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At least 19 records
All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

RApid Blade and Blade-Vortex InTeraction (RABBIT) GUI implementation via MATLAB Application Designer

Rotorcraft noise source identification and reduction is crucial to the emergence of the Urban Air Mobility (UAM) market. One key rotor noise source is Blade Vortex Interaction (BVI), caused by the rotor wake interacting with the rotor blades. The low-fidelity RApid Blade and Blade-Vortex InTeraction (RABBIT) tool was created to predict the location and characteristics of Blade-Vortex Interaction (BVI) noise. RABBIT enables engineers to quickly locate and understand designs or configurations that cause significant BVI noise. Furthermore, RABBIT can identify the time and location of blade overlap for coaxial rotors. RABBIT is not a general acoustic prediction tool, but instead utilizes vortex and wake parameters to visualize and predict only BVI noise. To date, RABBIT has been validated against CAMRAD II and ANOPP2/AARON for three NASA Revolutionary Vertical Lift Technology (RVLT) concept vehicles: the Quiet Single Main Rotor (QSMR), Side-by-Side, and Quadrotor. RABBIT has been shown to be a useful BVI prediction tool capable of visualizing BVI as a function of various parameters. Impulse factor and time rate of change of loading allows for a unique BVI prediction technique that provides information on impulse strength, location, and frequency. This presentation will highlight how MATLAB’s App Designer was utilized to enable users to navigate RABBIT easily and efficiently without prior experience with MATLAB or rotorcraft acoustics. RABBIT users can build and view rotors in real time with options to control blade chord, radius, phasing, and airfoil geometry. Furthermore, multiple rotors can be combined to create state-of-the-art multi-rotor vehicles or fleets. Editable tables, sliding bars, and push buttons were implemented within MATLAB’s App Designer for RABBIT’s GUI to allow engineers and designers to predict low order acoustic impact of BVI occurrences.

Natasha Lydia Schatzman↗
NASA NTRSDate not supplied

RApid Blade and Blade-Vortex InTeraction (RABBIT) Reimagined: Algorithm Improvement and User-Friendly Interface Implementation

Rotorcraft noise source identification and reduction is crucial to the emergence of the Urban Air Mobility (UAM) market. One key rotor noise source is Blade Vortex Interaction (BVI), caused by the rotor blades interacting with the rotor wake. The low-fidelity RApid Blade and Blade-Vortex InTeraction (RABBIT) tool was created to predict the location and characteristics of BVI noise. RABBIT enables engineers to quickly design and simulate UAM configurations and understand BVI occurrences for a desired flight condition. Furthermore, RABBIT can also identify the time and location of blade overlap for coaxial rotors. RABBIT is not a general acoustic prediction tool, but instead utilizes vortex and wake parameters to visualize and predict BVI aerodynamics. RABBIT algorithm has been further developed including reduction of computational time, accounting for BVI source time arrival, improved vortex strength modeling, and BVI impulse factor. A user-friendly app is presented with the intent of bringing RABBIT to the masses to allow engineers from various educational backgrounds to design and begin to understand BVI. Furthermore, RABBIT capabilities are highlighted by a parameter study highlighting key parameters that impact BVIalong with highlighting RABBIT’s ability to identify BVI occurrences from other rotors.

RApid↗
NASA NTRSDate not supplied

RABBIT: A Rapid Low Fidelity BVI Prediction Tool—Comparison and Validation using the NASA RVLT Toolchain

Rotorcraft noise source identification is at the forefront of civil rotorcraft applications with the emergence of the Urban Air Mobility (UAM) market. Blade Vortex Interaction (BVI) has been identified as one key source of noise produced by a rotor. To predict BVI occurrences for various Urban Air Mobility (UAM) configurations, the RApid Blade and Blade-Vortex InTeraction (RABBIT) tool was developed and utilized. The tool is built from a Beddoes Wake Model, and computes variables such as miss distance and BVI angle to calculate an impulse factor, which is able to visualize BVI for a given vehicle and flight condition. A complete checkout of this tool and comparison with CAMRADII and ANOPP2/AARON, is performed. A wake comparison between RABBIT and CAMRADII is presented, and BVI is compared with ANOPP2/AARON’s acoustic pressure time history to verify the tools effectiveness and accuracy. Three NASA Revolutionary Vertical Lift Technology (RVLT) concept vehicles were analyzed with increasing geometric and aerodynamic complexity, including the Quiet Single Main Rotor (QSMR), Side-by-Side, and Quadrotor. An analysis of the results concludes that RABBIT presents a low-fidelity tool that accurately predicts BVI location and intensity for multiple vehicle configurations and various flight conditions.

RABBIT↗
NASA NTRS1980

Late degeneration in rabbit tissues after irradiation by heavy ions

Results are presented for investigations of the late effects of heavy-ion irradiation on rabbit tissues which were undertaken to assess the hazards associated with the long-term exposure of humans to heavy ions in space during such activities as the construction of solar power stations or voyages to Mars. White rabbits approximately six weeks old were exposed to various doses of collimated beams of 400-MeV/n Ne ions, 570 MeV/n Ar ions and Co-60 gamma rays directed through both eyes, and the responses of the various tissues (hair follicles, skin, cornea, lens, retina, Harderian glands, bone and forebrain) were examined. Proliferating tissues are found to exhibit high damage levels in the early and late periods following irradiation, while terminally differentiating tissues repond to radiation most intensely in the late period, years after irradiation, with no intermediate recovery. The results obtained from rabbits are used to predict the occurrence of late tissue degeneration in the central nervous system, terminally differentiating systems and stem cells of humans one or more decades following exposure to radiation levels anticipated during long-duration space flights. The studies also indicate that tissues may be prematurely aged in the sense that tissue life spans may be shortened without the development of malignancies.

Lett, J. T.↗
NASA NTRS1981

Vehicle test report: South Coast technology electric conversion of a Volkswagen Rabbit

The South Coast Technology Volkswagen Rabbit, was tested at the Jet Propulsion Laboratory's (JPL) dynamometer facility and at JPL's Edwards Test Station (ETS). The tests were performed to characterize certain parameters of the South Coast Rabbit and to provide baseline data that will be used for the comparison of near term batteries that are to be incorporated into the vehicle. The vehicle tests were concentrated on the electrical drive system; i.e., the batteries, controller, and motor. The tests included coastdowns to characterize the road load, maximum effort acceleration, and range evaluation for both cyclic and constant speed conditions. A qualitative evaluation of the vehicle was made by comparing its constant speed range performance with those vehicles described in the document 'state of the Art assessment of Electric and Hybrid Vehicles'. The Rabbit performance was near to the best of the 1977 vehicles.

Price, T. W.↗
NASA NTRS2003

Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heart

INTRODUCTION: Mechanical stimulation can induce electrophysiologic changes in cardiac myocytes, but how mechanoelectric feedback in the intact heart affects action potential propagation remains unclear. METHODS AND RESULTS: Changes in action potential propagation and repolarization with increased left ventricular end-diastolic pressure from 0 to 30 mmHg were investigated using optical mapping in isolated perfused rabbit hearts. With respect to 0 mmHg, epicardial strain at 30 mmHg in the anterior left ventricle averaged 0.040 +/- 0.004 in the muscle fiber direction and 0.032 +/- 0.006 in the cross-fiber direction. An increase in ventricular loading increased average epicardial activation time by 25%+/- 3% (P < 0.0001) and correspondingly decreased average apparent surface conduction velocity by 16%+/- 7% (P = 0.007). Ventricular loading did not significantly alter action potential duration at 20% repolarization (APD20) but did at 80% repolarization (APD80), from 179 +/- 7 msec to 207 +/- 5 msec (P < 0.0001). The dispersion of APD20 was decreased with loading from 19 +/- 2 msec to 13 +/- 2 msec (P = 0.024), whereas the dispersion of APD80 was not significantly changed. These electrophysiologic changes with ventricular loading were not affected by the nonspecific stretch-activated channel blocker streptomycin (200 microM) and were not attributable to changes in myocardial perfusion or the presence of an electromechanical decoupling agent (butanedione monoxime) during optical mapping. CONCLUSION: Acute loading of the left ventricle of the isolated rabbit heart decreased apparent epicardial conduction velocity and increased action potential duration by a load-dependent mechanism that may not involve stretch-activated channels.

NASA Program Biomedical Research and Countermeasur↗
NASA NTRS2001

LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport

An interactive computer program, LabHEART, was developed to simulate the action potential (AP), ionic currents, and Ca handling mechanisms in a rabbit ventricular myocyte. User-oriented, its design allows switching between voltage and current clamp and easy on-line manipulation of key parameters to change the original formulation. The model reproduces normal rabbit ventricular myocyte currents, Ca transients, and APs. We also changed parameters to simulate data from heart failure (HF) myocytes, including reduced transient outward (I(to)) and inward rectifying K currents (I(K1)), enhanced Na/Ca exchange expression, and reduced sarcoplasmic reticulum Ca-ATPase function, but unaltered Ca current density. These changes caused reduced Ca transient amplitude and increased AP duration (especially at lower frequency) as observed experimentally. The model shows that the increased Na/Ca exchange current (I(NaCa)) in HF lowers the intracellular [Ca] threshold for a triggered AP from 800 to 540 nM. Similarly, the decrease in I(K1) reduces the threshold to 600 nM. Changes in I(to) have no effect. Combining enhanced Na/Ca exchange with reduced I(K1) (as in HF) lowers the threshold to trigger an AP to 380 nM. These changes reproduce experimental results in HF, where the contributions of different factors are not readily distinguishable. We conclude that the triggered APs that contribute to nonreentrant ventricular tachycardia in HF are due approximately equally (and nearly additively) to alterations in I(NaCa) and I(K1). A free copy of this software can be obtained at http://www.meddean.luc.edu/lumen/DeptWebs/physio/bers.html.

NASA Discipline Cardiopulmonary↗
NASA NTRS1996

Damage to the photoreceptor cells of the rabbit retina from 56Fe ions: effect of age at exposure, 1

Optic and proximate tissues of New Zealand white (NZW) rabbits at ages (approximately 3.5 years) near the middle of their median lifespan (5-7 years) were given 0.5-3.5 Gy of 465 MeV u-1 56Fe ions in the Bragg plateau region of energy deposition at a linear energy transfer (LET infinity) of 220 +/- 31 keV micrometer-1. Dose-dependent losses of retinal photoreceptor cells (rods) occurred until 1-2 years after irradiation, the period of this interim report. Similar cumulative losses of photoreceptor cells were seen during the period 1-2 years post-irradiation for rabbits given comparable exposures when young (6-9 weeks old). Since losses of photoreceptor cells at early times had not been determined previously, the current experiment, which was designed to simulate the responses of mature astronauts, redressed that deficiency.

NASA Program NSCORT↗
NASA NTRS1996

The effect of nonablative laser energy on joint capsular properties. An in vitro histologic and biochemical study using a rabbit model

The purpose of this study was to evaluate the effect of laser energy at nonablative levels on joint capsular histologic and biochemical properties in an in vitro rabbit model. The medial and lateral portions of the femoropatellar joint capsule from both stifles of 12 mature New Zealand White rabbits were used. Specimens were divided into three treatment groups (5 watts, 10 watts, and 15 watt) and one control group using a randomized block design. Specimens were placed in a 37 degrees bath of lactated Ringer's solution and laser energy was applied using a holmium:yttrium-aluminum-garnet laser in four transverse passes across the tissue at a velocity of 2 mm/sec with the handpiece set 1.5 mm from the synovial surface. Histologic analysis revealed thermal alteration of collagen (fusion) and fibroblasts (pyknosis) at all energy densities, with higher laser energy causing significantly greater morphologic changes over a larger area (P < 0.05). Application of laser energy did not significantly alter the biochemical parameters evaluated, including type I collagen content and nonreducible crosslinks (P > 0.05). This study demonstrated that nonablative laser energy caused significant thermal damage to the joint capsular tissue in an energy-dependent fashion, but type I collagen content and nonreducible crosslinks (P > 0.05). This study demonstrated that nonablative laser energy caused significant thermal damage to the joint capsular tissue in an energy-dependent fashion, but type I Collagen content and nonreducible corsslinks were not significantly altered.

NASA Discipline Musculoskeletal↗
NASA NTRS1995

Some growth factors stimulate cultured adult rabbit ventricular myocyte hypertrophy in the absence of mechanical loading

Cultured adult rabbit cardiac myocytes treated with recombinant growth factors display enhanced rates of protein accumulation (ie, growth) in response to insulin and insulin-like growth factors (IGFs), but epidermal growth factor, acidic or basic fibroblast growth factor, and platelet-derived growth factor failed to increase contractile protein synthesis or growth of the heart cells. Insulin and IGF-1 increased growth rates by stimulating anabolic while simultaneously inhibiting catabolic pathways, whereas IGF-2 elevated growth modestly by apparently inhibiting lysosomal proteolysis. Neutralizing antibodies directed against either IGF-1 or IGF-2 or IGF binding protein 3 blocked protein accumulation. A monoclonal antibody directed against the IGF-1 receptor also inhibited changes in protein turnover provoked by recombinant human IGF-1 but not IGF-2. Of the other growth factors tested, only transforming growth factor-beta 1 increased the fractional rate of myosin heavy chain (MHC) synthesis, with beta-MHC synthesis being elevated and alpha-MHC synthesis being suppressed. However, the other growth factors were able to modestly stimulate the rate of DNA synthesis in this preparation. Bromodeoxyuridine labeling revealed that these growth factors increased DNA synthesis in myocytes and nonmyocytes alike, but the heart cells displayed neither karyokinesis or cytokinesis. In contrast, cocultures of cardiac myocytes and nonmyocytes and nonmyocyte-conditioned culture medium failed to enhance the rate of cardiac MHC synthesis or its accumulation, implying that quiescent heart cells do not respond to "conditioning" by cardiac nonmyocytes. These findings demonstrated that insulin and the IGFs promote passively loaded cultured adult rabbit heart cells to hypertrophy but suggest that other growth factors tested may be limited in this regard.

NASA Discipline Cell Biology↗
NASA NTRS1988

Age dependency of base modification in rabbit liver DNA

Age-related modifications of DNA bases have been observed in the liver of the New Zealand white (NZW) rabbit (Oryctolagus cuniculus), a lagomorph with a median life span in captivity of 5-7 yr. The ages of the animals studied ranged from 6 wk to 9 yr. After the DNA had been extracted from the liver cell nuclei and hydrolyzed with acid, the bases were analyzed by column chromatography with Cellulofine gels (GC-15-m). Two peaks in the chromatogram, which eluted before the four DNA bases, contained modified bases. Those materials, which were obtained in relatively large amounts from old animals, were highly fluorescent, and were shown to be crosslinked base products by mass spectrometry. The yield of crosslinked products versus rabbit age (greater than 0.5 yr) can be fitted by an exponential function (correlation coefficient: 0.76 +/- 0.09).

NASA Discipline Radiation Health↗
NASA NTRS1972

The human, primate and rabbit ultraviolet action spectra

A 5000 watt xenon-mercury high pressure lamp was used to produce a continuous ultraviolet spectrum. Human and animal exposures were made to establish the photokeratitis threshold and abiotic action spectrum. The lower limit of the abiotic action spectrum was 220 nm while the upper limit was 310 nm. The radiant exposure threshold at 270 nm was 0.005 watts/sq cm for the rabbit, 0.004 watts/sq cm for the primate, and 0.004 watts/ sq cm for the human. The rabbit curve was bi-peaked with minimums at 220 nm, 240 nm and 270 nm. The primate curve was tri-peaked with minimums at 220 nm, 240 nm and 270 nm. The human data showed a rather shallow curve with a minimum at 270 nm. Formulas and calculations are given to predict minimum exposure times for ocular damage to man in outer space, to establish valid safety criteria, and to establish protective design criteria.

Pitts, D. G.↗
NASA NTRS1976

Behavioral fever in newborn rabbits

New Zealand white rabbit pups aged 12 to 72 hr were divided into three groups and given an intraperitoneal injection of Pseudomonas polysaccharide, a saline vehicle alone, and no treatment, respectively. The animals injected with pyrogen and maintained at an ambient temperature of 32 C for 2 hr did not develop fever. When placed in a thermally graded alleyway, the animals injected with pyrogen selected gradient positions that represented significantly higher temperatures than controls injected with saline. Further stay at selected positions for 5 min caused a considerable increase in the rectal temperature of the pyrogen-injected pups but not that of controls. The results support the hypothesis that newborn rabbits will develop a fever by behavioral means after a single injection of an exogenous pyrogen if the opportunity for thermoregulatory behavior is present. No fever develops if the pups must rely solely on internal thermoregulatory mechanisms. The behavioral system for producing a fever is mature at birth, but an adequate system of internal reflexes does not appear to develop for some days.

Satinoff, E.↗
NASA NTRS1980

Effectiveness of using thyrocalcitonin for the prevention of a calcium metabolic disorder in the mineralized tissues of rabbits with 30 days hypokinesia

A 30 day hypokinesia in rabbits led to a considerable lag in weight gain for the skeletal bones, reduction in Ca45 uptake, and an increase in isotope resorption rate in the rapidly metabolized fraction of extremity bones. On the other hand, Ca45 content in the teeth and maxillae increased, which may be explained by redistribution of isotope among the various mineralized tissues. Injection of thyrocalcitonin (50 IU/day) produced a distinct normalizing effect on Ca45 uptake and resorption in the mineralized tissues of rabbits kept hypokinetic.

Volozhin, A. I.↗
NASA NTRS1983

Vehicle test report: South Coast Technology electric Volkswagen Rabbit with developmental low-power armature chopper

Dynamometer performance of a South Coast Technology electric conversion of a Volkswagen (VW) Rabbit designated SCT-8 was tested. The SCT-8 vehicle was fitted with a transistorized chopper in the motor armature circuit to supplement the standard motor speed control via field weakening. The armature chopper allowed speed control below the motor base speed. This low speed control was intended to reduce energy loss at idle during stop-and-go traffic; to eliminate the need for using the clutch below base motor speed; and to improve the drivability. Test results indicate an improvement of about 3.5% in battery energy economy for the SAE J227a-D driving cycle and 6% for the C-cycle with only a minor reduction in acceleration performance. A further reduction of about 6% would be possible if provision were made for shutting down field power during the idle phases of the driving cycles. Drivability of the vehicle equipped with the armature chopper was significantly improved compared with the standard SCT Electric Rabbit.

Marte, J. E.↗
NASA NTRS1983

Central effects of some peptide and non-peptide opioids and naloxone on thermoregulation in the rabbit

The effects of several peptide and non-peptide opiods and naloxone on induced hyperthermia is studied in rabbits. The effect of tyical mu, kappa, and sigma receptor antagonists (morphine, ketocyclazcine and SKF 10,0 10, 047) and some opioid peptides (Beta-endorphin /BE/, methionine-enkaphalin /ME/, and D-Ala2-methionine-enkaphalin-amide /DAME/ are determined. The role of prostaglandins (PG), cAMP, and norepinephrine (NE) in morphine, BE, and DAME induced hyperthermia is investigated. In addition, the effect of naloxone on pyrogen, arachidonic acid, PGE2, prostacyclin, dibutyryl cAMP, and NE induced hyperthermia is determined. Among other results, it is found that the three receptor antagonists induced hyperthermia in rabbits. BE, ME, and DAME were also found to cause hyperthermia, and it is suggested that they act on the same type of receptor. It is also determined that neither NE nor cAMP is involved in the hyperthermia due to morphine, BE, and DAME. It is suggested that an action of endogenous peptides on naloxone sensitive receptors plays little role in normal thermoregulation or in hyperthermia.

Kandasamy, S. B.↗
NASA NTRS1983

Late skin damage in rabbits and monkeys after exposure to particulate radiations

Preliminary results are reported of experiments on the late effects of exposure to particulate radiations on stem cell populations. Skin biopsies were taken from the ears of rabbits irradiated 2-5 years previously with 530 MeV/amu Ar ions (LET 90 keV/micron), or 365 MeV/amu Ne ions (LET 35 keV micron), and from the chests and inner thighs of rhesus monkeys irradiated 16-18 years previously with 32-MeV protons (LET about 1.2 keV/micron). Skin fibroblast cultures obtained from the biopsy samples in rabbits were observed to undergo dose-dependent decreases in in vitro life span, with estimated survival curves showing the effects of Ar-ion irradiation to be more severe than those of Ne-ion irradiation. In addition, the healing of the biopsy wound was observed to become slower as radiation dose increased. In the monkey, radiation reduced the average number of fibroblasts at the time of cessation of growth in culture. Results thus demonstrate the capacity of skin sampling to reveal stem cell destruction, and have important implications for astronauts and other persons at risk of particle exposure with regard to healing responses to trauma or surgery.

Bergtold, D. S.↗