Langley Research Antenna System (LRAS)
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EG&G Florida, Inc., KSC base operations contractor Launch Readiness Assessment System
A computerized Launch Readiness Assessment System (LRAS) which compares 'current status' of readiness against the 'required status' of readiness for the Space Shuttle. The five subsystems of the LRAS are examined in detail. The LRAS Plan specifies the overall system requirements, procedures, and reports. The LRAS Manager drives the operation of the LRAS system. The Responding Units (RU) maintain support plans and procedures which specify the detail requirements for each mission or milestone. The Master Data Tables contain the milestone, responsible RU relationships, and requirements assessment categories. The LRAS Status System serves as the launch readiness assessment reporting system. The relationships between these subsystems are displayed in diagrams.
Geaslen, W. D.↗
NASA's Lunar Robotic Architecture Study
This report documents the findings and analysis of a 60-day agency-wide Lunar Robotic Architecture Study (LRAS) conducted by the National Aeronautics and Space Administration (NASA). Work on this study began in January 2006. Its purpose was to: Define a lunar robotics architecture by addressing the following issues: 1) Do we need robotic missions at all? If so, why and under what conditions? 2) How would they be accomplished and at what cost? Are they within budget? 3) What are the minimum requirements? What is the minimum mission set? 4) Integrate these elements together to show a viable robotic architecture. 5) Establish a strategic framework for a lunar robotics program. The LRAS Final Report presents analysis and recommendations concerning potential approaches related to NASA s implementation of the President's Vision for Space Exploration. Project and contract requirements will likely be derived in part from the LRAS analysis and recommendations contained herein, but these do not represent a set of project or contract requirements and are not binding on the U.S. Government unless and until they are formally and expressly adopted as such. Details of any recommendations offered by the LRAS Final Report will be translated into implementation requirements. Moreover, the report represents the assessments and projects of the report s authors at the time it was prepared; it is anticipated that the concepts in this report will be analyzed further and refined. By the time some of the activities addressed in this report are implemented, certain assumptions on which the report s conclusions are based will likely evolve as a result of this analysis. Accordingly, NASA, and any entity under contract with NASA, should not use the information in this report for final project direction. Since the conclusion of this study, there have been various changes to the Agency's current portfolio of lunar robotic precursor activities. First, the Robotic Lunar Exploration Program (RLEP) has been renamed the Lunar Precursor and Robotic Program (LPRP). On May 17, 2006, the Lunar Reconnaissance Orbiter (LRO) was confirmed to enter its implementation phase. Last, a new low-cost secondary payload known as the Lunar Crater Observation and Sensing Satellite (LCROSS) was co-manifested to launch with LRO in 2008. These changes are consistent with the conclusions and recommendations of this study, but came too late to be specifically reflected in this report.
Mulville, Daniel R.↗
Optical Characterization of CLPS MiniatureLaser Retroreflector Arrays
Laser retroreflector arrays (LRAs) consisting of corner cube retroreflectors (CCRs) can act as fiducial markers for decades of laser ranging on the Moon and other planetary bodies. Upcoming lunar lander missions from government space agencies and commercial partners offer a unique opportunity to support lunar science and exploration through the deployment of small LRAs on lander decks. Placement of an LRA on the deck of a lander or rover enables tracking with an orbital laser altimeter to aprecision on the order of centimeters. When mounted alongside a suite of scientific instruments the LRA enables precise geolocation of those instruments in the lunar geodetic frame. Finally, optical markers such as LRAs can support precision autonomous navigation and landing regardless of lighting conditions, an especially valuable capability for lunar polar exploration where long shadows complicate terrain relative nagivation using imaging methods.
Daniel R. Cremons↗
CD8 Lymphocyte Depletion Enhances the Latency Reversal Activity of the SMAC Mimetic AZD5582 in ART-Suppressed Simian Immunodeficiency Virus-Infected Rhesus Macaques
ABSTRACT Inducing latency reversal to reveal infected cells to the host immune system represents a potential strategy to cure human immunodeficiency virus (HIV) infection. In separate studies, we have shown previously that CD8 + T cells may contribute to the maintenance of viral latency and have identified a novel SMAC (second mitochondrial activator of caspases) mimetic/IAP (inhibitor of apoptosis protein) inhibitor (AZD5582) capable of reversing HIV/simian immunodeficiency virus (SIV) latency in vivo by activating the noncanonical (nc) NF-κB pathway. Here, we use AZD5582 in combination with antibody (Ab)-mediated depletion of CD8α + cells to further evaluate the role of CD8 + T cells in the maintenance of viral latency. Six rhesus macaques (RMs) were infected with SIV mac239 and treated with antiretroviral therapy (ART) starting at week 8 postinfection. After 84 to 85 weeks of ART, all animals received a single dose of the anti-CD8α depleting Ab MT807R1 (50 mg/kg of body weight, administered subcutaneously [s.c.]), followed by five weekly doses of AZD5582 (0.1 mg/kg, administered intravenously [i.v.]). Following combined treatment with CD8α depletion and AZD5582, 100% of RMs experienced on-ART viremia levels above 60 copies per ml of plasma. In comparator groups of SIV-infected, ART-suppressed RMs treated with AZD5582 only or CD8α depletion only, on-ART viremia was experienced by 56% and 57% of the animals, respectively. Furthermore, the increased frequency of viremic episodes during the treatment period was greater in the group treated with CD8α depletion plus AZD5582 than in the other groups. Mathematical modeling of virus reactivation suggested that in addition to viral dynamics during acute infection, CD8α depletion influenced the response to AZD5582. This work suggests that the latency reversal induced by activation of the ncNF-κB signaling pathway with AZD5582 can be enhanced by CD8α + cell depletion. IMPORTANCE A favored approach to curing HIV infection aims at inducing viral expression using latency-reversing agents (LRAs) to allow the elimination of infected cells. Here, we tested a combination of two recently identified LRAs, the SMAC mimetic/IAP inhibitor AZD5582, which activates the noncanonical NF-κB pathway, and the antibody (Ab) MT807R1, which depletes CD8α + cells, in SIV-infected rhesus macaques (RMs) on ART. Latency reversal, as defined by increased on-ART viremia, was observed in all six SIV-infected, ART-treated RMs that received this combined treatment. Furthermore, comparison of viral reactivation between these animals and groups of SIV-infected, ART-treated RMs treated with AZD5582 only or CD8α + cell depletion only showed more frequent increases in viremic episodes when the two treatments were combined. This study provides additional evidence that CD8 + T cells may contribute to the maintenance of HIV/SIV latency on ART and potentially inhibit latency reversal during HIV cure approaches.
59 BASIC BIOLOGICAL SCIENCES↗
Small and Lightweight Laser Retro-Reflector Arrays for Lunar Landers
A set of small and lightweight laser retro-reflector arrays (LRAs) was fabricated and tested for use on lunar landersunder NASA's Commercial Lunar Payload Service program. Each array contains eight 1.27-cm-diameter cornercube retro-reflectors mounted on a dome-shaped aluminum structure. The arrays are 5.0cmin diameter at the base,1.6 cm in height, and 20 g in mass. They can be tracked by an orbiting laser altimeter, such as the Lunar OrbiterLaser Altimeter, froma distance of a few hundred kilometers or by a landing lidar on future lunar landers. TheLRAsdemonstrated a diffraction-limited optical performance. They were designed and tested to survive and function ontheMoon for decades,well after the lander missions are completed.
Sun, Xiaoli↗
Extending Science from Lunar Laser Ranging
The Lunar Laser Ranging (LLR) experiment has accumulated 50 years of range data of improving accuracy from ground stations to the laser retroreflector arrays (LRAs) on the lunar surface. The upcoming decade offers several opportunities to break new ground in data precision through the deployment of the next generation of single corner-cube lunar retroreflectors and active laser transponders. This is likely to expand the LLR station network. Lunar dynamical models and analysis tools have the potential to improve and fully exploit the long temporal baseline and precision allowed by millimetric LLR data. Some of the model limitations are outlined for future efforts. Differential observation techniques will help mitigate some of the primary limiting factors and reach unprecedented accuracy. Such observations and techniques may enable the detection of several subtle signatures required to understand the dynamics of the Earth- Moon system and the deep lunar interior. LLR model improvements would impact multi- disciplinary fields that include lunar and planetary science, Earth science, fundamental physics, celestial mechanics and ephemerides.
Vishnu Viswanathan↗
Next generation lunar laser retroreflectors for fundamental physics and lunar science
Lunar Laser Ranging (LLR) data represent a powerful tool to understand the dynamics of the Earth-Moon system and the deep lunar interior. Over the past five decades, the ground station technology has significantly improved, whereas the lunar laser retroreflector arrays (LRAs) on the lunar surface did not. Current instrumental LLR error budget is dominated by the spread of the returning laser pulse due to the large size of the arrays. Next-generation single solid lunar Cube Corner Retroreflectors (CCRs) of large optical diameter (whose LLR performance is unaffected by that time spread) aim to fully exploit the current laser ranging station capabilities to attain LLR accuracy below current centimeter value down to the desired millimeter level and much higher data collection rates. Such improvements will have a significant impact, enabling more refined ephemerides, improved tests of General Relativity (GR) and of other theories of relativistic gravity in the Sun-Earth-Moon system and improved knowledge of the properties of the lunar interior.
L. Porcelli↗