3D fast dual-echo spoiled gradient sequence (FLEX) for volumetric fat-suppressed T1-weighted imaging before and post contrast agent injection. The flexible FTED sequence replaces each single readout during every echo-spacing period of FSE with three fast-switching bipolar readouts to produce three raw images in a single acquisition. These three raw images are then post-processed using a Dixon algorithm to generate separate water-only and fat-only images. The FLEX sequence acquires two echoes using dual-echo readout after each RF excitation and the corresponding images are post-processed using a similar Dixon algorithm to yield water-only and fat-only images. The sb-MRI protocol was implemented on a 3T MRI scanner and used for patients who had undergone concurrent clinical MRI for breast cancer screening. Results: With the same scan parameters (eg, spatial coverage, field of view, spatial and temporal resolution) as the clinical protocol, the total scan-time of the sb-MRI protocol (including the localizer, bilateral T2-weighted, and dynamic contrast-enhanced T1-weighted images) was 11 minutes. In comparison, the clinical breast MRI protocol took 43 minutes. Uniform fat suppression and high image quality were consistently achieved by sb-MRI. Conclusion: We demonstrated a sb-MRI protocol comprising both T2-weighted and dynamic contrast-enhanced T1-weighted images can be performed in approximately ten minutes. The spatial and temporal resolution of the images easily satisfies the current breast MRI accreditation guidelines by the American College of Radiology. The protocol has the potential of making breast MRI more widely accessible to and more tolerable by the patients. JMA is the inventor of United States patents that are owned by the University of Texas Board of Regents and currently licensed to GE Healthcare and Siemens Gmbh.

60 APPLIED LIFE SCIENCES↗

Fluidization of collisionless plasma turbulence

In a collisionless, magnetized plasma, particles may stream freely along magnetic field lines, leading to “phase mixing” of their distribution function and consequently, to smoothing out of any “compressive” fluctuations (of density, pressure, etc.). This rapid mixing underlies Landau damping of these fluctuations in a quiescent plasma—one of the most fundamental physical phenomena that makes plasma different from a conventional fluid. Nevertheless, broad power law spectra of compressive fluctuations are observed in turbulent astrophysical plasmas (most vividly, in the solar wind) under conditions conducive to strong Landau damping. Elsewhere in nature, such spectra are normally associated with fluid turbulence, where energy cannot be dissipated in the inertial-scale range and is, therefore, cascaded from large scales to small. By direct numerical simulations and theoretical arguments, it is shown here that turbulence of compressive fluctuations in collisionless plasmas strongly resembles one in a collisional fluid and does have broad power law spectra. This “fluidization” of collisionless plasmas occurs, because phase mixing is strongly suppressed on average by “stochastic echoes,” arising due to nonlinear advection of the particle distribution by turbulent motions. Other than resolving the long-standing puzzle of observed compressive fluctuations in the solar wind, our results suggest a conceptual shift for understanding kinetic plasma turbulence generally: rather than being a system where Landau damping plays the role of dissipation, a collisionless plasma is effectively dissipationless, except at very small scales. The universality of “fluid” turbulence physics is thus reaffirmed even for a kinetic, collisionless system.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Evolution of 1 / f Flux Noise in Superconducting Qubits with Weak Magnetic Fields

The microscopic description of 1/f magnetic flux noise in superconducting circuits has remained an open question for several decades despite extensive experimental and theoretical investigation. Recent progress in superconducting devices for quantum information has highlighted the need to mitigate sources of qubit decoherence, driving a renewed interest in understanding the underlying noise mechanism(s). Though a consensus has emerged attributing flux noise to surface spins, their identity and interaction mechanisms remain unclear, prompting further study. Here, we apply weak in-plane magnetic fields to a capacitively shunted flux qubit (where the Zeeman splitting of surface spins lies below the device temperature) and study the flux-noise-limited qubit dephasing, revealing previously unexplored trends that may shed light on the dynamics behind the emergent 1/f noise. Notably, we observe an enhancement (suppression) of the spin-echo (Ramsey) pure-dephasing time in fields up to B = 100 G. With direct noise spectroscopy, we further observe a transition from a 1/f to approximately Lorentzian frequency dependence below 10 Hz and a reduction of the noise above 1 MHz with increasing magnetic field. Here, we suggest that these trends are qualitatively consistent with an increase of spin cluster sizes with magnetic field. These results should help to inform a complete microscopic theory of 1/f flux noise in superconducting circuits.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Magnetic resonance imaging features of pubic symphysis urinary fistula with pubic bone osteomyelitis in the treated prostate cancer patient

Introduction: Pubic bone osteomyelitis with pubic symphysis urinary fistula represents a debilitating complication of radiation and ablative treatments for prostate cancer. The definitive radiographic diagnosis of this clinical entity is not described. In this study, we characterize the plain film and magnetic resonance imaging findings of pubic osteomyelitis. Materials and Methods: We reviewed a database of prostate cancer survivors with diagnosed pubic osteomyelitis from 2011 to 2015. These patients underwent pelvic plain radiographs and magnetic resonance imaging with T1-weighted and fat-suppressed T2-weighted fast spin echo sequences. Intravenous gadolinium was utilized. The diagnosis was verified with extirpative surgery. 16 patients with diagnosed pubic osteomyelitis from 2011 to 2015 underwent imaging at our institution. Results: All patients demonstrated increased signal on T2- weighted sequences and decreased signal on T1-weighted sequences along the pubic symphysis and the marrow of the involved pubic rami. Inflammatory myositis with diastasis of the pubic symphysis and cortical bone erosion were identified in the majority of patients. Fluid collections were identified in 75% of patients. 63% of conventional radiographs demonstrated no radiographic evidence of pubic osteomyelitis. Conclusion: Magnetic resonance imaging of pubic symphysis osteomyelitis in the prostate cancer survivor is characterized by high signal on T2-weighted images and low signal on T1-weighted images of the involved pubic rami, with the majority of patients demonstrating regional myositis. Imaging data combined with clinical assessment should prompt diagnosis and management of pubic osteomyelitis. Conventional radiography is generally insensitive to these findings. We consider magnetic resonance imaging to be the definitive diagnostic modality for this clinical entity.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Crosstalk Suppression in Individually Addressed Two-Qubit Gates in a Trapped-Ion Quantum Computer

Crosstalk between target and neighboring spectator qubits due to spillover of control signals represents a major error source limiting the fidelity of two-qubit entangling gates in quantum computers. We show that in our laser-driven trapped-ion system coherent crosstalk error can be modeled as residual $X\hat{σ}_{\phi}$ interaction and can be actively canceled by single-qubit echoing pulses. We propose and demonstrate a crosstalk suppression scheme that eliminates all first-order crosstalk utilizing only local control of target qubits, as opposed to an existing scheme which requires control over all neighboring qubits. We report a two-qubit Bell state fidelity of 99.52(6)% with the echoing pulses applied after collective gates and 99.37(5)% with the echoing pulses applied to each gate in a five-ion chain. Finally, this scheme is widely applicable to other platforms with analogous interaction Hamiltonians.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Accurate and absolute diffusion measurements of Rhodamine 6G in low-concentration aqueous solutions by the PGSE-WATERGATE sequence

A pulsed field gradient spin-echo nuclear magnetic resonance (NMR) sequence with solvent suppression (PGSE-WATERGATE) was applied to accurately measure the diffusion coefficients of Rhodamine 6G (Rh6G) in low-concentration aqueous solutions. Three samples with Rh6G concentrations of C{sub Rh6G} = 1, 4.5, and 25 μM were investigated. The precise determination of the diffusion coefficients in this low-concentration range was made possible by using a cryogenically cooled NMR probe and by the effective solvent suppression of the PGSE-WATERGATE sequence. The present results bridge the gap between diffusion data measured by fluorescence correlation spectroscopy in the single molecule limit and diffusivities obtained by pulsed field gradient NMR (PFG-NMR) without solvent suppression at higher concentrations. To further extend the concentration range, the diffusion coefficient of Rh6G was also measured on a sample with C{sub Rh6G} = 410 μM by PFG-NMR. The overall concentration dependence of the Rh6G diffusion at 25 °C is discussed in terms of dimerization of the Rh6G molecules. The concentration-dependent monomer/dimer proportion is deduced from the diffusion data.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis

Background To apply quantitative whole‐brain T 1 ‐rho (T 1ρ ) and T 2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty‐three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age‐matched healthy controls were imaged at 3 Tesla. An axial T 1ρ ‐weighted three‐dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin‐lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T 2 maps were also acquired. Results Whole brain white matter (WM) T 1ρ maps were elevated compared with controls ( P = 0.002). WM lesion T 1ρ and T 2 values were highly correlated (r = 0.83), but T 1ρ demonstrated 25% better contrast to noise ratio ( P < 0.001). WM lesion T 1ρ correlated with disease duration. Gray matter T 1ρ was negatively correlated with the Expanded Disability Status Scale, r = −0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T 1ρ , but not on T 2 (r T1ρ = −0.63, p T1ρ = 0.03; r T2 = −0.17, p T2 = 0.6). Conclusion T 1ρ MRI demonstrates enhanced lesion contrast compared with T 2 , and in some cases may provide complementary information. T 1ρ may provide a useful measure of demyelinating processes in MS. J. MAGN. RESON. IMAGING 2015;42:1623–1630.

Gonyea, Jay V.↗

EEHG Performance and Scaling Laws

This note will calculate the idealized performance of echo-enabled harmonic generation performance (EEHG), explore the parameter settings, and look at constraints determined by incoherent synchrotron radiation (ISR) and intrabeam scattering (IBS). Another important effect, time-of-flight variations related to transverse emittance, is included here but without detailed explanation because it has been described previously. The importance of ISR and IBS is that they lead to random energy shifts that lead to temporal shifts after the various beam manipulations required by the EEHG scheme. These effects give competing constraints on the beamline. For chicane magnets which are too compact for a given R56, the magnetic fields will be sufficiently strong that ISR will blur out the complex phase space structure of the echo scheme to the point where the bunching is strongly suppressed. The effect of IBS is more omnipresent, and requires an overall compact beamline. It is particularly challenging for the second pulse in a two-color attosecond beamline, due to the long delay between the first energy modulation and the modulator for the second pulse.

43 PARTICLE ACCELERATORS↗

X-ray scattering echoes and ghost halos from the intergalactic medium: relation to the nature of AGN variability

X-ray bright quasars might be used to trace dust in the circumgalactic and intergalactic medium through the phenomenon of X-ray scattering, which is observed around Galactic objects whose light passes through a sufficient column of interstellar gas and dust. Of particular interest is the abundance of gray dust larger than 0.1 μm, which is difficult to detect at other wavelengths. To calculate X-ray scattering from large grains, one must abandon the traditional Rayleigh-Gans approximation. The Mie solution for the X-ray scattering optical depth of the universe is ∼1%. This presents a great difficulty for distinguishing dust scattered photons from the point source image of Chandra, which is currently unsurpassed in imaging resolution. The variable nature of AGNs offers a solution to this problem, as scattered light takes a longer path and thus experiences a time delay with respect to non-scattered light. If an AGN dims significantly (≳3 dex) due to a major feedback event, the Chandra point source image will be suppressed relative to the scattering halo, and an X-ray echo or ghost halo may become visible. I estimate the total number of scattering echoes visible by Chandra over the entire sky: N{sub ech}∼10{sup 3}(ν{sub fb}/yr{sup −1}), where ν{sub fb} is the characteristic frequency of feedback events capable of dimming an AGN quickly.

79 ASTRONOMY AND ASTROPHYSICS↗

Two-dimensional NMR measurement and point dipole model prediction of paramagnetic shift tensors in solids

A new two-dimensional Nuclear Magnetic Resonance (NMR) experiment to separate and correlate the first-order quadrupolar and chemical/paramagnetic shift interactions is described. This experiment, which we call the shifting-d echo experiment, allows a more precise determination of tensor principal components values and their relative orientation. It is designed using the recently introduced symmetry pathway concept. A comparison of the shifting-d experiment with earlier proposed methods is presented and experimentally illustrated in the case of {sup 2}H (I = 1) paramagnetic shift and quadrupolar tensors of CuCl{sub 2}⋅2D{sub 2}O. The benefits of the shifting-d echo experiment over other methods are a factor of two improvement in sensitivity and the suppression of major artifacts. From the 2D lineshape analysis of the shifting-d spectrum, the {sup 2}H quadrupolar coupling parameters are 〈C{sub q}〉 = 118.1 kHz and 〈η{sub q}〉 = 0.88, and the {sup 2}H paramagnetic shift tensor anisotropy parameters are 〈ζ{sub P}〉 = − 152.5 ppm and 〈η{sub P}〉 = 0.91. The orientation of the quadrupolar coupling principal axis system (PAS) relative to the paramagnetic shift anisotropy principal axis system is given by (α,β,γ)=((π)/2 ,(π)/2 ,0). Using a simple ligand hopping model, the tensor parameters in the absence of exchange are estimated. On the basis of this analysis, the instantaneous principal components and orientation of the quadrupolar coupling are found to be in excellent agreement with previous measurements. A new point dipole model for predicting the paramagnetic shift tensor is proposed yielding significantly better agreement than previously used models. In the new model, the dipoles are displaced from nuclei at positions associated with high electron density in the singly occupied molecular orbital predicted from ligand field theory.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Size and shape fluctuations of ultrasoft colloids

An ultrasoft colloidal particle fluctuates due to its flexibility. Such fluctuation is essential for colloidal structure and dynamics, but is challenging to quantify experimentally. We use dendrimers as a model system to study the fluctuation of ultrasoft colloids. By considering the dynamic polydispersity in the small-angle neutron scattering (SANS) model and introducing the fluctuation of invasive water into the contrast in SANS, we reveal the fluctuating amplitudes of the size and shape of the dendrimer of generation 6 at finite concentrations. The size fluctuation is suppressed while the shape fluctuation increases as the weight fraction of dendrimers passes 11%. With neutron spin echo data, we suggest that such a crossover originates from the competition between the inter- and intraparticle dynamics. Further investigation on lower-generation samples shows a contrary result, which suggests a structural basis for these dynamic phenomena.

42 ENGINEERING↗

Classical gluon fields of relativistic color charges

The objective of the present study is to consider in more detail the exotic color-charge-glow effect discovered recently and to analyze its possible physical manifestations associated with the treatment of ensembles of color-charged particles at a classical level. The ways in which this effect may appear in arbitrary systems consisting of pointlike massive particles and admitting the partition into elementary configurations like color charges and color dipoles are studied. The possible influence of this effect on particle dynamics (in particular, on gluon distributions) is also examined. Particle collisions at a given impact parameters are considered for a natural regularization of emerging expressions. It is shown that, in the case of reasonable impact-parameter values, collisions may proceed in the electrodynamic mode, in which case the charge-glow contribution to field strengths is suppressed in relation to what we have in the electrodynamic picture. From an analysis of the color-echo situation, it follows that the above conclusion remains valid for more complicated particle configurations as well, since hard gluon fields may arise only owing to a direct collision rather than owing to any echo-like effects.

74 ATOMIC AND MOLECULAR PHYSICS↗

Two-component Model of the Neutron Diffuse Scattering in the Relaxor Ferroelectric PZN-4.5%PT

We report measurements of the neutron diffuse scattering in a single crystal of the relaxor ferroelectric material 95.5% Pb(Zn{sub 1/3}Nb{sub 2/3})O{sub 3}-4.5%PbTiO{sub 3}. Our results suggest that the nanometer scale structure in this compound exhibits both <100> and <110> polarizations, which contribute to different portions of the total diffuse scattering intensity. These contributions can be distinguished by the differing responses to an electric field applied along [001]. While diffuse scattering intensities associated with <110> (T2-type) polarizations show little to no change in a [001] field, those associated with <100> (T1-type) polarizations are partially suppressed by the field at temperatures below the Curie temperature T{sub C} {approx} 475 K. Neutron spin-echo measurements show that the diffuse scattering at (0.05,0,1) is largely dynamic at high temperature and gradually freezes on cooling, becoming mostly static at 200 K.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗