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At least 19 records

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NASA NTRS1993

On the cause of thin current sheets in the near-Earth magnetotail and their possible significance for magnetospheric substorms

The formation of thin current sheets in the near-Earth magnetotail during substorm growth phases is addressed in terms of a simple model. An appropriate part of the unperturbed magnetotail is represented by a plane sheet model. Perturbations are applied to the upper and to the left boundaries, representing the magnetopause and the near-Earth tail boundary, where the perturbation at the latter models the interaction between the tail and the inner magnetosphere. Treating the perturbation as ideal (dissipation-free), we found that singular current sheets develop in the midplane of the tail. The analytical results are explored numerically. Using realistic dimensions of the domain considered, the influence of the earthward boundary on current sheet formation dominates. It is argued that current sheet formation of this type plays an important role in the processes associated with the onset of magnetospheric substorms.

Schindler, K.↗

NASA NTRS2020

Evolution of Pitch Angle Distributions of Relativistic Electrons During Geomagnetic Storms: Van Allen Probes Observations

We present a study analyzing relativistic and ultra relativistic electron energization and the evolution of pitch angle distributions using data from the Van Allen Probes. We study the connection between energization and isotropization to determine if there18is a coherence across storms and across energies. Pitch angle distributions are fit with a J(sub 0) sin(sup n)θ function, and the variable ’n’ is characterized as the pitch angle index and tracked over time. Our results show that, consistently across all storms with ultra relativistic electron energization, electron distributions are most anisotropic within around a day of Dst(sub min) and become more isotropic in the following week. Also, each consecutively higher energy channel is associated with higher anisotropy after storm main phase. Changes in the pitch angle index are reflected in each energy channel; when 1.8 MeV electron pitch angle distributions increase (or decrease) in pitch angle index, so do the other energy channels. We show that the peak anisotropies differ between CME- and CIR- driven storms and measure the relaxation rate as the anisotropy falls after the storm. The isotropization rate in pitch angle index for CME-driven storms is -0.15±0.02 day(sup −1) at 1.8 MeV, -0.30±0.01 day(sup −1) at 3.4 MeV, and -0.39±0.02 day(sup −1) at 5.2 MeV. For CIR-driven storms, the isotropization rates are -0.10±0.01 day(sup −1) for 1.8 MeV, -0.13±0.02 day(sup −1) for 3.4 MeV, and -0.11±0.0231 day(sup −1) for 5.2 MeV. This study shows that there is a global coherence across energies and that storm type may play a role in the evolution of electron pitch angle distributions. Plain Language Summary Using Van Allen Probes data, we measure pitch angle distributions of relativistic and ultra relativistic electrons. Anisotropic pitch angle distributions are sharply peaked around 90 degrees. More evenly distributed pitch angles are isotropic. Our results show that, consistently across all storms with ultra relativistic electron enhancements, electrons are most anistropic within around a day of storm onset and slowly isotropize in the following week. In addition, each consecutively higher energy channel is also associated with higher anisotropy after the main phase of geomagnetic storms, a characteristic which holds through the storm and recovery. Changes in the pitch angle index are reflected in each energy channel; when 1.8 MeV electrons increase (or decrease) in pitch angle index, so do all the other energy channels. In a superposed epoch study, we show that the peak anisotropies differ between different storm drivers (namely, coronal mass ejections and corotating interaction regions) and measure the isotropization rate as the anisotropy falls after the storm. This study shows that there is a global coherence across energies and that storm type may play a role in the evolution of electron pitch angle distributions.

pitch angle distributions↗

NASA NTRS1978

s-process studies - Xenon and krypton isotopic abundances

We propose an analysis of the s-process contributions to the isotopes of xenon and krypton. The object is to aid studies of the possibility that meteorites may contain gas that was carried in presolar grains that were grown in stellar ejecta and that were not degassed prior to incorporation into parent bodies. That model suggests routine interstellar fractionation of s-isotopes from r-isotopes owing to differential incorporation into dust. We show that a deficiency of s-process nuclei cannot yield details of Xe-X, but the gross similarities are strong enough to lead one to think that such a deficiency may play a role in a more complicated explanation. We predict the existence of an s-rich complement somewhere if fractional separation of this type has played a role in Xe-X. We show that the analogous decomposition of krypton is more uncertain, and we call for measurements of neutron-capture cross sections to alleviate these uncertainties.

Clayton, D. D.↗

NASA NTRS1975

Effect of small ionospheric irregularities on radio wave absorption

The ionospheric absorption of a radio wave caused by small-scale irregularities with a gaussian autocorrelation function is calculated for various values of the linear scale height, the radio frequency, the scale size of the irregularities, and the mean-square fractional electron density fluctuations. The absorption is due to scattering of the radio wave into plasma oscillations by the irregularities. It is concluded that the absorption due to such irregularities with a mean-square fractional electron density deviation greater than about 0.000001 exceeds the normal collisional height-integrated absorption. Absorption of this type could play a significant part in heating experiments or in an ionosphere containing naturally occurring irregularities.

Chen, H. C.↗

NASA NTRS2009

Cell Cycle Progression of Human Cells Cultured in Rotating Bioreactor

Space flight has been shown to alter the astronauts immune systems. Because immune performance is complex and reflects the influence of multiple organ systems within the host, scientists sought to understand the potential impact of microgravity alone on the cellular mechanisms critical to immunity. Lymphocytes and their differentiated immature form, lymphoblasts, play an important and integral role in the body's defense system. T cells, one of the three major types of lymphocytes, play a central role in cell-mediated immunity. They can be distinguished from other lymphocyte types, such as B cells and natural killer cells by the presence of a special receptor on their cell surface called T cell receptors. Reported studies have shown that spaceflight can affect the expression of cell surface markers. Cell surface markers play an important role in the ability of cells to interact and to pass signals between different cells of the same phenotype and cells of different phenotypes. Recent evidence suggests that cell-cycle regulators are essential for T-cell function. To trigger an effective immune response, lymphocytes must proliferate. The objective of this project is to investigate the changes in growth of human cells cultured in rotating bioreactors and to measure the growth rate and the cell cycle distribution for different human cell types. Human lymphocytes and lymphoblasts will be cultured in a bioreactor to simulate aspects of microgravity. The bioreactor is a cylindrical culture vessel that incorporates the aspects of clinostatic rotation of a solid fluid body around a horizontal axis at a constant speed, and compensates gravity by rotation and places cells within the fluid body into a sustained free-fall. Cell cycle progression and cell proliferation of the lymphocytes will be measured for a number of days. In addition, RNA from the cells will be isolated for expression of genes related in cell cycle regulations.

Parks, Kelsey↗

NASA NTRS1980

Experimental study of supersonic viscous leeside flow over a slender delta wing

An investigation was conducted to study in detail the vortical flow over the leeward side of a 70 deg swept delta wing having subsonic and supersonic leading edges. Two types of flow were encountered and studied, namely leading edge separation and separation with a shock. Especially for the latter type, Reynolds number plays an important role and unexpected strong streamwise vortices were observed. An optical method is described to obtain a first aproximation of shear stress values in the streamwise direction across the wing span.

Szodruch, J.↗

NASA NTRS1987

The role of resonances in planetary rings

The new observations of planetary rings, including those acquired during the encounters of Voyager with Jupiter, Saturn, and Uranus, and the discovery of incomplete rings around Neptune, reveal the great importance of resonances in determining the dynamics and the shape of planetary rings. Several types of resonances play a part in planetary rings. Current questions of interest are related to the nonlinear theory of density waves, the confinement of the Uranian rings, and the arcs of rings around Neptune.

Borderies, N.↗

NASA NTRS1990

Investigating motion sickness using the conditioned taste aversion paradigm

The avoidance of foods which are associated with uncomfortable or aversive internal states has long been recognized. Many people are aware, either directly or via anecdotal reports, of individuals who avoid foods which were eaten just before the onset of sickness. Awareness of this phenomenon can be traced to the writings of John Locke. The disruption of diet during cancer therapy is sometimes ascribed to the attribution of an unpleasant quality to foods eaten preceding the sickness induced by therapy itself. In addition, it has long been recognized by the manufacturers of rodent poisons that animals avoid the injection of food treated with nonlethal doses of poison. An important part of the laboratory study of this phenomenon was directed toward studying the role learning plays in this type of avoidance behavior. Following the lead of Garcia and his associates, this avoidance has come to be interpreted as arising from a form of classical conditioning. In typical laboratory studies of this behavior, a novel food is ingested just prior to exposure to some stimulus, commonly poisoning or irradiation, which produces illness. Following the terminology of classical conditioning, it is common to describe this procedure as one of 'pairing' a conditioned stimulus (CS), the novel food, with an unconditioned stimulus (US), the illness induced by toxicosis or irradiation. Avoidance of the food in succeeding feeding opportunities is viewed as a learned response or a conditioned taste aversion (CTA). Garcia et al. asserted that motion sickness could produce 'gustatory' aversions, but passive motion was first reported as an US to establish CTA by Green and Rachlin. The purpose is to review the manner in which CTA has been used to study motion sickness. Numerous reviews concentrating on other aspects of CTA are available in the existing literature. Readers are encouraged to consult the various papers and edited books for extensive information on other aspects of this literature.

Robert A Fox↗

NASA NTRS1994

Eccentric exercise testing and training

Some researchers and practitioners have touted the benefits of including eccentric exercise in strength training programs. However, others have challenged its use because they believe that eccentric actions are dangerous and lead to injuries. Much of the controversy may be based on a lack of understanding of the physiology of eccentric actions. This review will present data concerning eccentric exercise in strength training, the physiological characteristics of eccentric exercise, and the possible stimulus for strength development. Also a discussion of strength needs for extended exposure to microgravity will be presented. Not only is the use of eccentric exercise controversial, but the name itself is fraught with problems. The correct pronunciation is with a hard 'c' so that the word sounds like ekscentric. The confusion in pronunciation may have been prevented if the spelling that Asmussen used in 1953, excentric, had been adopted. Another problem concerns the expressions used to describe eccentric exercise. Commonly used expressions are negatives, eccentric contractions, lengthening contractions, resisted muscle lengthenings, muscle lengthening actions, and eccentric actions. Some of these terms are cumbersome (i.e., resisted muscle lengthenings), one is slang (negatives), and another is an oxymoron (lengthening contractions). Only eccentric action is appropriate and adoption of this term has been recommended by Cavanagh. Despite the controversy that surrounds eccentric exercise, it is important to note that these types of actions play an integral role in normal daily activities. Eccentric actions are used during most forms of movement, for example, in walking when the foot touches the ground and the center of mass is decelerated and in lowering objects, such as placing a bag of groceries in the car.

Clarkson, Priscilla M.↗

NASA NTRS1996

Ring Bubbles of Dolphins

The article discusses how dolphins create and play with three types of air-filled vortices. The underlying physics is discussed. Photographs and sketches illustrating the dolphin's actions and physics are presented. The dolphins engage in this behavior on their own initiative without food reward. These behaviors are done repeatedly and with singleminded effort. The first type is the ejection of bubbles which, after some practice on the part of the dolphin, turn into toroidal vortex ring bubbles by the mechanism of baroclinic torque. These bubbles grow in radius and become thinner as they rise vertically to the surface. One dolphin would blow two in succession and guide them to fuse into one. Physicists call this a vortex reconnection. In the second type, the dolphins first create an invisible vortex ring in the water by swimming on their side and waving their tail fin (also called flukes) vigorously. This vortex ring travels horizontally in the water. The dolphin then turns around, finds the vortex and injects a stream of air into it from its blowhole. The air "fills-out" the core of the vortex ring. Often, the dolphin would knock-off a smaller ring bubble from the larger ring (this also involves vortex reconnection) and steer the smaller ring around the tank. One other dolphin employed a few other techniques for planting air into the fluke vortex. One technique included standing vertically in the water with tail-up, head-down and tail piercing the free surface. As the fluke is waved to create the vortex ring, air is entrained from above the surface. Another technique was gulping air in the mouth, diving down, releasing air bubbles from the mouth and curling them into a ring when they rose to the level of the fluke. In the third type, demonstrated by only one dolphin, the longitudinal vortex created by the dorsal fin on the back is used to produce 10-15 foot long helical bubbles. In one technique she swims in a curved path. This creates a dorsal fin vortex since centrifugal force has to be balanced by a lift-like force. She then re-traces her path and injects air into the vortex from her blowhole. She can even make a ring reconnect from the helix. In the second technique, demonstrated a few times, she again swims in a curved path, releases a cloud or group of bubbles from her blowhole and turns sharply away (Which presumably strengthens the vortex). As the bubbles encounter the vortex, they travel to the center of the vortex, merge and, in a flash, elongate along the core of the vortex. In all the three types, the air-water interface is shiny smooth and stable because the pressure gradient in the vortex flow around the bubble stabilizes it. A lot of the interesting physics still remains to be explored.

Shariff, Karim↗

NASA NTRS2006

The Effect of Bonding on the Fragmentation of Small Systems

Recent dissociative recombination (DR) experiments have reported that the observed reaction products depend on the structure, bonding, and charge centre of the molecular ion. For examples, the dominant product channel observed in the DR of D5(+)(2), N2O2(+)(1), and D5O2(+)(3) suggests that the former two ions have the form D3(+) D2, and NO(+) NO(1), respectively, whilst the latter is known to have the form D2O D(+) D2O (3). Here we compare and contrast these observations by investigating the DR of one of the simplest such systems, Li(+) H2. This system, a weakly bound cluster with the charge centre located on the lithium atom, will provide us with an excellent opportunity for investigating the role played by the type of bonds and charge centre in the DR process.

Thomas, R. D.↗

NASA NTRS1999

Molecular Mechanisms Regulating Muscle Fiber Composition Under Microgravity

The overall goal of this project is to reveal the molecular mechanisms underlying the selective and debilitating atrophy of specific skeletal muscle fiber types that accompanies sustained conditions of microgravity. Since little is currently known about the regulation of fiber-specific gene expression programs in mammalian muscle, elucidation of the basic mechanisms of fiber diversification is a necessary prerequisite to the generation of therapeutic strategies for attenuation of muscle atrophy on earth or in space. Vertebrate skeletal muscle development involves the fusion of undifferentiated mononucleated myoblasts to form multinucleated myofibers, with a concomitant activation of muscle-specific genes encoding proteins that form the force-generating contractile apparatus. The regulatory circuitry controlling skeletal muscle gene expression has been well studied in a number of vertebrate animal systems. The goal of this project has been to achieve a similar level of understanding of the mechanisms underlying the further specification of muscles into different fiber types, and the role played by innervation and physical activity in the maintenance and adaptation of different fiber phenotypes into adulthood. Our recent research on the genetic basis of fiber specificity has focused on the emergence of mature fiber types and have implicated a group of transcriptional regulatory proteins, known as E proteins, in the control of fiber specificity. The restriction of E proteins to selected muscle fiber types is an attractive hypothetical mechanism for the generation of muscle fiber-specific patterns of gene expression. To date our results support a model wherein different E proteins are selectively expressed in muscle cells to determine fiber-restricted gene expression. These studies are a first step to define the molecular mechanisms responsible for the shifts in fiber type under conditions of microgravity, and to determine the potential importance of E proteins as upstream targets for the effects of weightlessness. In the past year we have determined that the expression of E Proteins is restricted to specific fiber types by post-transcriptional mechanisms. By far, the most prevalent mechanism of cellular control for achieving post-transcriptional regulation of gene expression is selective proteolysis -through the ubiquitin -proteasome pathway. Steady-state levels of HEB message are similar in all fast and slow skeletal muscle fiber types, yet the protein is restricted to Type IIX fibers. HEB appears to be a nodal point for regulating fiber-specific transcription, as expression of the transcription factor is regulated at the post-transcriptional level. It is not clear at present whether the regulation is at the level of protein synthesis or degradation. We are now poised to evaluate the biological role of ubiquitination in fiber specific-gene expression by controlling the post-transcriptional expression of E Proteins. The use of metabolic labelling and pharmacological inhibitors of the ubiquitin pathway will be used to identify the mode of regulation of the Type IIX expression pattern. The potential role of specific kinases in effecting the restriction of HEB expression will be examined by using both inhibitors and activators. The results of these studies will provide the necessary information to evaluate the biological role of E proteins in controlling fiber type transitions, and in potentially attenuating the atrophic effects of microgravity conditions. We have also recently shown that ectopic expression of the HEB protein transactivates the Type IIX-specific skeletal a-actin reporter. The 218 bp skeletal a-actin promoter drives transgene expression solely in mature Type IIX fibers. A mouse also carrying the transgene MLCI/HEB (which ectopically expresses the E Protein HEB in Type IIB fibers) forces expression of the skeletal a-actin reporter gene in Type IIB fibers. We can now dissect the composition of this fiber-specific cis-element. The skeletal a-actin promoter is quite compact and has been extensively characterized in vitro for activity and binding factors. The single E box may act as a binding target of myogenic factor/HEB heterodimer to allow for IIX expression. The HEB transcription factor may recognize either the precise flanking sequences of the E Box, or perhaps interacting with other proteins bound nearby, and activating expression in Type IIX fibers. This E box will be both ablated, and alternatively, as ablation may well destroy any muscle-specific transcriptional activity, flanking sequences substituted with those surrounding the E box (El) of the myogenin promoter. Modification of fiber-specific transgene expression will be tested in transgenic mice. The results of these studies will provide basic information on the regulatory circuitry underlying fiber specificity, and will form the basis for building appropriate transgenic regulatory cassettes to effect fiber transitions in subsequent experimental manipulations on unweighted muscles.

Rosenthal, Nadia A.↗

NASA NTRS2002

Mechanics of vimentin intermediate filaments

It is increasingly evident that the cytoskeleton of living cells plays important roles in mechanical and biological functions of the cells. Here we focus on the contribution of intermediate filaments (IFs) to the mechanical behaviors of living cells. Vimentin, a major structural component of IFs in many cell types, is shown to play an important role in vital mechanical and biological functions such as cell contractility, migration, stiffness, stiffening, and proliferation.

Review↗

NASA NTRS1982

An association between coronal structures and type III burst sources

Observations of the coronal structures overlying type III radio burst producing regions, obtained with the HAO Coronograph/Polarimeter on board the Solar Maximum Mission, have been combined with observations of the type III bursts from the Mark III Nancay Radioheliograph at 169 MHz. A first qualitative comparison of the data, performed for two periods, indicates that the corona overlying type III producing sites is composed of small, discrete, over-dense structures, which are sometimes diverging and short-lived. The type III burst sources are complex, exhibiting elementary components. It is suggested that the type III burst structure follows that of the corona and that discrete structures may play a fundamental role for type III production.

Trottet, G.↗

NASA NTRS2008

Modeling, Simulation, and Parameter Estimation of Lateral Spacecraft Fuel Slosh

Predicting the effect of fuel slosh on a spacecraft and/or launch vehicle attitude control system is a very important and a challenging task. Whether the spacecraft is under spinning or lateral moving conditions, the dynamic effect of the fuel slosh will help determine whether the spacecraft will remain on its chosen trajectory. There are three categories of slosh that can be caused by launch vehicle and/or spacecraft maneuvers when the fuel is in the presence of an acceleration field. These include bulk fluid motion, subsurface wave motion, and free surface slosh. Each of these slosh types have a periodic component that is defined by either a spinning or lateral motion. For spinning spacecraft, all three types of slosh can play a major role in determining stability. Bulk fluid motion and free surface slosh can affect the lateral slosh characteristics. For either condition, the possibility for an unpredicted coupled resonance between the spacecraft and its on board fuel can have mission threatening affects. This on-going research effort aims at improving the accuracy and efficiency of modeling techniques used to predict these types of lateral fluid motions. In particular, efforts will focus on analyzing the effects of viscoelastic diaphragms on slosh dynamics.

Chatman, Yadira↗

NASA NTRS1992

Exercise training, glucose transporters, and glucose transport in rat skeletal muscles

It was previously found that voluntary wheel running induces an increase in the insulin-sensitive glucose transporter, i.e., the GLUT4 isoform, in rat plantaris muscle (K. J. Rodnick, J. O. Holloszy, C. E. Mondon, and D. E. James. Diabetes 39: 1425-1429, 1990). The present study was undertaken to determine whether 1) the increase in muscle GLUT4 protein is associated with an increase in maximally stimulated glucose transport activity, 2) a conversion of type IIb to type IIa or type I muscle fibers plays a role in the increase in GLUT4 protein, and 3) an increase in the GLUT1 isoform is a component of the adaptation of muscle to endurance exercise. Five weeks of voluntary wheel running that resulted in a 33% increase in citrate synthase activity induced a 50% increase in GLUT4 protein in epitrochlearis muscles of female Sprague-Dawley rats. The rate of 2-deoxy-glucose transport maximally stimulated with insulin or insulin plus contractions was increased approximately 40% (P less than 0.05). There was no change in muscle fiber type composition, evaluated by myosin ATPase staining, in the epitrochlearis. There was also no change in GLUT1 protein concentration. We conclude that an increase in GLUT4, but not of GLUT1 protein, is a component of the adaptive response of muscle to endurance exercise and that the increase in GLUT4 protein is associated with an increased capacity for glucose transport.

NASA Discipline Cell Biology↗

NASA NTRS2001

Analysis of the myosins encoded in the recently completed Arabidopsis thaliana genome sequence

BACKGROUND: Three types of molecular motors play an important role in the organization, dynamics and transport processes associated with the cytoskeleton. The myosin family of molecular motors move cargo on actin filaments, whereas kinesin and dynein motors move cargo along microtubules. These motors have been highly characterized in non-plant systems and information is becoming available about plant motors. The actin cytoskeleton in plants has been shown to be involved in processes such as transportation, signaling, cell division, cytoplasmic streaming and morphogenesis. The role of myosin in these processes has been established in a few cases but many questions remain to be answered about the number, types and roles of myosins in plants. RESULTS: Using the motor domain of an Arabidopsis myosin we identified 17 myosin sequences in the Arabidopsis genome. Phylogenetic analysis of the Arabidopsis myosins with non-plant and plant myosins revealed that all the Arabidopsis myosins and other plant myosins fall into two groups - class VIII and class XI. These groups contain exclusively plant or algal myosins with no animal or fungal myosins. Exon/intron data suggest that the myosins are highly conserved and that some may be a result of gene duplication. CONCLUSIONS: Plant myosins are unlike myosins from any other organisms except algae. As a percentage of the total gene number, the number of myosins is small overall in Arabidopsis compared with the other sequenced eukaryotic genomes. There are, however, a large number of class XI myosins. The function of each myosin has yet to be determined.

NASA Discipline Plant Biology↗

NASA NTRS2012

Persistent Doppler Shift Oscillations Observed with HINODE-EIS in the Solar Corona: Spectroscopic Signatures of Alfvenic Waves and Recurring Upflows

Using data obtained by the EUV Imaging Spectrometer on board Hinode, we have performed a survey of obvious and persistent (without significant damping) Doppler shift oscillations in the corona. We have found mainly two types of oscillations from February to April in 2007. One type is found at loop footpoint regions, with a dominant period around 10 minutes. They are characterized by coherent behavior of all line parameters (line intensity, Doppler shift, line width, and profile asymmetry), and apparent blueshift and blueward asymmetry throughout almost the entire duration. Such oscillations are likely to be signatures of quasi-periodic upflows (small-scale jets, or coronal counterpart of type-II spicules), which may play an important role in the supply of mass and energy to the hot corona. The other type of oscillation is usually associated with the upper part of loops. They are most clearly seen in the Doppler shift of coronal lines with formation temperatures between one and two million degrees. The global wavelets of these oscillations usually peak sharply around a period in the range of three to six minutes. No obvious profile asymmetry is found and the variation of the line width is typically very small. The intensity variation is often less than 2%. These oscillations are more likely to be signatures of kink/Alfv´en waves rather than flows. In a few cases, there seems to be a π/2 phase shift between the intensity and Doppler shift oscillations, which may suggest the presence of slow-mode standing waves according to wave theories. However, we demonstrate that such a phase shift could also be produced by loops moving into and out of a spatial pixel as a result of Alfv´enic oscillations. In this scenario, the intensity oscillations associated with Alfv´enic waves are caused by loop displacement rather than density change. These coronal waves may be used to investigate properties of the coronal plasma and magnetic field.

Solar Corona↗