Results for “Pathways Showcase”

Pathways Showcase discussing work on dual exposure high speed digital camera testing in the Advanced Imaging Analysis Lab (AIAL). Intended for public release.

High speed film↗

DOE OSTI2025

genomeocean: a pretrained microbial genome foundational model (genomeoceanLLM) v1.0

We present Genomeocean, a foundational genome language model that represents the microbial genome sequences from complex environmental samples. By training on a large, diverse metagenomic dataset, Genomeocean learns species-specific sequence composition and can generate long, realistic open reading frames (ORFs). Our model employs a Byte-pair-encoding (BPE) tokenization strategy, allowing it to efficiently process large genomic datasets and generate long sequences up to 50kb. We demonstrate that fine-tuning Genomeocean can generate novel gene clusters encoding biosynthetic pathways, showcasing its ability to model both fundamental and complex biological processes. Our work establishes Genomeocean as a powerful tool for understanding microbial genome biology and paves the way for its application in a range of fields, from synthetic biology to microbiome research.

Wang, Zhong [Lawrence Berkeley National Laboratory↗

NASA NTRSDate not supplied

2021 NE-XF Pathways Internship Student Showcase Presentation

Branch of Fluid Mechanics concern with the mechanics and properties of gases and its application to engineering systems. Applications of Pneumatics in the Aerospace systems: (1) Flight Hardware - Reaction Control, Systems, Rocket Pressure Fed Systems (2) Ground Operations – Valve Actuation, Inert Environment (Purge), Tube Drying/Cleaning NE-XFPneumatics Engineering provides design & operation expertise to support EGS. Commodities used at KSC systems: Gaseous Helium (GHe) Gaseous Oxygen (GO2) Gaseous Nitrogen (GN2) Breathing Air (BAIR) Support other subsystems: LH2, LO2, Ground Main Propulsion System (GMPS), etc.

Environmental and Life Support Systems↗

NASA NTRS2018

What is EA?

An enterprise architecture (EA) is a conceptual blueprint that defines the structure and operation of an organization. The intent of an enterprise architecture is to determine how an organization can most effectively achieve its current and future objectives. A single slide PowerPoint, size 36" x 48" has been produced for printing onto a poster board for display in the Pathways Internship showcase November 2018. This poster board presentation is a display of my internship from 2014 to present, to include my NIFS (NASA Interns, Fellowships, Scholarships) internship, ITSS (Information Technology Support Services) contract, and current Pathways internship. The presentation discusses my years producing deliverables for: the ISS (International Space Station) Anomaly Project in 2014, the FJET (Frangible Joint Empirical Test) database project in 2015, the CUI (Compact Unique Identifier) project in early 2016, and various Enterprise Architecture deliverables and contributions such as the Roadmap SQL (Structured Query Language) stored procedure and architectural views of Program data elements.

MySQL↗

DOE OSTI2024

Catalytically Active Site Mapping Realized through Energy Transfer Modeling

Abstract The demands of a sustainable chemical industry are a driving force for the development of heterogeneous catalytic platforms exhibiting facile catalyst recovery, recycling, and resilience to diverse reaction conditions. Homogeneous‐to‐heterogeneous catalyst transitions can be realized through the integration of efficient homogeneous catalysts within porous matrices. Herein, we offer a versatile approach to understanding how guest distribution and evolution impact the catalytic performance of heterogeneous host–guest catalytic platforms by implementing the resonance energy transfer (RET) concept using fluorescent model systems mimicking the steric constraints of targeted catalysts. Using the RET‐based methodology, we mapped condition‐dependent guest (re)distribution within a porous support on the example of modular matrices such as metal–organic frameworks (MOFs). Furthermore, we correlate RET results performed on the model systems with the catalytic performance of two MOF‐encapsulated catalysts used to promote CO 2 hydrogenation and ring‐closing metathesis. Guests are incorporated using aperture‐opening encapsulation, and catalyst redistribution is not observed under practical reaction conditions, showcasing a pathway to advance catalyst recyclability in the case of host–guest platforms. These studies represent the first generalizable approach for mapping the guest distribution in heterogeneous host–guest catalytic systems, providing a foundation for predicting and tailoring the performance of catalysts integrated into various porous supports.

Thompson, William J.↗

DOE OSTI2024

Catalytically Active Site Mapping Realized through Energy Transfer Modeling

Abstract The demands of a sustainable chemical industry are a driving force for the development of heterogeneous catalytic platforms exhibiting facile catalyst recovery, recycling, and resilience to diverse reaction conditions. Homogeneous‐to‐heterogeneous catalyst transitions can be realized through the integration of efficient homogeneous catalysts within porous matrices. Herein, we offer a versatile approach to understanding how guest distribution and evolution impact the catalytic performance of heterogeneous host–guest catalytic platforms by implementing the resonance energy transfer (RET) concept using fluorescent model systems mimicking the steric constraints of targeted catalysts. Using the RET‐based methodology, we mapped condition‐dependent guest (re)distribution within a porous support on the example of modular matrices such as metal–organic frameworks (MOFs). Furthermore, we correlate RET results performed on the model systems with the catalytic performance of two MOF‐encapsulated catalysts used to promote CO 2 hydrogenation and ring‐closing metathesis. Guests are incorporated using aperture‐opening encapsulation, and catalyst redistribution is not observed under practical reaction conditions, showcasing a pathway to advance catalyst recyclability in the case of host–guest platforms. These studies represent the first generalizable approach for mapping the guest distribution in heterogeneous host–guest catalytic systems, providing a foundation for predicting and tailoring the performance of catalysts integrated into various porous supports.

Thompson, William J.↗

NASA NTRS2018

ECLSS ORION GFAST

Pathway Student Showcase - Environmental Control and Life Support System for Orion Ground and Flight Application Software Team

Stewart, Raymond↗

NASA NTRS2015

Manual Asset Inventory: NASA Kennedy Space Center

The National Aeronautics and Aerospace Administration (NASA) relies in the security and protection of the information and information systems to know the devices that are connected to the Agency networks whether these are business, mission, research, or engineering devices. The Agency uses different Information Technology resources in order to do this process automatically, however, there are some devices that need to be reported manually. As a result of this, every month the Agency distributes among its Information System Owners (ISOs) the Manual Asset Inventory, a document that consists of a Microsoft Excel spreadsheet with twenty field descriptions cells that has to be filled out by the ISO of every Security Plan in the Center [fifty three in total] and uploaded into the IT Security Enterprise Data Warehouse (ITSEC-EDW).

Presentation↗