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Results for “Endogenous uncertainty”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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Lila: Optimal Dispatching in Probabilistic Temporal Networks using Monte Carlo Tree Search

Executing a Probabilistic Simple Temporal Network (PSTN) amounts at scheduling, i.e. \textit{dispatch}, a set of events under time uncertainty. This constitutes a NP-hard online optimization problem. The right execution time must be dynamically assigned to each event of the PSTN such that the temporal constraints are met, whereas activity durations are progressively observed as the execution unfolds. We propose a dispatching algorithm based on Monte Carlo Tree Search, called Lila, with the following characteristics: (i) it is an anytime algorithm, both offline and online, proven asymptotically optimal; (ii) it returns the current probability of success, either before or at any moment during operations; (iii) it handles any possible continuous or discrete, even non-parametric, probability distributions, as well as inter-dependencies between random variables, exogenous and endogenous uncertainty; and (iv) can be easily extended to handle probabilistic external events, PSTNs with resources, PSTNs with cutoff times and precondition chains, etc. Lila is universal in the sense that it can handle any dispatching protocol, simply by specifying it to the algorithm. It has the unlimited flexibility offered by the simulation paradigm, whilst it asymptotically converges to optimal decisions and/or robustness approximations.

Chien, Steve A.↗

Vasopressin release induced by water deprivation - Effects of centrally administered saralasin

Uncertainty exists as to whether endogenous angiotensin activates brain mechanisms controlling vasopressin (AVP) secretion during dehydration. Various doses of saralasin were injected into a lateral cgrebroventricle (IVT) of conscious, male rats deprived of water for 48 h. The rats were killed at different times. The concentration of AVP in the plasma p(AVP), measured by radioimmunoassay, was unaffected by saralasin. IVT pretreatment with 1-Sar-8-Ile-angiotensin II blocked maximal AVP release by IVT angiotensin, but this pretreatment did not reduce p(AVP) after 24, 48 or 72 hr water deprivation. A 3-hour continuous IVT infusion of CSF or saralasin (10 micrograms/hour) into 48-hour water-deprived rats revealed equivalent p(AVP) concentration and urine volumes. When the infusions were continued for 3 h more with water available, control and saralasin-treated rats: (1) drank at similar rates, (2) excreted similar amounts of urine, and (3) reduced their p(AVP) concentration levels to the same extent. IVT saralasin did not affect p(AVP) concentration of rats dehydrated with hypertonic NaCl. Combined IVT saralasin and atropine reduced p(AVP) concentration of 48-hour water deprived rats about 30 percent (p less than 0.05). It is concluded that redundancy exists for sensing, integrating and releasing vasopressin in dehydrated rats.

Keil, L. C.↗

The statistical analysis of circadian phase and amplitude in constant-routine core-temperature data

Accurate estimation of the phases and amplitude of the endogenous circadian pacemaker from constant-routine core-temperature series is crucial for making inferences about the properties of the human biological clock from data collected under this protocol. This paper presents a set of statistical methods based on a harmonic-regression-plus-correlated-noise model for estimating the phases and the amplitude of the endogenous circadian pacemaker from constant-routine core-temperature data. The methods include a Bayesian Monte Carlo procedure for computing the uncertainty in these circadian functions. We illustrate the techniques with a detailed study of a single subject's core-temperature series and describe their relationship to other statistical methods for circadian data analysis. In our laboratory, these methods have been successfully used to analyze more than 300 constant routines and provide a highly reliable means of extracting phase and amplitude information from core-temperature data.

NASA Discipline Regulatory Physiology↗