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Results for “Regional Managers”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 19 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2016

Patterns of Local-Regional Management Following Neoadjuvant Chemotherapy in Breast Cancer: Results From ACOSOG Z1071 (Alliance)

Purpose: American College of Surgeons Oncology Group Z1071 was a prospective trial evaluating the false negative rate of sentinel lymph node (SLN) surgery after neoadjuvant chemotherapy (NAC) in breast cancer patients with initial node-positive disease. Radiation therapy (RT) decisions were made at the discretion of treating physicians, providing an opportunity to evaluate variability in practice patterns following NAC. Methods and Materials: Of 756 patients enrolled from July 2009 to June 2011, 685 met all eligibility requirements. Surgical approach, RT, and radiation field design were analyzed based on presenting clinical and pathologic factors. Results: Of 401 node-positive patients, mastectomy was performed in 148 (36.9%), mastectomy with immediate reconstruction in 107 (26.7%), and breast-conserving surgery (BCS) in 146 patients (36.4%). Of the 284 pathologically node-negative patients, mastectomy was performed in 84 (29.6%), mastectomy with immediate reconstruction in 69 (24.3%), and BCS in 131 patients (46.1%). Bilateral mastectomy rates were higher in women undergoing reconstruction than in those without (66.5% vs 32.2%, respectively, P<.0001). Use of internal mammary RT was low (7.8%-11.2%) and did not differ between surgical approaches. Supraclavicular RT rate ranged from 46.6% to 52.2% and did not differ between surgical approaches but was omitted in 193 or 408 node-positive patients (47.3%). Rate of axillary RT was more frequent in patients who remained node-positive (P=.002). However, 22% of patients who converted to node-negative still received axillary RT. Post-mastectomy RT was more frequently omitted after reconstruction than mastectomy (23.9% vs 12.1%, respectively, P=.002) and was omitted in 19 of 107 patients (17.8%) with residual node-positive disease in the reconstruction group. Conclusions: Most clinically node-positive patients treated with NAC undergoing mastectomy receive RT. RT is less common in patients undergoing reconstruction. There is wide variability in RT fields. These practice patterns conflict with expert recommendations and ongoing trial guidelines. There is a significant need for greater uniformity and guidelines regarding RT following NAC.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
NASA NTRS2007

Regional Sediment Management Experiment Using the Visible/Infrared Imager/Radiometer Suite and the Landsat Data Continuity Mission Sensor

The central aim of this RPC (Rapid Prototyping Capability) experiment is to demonstrate the use of VIIRS (Visible/Infrared Imager/ Radiometer Suite and LDCM (Landsat Data Continuity Mission) sensors as key input to the RSM (Regional Sediment Management) GIS (geographic information system) DSS (Decision Support System). The project affects the Coastal Management National Application.

Estep, Leland↗
DOE OSTI2014

Management of the Regional Lymph Nodes Following Breast-Conservation Therapy for Early-Stage Breast Cancer: An Evolving Paradigm

Radiation therapy to the breast following breast conservation surgery has been the standard of care since randomized trials demonstrated equivalent survival compared to mastectomy and improved local control and survival compared to breast conservation surgery alone. Recent controversies regarding adjuvant radiation therapy have included the potential role of additional radiation to the regional lymph nodes. This review summarizes the evolution of regional nodal management focusing on 2 topics: first, the changing paradigm with regard to surgical evaluation of the axilla; second, the role for regional lymph node irradiation and optimal design of treatment fields. Contemporary data reaffirm prior studies showing that complete axillary dissection may not provide additional benefit relative to sentinel lymph node biopsy in select patient populations. Preliminary data also suggest that directed nodal radiation therapy to the supraclavicular and internal mammary lymph nodes may prove beneficial; publication of several studies are awaited to confirm these results and to help define subgroups with the greatest likelihood of benefit.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2017

Use of significance thresholds to integrate cumulative effects into project-level socio-economic impact assessment in Canada

A longstanding critique of project-level environmental assessment is that it is weak at addressing cumulative effects, and because of this many argue that cumulative effects are best managed at a regional scale. However, in the absence of regional management it is important that project-level assessment supports cumulative effects management as best as possible. In this paper we present case study socio-economic impact assessments of liquefied natural gas development on Aboriginal groups on Canada's west coast. The case studies use an analytical structure modified from typical Canadian practice including unambiguous and non-arbitrary significance thresholds grounded in stakeholder values to focus baselines, impact assessment, and significance determination on cumulative effects. This approach is found to be more capable of informing decision-makers on cumulative effects as well as more rigorous and transparent than typical assessments. Much of this approach is not conceptually new, but at least in western Canada such an approach is not typically used or meaningfully implemented by practitioners. As such, the case studies serve to illustrate how practice can bolster project-level assessment. - Highlights: •Typical project assessment is weak with respect to cumulative effects. •Modified analysis structure and thresholds enable a focus on cumulative effects. •Clear, value-based thresholds make analysis rigorous, transparent, and democratic.

03 NATURAL GAS↗
DOE OSTI2019

Trends in Regional Nodal Management of Breast Cancer Patients with Low Nodal Burden

Background: American College of Surgeons Oncology Group Z0011 confirms the safety of omitting axillary lymph node dissection (ALND) and regional nodal irradiation (RNI) in breast cancer patients with one to two positive sentinel lymph nodes (SLNs), without compromising disease-free survival (DFS) and overall survival (OS). In contrast, the NCIC MA20 trial showed improved DFS in node-positive patients undergoing ALND and RNI. We sought to examine how these data have influenced the management of patients with limited nodal burden. Methods: Using the National Cancer Database, patients diagnosed between 2010 and 2015 and who met the criteria for Z0011 were identified. Logistic regression was used to analyze factors associated with practice patterns. The Cox proportional hazards model was used to assess the association of ALND and RNI with OS. Results: Omission of ALND in Z0011-eligible patients reached 89.2% in 2015. This Z0011-compliant group was more likely to undergo RNI compared with the non-compliant group (36.4% vs. 31.3%; p < 0.05), with RNI increasing to 43.8% by 2015. Factors associated with the use of RNI included later year of diagnosis [odds ratio (OR) 1.8, 95% confidence interval (CI) 1.6–2.1], hormone receptor-negative tumor (OR 1.2, 95% CI 1.1–1.4), grade 3 tumor (OR 1.2, 95% CI 1.1–1.3), treatment at a non-academic site (OR 1.2, 95% CI 1.1–1.3) and two versus one positive SLN (OR 2.0, 95% CI 1.8–2.2). With 43 months median follow-up, RNI was not associated with improved OS. Conclusion: Since the publication of Z0011, the omission of ALND has become widespread; however nearly half of these women now receive RNI. The optimal radiation therapy approach for this low nodal burden population warrants further study.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
NASA NTRS2002

Crew Factors in Flight Operations XIV: Alertness Management in Regional Flight Operations Education Module

Regional operations encompass a broad range of pilots and equipment. This module is intended to help all those involved in regional aviation, including pilots, schedulers, dispatchers, maintenance technicians, policy makers, and others, to understand the physiological factors underlying fatigue, how flight operations affect fatigue, and what can be done to counteract fatigue and maximize alertness and performance in their operations. The overall purpose of this module is to promote aviation safety, performance, and productivity. It is intended to meet three specific objectives: (1) to explain the current state of knowledge about the physiological mechanisms underlying fatigue; (2) to demonstrate how this knowledge can be applied to improving flight crew sleep, performance, and alertness; and (3) to offer strategies for alertness management. Aviation Safety Reporting System (ASRS) and National Transportation Safety Board (NISH) reports are used throughout this module to demonstrate that fatigue is a safety issue in the regional operations community. The appendices at the end of this module include the ASRS reports used for the examples contained in this publication, brief introductions to sleep disorders and relaxation techniques, summaries of relevant NASA publications, and a list of general readings on sleep, sleep disorders, and circadian rhythms.

Rosekind, Mark R.↗
DOE OSTI2014

Region templates: Data representation and management for high-throughput image analysis

Compartment fires exhibit unique features associated with smoke accumulation and restricted air ventilation. The objective of the present study is to evaluate the ability of CFD-based fire models to simulate these features and in particular the effects of flame extinction that results from under-ventilated fire conditions. The study is performed using FireFOAM; FireFOAM is an advanced fire modeling software developed by FM Global and is based on a general-purpose open-source software called OpenFOAM. A new flame extinction model based on the concept of a critical value of the flame Damköhler number is incorporated into FireFOAM. The performance of the extinction model is evaluated via comparisons with a previously developed experimental database corresponding to a reduced-scale, heptane-fueled, compartment fire configuration. The numerical simulations also include a description of fuel evaporation driven by the computed gas-to-liquid heat feedback. Comparisons between experimental data and numerical results provide a suitable test bed to evaluate the ability of CFD-based fire models to describe the transition from over- to under-ventilated fire conditions, as well as the transition from extinction-free conditions to conditions in which the flame experiences partial or total quenching.

Energy & Fuels↗
DOE OSTI2016

Assessing and Managing the Current and Future Pest Risk from Water Hyacinth, (Eichhornia crassipes), an Invasive Aquatic Plant Threatening the Environment and Water Security

Understanding and managing the biological invasion threats posed by aquatic plants under current and future climates is a growing challenge for biosecurity and land management agencies worldwide. Eichhornia crassipes is one of the world’s worst aquatic weeds. Presently, it threatens aquatic ecosystems, and hinders the management and delivery of freshwater services in both developed and developing parts of the world. A niche model was fitted using CLIMEX, to estimate the potential distribution of E. crassipes under historical and future climate scenarios. Under two future greenhouse gas emission scenarios for 2080 simulated with three Global Climate Models, the area with a flavourable temperature regime appears set to shift polewards. The greatest potential for future range expansion lies in Europe. Elsewhere in the northern hemisphere temperature gradients are too steep for significant geographical range expansion under the climate scenarios explored here. In the Southern Hemisphere, the southern range boundary for E. crassipes is set to expand southwards in Argentina, Australia and New Zealand; under current climate conditions it is already able to invade the southern limits of Africa. The opportunity exists to prevent its spread into the islands of Tasmania in Australia and the South Island of New Zealand, both of which depend upon hydroelectric facilities that would be threatened by the presence of E. crassipes. In Europe, efforts to slow or stop the spread of E. crassipes will face the challenge of limited internal biosecurity capacity. The modelling technique demonstrated here is the first application of niche modelling for an aquatic weed under historical and projected future climates. It provides biosecurity agencies with a spatial tool to foresee and manage the emerging invasion threats in a manner that can be included in the international standard for pest risk assessments. It should also support more detailed local and regional management.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2016

Greening of the Earth and its drivers

Global environmental change is rapidly altering the dynamics of terrestrial vegetation, with consequences for the functioning of the Earth system and provision of ecosystem services 1, 2 . Yet how global vegetation is responding to the changing environment is not well established. Here we use three long-term satellite leaf area index (LAI) records and ten global ecosystem models to investigate four key drivers of LAI trends during 1982 2009. We show a persistent and widespread increase of growing season integrated LAI (greening) over 25% to 50% of the global vegetated area, whereas less than 4% of the globe shows decreasing LAI (browning). Factorial simulations with multiple global ecosystem models suggest that CO 2 fertilization effects explain 70% of the observed greening trend, followed by nitrogen deposition (9%), climate change (8%) and land cover change (LCC) (4%). CO 2 fertilization effects explain most of the greening trends in the tropics, whereas climate change resulted in greening of the high latitudes and the Tibetan Plateau. LCC contributed most to the regional greening observed in southeast China and the eastern United States. In conclusion, the regional effects of unexplained factors suggest that the next generation of ecosystem models will need to explore the impacts of forest demography, differences in regional management intensities for cropland and pastures, and other emerging productivity constraints such as phosphorus availability.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2018

Humidity determines snowpack ablation under a warming climate

Significance Changes in the amount and timing of snowmelt have large effects on water for society and ecosystems. Using long-term records from across the western United States, we demonstrate that atmospheric humidity is a major control on how seasonal snow responds to warming temperatures. Specifically, we observe an increase in the frequency and magnitude of episodic winter melt events under higher humidity that may alter the timing of water availability. In lower-humidity regions, however, warming is associated with increased sublimation and/or evaporation from the snowpack further reducing the amount of available water in these dry regions. Management approaches to address these changes in snowmelt water resources from continued warming will require improved estimation of variable and changing atmospheric humidity.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2016

Isolation, Migration, and Local Recruitment Drive Persistence of Cutthroat Trout in Tributaries near American Falls Reservoir

Abstract We analyzed 67 SNPs to describe the genetics of Yellowstone Cutthroat Trout Oncorhynchus clarkii bouvieri in seven tributaries near American Falls Reservoir, Idaho. We detected Yellowstone Cutthroat Trout in all but one site despite significant historical stocking of Rainbow Trout O. mykiss. Three of four relatively low-elevation sites near the reservoir contained Yellowstone Cutthroat Trout in sympatry with early-generation hybrids and Rainbow Trout yet contained no physical barriers to admixture. A posteriori assignment tests suggested that migrants from a nearby headwater population in Ross Fork Creek and possibly recruitment by local-origin Yellowstone Cutthroat Trout with fluvial or adfluvial life histories drive persistence in these sites. In contrast, hybridization was rare or absent in headwater populations and was associated with complete or apparent physical isolation. We also compared genetic diversity of our samples with Yellowstone basin Yellowstone Cutthroat Trout and Bear River Bonneville Cutthroat Trout O. c. utah to examine possible historical gene flow resulting from hydrogeological connections during the Pleistocene. Multivariate analysis showed that most genetic variation among individuals was explained by divergence of Yellowstone basin Yellowstone Cutthroat Trout from our samples and Bear River Bonneville Cutthroat Trout, which supports recent mtDNA studies and a possible change in taxonomic nomenclature. Our results indicate that, due to relative isolation and downstream emigration, headwater populations are critical to the persistence of Yellowstone Cutthroat Trout and thus loss of such populations would likely threaten the subspecies throughout the region. Management actions to reduce threats from established, nonnative Rainbow Trout populations will likely have to be multifaceted and may include a combination of targeted removal of Rainbow Trout and hybrids and the use of physical barriers to prevent further dispersal. Received April 19, 2015; accepted February 7, 2016 Published online May 31, 2016

Bingham, Daniel M.↗
DOE OSTI2026

Engineering Layer For System Analysis

ELSA offers various utility classes and methods to streamline the definition of regions, materials, and geometries in nuclear simulations. Key features include generating OpenMC regions, managing material properties, and providing convenient abstractions for complex geometrical and physical configurations. Additionally, ELSA supports the creation of submodels, enabling users to build modular and reusable components for their simulations. The codebase also includes robust extrusion and revolution capabilities, facilitating the efficient creation of 3D parametric geometries from 2D profiles through linear and rotational transformations.

Ferney, Paul [Idaho National Laboratory (INL), Ida↗
DOE OSTI2020

High-performance computing in water resources hydrodynamics

In this work, we present a vision of future water resources hydrodynamics codes that can fully utilize the strengths of modern high-performance computing. The advances to computing power, formerly driven by the improvement of central processing unit processors, now focus on parallel computing and, in particular, the use of graphics processing units (GPUs). However, this shift to a parallel framework requires refactoring the code to make efficient use of the data as well as changing even the nature of the algorithm that solves the system of equations. These concepts along with other features such as the precision for the computations, dry regions management, and input/output data are analyzed in this paper. A 2D multi-GPU flood code applied to a large-scale test case is used to corroborate our statements and ascertain the new challenges for the next-generation parallel water resources codes.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2026

Integrated Energy-Water Data for Cross-Sector Resilience

This white paper focuses on the “energy-for-water” domain, addressing the urgent need for integrated, empirical data to support regional management, benchmarking, and research on improving efficiency and developing technologies for water and wastewater management systems. The costs and energy required for the supply, treatment, and distribution of water and wastewater lack a standard data collection mechanism and centralized database or storage infrastructure, limiting data-driven decision-making across interdependent infrastructure systems.

42 ENGINEERING↗
NASA NTRS1974

Monitoring the vernal advancement and retrogradation (green wave effect) of natural vegetation

The author has identified the following significant results. From the data that have been analyzed thus far, it is apparent that certain parameters of the vegetation (green biomass and vegetation moisture content) are well correlated with ERTS data at some sites, yet the relationship is poor at other locations. The analyses indicate that the green wave development (spring) can be readily detected in the Great Plains Corridor. Consequently, ERTS-1 data provide a new tool for monitoring range readiness on a regional basis. The onset of summer drought and its duration can also be monitored. Data from ten G.P.C. sites suggest that the satellite coverage has been adequate to monitor the status of rangeland vegetation for regional management purposes.

Rouse, J. W., Jr.↗
NASA NTRS2003

Marine ecosystem appropriation in the Indo-Pacific: a case study of the live reef fish food trade

Our ecological footprint analyses of coral reef fish fisheries and, in particular, the live reef fish food trade (FT), indicate many countries' current consumption exceeds estimated sustainable per capita global, regional and local coral reef production levels. Hong Kong appropriates 25% of SE Asia's annual reef fish production of 135 260-286 560 tonnes (t) through its FT demand, exceeding regional biocapacity by 8.3 times; reef fish fisheries demand out-paces sustainable production in the Indo-Pacific and SE Asia by 2.5 and 6 times. In contrast, most Pacific islands live within their own reef fisheries means with local demand at < 20% of total capacity in Oceania. The FT annually requisitions up to 40% of SE Asia's estimated reef fish and virtually all of its estimated grouper yields. Our results underscore the unsustainable nature of the FT and the urgent need for regional management and conservation of coral reef fisheries in the Indo-Pacific.

Fishes↗