Increasing resistance to oxygen deficiency by means of drugs
Indole and hydrazine drug derivatives to increase resistance to oxygen deficiency
OXYGEN DEFICIENCY↗
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Antiferromagnetism and superconductivity in oxygen-deficient YBa2Cu3O(x)
Positive-muon spin-rotation and -relaxation measurements of the oxygen-deficient perovskite YBa2Cu3O(x) have revealed local antiferromagnetic order for x = 6.0-6.4 with a Neel temperature TN that decreases rapidly with increasing oxygen content x. For slowly annealed samples with x = 6.35-6.5 the superconducting transition temperature Tc increases smoothly with x from 25 K at x = 6.348 to 60 K at x = 6.507. Two such samples with x = 6.348 and x = 6.400 appear to 'switch' from superconductivity to antiferromagnetic order at lower temperatures.
Brewer, J. H.↗
Effect of hypothermia on oxygen deficiency at high altitudes
Effect of hypothermia on tolerance of acute hypoxia in dogs at high altitude
DOG↗
Resistance of rats to severe oxygen deficiency during radiation sickness
Resistance of rats to hypoxia during radiation sickness caused by whole-body X-ray irradiation
RAT↗
Toxicity changes in the central nervous system. oxygen deficiency and its influence on the central nervous system final technical report
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Boellaard, J. W.↗
Mechanisms controlling the respiratory surface of blood in connection with oxygen deficiency
Erythrocytosis mechanisms for respiratory blood surface increase during adaptation to hypoxia
Gorozhanin, L. G.↗
Oxygen Deficiency in Spaceflight & its Impact on Plants’ Adaptive Changes
The goal of this study was to investigate the effects of hypoxic conditions in spaceflight. The distribution of genes involved with hypoxia in Arabidopsis thaliana and Brassica rapa were analyzed with the results from past spaceflight experiments to evaluate genes for future studies. Transcriptomes data of two different spaceflight studies of Arabidopsis thaliana from the NASA GeneLab database, GLDS-7 and GLDS-17, were compared. DNA microarrays were utilized for transcription profiling to conduct these studies. For GLDS-7, the response in spaceflight was studied with approaches that collected gene expression data. Leaves, hypocotyls, and root tissues were compared to the whole plant. For GLDS-17, seedlings and undifferentiated cultured cells were placed in the Biological Research in Canisters (BRIC), specifically BRIC-16. The genes related to hypoxia in Arabidopsis thaliana from these two studies were compared to genes in Brassica rapa with the TOAST database to evaluate similarities. When transcriptomes were analyzed for GLDS-7 and 17, genes that were considered significant had p-values ≤ 0.05 and log fold change values ≤ -1 or ≥1. Sixteen genes fulfilled the criteria. The genes related to hypoxia were alcohol dehydrogenase, elongation factor, ethylene-responsive factor, GUS, heat-shock proteins, NAP, RAP2.12, and RD20. The genes most impacted by spaceflight were heat-shock proteins. These genes were compared with Brassica rapa through Arabidopsis Ensemble Orthology from the TOAST Database. Similarities were seen in alcohol dehydrogenase, elongation factor, ethylene-responsive factor, heat-shock proteins, NAP, and RAP2.12. Overall, transcription profiling indicates that plants’ survival in spaceflight is dependent on adaptive changes with gene expression. This study also indicates that there are similarities in gene expression between Arabidopsis thaliana and Brassica rapa with comparable gene expression. Future studies could include analyzing additional species to understand which genes could be modified to ensure better yield of space crops amid hypoxic conditions.
hypoxia↗
Oxygen Deficiency in Spaceflight & its Impact on Plants' Adaptive Changes
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hypoxia↗
Spin bipolaron in the framework of emery model for high-T(sub c) copper oxide superconductors
The high-T(sub c) oxide compounds discovered recently exhibit a number of interesting physical properties. Two-dimensional antiferromagnetic spin order has been observed in these materials at the oxygen deficiency. This fact can be explained by strong correlation of the spins, situated on Cu sites in the conducting planes of the oxide superconductors. The doping or the oxygen deficiency lead to the occurrence of holes, occupying the oxygen p-orbitals according to the Emery model. At the small hole concentration they can move along the antiferromagnetic lattice of spins, localized on Cu sites. Researchers consider the two holes situation and describe in what way their behavior depends on the antiferromagnetic exchange interation J. It is known that in the framework of Hubbard model with strong on-site Coulomb repulsion, a single hole can form a spin polaron of the large radius. It is reasonable to admit that two holes with parallel spins (triplet) form the spin bipolaron complex owing to the hole excitations' capability to polarize Cu spin surroundings. Such an excitation was considered in the phenomenological way. Here the problem is discussed on the basis of the microscopic approach in the framework of the variational principle. A special kind of wave function is used for such a purpose. The wave function is constructed by generalizing the trial functions proposed in over two holes excitation situation (triplet) and then the region of spin bipolaron existance in the framework of Emery model is studied. In this model the Hamiltonian can be easily rewritten by forming the oxygen states transforming as the irreducible representations of the group D(sub 4).
Golub, A. A.↗
Thermoelectric Properties in the TiO2/SnO2 System
Nanotechnology has provided a new interest in thermoelectric technology. A thermodynamically driven process is one approach in achieving nanostructures in bulk materials. TiO2/SnO2 system exhibits a large spinodal region with exceptional stable phase separated microstructures up to 1400 C. Fabricated TiO2/SnO2 nanocomposites exhibit n-type behavior with Seebeck coefficients greater than -300 .V/K. Composites exhibit good thermal conductance in the range of 7 to 1 W/mK. Dopant additions have not achieved high electrical conductivity (<1000 S/m). Formation of oxygen deficient composites, TixSn1-xO2-y, can change the electrical conductivity by four orders of magnitude. Achieving higher thermoelectric ZT by oxygen deficiency is being explored. Seebeck coeffcient, thermal conductivity, electrical conductance and microstructure will be discussed in relation to composition and doping.
Dynys, F.↗
Operational considerations in monitoring oxygen levels at the National Transonic Facility
Laboratory monitoring of the level of oxygen in sample gas mixtures is a process which can be performed with accurate and repeatable results. Operations at the National Transonic Facility require the storage and pumping of large volumes of liquid nitrogen. To protect against the possibility of a fault resulting in a localized oxygen deficient atmosphere, the facility is equipped with a monitoring system with an array of sensors. During the early operational stages, the system produced recurrent alarms, none of which could be traced to a true oxygen deficiency. A thorough analysis of the system was undertaken with primary emphasis placed on the sensor units. These units sense the partial pressure of oxygen which, after signal conditioning, is presented as a % by volume indication at the system output. It was determined that many of the problems experienced were due to a lack of proper accounting for the partial pressure/% by volume relationship, with a secondary cause being premature sensor failure. Procedures were established to consider atmospherically induced partial pressure variations. Sensor rebuilding techniques were examined, and those elements contributing to premature sensor failure were identified. The system now operates with a high degree of confidence and reliability.
Zalenski, M. A.↗
Unexpected Source and Transport of Iron from the Deep Peru Margin
Iron is the most important micronutrient in the ocean, but the nature and magnitude of its sources and sinks to the ocean are poorly constrained. Here we assess our understanding of the sources and sinks of iron in margin environments by synthesizing observations from the U.S. GEOTRACES GP16 Eastern Tropical Pacific Zonal Transect (EPZT) cruise near the Peru margin. GP16 observations showed elevated dissolved iron (dFe) concentrations along the margin, but a larger westward plume of dFe at slope depths (1000-3000 m) in oxygenated waters, rather than at shelf depths (100-300 m) in oxygen deficient waters. We examine the potential explanations for this unexpected observation. Multiple tracers from GP16 suggest that sediment resuspension was important at slope depths, which would lead to enhanced benthic flux of dFe above what was previously measured. The difference in the apparent persistence and penetration of shelf vs slope plumes of dFe into the interior of the ocean likely results from faster removal rates of the shelf dFe compared to slope dFe. DFe sourced from the shelf was almost entirely in the dFe(II) form, whereas dFe sourced from the slope was almost entirely in the dFe(III) form. Although benthic dFe(II) diffuses into oxygen deficient overlying waters, there is still oxidation of dFe(II), which precipitates to particulate Fe(III). In contrast, the slope plume appears to persist in a stabilized dFe(III) form. We hypothesize that sediment porewaters with moderate organic carbon delivery to sediments and shallow oxygen penetration are especially good sources of persistent dFe to the water column.
iron↗
Adaptation to different forms of hypoxia. Communication 1 - Effect of gradual and sudden hypoxia
Adaptation to gradual hypoxia and effects of sudden inhalation of oxygen-deficient gas mixture investigated in cats
CAT↗
The Sensitivity of the Equatorial Pacific ODZ to Particulate Organic Matter Remineralization in A Climate Model Under Pre-Industrial Conditions
Marine oxygen plays a fundamental role in regulating the transfer of organic carbon and nutrients to their dissolved inorganic forms, serving as the terminal electron acceptor for heterotrophic respiration. Oxygen can become limiting to these processes in coastal and open-ocean oxygen deficient zones (ODZs). The maintenance of ODZs depends on the balance between physical processes such as ventilation and biogeochemical processes such as remineralization. These two processes act in opposing directions on ODZs, with ventilation responsible for transporting oxygen from the surface, where it is near saturation with the partial pressure of O2 in the atmosphere, to deeper oxygen-depleted layers, and remineralization acting to consume oxygen through biogeochemical processes such as microbial degradation throughout the water column. Remineralization is represented in all CMIP6 models, but the actual parameterizations, as well as their magnitude, are widely varying. In this study, we examine the sensitivity to remineralization of the equatorial Pacific ODZ O2 ol/kg) in a model; the NASA GISS Ocean Biogeochemical Model (NOBM-G) embedded in the NASA-GISS coupled atmosphere-ocean model. We find that increasing the remineralization rate shoals the ODZ onset depth (i.e. the regionally averaged upper bound of the ODZ), and decreases ODZ volume and regional-averaged thickness. Changes in biological consumption and vertical convergence of oxygen are identified as the primary contributors to changes in ODZ onset depth. ODZ thickness is mainly influenced by the shoaling of the bottom boundary of the ODZ, which decreases with maximum remineralization rate due to decreasing oxygen consumption and increasing horizontal oxygen convergence in deep waters. On the other hand, vertically-averaged ODZ area has a more complex, non-monotonic relationship with maximum remineralization rate. While these findings suggest an important role for remineralization in determining the shape of the ODZ in our model, the relative importance of remineralization vs. other physical parameterizations remains to be established. While our results reflect the structure of our ocean biogeochemical model, the relationship of remineralization to ODZ characteristics in other models should be examined to better inform model inter-comparisons.
Oxygen-deficient zone↗
Effect of shock pressure on the structure and superconducting properties of Y-Ba-Cu-O in explosively fabricated bulk metal-matrix composites
While it is now well established that copper-oxide-based powder, or virtually any other ceramic superconductor powder, can be consolidated and encapsulated within a metal matrix by explosive consolidation, the erratic superconductivity following fabrication has posed a major problem for bulk applications. The nature of this behavior was found to arise from microstructural damage created in the shock wave front, and the residual degradation in superconductivity was demonstrated to be directly related to the peak shock pressure. The explosively fabricated or shock loaded YBa2Cu3Ox examples exhibit drastically altered rho (or R) - T curves. The deterioration in superconductivity is even more noticeable in the measurement of ac magnetic susceptibility and flux exclusion or shielding fraction which is also reduced in proportion to increasing peak shock pressure. The high-frequency surface resistance (in the GHz range) is also correspondingly compromised in explosively fabricated, bulk metal-matrix composites based on YBa2Cu3O7. Transmission electron microscopy (including lattice imaging techniques) is being applied in an effort to elucidate the fundamental (microstructural) nature of the shock-induced degradation of superconductivity and normal state conductivity. One focus of TEM observations has assumed that oxygen displaced from b-chains rather than oxygen-vacancy disorder in the basal plane of oxygen deficient YBa2Cu3Ox may be a prime mechanism. Shock-wave displaced oxygen may also be locked into new positions or interstitial clusters or chemically bound to displaced metal (possibly copper) atoms to form precipitates, or such displacements may cause the equivalent of local lattice cell changes as a result of stoichiometric changes. While the shock-induced suppression of T(sub c) is not desirable in the explosive fabrication of bulk metal-matrix superconductors, it may be turned into an advantage if the atomic-scale distortion can be understood and controlled as local flux pinning sites.
Murr, L. E.↗
Effect of shock pressure on the structure and superconducting properties of Y-Ba-Cu-O in explosively fabricated bulk metal-matrix composites
While it is now well established that copper-oxide-based power, or virtually any other ceramic superconductor powder, can be consolidated and encapsulated within a metal matrix by explosive consolidation, the erratic superconductivity following fabrication has posed a major problem for bulk applications. The nature of this behavior was found to arise from microstructural damage created in the shock wave front, and the residual degradation in superconductivity was demonstrated to be directly related to the peak shock pressure. The explosively fabricated or shock loaded YBa2Cu3Ox examples exhibit drastically altered rho (or R) - T curves. The deterioration in superconductivity is even more noticeable in the measurement of ac magnetic susceptibility and flux exclusion or shielding fraction which is also reduced in proportion to increasing peak shock pressure. The high frequency surface resistance (in the GHz range) is also correspondingly compromised in explosively fabricated, bulk metal-matrix composites based on YBa2Cu3O7. Transmission electron microscopy (including lattice imaging techniques) is being applied in an effort to elucidate the fundamental (microstructural) nature of the shock-induced degradation of superconductivity and normal state conductivity. One focus of TEM observations has assumed that oxygen displaced from b-chains rather than oxygen-vacancy disorder in the basal plane of oxygen deficient YBa2Cu3Ox may be a prime mechanism. Shock-wave displaced oxygen may also be locked into new positions or interstitial clusters or chemically bound to displaced metal (possibly copper) atoms to form precipitates, or such displacements may cause the equivalent of local lattice cell changes as a result of stoichiometric changes. While the shock-induced suppression of T(sub c) is not desirable in the explosive fabrication of bulk metal-matrix superconductors, it may be turned into an advantage if the atomic-scale distortion can be understood and controlled as local flux pinning sites.
Murr, L. E.↗
Advances in PSP Testing in LaRC High Reynolds Number Facilities
The use of luminescent coatings for the global measurement of surface aerodynamic properties at full-flight Reynolds numbers has been ongoing at the NASA Langley Research Center since the late 1990s, beginning with Temperature Sensitive Paint (TSP) for boundary layer analysis at the 0.3-m Transonic Cryogenics Tunnel. Since then, significant work has been made to extend these measurements to pressure using Pressure Sensitive Paint (PSP) as well as develop systems for application in larger scale, full-flight Reynolds number facilities, such as the National Transonic Facility (NTF). Recently, a system for the measurement of time-resolved pressure using recently developed unsteady PSP (uPSP) formulations has been designed and implemented in the Transonic Dynamics Tunnel (TDT). The use of PSP (or uPSP) in either of these large scale, full-fight Reynolds number wind tunnels is complicated by the fact that both facilities operate best in oxygen deficient environments; however, the PSP technique relies on the presence of oxygen to work. The NTF is typically operated in cryogenic conditions, which is achieved using liquid nitrogen. In this facility, temperatures can reach as low as 116 K (-250 °F) with nominal oxygen concentrations of less than 50 ppm. This has resulted in the development of specialized PSP formulations that can operate in the cryogenic environment with the introduction of low amounts of oxygen (typically less than 2000 ppm) for PSP response. Likewise, to achieve full-flight Reynolds number conditions in the TDT, the atmosphere in the tunnel is replaced with a “heavy gas” of R-134A (1,1,1,2-tetrafluoroethane), which also has minimal oxygen native in the flow. The use of uPSP in this case will also depend on the introduction of trace amounts of oxygen, with the precise concentrations to be determined in an upcoming test. This presentation will describe some recent advancements that have been made for PSP measurements in both facilities. For the NTF system, there has been significant development of enhanced lighting for use at cryogenic conditions, as well as improvements in the application efficiency of the PSP. Furthermore, there are efforts underway to incorporate advanced data analysis techniques to acquire additional surface aerodynamic properties using the PSP technique that can yield not only improved experimental efficiency, but also provide data needed for next generation vehicle design and development. For the uPSP system in TDT, significant efforts to improve the data transfer rates to a high-performance computing environment for analysis are underway and performance and initial results from the system in the heavy-gas environment will be presented.
Pressure Sensitive Paint↗
A Portable Oxygen Subsystem - Description and preliminary thermal performance prediction
This paper describes the use, operation, and preliminary thermal modeling of a Portable Oxygen Subsystem (POS). The POS is a partial rebreather which is being developed for Shuttle Orbiter support. Normally used as a pre-breather for denitrogenization prior to EVA, this semi-closed, breath powered breathing system can also be used for emergencies in the event of a contaminated or oxygen-deficient cabin atmosphere, to support an emergency transfer between vehicles, or as a clean oxygen supply in the event of a contaminated ambient atmosphere in the vicinity of the Orbiter after landing.
Sribnik, F.↗