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At least 19 records

Effect of 29 days of simulated microgravity on maximal oxygen consumption and fat-free mass of rats

Effects of a 29-days exposure to simulated microgravity on the values of maximal oxygen consumption and fat-free mass (FFM) and on the mechanical efficiency of running were investigated in rats randomly assigned to one of three regimens: head-down suspension (HDS) at 45 deg, horizontal suspension (HS), or cage control (CC). Before suspension and on days 7, 14, 21, and 28, five exercise performance tests were carried out, with measurements related to maximal oxygen consumption, treadmill run time, and mechanical efficiency. It was found that maximal oxygen consumption of both HDS and HS groups decreased significantly at day 7, after which the HDS rats remained decreased while the HS rats returned to presuspension values. Apparent mechanical efficiency in the HDS and HS groups decreased by 22-35 percent during the experimental period, and FFM decreased significantly.

Woodman, Christopher R.↗

Oxygen consumption of animals under conditions of hypokinesia

The influence of hypokinesia on the oxygen consumption of rats, dog, and squirrels was investigated. Three periods of gaseous exchange were revealed in rats under conditions of a limited motor activity. During the first 10-15 days O2 consumption displayed a sharp elevation; on the 20th-30th day, it became stabilized at a higher level (in comparison with control) and it sharply rose again on the 40th-100th day. In dogs, hypokinesia produced a reduction of O2 consumption and then a tendency to its elevation was seen. A short period of physical exercises in squirrels after hypokinesia led to increased oxygen consumption at rest.

Loginova, Y. N.↗

Improving the Accuracy of Predicting Maximal Oxygen Consumption (VO2pk)

Maximal oxygen (VO2pk) is the maximum amount of oxygen that the body can use during intense exercise and is used for benchmarking endurance exercise capacity. The most accurate method to determineVO2pk requires continuous measurements of ventilation and gas exchange during an exercise test to maximal effort, which necessitates expensive equipment, a trained staff, and time to set-up the equipment. For astronauts, accurate VO2pk measures are important to assess mission critical task performance capabilities and to prescribe exercise intensities to optimize performance. Currently, astronauts perform submaximal exercise tests during flight to predict VO2pk; however, while submaximal VO2pk prediction equations provide reliable estimates of mean VO2pk for populations, they can be unacceptably inaccurate for a given individual. The error in current predictions and logistical limitations of measuring VO2pk, particularly during spaceflight, highlights the need for improved estimation methods.

Downs, Meghan E.↗

Oxygen Consumption of Tilapia and Preliminary Mass Flows through a Prototype Closed Aquaculture System

Performance of NASA's prototype CELSS Breadboard Project Closed Aquaculture System was evaluated by estimating gas exchange quantification and preliminary carbon and nitrogen balances. The total system oxygen consumption rate was 535 mg/hr kg/fish (cv = 30%) when stocked with Tilapia aurea populations (fresh weights of 97 +/- 19 to 147 +/- 36 g/fish for various trials). Oxygen consumption by T. aurea (260 mg/hr kg/fish) contributed to approximately one-half of total system demand. Continuous carbon dioxide quantification methods were analyzed using the,relation of carbon dioxide to oxygen consumption. Overall food conversion rates averaged 18.2 +/- 3.2%. Major pathways for nitrogen and carbon in the system were described with preliminary mass closure of 60-80% and 60% for nitrogen and carbon.

Muller, Matthew S.↗

Oxygen consumption during cold exposure at 2.1 G in rats adapted to hypergravic fields

The thermoregulation ability of rats exposed to various gravitational fields is examined. Male Sprague-Dawley rats were exposed to 22 C and 1 G, and 9 C and 2.1 G in experiment one, 1 G, 2.4 G, 5.8 G and 22 + or - 1.5 C in experiment two, and 1 G, 19-22 C, and 5 C in experiment three. It is observed that the core temperature in the control rats was 36.8 + or 0.4 C at 22C and 30.8 + or - 0.6 C at 9 C, and oxygen consumption dropped from 37 + or - 0.3 C core temperature at 22 C, 36.4 + or - 0.3 C at 9 C, 0.4 oxygen consumption was 8.18 + or - 0.9 ml/min at 22 C, and 14.2 + or - 0.4 ml/min at 9 C. The data from experiment two reveal that tail temperature in the control rats peaked at 2.4 G and at 5.8 G for the acclimated rats, and in experiment three a greater decrease in core temperature is detected in the 2.1-G rats. It is noted that prior acclimation to 2.1 G enhances the thermoregulation ability when exposed to the cold.

Horowitz, J.↗

Autonomic control of cardiac function and myocardial oxygen consumption during hypoxic hypoxia.

Investigation in 19 conscious dogs of the importance of the sympathetic nervous system in the coronary and cardiac response to altitude (hypoxic) hypoxia. Beta-adrenergic blockade was used to minimize the cardiac effect associated with sympathetic receptors. It is shown that the autonomic nervous system, and particularly the sympathetic nervous system, is responsible for the increase in ventricular function and myocardial oxygen consumption that occurs during hypoxia. Minimizing this response through appropriate conditioning and training may improve the operating efficiency of the heart and reduce the hazard of hypoxia and other environmental stresses, such as acceleration, which are encountered in advanced aircraft systems.

Erickson, H. H.↗

Plant respirometer enables high resolution of oxygen consumption rates

Plant respirometer permits high resolution of relatively small changes in the rate of oxygen consumed by plant organisms undergoing oxidative metabolism in a nonphotosynthetic state. The two stage supply and monitoring system operates by a differential pressure transducer and provides a calibrated output by digital or analog signals.

Foster, D. L.↗

Oxygen consumption measurements during continual centrifugation of mice.

A simple method is described for measurement of metabolism of conscious, unrestrained animals, during chronic centrifugation or other conditions of isolation (23.75 hr/day) from the investigators in an essentially normal atmospheric environment for as long as seven days. This involves telemetry of pressure changes in a metabolic chamber. At 7 G's, increased O2 intake lasting two to seven days and a decreased excursion of the day-night difference were measured for male white mice with less effect or even an opposite effect at lower fields. Base-line measurements of metabolic rate per mouse are less affected by animal size than expected from the surface area law.

Fethke, W.↗

Influence of simulated microgravity on the maximal oxygen consumption of nontrained and trained rats

The effects of microgravity and endurance training (TR) on maximal O2 consumption was investigated in trained and nontrained (NT) rats subjected to head-down suspension (HDS) by comparing maximal O2 consumption, treadmill run time (RT), and mechanical efficiency (ME) of treadmill running in HDS rats, both NT and TR, and in respective cage controls. It was found that HDS for 28 days was associated with significant reduction in absolute maximal O2 consumption in both TR and NT rats. Relative maximal O2 consumption, however, was significantly reduced in TR but not NT rats. Reductions in RT and ME occurring in both TR and NT rats after 28 days of HDS were similar. The TR rats exhibited greater diuretic, natriuretic, and kaliuretic responses to HDS than the NT rats.

Woodman, Christopher R.↗