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A Spread-Spectrum SQUID Multiplexer
The transition-edge sensor (TES) is a mature, high-resolution x-ray spectrometer technology that provides a much higher efficiency than dispersive spectrometers such as gratings and crystal spectrometers. As larger arrays are developed, time-division multiplexing schemes operating at MHz frequencies are being replaced by microwave SQUID multiplexers using frequency-division multiplexing at GHz frequencies. However, the multiplexing factor achievable with microwave SQUIDs is limited by the high slew rate on the leading edge of x-ray pulses. In this paper, we propose a new multiplexing scheme for high-slew-rate TES x-ray calorimeters: the spread-spectrum SQUID multiplexer, which has the potential to enable higher multiplexing factors, especially in applications with lower photon-arrival rates.
On-Sky Performance of the SPT-3G Frequency-Domain Multiplexed Readout
Frequency-domain multiplexing (fMux) is an established technique for the readout of large arrays of transition-edge sensor (TES) bolometers. Each TES in a multiplexing module has a unique AC voltage bias that is selected by a resonant filter. This scheme provides for the operation and readout of multiple bolometers on a single pair of wires, reducing thermal loading onto sub-Kelvin stages. The current receiver on the South Pole Telescope, SPT-3G, uses a 68x fMux system to operate its large-format camera of ~16,000 TES bolometers. We present here the successful implementation and performance of the SPT-3G readout as measured on-sky. Characterization of the noise reveals a median pair-differenced 1/f knee frequency of 33 mHz, indicating that low-frequency noise in the readout will not limit SPT-3G’s measurements of sky power on large angular scales. Measurements further show that the median readout white noise level in each of the SPT-3G observing bands is below the expectation for photon noise, demonstrating that SPT-3G is operating in the photon-noise-dominated regime.
Error-Correcting Codes for Code-Division Multiplexed TES Detectors
Transition edge sensors (TESs) have proven to be highly sensitive and versatile X-ray spectrometers. Upcoming missions, including Athena X-IFU, will rely on highly multiplexed focal planes where more than 32 TES pixels are read out using a single SQUID amplifier channel. We have implemented an error correction algorithm for code-division multiplexed TES signals that can compensate for potential failures of individual SQUID readout channels and that is both scalable and easily implemented in hardware. We present this algorithm for error correction and show results of laboratory tests to assess algorithm performance at recovering TES channels after a SQUID failure.
Recovery of coincident frequency domain multiplexed detector pulses using sequential deconvolution
Multiplexing of radiation detector signals into a single channel significantly reduces the need for a large number of digitizer channels, which reduces the cost and the power consumption of a data acquisition system. We previously demonstrated frequency domain multiplexing by convolution using a prototype system that multiplexed two EJ-309 organic scintillators signals into a single channel. Each detector pulse was converted to a damped sinusoid which was then combined into a single channel. The combined signal was digitized and the original detector signal was recovered from the damped sinusoid by deconvolution. In this paper, we demonstrate the recovery of multiple detector signals that arrive during the same digitized record via a new sequential deconvolution method. Here, when two detectors produce signals in the same digitized record and their pulses do not overlap in time, we found that the charge, arrival time, and particle type can be estimated fairly precisely for the first pulse, but the second pulse exhibits substantial degradation in the precision of the estimated charge and arrival time. When the pulses overlap in time, we demonstrate both theoretically and experimentally that the part of the first pulse that does not overlap with the second can be recovered accurately, so the arrival time and amplitude of the first pulse can be estimated fairly precisely, but not the charge or particle type. None of these quantities can be estimated precisely for the second pulse when the two pulses overlap.
Performance and characterization of the SPT-3G digital frequency-domain multiplexed readout system using an improved noise and crosstalk model
The third-generation South Pole Telescope camera (SPT-3G) improves upon its predecessor (SPTpol) by an order of magnitude increase in detectors on the focal plane. The technology used to read out and control these detectors, digital frequency-domain multiplexing (DfMUX), is conceptually the same as used for SPTpol, but extended to accommodate more detectors. A nearly 5× expansion in the readout operating bandwidth has enabled the use of this large focal plane, and SPT-3G performance meets the forecasting targets relevant to its science objectives. However, the electrical dynamics of the higher-bandwidth readout differ from predictions based on models of the SPTpol system due to the higher frequencies used and parasitic impedances associated with new cryogenic electronic architecture. To address this, we present an updated derivation for electrical crosstalk in higher-bandwidth DfMUX systems and identify two previously uncharacterized contributions to readout noise, which become dominant at high bias frequency. The updated crosstalk and noise models successfully describe the measured crosstalk and readout noise performance of SPT-3G. These results also suggest specific changes to warm electronics component values, wire-harness properties, and SQUID parameters, to improve the readout system for future experiments using DfMUX, such as the LiteBIRD space telescope.
Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis
Rationale: The monitoring of TB treatments in clinical practice and clinical trials relies on traditional sputum-based culture status indicators at specific time points. Accurate, predictive, blood-based protein markers would provide a simpler and more informative view of patient health and response to treatment. Objective: We utilized sensitive, high throughput multiplexed ion mobility-mass spectrometry (IM-MS) to characterize the serum proteome of TB patients at the start of and at 8 weeks of rifamycin-based treatment. We sought to identify treatment specific signatures within patients as well as correlate the proteome signatures to various clinical markers of treatment efficacy. Methods: Serum samples were collected from 289 subjects enrolled in CDC TB Trials Consortium Study 29 at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment). Serum proteins were immunoafinity-depleted of high abundant components, digested to peptides and analyzed for data acquisition utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS). Linear mixed models were utilized to identify serum protein changes in the host response to antibiotic treatment as well as correlations with culture status end points. Results: A total of 10,137 peptides corresponding to 872 proteins were identified, quantified, and used for statistical analysis across the longitudinal patient cohort. In response to TB treatment, 244 proteins were sig- ni?cantly altered. Pathway/network comparisons helped visualize the interconnected proteins, identifying up regulated (lipid transport, coagulation cascade, endopeptidase activity) and down regulated (acute phase) processes and pathways in addition to other cross regulated networks (inflammation, cell adhesion, extracellular matrix). Detection of possible lung injury serum proteins such as HPSE, significantly downregulated upon treatment. Analyses of microbiologic data over time identified a core set of serum proteins (TTHY, AFAM, CRP, RET4, SAA1, PGRP2) which change in response to treatment and also strongly correlate with culture status. A similar set of proteins at baseline were found to be predictive of week 6 and 8 culture status. Conclusion: A comprehensive host serum protein dataset reflective of TB treatment effect is defined. A repeating set of serum proteins (TTHY, AFAM, CRP, RET4, SAA1, PGRP2, among others) were found to change significantly in response to treatment, to strongly correlate with culture status, and at baseline to be predictive of future culture conversion. If validated in cohorts with long term follow-up to capture failure and relapse of TB, these protein markers could be developed for monitoring of treatment in clinical trials and in patient care.
Multiplex qPCR for detection and quantification of Sphaerulina musiva in Populus stems
Not provided.
Mapping of exhaust gas recirculation and combustion-residual backflow in the intake ports of a heavy-duty diesel engine using a multiplexed multi-species absorption spectroscopy sensor [Mapping of EGR and combustion residual backflow in the intake ports of a heavy duty diesel engine using a multiplexed multi-species absorption spectroscopy sensor]
Here, the combustion-residual backflow into the intake ports of a commercial diesel engine (Cummins ISX series) was spatiotemporally mapped using a multiplexed multi-species absorption spectroscopy sensor system; the resulting cycle- and cylinder-resolved measurements are applicable for assessing cylinder charge uniformity, control strategies, and computational fluid dynamics tools. On-engine measurements were made using four compact (3/8 in Outside Diameter) stainless steel probes which enabled simultaneous multi-point measurements, required minimal engine hardware modification, and featured a novel tip design for measurement of gas flows parallel to the probe axis. Three sensor probes were used to perform simultaneous backflow measurements in intake runners corresponding to three of the six engine cylinders, and a fourth probe was installed in the intake manifold plenum for tracking dynamics introduced by an external exhaust gas recirculation mixer. Near-crank-angle resolved measurements (5 kHz, that is, 1.2 crank angle resolution at 1000 RPM) were performed during steady-state engine operation at various levels of external exhaust gas recirculation to measure the gas properties and penetration distance of the backflow into the intake runners on a cylinder- and cycle-basis. Validation of computational fluid dynamics model results is also presented to demonstrate the utility of such measurements in advancing engine research.
Multiplex PCR Targeted Amplicon Sequencing (MTA-Seq): Simple, Flexible, and Versatile SNP Genotyping by Highly Multiplexed PCR Amplicon Sequencing
Next-generation sequencing (NGS) technologies have enabled genome re-sequencing for exploring genome-wide polymorphisms among individuals, as well as targeted re-sequencing for the rapid and simultaneous detection of polymorphisms in genes associated with various biological functions. Therefore, a simple and robust method for targeted re-sequencing should facilitate genotyping in a wide range of biological fields. In this study, we developed a simple, custom, targeted re-sequencing method, designated “multiplex PCR targeted amplicon sequencing (MTA-seq),” and applied it to the genotyping of the model grass Brachypodium distachyon. To assess the practical usability of MTA-seq, we applied it to the genotyping of genome-wide single-nucleotide polymorphisms (SNPs) identified in natural accessions (Bd1-1, Bd3-1, Bd21-3, Bd30-1, Koz-1, Koz-3, and Koz-4) by comparing the re-sequencing data with that of reference accession Bd21. Examination of SNP-genotyping accuracy in 443 amplicons from eight parental accessions and an F1 progeny derived by crossing of Bd21 and Bd3-1 revealed that ~95% of the SNPs were correctly called. The assessment suggested that the method provided an efficient framework for accurate and robust SNP genotyping. The method described here enables easy design of custom target SNP-marker panels in various organisms, facilitating a wide range of high-throughput genetic applications, such as genetic mapping, population analysis, molecular breeding, and genomic diagnostics.
Precise Editing at DNA Replication Forks Enables Multiplex Genome Engineering in Eukaryotes
Not provided.
Spatiotemporal multiplexing based on hexagonal multicore optical fibres
Based on a genetic algorithm, we have solved in this paper the problem of finding the parameters of optical Gaussian pulses which make their efficient nonlinear combining possible in one of the peripheral cores of a 7-core hexagonal fibre. Two approaches based on individual selection of peak powers and field phases of the pulses launched into the fibre are considered. Finally, the found regimes of Gaussian pulse combining open up new possibilities for the development of devices for controlling optical radiation.
Multiplexed gene synthesis in emulsions for exploring protein functional landscapes
Not provided.
Two-Level Switches for Advanced Time-Division Multiplexing
Superconducting quantum interference device (SQUID)-based time-division multiplexing (TDM) is a mature and widely implemented technology used to read out transition-edge sensor arrays. As the number of pixels in modern arrays continues to increase, a higher multiplexing factor is required to reduce the number of wires and amplifier channels. Yet, as the multiplexing factor is increased, the number of row-select wires (used to turn on a row of TDM SQUIDs in a two-dimensional configuration) also increases, limiting the reduction in array wires. We introduce a more advanced TDM architecture that enforces multi-level switching between subgroups of pixels. We show that this technique can dramatically reduce the number of required row-select lines. We also present the design, fabrication, and testing of a TDM multiplexer incorporating a two-level switch, which implements a second switch for each group of ten TDM pixels. In this application, a multiplexing factor of 100 can be addressed using ten group-select wiring pairs and ten row-select wiring pairs. We demonstrate multiplexer functionality and present measured operating margins of this new TDM multiplexer.
Dielectric Broadband Metasurfaces for Fiber Mode-Multiplexed Communications
A subwavelength-thick spatial-mode multiplexer based on a highly transparent all-dielectric Mie-resonant metasurface is demonstrated with a broadband response covering major optical communication wavelength bands. The metasurface is employed to convert simultaneously each orthogonal polarization of LP 01 inputs into individual higher-order TM 01 and TE 01 vectorial modes, without the need of a polarization diversity setup. This is not feasible using current mode multiplexing approaches. An LP 01 polarization-multiplexed 51×64-QAM superchannel, with a 10.3 bits/s/Hz spectral-efficiency and total bit-rate of 13.2 Tb/s, is converted to higher-order modes with the metasurface multiplexer, and then mode-multiplexed data is transmitted over a multimode fiber. The results demonstrate the potential application of these metadevice-based mode multiplexers in space-division multiplexed systems.
A Scalable Readout for Microwave SQUID Multiplexing of Transition-Edge Sensors
The readout requirements for instruments based on transition-edge sensors (TESs) have dramatically increased over the last decade as demand for systems with larger arrays and faster sensors has grown. Emerging systems are expected to contain many thousands of sensors and/or sensors with time constants as short as 100 ms. These requirements must be satisfied while maintaining low noise, high dynamic range, and low crosstalk. A promising readout candidate for future TES arrays is the microwave SQUID multiplexer, which offers several gigahertz of readout bandwidth per pair of coaxial cables. In microwave SQUID multiplexing, sensor signals are coupled to RF-SQUIDs embedded in superconducting microwave resonators, which are probed via a common microwave feedline and read out using gigahertz signals. This form of SQUID multiplexing moves complexity from the cryogenic stages to room temperature hardware and digital signal processing firmware which must synthesize the microwave tones and process the information contained within them. To demultiplex signals from the microwave SQUID multiplexer, we have implemented an FPGA-based firmware architecture that is flexible enough to read out a variety of differently optimized TESs. A gamma-ray spectrometer targeted at nuclear materials accounting applications, known as SLEDGEHAMMER, is an early adopter of microwave SQUID multiplexing and is driving our current firmware development effort. This instrument utilizes 300 kHz full-width half-maximum resonators with 256 channels in a one gigahertz wide band. We have recently demonstrated undegraded readout of 128 channels using two ROACH2s on a single pair of coaxial cables. This manuscript describes the firmware implementation for the readout electronics of these early array-scale demonstrations.