Astrophysical exclusion of photon-neutrino weak coupling
Photon-neutrino coupling theory of weak interactions, noting exclusion by astrophysical data for white dwarfs
Stothers, R. B.↗
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Four-fermion interaction Lagrangians
Pauli exclusion principle and Fierz rearrangement theorem shown to limit arbitrariness of Lorentz invariant interaction Lagrangian for self-coupled Dirac field
LAGRANGE EQUATION↗
A role for cysteine 3635 of RYR1 in redox modulation and calmodulin binding
Oxidation of the skeletal muscle Ca(2+) release channel (RYR1) increases its activity, produces intersubunit disulfide bonds, and blocks its interaction with calmodulin. Conversely, bound calmodulin protects RYR1 from the effects of oxidants (Zhang, J.-Z., Wu, Y., Williams, B. Y., Rodney, G., Mandel, F., Strasburg, G. M., and Hamilton, S. L. (1999) Am. J. Physiol. 276, Cell Physiol. C46-C53). In addition, calmodulin protects RYR1 from trypsin cleavage at amino acids 3630 and 3637 (Moore, C. P., Rodney, G., Zhang, J.-Z., Santacruz-Toloza, L., Strasburg, G. M., and Hamilton, S. L. (1999) Biochemistry 38, 8532-8537). The sequence between these two tryptic sites is AVVACFR. Alkylation of RYR1 with N-ethylmaleimide (NEM) blocks both (35)S-apocalmodulin binding and oxidation-induced intersubunit cross-linking. In the current work, we demonstrate that both cysteines needed for the oxidation-induced intersubunit cross-link are protected from alkylation with N-ethylmaleimide by bound calmodulin. We also show, using N-terminal amino acid sequencing together with analysis of the distribution of [(3)H]NEM labeling with each sequencing cycle, that cysteine 3635 of RYR1 is rapidly labeled by NEM and that this labeling is blocked by bound calmodulin. We propose that cysteine 3635 is located at an intersubunit contact site that is close to or within a calmodulin binding site. These findings suggest that calmodulin and oxidation modulate RYR1 activity by regulating intersubunit interactions in a mutually exclusive manner and that these interactions involve cysteine 3635.
Non-NASA Center↗
Exclusive Reactions Involving Pions and Nucleons
The HZETRN code requires inclusive cross sections as input. One of the methods used to calculate these cross sections requires knowledge of all exclusive processes contributing to the inclusive reaction. Conservation laws are used to determine all possible exclusive reactions involving strong interactions between pions and nucleons. Inclusive particle masses are subsequently determined and are needed in cross-section calculations for inclusive pion production.
Norbury, John W.↗
The Ultimate Monte Carlo: Studying Cross-Sections With Cosmic Rays
The high-energy physics community has been discussing for years the need to bring together the three principal disciplines that study hadron cross-section physics - ground-based accelerators, cosmic-ray experiments in space, and air shower research. Only recently have NASA investigators begun discussing the use of space-borne cosmic-ray payloads to bridge the gap between accelerator physics and air shower work using cosmic-ray measurements. The common tool used in these three realms of high-energy hadron physics is the Monte Carlo (MC). Yet the obvious has not been considered - using a single MC for simulating the entire relativistic energy range (GeV to EeV). The task is daunting due to large uncertainties in accelerator, space, and atmospheric cascade measurements. These include inclusive versus exclusive cross-section measurements, primary composition, interaction dynamics, and possible new physics beyond the standard model. However, the discussion of a common tool or ultimate MC might be the very thing that could begin to unify these independent groups into a common purpose. The Offline ALICE concept of a Virtual MC at CERN s Large Hadron Collider (LHC) will be discussed as a rudimentary beginning of this idea, and as a possible forum for carrying it forward in the future as LHC data emerges.
Wilson, Thomas L.↗
Rarefied flow past a flat plate at incidence
Results of a numerical study using the direct simulation Monte Carlo (DSMC) method are presented for the transitional flow about a flat plate at 40 deg incidence. The plate has zero thickness and a length of 1.0 m. The flow conditions simulated are those experienced by the Shuttle Orbiter during reentry at 7.5 km/s. The range of freestream conditions are such that the freestream Knudsen number values are between 0.02 and 8.4, i.e., conditions that encompass most of the transitional flow regime. The DSMC simulations show that transitional effects are evident when compared with free molecule results for all cases considered. The calculated results demonstrate clearly the necessity of having a means of identifying the effects of transitional flow when making aerodynamic flight measurements as are currently being made with the Space Shuttle Orbiter vehicles. Previous flight data analyses have relied exclusively on adjustments in the gas-surface interaction models without accounting for the transitional effect which can be comparable in magnitude. The present calculations show that the transitional effect at 175 km would increase the Space Shuttle Orbiter lift-drag ratio by 90 percent over the free molecule value.
Dogra, Virendra K.↗
Rarefied flow past a flat plate at incidence
Results of a numerical study using the direct simulation Monte Carlo (DSMC) method are presented for the transitional flow about a flat plate at 40 deg incidence. The plate has zero thickness and a length of 1.0 m. The flow conditions simulated are those experienced by the Shuttle Orbiter during reentry at 7.5 km/s. The range of freestream conditions are such that the freestream Knudsen number values are between 0.02 and 8.4, i.e., conditions that encompass most of the transitional flow regime. The DSMC simulations show that transitional effects are evident when compared with free molecule results for all cases considered. The calculated results demonstrate clearly the necessity of having a means of identifying the effects of transitional flow when making aerodynamic flight measurements as are currently being made with the Space Shuttle Orbiter vehicles. Previous flight data analyses have relied exclusively on adjustments in the gas-surface interaction models without accounting for the transitional effect which can be comparable in magnitude. The present calculations show that the transitional effect at 175 km would increase the Space Shuttle Orbiter lift-drag ratio by 90 percent over the free molecule value.
Dogra, Virendra K.↗
High-beta effects and anomalous diffusion in plasmas expanding into magnetic fields
A metallic laser-produced plasma is allowed to expand transversely into an applied magnetic field, under conditions where the typical ion cyclotron radius is much larger, and the electron cyclotron radius much smaller, than the experimental dimensions. A stationary background plasma may also be present. Initially, the flow energy density exceeds (B squared/8 times pi), where B is the ambient magnetic field. Magnetic coil probes, Langmuir probes, and microwave diagnostics are used to study the plasma-field interaction. Field compression at the leading edge and field exclusion within the expanding plasma are seen. The diagnostic measurements and comparison with a theoretical model demonstrate plasma turbulence and anomalously high diffusion of field into the expanding plasma.
Koopman, D. W.↗
Effective Forces Between Colloidal Particles
Colloidal suspensions have proven to be excellent model systems for the study of condensed matter and its phase behavior. Many of the properties of colloidal suspensions can be investigated with a systematic variation of the characteristics of the systems and, in addition, the energy, length and time scales associated with them allow for experimental probing of otherwise inaccessible regimes. The latter property also makes colloidal systems vulnerable to external influences such as gravity. Experiments performed in micro-ravity by Chaikin and Russell have been invaluable in extracting the true behavior of the systems without an external field. Weitz and Pusey intend to use mixtures of colloidal particles with additives such as polymers to induce aggregation and form weak, tenuous, highly disordered fractal structures that would be stable in the absence of gravitational forces. When dispersed in a polarizable medium, colloidal particles can ionize, emitting counterions into the solution. The standard interaction potential in these charged colloidal suspensions was first obtained by Derjaguin, Landau, Verwey and Overbeek. The DLVO potential is obtained in the mean-field linearized Poisson-Boltzmann approximation and thus has limited applicability. For more precise calculations, we have used ab initio density functional theory. In our model, colloidal particles are charged hard spheres, the counterions are described by a continuum density field and the solvent is treated as a homogeneous medium with a specified dielectric constant. We calculate the effective forces between charged colloidal particles by integrating over the solvent and counterion degrees of freedom, taking into account the direct interactions between the particles as well as particle-counterion, counterion-counterion Coulomb, counterion entropic and correlation contributions. We obtain the effective interaction potential between charged colloidal particles in different configurations. We evaluate two- and three-body forces in the bulk as well as study the influence of soft walls. We qualitatively explain the effects of the walls on the forces and demonstrate that many-body effects are negligible in our system. With adjustments in the parameters, the DLVO pair-potential can describe the results quantitatively. Besides electrostatic interactions, entropic depletion effects that arise from (hard-core) exclusion play an important role in determining the behavior of multi-component colloidal suspensions. A standard theory for depletion forces is due to Asakura and Oosawa and is based on the ideal gas approximation. To go beyond this approximation, we have studied entropic forces in molecular dynamics simulations of systems of hard spheres (the effects of the solvent have been ignored). The effective depletion forces for these systems can be found either from equilibrium distribution functions or from direct momentum transfer calculations. Our results obtained by either method show qualitative differences from the Asakura-Oosawa forces, indicating a longer range, higher value at contact and most importantly a more complicated structure, comprising of several maxima and minima. Our calculations include the determination of effective forces between two spheres, a hard sphere and a wall, and the behavior of a hard sphere near a step-edge and a corner. We also demonstrate that such entropic forces do not necessarily satisfy pairwise additivity.
Tehver, Riina↗
Multiple arm coordination using concurrent processing
The use of concurrent processing for robot arm coordination is considered, and a hierarchically structured set of routines for the completion of coordinated tasks is discussed. Concurrent programming controls interacting concurrent processes by providing techniques to handle the problems of mutual exclusion, synchronization, and communication. The process is demonstrated for the example of the producer-consumer problem. Software supporting a concurrent environment to control a robotic system is being developed in which parallel rather than sequential thought processes are used.
Basta, Robert A.↗
Reverse osmosis filtration for space mission wastewater: membrane properties and operating conditions
Reverse osmosis (RO) is a compact process that has potential for the removal of ionic and organic pollutants for recycling space mission wastewater. Seven candidate RO membranes were compared using a batch stirred cell to determine the membrane flux and the solute rejection for synthetic space mission wastewaters. Even though the urea molecule is larger than ions such as Na+, Cl-, and NH4+, the rejection of urea is lower. This indicates that the chemical interaction between solutes and the membrane is more important than the size exclusion effect. Low pressure reverse osmosis (LPRO) membranes appear to be most desirable because of their high permeate flux and rejection. Solute rejection is dependent on the shear rate, indicating the importance of concentration polarization. A simple transport model based on the solution-diffusion model incorporating concentration polarization is used to interpret the experimental results and predict rejection over a range of operating conditions. Grant numbers: NAG 9-1053.
Non-NASA Center↗
Hematopoietic Stem Cell Therapy to Countermeasure Cancer in Astronauts during Exploration of Deep Space
Exposure to cosmic radiation can cause chromosomal mutations, which may lead to cancer in astronauts engaged in space exploration. Therefore, our goals are to develop countermeasures to prevent space-induced cancer using hematopoietic stem cell therapy (HSCT) and gene therapy. This presentation focuses on HSCT for cancer. Our previous experiments on a simulated, space-induced immuno-deficiency model (mouse hind limb unloading ) indicated that transplanted hematopoietic stem cells (HSCs) could enhance the host's immunity by effectively eliminating bacterial infection (Ohi S, et. al. J Grav Physiol 10, P63-64, 2003; Ohi S, et. al. Proceedings of the Space Technology and Applications International Forum (STAIF) . American Institute of Physics, New York, pp. 938-950, 2004). Hence, we hypothesized that the HSCs might be effective in combating cancer as well. Studies of cocultured mouse HSCs with beta-galactosidase marked rat gliosarcoma spheroids (9L/lacZ), a cancer model, indicated antagonistic interactions , resulting in destruction of the spheroids by HSCs. Trypan Blue dye-exclusion assays were consistent with the conclusion. These results show potential usehlness of HSCT for cancer. Currently, the NASA Hydrodynamic Focusing Bioreactor (HFB), a space analog tissue/cell culture system, is being used to study invasion of the gliosarcoma (GS) spheroids into mouse brain with or without co-cultured HSCs. This may simulate the metastasis of gliosarcoma to brain. There is a tendency for the HSCs to inhibit invasion of GS spheroids into brain, as evidenced by the X-gal staining.
Ohi, S.↗
Vibrational Frequencies and Spectroscopic Constants for 1(sup 3)A' HNC and 1(sup 3)A' HOC+ from High-Accuracy Quartic Force Fields
The spectroscopic constants and vibrational frequencies for the 1(sup 3)A' states of HNC, DNC, HOC+, and DOC+ are computed and discussed in this work. The reliable CcCR quartic force field based on high-level coupled cluster ab initio quantum chemical computations is exclusively utilized to provide the anharmonic potential. Then, second order vibrational perturbation theory and vibrational configuration interaction methods are employed to treat the nuclear Schroedinger equation. Second-order perturbation theory is also employed to provide spectroscopic data for all molecules examined. The relationship between these molecules and the corresponding 1(sup 3)A' HCN and HCO+ isomers is further developed here. These data are applicable to laboratory studies involving formation of HNC and HOC+ as well as astronomical observations of chemically active astrophysical environments.
Astrochemistry↗
Data-Driven Method for Nonlinear Modal Interaction Identification in Fighter Aircraft
The purpose of this paper is to report a new data-driven analysis methodology for identifying nonlinear modal interactions and its application to aeroelastic wind-tunnel data from a generic fighter configuration, which reveals global modal interactions in this system caused by multiple resonance capture events initiated by local nonlinearities. It is shown that during supersonic testing at the Transonic Dynamics Tunnel, vibro-impacts at the embedded external fuel tank shakers on the inboard underwing stations of the generic fighter introduce strong nonlinearity that gives rise to nonlinear modal interactions. Specifically, time–frequency analysis of the acceleration data demonstrates that 6∶5 and 7∶6 transient resonance captures occur across the aircraft exclusively during this vibro-impact forcing window. Further analysis suggests that these resonance captures are dependent on Mach number. These results show experimentally that local vibro-impacts can cause global nonlinear effects in an aeroelastic system and that these effects can be identified using the new methodology herein. The data-driven analysis scheme employed shows applicability to full-aircraft flight test data for identifying nonlinear modal interactions without knowledge of the precise nonlinear contributors.
nonlinear dynamics↗
A Methodology for Multiple Rule System Integration and Resolution Within a Singular Knowledge Base
Expert Systems which support knowledge representation by qualitative modeling techniques experience problems, when called upon to support integrated views embodying description and explanation, especially when other factors such as multiple causality, competing rule model resolution, and multiple uses of knowledge representation are included. A series of prototypes are being developed to demonstrate the feasibility of automating the process of systems engineering, design and configuration, and diagnosis and fault management. A study involves not only a generic knowledge representation; it must also support multiple views at varying levels of description and interaction between physical elements, systems, and subsystems. Moreover, it will involve models of description and explanation for each level. This multiple model feature requires the development of control methods between rule systems and heuristics on a meta-level for each expert system involved in an integrated and larger class of expert system. The broadest possible category of interacting expert systems is described along with a general methodology for the knowledge representation and control of mutually exclusive rule systems.
Kautzmann, Frank N., III↗
Hot Subdwarf Stars Among the Objects Rejected from the PG Catalog: a First Assessment Using GALEX Photometry
The hot subdwarf (sd) stars in the Palomar Green (PG) catalog of ultraviolet excess (UVX) objects play a key role in investigations of the frequency and types of binary companions and the distribution of orbital periods. These are important for establishing whether and by which channels the sd stars arise from interactions in close binary systems. It has been suggested that the list of PG sd stars is biased by the exclusion of many stars in binaries, whose spectra show the Ca I1 K line in absorption. A total of 1125 objects that were photometrically selected as candidates were ultimately rejected from the final PG catalog using this K-line criterion. We study 88 of these 'PG-Rejects' (PGRs), to assess whether there are significant numbers of unrecognized sd stars in binaries among the PGR objects. The presence of a sd should cause a large UVX, compared with the cool K-line star. We assemble GALEX, Johnson V, and 2MASS photometry and compare the colors of these PGR objects with those of known sd stars, cool single stars, and hot+cool binaries. Sixteen PGRs were detected in both the far- and near-ultraviolet GALEX passbands. Eleven of these, plus the 72 cases with only an upper limit in the far-ultraviolet band, are interpreted as single cool stars, appropriately rejected by the PG spectroscopy. Of the remaining five stars, three are consistent with being sd stars paired with a cool main sequence companion, while two may be single stars or composite systems of another type. We discuss the implications of these findings for the 1125 PGR objects as a whole. An enlarged study is desirable to increase confidence in these first results and to identify individual sd+cool binaries or other composites for follow-up study. The GALEX AIS data have sufficient sensitivity to carry out this larger study.
Wade, Richard A.↗
The Plasmasphere as "Seen" by the IMAGE Mission
The Imager for Magnetopause-to-Aurora Global Exploration (IMAGE) is the first mission designed exclusively to remotely measure the magnetosphere. As such, it will reveal the ring current, plasmasphere, polar cusp, and magnetopause as whole extended, interacting systems. For the first time, our impressions of the global magnetosphere, synthesized through many years of whistler and in situ measurement, will be replaced by images. The overall morphology of each system of plasma and the correspondence of changes between them in response to the sun and solar wind will become available. The Extreme Ultraviolet Imager (EUV) and the Radio Plasma Imager (RPI) are the two IMAGE instruments which will remotely measure and image the plasmasphere. What we expect to "see" from these instruments and how it may be interpreted is the subject of this presentation. The EUV instrument includes three optical cameras, with an almost 90 degree field of view, transverse to the spin axis. EUV is designed to see He+ ions in resonantly scatter solar light at 30.4rim. The IMAGE spacecraft will spin with a period of about 2 minutes, with its spin axis parallel to the orbit normal. The IMAGE orbit will be highly inclined, with a high latitude apogee at a geocentric distance of 8RE and perigee of about 1.2RE. The normal observing integration time of 10 minutes will easily see to the outer edge of the plasmasphere. The RPI instrument makes use of three orthoganal dipole antennas: two in the spin plane with a tip-to-tip length of 500m and one along the spin axis with a length of 20 meters. Using coded pulse transmissions, the RPI instrument will broadcast from 3kHz to 3MHz. With one minute resolution, plasma densities from about 0.1 cm(exp -3) to 100,000 cm(exp -3), along with line-of-sight bulk velocities and locations, will be obtained from all returned radio wave signals. When transmitting from the high latitude magnetospheric cavity, RPI will measure density profiles for the major plasma structures in the magnetosphere, including the magnetopause, polar cusp, and plasmasphere. RPI should also see isolated density irregularities and possibly the plasma sheet. Observations The EUV instrument will return line-of-sight integrated images through the optically thin helium medium of the plasmasphere and magnetosphere. A variety of techniques have been suggested for the translation of the images into physically useful data, such as plasmapause location and three dimensional density distribution. The RPI instrument will return quantitative density values and line-of-sight velocity as a function of position along reflecting wave propagation paths. How they may be used individually and together to study plasmaspheric dynamics and global structure will be discussed. Attention will also be given to the data products and how access to IMAGE data will be provided by the IMAGE team and the NSSDC.
Gallagher, D. L.↗
Recent Developments in the Radiation Belt Environment Model
The fluxes of energetic particles in the radiation belts are found to be strongly controlled by the solar wind conditions. In order to understand and predict the radiation particle intensities, we have developed a physics-based Radiation Belt Environment (RBE) model that considers the influences from the solar wind, ring current and plasmasphere. Recently, an improved calculation of wave-particle interactions has been incorporated. In particular, the model now includes cross diffusion in energy and pitch-angle. We find that the exclusion of cross diffusion could cause significant overestimation of electron flux enhancement during storm recovery. The RBE model is also connected to MHD fields so that the response of the radiation belts to fast variations in the global magnetosphere can be studied.Weare able to reproduce the rapid flux increase during a substorm dipolarization on 4 September 2008. The timing is much shorter than the time scale of wave associated acceleration.
Fok, M.-C.↗