Mammalian Hibernation III, International Symposium on Natural Mammalian Hibernation, 3rd, University of Toronto, Toronto, Canada, September 13-16, 1965, Proceedings.
Mammalian hibernation - Conference, Toronto, September 1965
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Mammalian hibernation - Conference, Toronto, September 1965
Serotonergic fibers project to the hippocampus, a brain area previously shown to have distinctive changes in electroencephalograph (EEG) activity during entrance into and arousal from hibernation. The EEG activity is generated by pyramidal cells in both hibernating and nonhibernating species. Using the brain slice preparation, we characterized serotonergic responses of these CA1 pyramidal cells in euthermic, cold-acclimated, and hibernating Syrian hamsters. Stimulation of Shaffer-collateral/commissural fibers evoked fast synaptic excitation of CA1 pyramidal cells, a response monitored by recording population spikes (the synchronous generation of action potentials). Neuromodulation by serotonin (5-HT) decreased population spike amplitude by 54% in cold-acclimated animals, 80% in hibernating hamsters, and 63% in euthermic animals. The depression was significantly greater in slices from hibernators than from cold-acclimated animals. In slices from euthermic animals, changes in extracellular K+ concentration between 2.5 and 5.0 mM did not significantly alter serotonergic responses. The 5-HT1A agonist 8-hydroxy-2(di-n-propylamino)tetralin mimicked serotonergic inhibition in euthermic hamsters. Results show that 5-HT is a robust neuromodulator not only in euthermic animals but also in cold-acclimated and hibernating hamsters.
Because the surface of the Moon drops to cryogenic temperatures, no solar-powered lunar spacecraft have reliably operated beyond a single lunar day. Passive thermal control cannot keep a spacecraft sufficiently warm for the 354-hour lunar night, and active thermal control requires a dramatic increase in battery mass at the expense of payload mass. Extreme conditions seen on the lunar surface suggest a radioisotope solution is ideal, but mass, cost, and schedule are inconsistent with low-cost frequent flight intent of the commercial lunar payload services (CLPS) program. To solve the issue of lunar night survivability without radioisotope sources of power and heat, a lunar power hibernation approach is being developed at the Glenn Research Center, which exploits the ability of common 18650 Lithium-ion cells to passively survive cryogenic freeze-thaw cycles and recover without apparent performance degradation. A key aspect of this hibernation approach is the use of cryogenically operable electronics that safely manage the restoration of the battery thermal environment at lunar dawn. A spacecraft utilizing this strategy will operate into the lunar night on batteries until the state of charge or spacecraft temperature reaches a predetermined threshold. At this point, systems are shut down and the battery is isolated from the main bus to prevent charge or discharge during the freezing and thawing transitions. The system remains passive until lunar dawn, where temperatures can reach as low as 50 K. All electronics must be tolerant to these conditions. When the solar arrays are finally illuminated at lunar dawn, the main bus power electronics will initiate a “cold start” and begin regulating array power. The main bus electronics must be designed to operate at cryogenic temperatures. Array power is used to warm the battery and passive electronics back to operational temperatures. Once batteries are returned to normal temperatures, diagnostics and precharging is performed, as needed, and the battery is reconnected. The overall spacecraft system reboots and returns to nominal operations until lunar night returns. To assure that we can develop batteries suited for many hibernation freeze/thaw cycles, STMD Space Technology Research Grant Program (STRG) has selected two principal investigators that will thoroughly characterize of the Li-ion cell through the freeze-thaw process, investigate degradation mechanisms, and identify potential diagnostic techniques. STMD STRG is also funding an investigation of Gallium-Nitride semiconductors for cryogenic power applications. This work includes physics-informed modeling that considers cryogenic conductivity, carrier mobility, and quantum effects that govern semiconductor performance at cryogenic temperatures. These models can enable engineers to develop accurate cryogenic simulation models that assist in the design of power controls stable over the entire lunar surface temperature range. Meanwhile, Glenn is performing cryogenic testing of batteries and electronics, establishing design guidelines for power applications in extreme cold lunar environment, and potentially developing a hibernation technology demonstrator. The hibernation approach will enable low-cost lunar robotic missions to extend their operating lifetime to many months while minimizing development costs and impact on payload capacity. The need for cryogenically operable electronics is restricted to only main bus power and battery controls, as the majority of systems simply need to passively tolerate cryogenic temperatures. This allows developers to continue to exploit the cost savings of legacy and COTS hardware with minimum modification. For these reasons, lunar power hibernation is a viable near-term solution for lunar night survivability for solar powered commercial landers.
Measurements of blood pressure, heart rate, red blood cell and plasma volumes, and relative distribution of cardiac output were made on hibernating and hypothermic adult male and female golden hamsters weighing 120-140 g to study the mechanisms underlying the elimination or marked depression of renal function in hibernation and hypothermia. The results suggest that the elimination or marked depression in renal function reported in hibernation and hypothermia may partly be explained by alterations in cardiovascular system function. Renal perfusion pressure which decreases nearly 60% in both hibernation and hypothermia and a decrease in plasma volume of roughly 35% in the hypothermic animal might both be expected to markedly alter glomerular function.
Lunar Surface temperatures can span from equatorial highs near 400K and polar lows of 50K. The extreme cold combined with the 354-hour duration of the lunar night is particularly challenging for small robotic lander missions. NASA’s Commercial Lunar Payload Services (CLPS) missions involve robotic landers intended to provide low-cost access to the lunar surface. Current CLPS Missions are solar powered and are only intended to survive a single lunar day. The ability to survive the night and continue operations over many lunar cycles would provide a dramatic increase in science productivity. The Power Hibernation approach relies on battery cells that can tolerate the extreme cold night and recover once temperatures return to normal. System recovery from hibernation depends on power electronics that can “cold start” at lunar dawn and operate on solar array output alone. Once battery and avionics systems are restored the spacecraft resumes daytime operations. The challenge is to achieve this capability with minimum impact to the spacecraft design and payload capacity. This talk will describe recent and ongoing investigations in battery and electronics technologies that will enable power hibernation and recovery.
Lunar Surface temperatures can span from equatorial highs near 400K and polar lows of 50K. The extreme cold combined with the 354-hour duration of the lunar night is particularly challenging for small robotic lander missions. NASA’s Commercial Lunar Payload Services (CLPS) missions involve robotic landers intended to provide low-cost access to the lunar surface. Current CLPS Missions are solar powered and are only intended to survive a single lunar day. The ability to survive the night and continue operations over many lunar cycles would provide a dramatic increase in science productivity. The Power Hibernation approach relies on battery cells that can tolerate the extreme cold night and recover once temperatures return to normal. System recovery from hibernation depends on power electronics that can “cold start” at lunar dawn and operate on solar array output alone. Once battery and avionics systems are restored the spacecraft resumes daytime operations. The challenge is to achieve this capability with minimum impact to the spacecraft design and payload capacity. This talk will describe recent and ongoing investigations in battery and electronics technologies that will enable power hibernation and recovery.
The objectives of this research were to develop and test telemetry equipment suitable for monitoring physiological parameters and activity of a hibernating bear in its den, to monitor this data and other environmental information with the Nimbus 3 IRLS data collection system, and to refine immobilizing, handling, and other techniques required in future work with wild bears under natural conditions. A temperature-telemetering transmitter was implanted in the abdominal cavity of a captive black bear and body temperature data was recorded continuously during a 3 month hibernation period. Body temperatures ranging between 37.5 and 31.8 C were observed. Body temperature and overall activity were influenced by disturbances and ambient den temperature. Nychthemeral temperature changes were not noticable. A load cell weight recording device was tested for determining weight loss during hibernation. Monitoring of data by satellite was not attempted. The implanted transmitter was removed and the bear was released with a radiolocation collar at the conclusion of the experiment.
Venous and arterial blood gases in hibernating and normothermic ground squirrels, showing venous oxygen and carbon dioxide partial pressures reduction in hibernation
Responses of normothermic and hibernating marmots to manipulations of the preoptic-hypothalamic temperature (T-PO) were experimentally investigated. An exponential increase in open-loop gain (OLG) occurred with decreases in temperature; it is concluded that this response can be explained by recruitment of cold-sensitive neurons brought about by low-temperature inactivation of inhibitory neurons. Marmots not only seek out the hibernating state, but also utilize all the thermoregulatory means they possess to remain in it for a given period of time.
Bioenergetic studies on hamsters during depressed metabolic states are reported. External support of blood glucose extended the survival times of hibernating animals. Radioresistance increased in hibernating as well as in hypothermic hamsters. Marked changes in hamster catecholamine turnover rates were observed during acclimatization to high temperature stress. High radioresistance levels of the gerbil gastrointestinal system were attributed in part to the ability of the gut to maintain functional integrity.
We use WHT spectroscopy and imaging to show that nova Vul 1670 (= CK Vul) has been incorrectly identified, and thus its luminosity cannot be used as evidence that novae fade into a 'hibernation' phase within 300 yr of their outbursts. INT spectroscopy is used to correct the magnitude of nova Sge 1783 (= WY Sge) for inclination, this result also implying that novae do not fade significantly. We therefore suggest that, while novae decline in the first 60 yr after outburst, thereafter their luminosity remains constant, and they never undergo a 'hibernation' phase. We show that this idea is consistent with the space density of novae and novalike variables, the outburst interval of SS Cyg and the current luminosities of old novae.
NASA Glenn Research Center has been working on a solution to surviving the lunar night based on the discovery that Li-Ion cells can survive the freeze/thaw process. This implies that a lunar surface spacecraft could hibernate through the coldest portions of the night and recover at lunar dawn. Survival and recovery also depend on power electronics capable of tolerating the cold and reliably starting at lunar dawn based on solar array output alone. GRC is working with STMD Space Technology Research Grant investigators to characterize Li-ion cells through the freeze-thaw process and fully understand the electro-chemical and thermal-mechanical processes to assure reliable cell hibernation and recovery. Further, we are working with investigators to determine what power semiconductor material, transistor technology, and power architecture is best suited for reliable cold start at lunar dawn and methodically restoring the power system to full operation for the next lunar cycle.
Effect of x-ray irradiation during hibernation on tissue catecholamine contents
In vitro study of D-glucose intestinal absorption in active and hibernating, irradiated and nonirradiated ground squirrel
Data processing and parameters for power spectral analysis of hibernation
Processing and analyzing hibernation data recorded on digital magnetic tape
Effect of hibernation on weight, mitochondrial nitrogen content, and enzymatic activity of brown fat and liver of ground squirrel, citellus lateralis
Effect of low temperature on oxidative phosphorylation in hibernators and nonhibernators