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Improved Method for Evaluating and Specifying the Chromaticity of Light Sources
This article recommends a method for calculating and specifying light source chromaticity using the CIE 2015 10° color matching functions (CMFs), which, according to analysis of existing psychophysical experiment data, can reduce visual mismatch compared to specifications based on the traditional CIE 1931 2° CMFs. Specifically, this work evaluates, documents, and recommends for adoption a supporting system of measures to be used with the CIE 2015 10° CMFs: a new uniform chromaticity scale (UCS) diagram with coordinates (s, t), a measure of correlated color temperature (CCTst), and a measure of distance from the Planckian locus (Dst). It also presents options for updating nominal classification quadrangles. A complete method of this nature has not yet been standardized, which may be contributing to the slow uptake of the CIE 2015 CMFs. The proposed tools are analogous to u, v, CCT, Duv, and the ANSI C78.377 nominal classification quadrangles that are currently specified in the CIE 1960 UCS using the CIE 1931 2° CMFs. While conceptually equivalent, the differences between the current standard method and the new st system are important for reducing unintended mismatch in the chromaticity of light. Furthermore, the implications of changing chromaticity specification methods are identified by a comparison over a diverse set of real light source SPDs. Finally, as a step toward improving the design and specification of light sources for illumination purposes, we propose a process for implementing the recommendations.
Permeability Evolution and Frictional Stability of Fabricated Fractures With Specified Roughness
Roughness is widely observed on natural fractures, and its impact on the potential for induced seismicity and associated fluid migration in the subsurface remains unclear. Here we perform fracture shearing and fluid flow experiments on artificially fabricated fractures with specified roughness to investigate the role of fracture roughness on frictional properties and permeability evolution. Given the experimental conditions, we observe that rough fractures show high roughness ratio S q /L w and return higher frictional strength due to the presence of cohesive interlocking asperities. Rough fracture surfaces show velocity strengthening behavior in the initial shearing stage, which may evolve to velocity neutral and velocity weakening at greater displacements—suggesting a dynamic weakening that rough fractures become less stable with shearing. The surface roughness exerts a dominant control on permeability evolution over the entire shearing history. Permeability declines monotonically by about 2 orders of magnitude for smooth fractures. For high roughness fractures, the permeabilities evolve episodically due to cycled compaction and dilation during shearing. With a slip distance of 6 to 8 mm, permeability of the rough surface may enhance up to an order of magnitude, but significant permeability reduction may also occur for rough samples when asperities are highly worn with gouge clogging flow paths. However, there is no obvious correlation between permeability evolution and frictional behavior for rough fracture samples when fractures are subject to sudden sliding velocity changes.
A Comparative Metagenomic Analysis of Specified Microorganisms in Groundwater for Non-Sterilized Pharmaceutical Products
In pharmaceutical manufacturing, ensuring product safety involves the detection and identification of microorganisms with human pathogenic potential, including Burkholderia cepacia complex (BCC), Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus aureus, Clostridium sporogenes, Candida albicans, and Mycoplasma spp., some of which may be missed or not identified by traditional culture-dependent methods. In this study, we employed a metagenomic approach to detect these taxa, avoiding the limitations of conventional cultivation methods. We assessed the groundwater microbiome’s taxonomic and functional features from samples collected at two locations in the spring and summer. All datasets comprised 436–557 genera with Proteobacteria, Bacteroidota, Firmicutes, Actinobacteria, and Cyanobacteria accounting for > 95% of microbial DNA sequences. The aforementioned species constituted less than 18.3% of relative abundance. Escherichia and Salmonella were mainly detected in Hot Springs, relative to Jefferson, while Clostridium and Pseudomonas were mainly found in Jefferson relative to Hot Springs. Multidrug resistance efflux pumps and BlaR1 family regulatory sensor-transducer disambiguation dominated in Hot Springs and in Jefferson. These initial results provide insight into the detection of specified microorganisms and could constitute a framework for the establishment of comprehensive metagenomic analysis for the microbiological evaluation of pharmaceutical-grade water and other non-sterile pharmaceutical products, ensuring public safety.
Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
Controlling nanocarrier interactions with the immune system requires a thorough understanding of the surface properties that modulate protein adsorption in biological fluids, since the resulting protein corona redefines cellular interactions with nanocarrier surfaces. Albumin is initially one of the dominant proteins to adsorb to nanocarrier surfaces, a process that is considered benign or beneficial by minimizing opsonization or inflammation. Here, we demonstrate the surface chemistry of a model nanocarrier can be engineered to stabilize or denature the three-dimensional conformation of adsorbed albumin, which respectively promotes evasion or non-specific clearance in vivo. Interestingly, certain common chemistries that have long been considered to convey stealth properties denature albumin to promote nanocarrier recognition by macrophage class A1 scavenger receptors, providing a means for their eventual removal from systemic circulation. We establish that the surface chemistry of nanocarriers can be specified to modulate adsorbed albumin structure and thereby tune clearance by macrophage scavenger receptors.
Initializing FLAG at Specified Density and Pressure
Five of the material-initialization nodes available in FLAG, stre, ptre, teofrp, reoftp, and ptofre , were studied as to their ability to initialize a material at a precise pressure and density. Using a fast, one-dimensional setup, initializations were attempted for each node at a pressure 1 bar and a density near ambient for six SESAME equations of state, 3720 (Al), 2024 (Be), 3337 (Cu), and 2705 (Au), and 7247 (LiD), and 2964 (Ti6Al4V). Only the teofrp node consistently reproduced the specified pressure and density to better than six significant figures.
Method for identifying aircraft that exceed a specified noise condition in a defined geographical area
The invention is a method for identifying aircraft, flying at supersonic speeds, that exceed a specified noise condition in a defined geographical area that may be employed once restrictions to supersonic aircraft flights over the United States are lifted.
EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
Abstract not provided
ADLES: Specifying, deploying, and sharing hands-on cyber-exercises
Not Available
Specifying angular reference for robust three-phase state estimation
While the phase angle of any of the bus voltages can be chosen as the angular reference in the state estimation formulation of positive sequence networks, the same approach does not readily extend to three-phase network state estimation problem. It is commonly assumed that there is at least one bus where the bus voltages are perfectly balanced with phase angles displaced ±120° and these balanced three phase voltages are used as the three-phase reference in solving the three-phase state estimation problem. This assumption may be quite realistic in transmission networks, and for distribution networks with a strong transmission system connection. However, it might not be realistic to assume existence of a perfectly balanced reference bus in today’s distribution systems with ever increasing penetration of renewable sources or for isolated operation of microgrids. In this paper, a novel state estimation formulation will be presented which facilitates correct solution irrespective of the existence of buses with perfectly balanced voltages. The new formulation is general, and lends itself to bad data processing. It yields accurate results in any three-phase power system irrespective of its operating conditions (balanced or highly unbalanced), configuration (isolated microgrid, connected to transmission system, etc.) and whether or not it contains any synchronous generators. The performance of the method is validated using the IEEE 123 bus three-phase system.
HAND transcription factors cooperatively specify the aorta and pulmonary trunk
Congenital heart defects (CHDs) affecting the cardiac outflow tract (OFT) constitute a significant cause of morbidity and mortality. The OFT develops from migratory cell populations which include the cardiac neural crest cells (cNCCs) and secondary heart field (SHF) derived myocardium and endocardium. The related transcription factors HAND1 and HAND2 have been implicated in human CHDs involving the OFT. Although Hand1 is expressed within the OFT, Hand1 NCC-specific conditional knockout mice (H1CKOs) are viable. Here we show that these H1CKOs present a low penetrance of OFT phenotypes, whereas SHF-specific Hand1 ablation does not reveal any cardiac phenotypes. Further, HAND1 and HAND2 appear functionally redundant within the cNCCs, as a reduction/ablation of Hand2 on an NCC-specific H1CKO background causes pronounced OFT defects. Double conditional Hand1 and Hand2 NCC knockouts exhibit persistent truncus arteriosus (PTA) with 100% penetrance. NCC lineage-tracing and Sema3c in situ mRNA expression reveal that Sema3c-expressing cells are mis-localized, resulting in a malformed septal bridge within the OFTs of H1CKO;H2CKO embryos. Interestingly, Hand1 and Hand2 also genetically interact within the SHF, as SHF H1CKOs on a heterozygous Hand2 background exhibit Ventricular Septal Defects (VSDs) with incomplete penetrance. Previously, we identified a BMP, HAND2, and GATA-dependent Hand1 OFT enhancer sufficient to drive reporter gene expression within the nascent OFT and aorta. Using these transcription inputs as a probe, we identify a novel Hand2 OFT enhancer, suggesting that a conserved BMP-GATA dependent mechanism transcriptionally regulates both HAND factors. These findings support the hypothesis that HAND factors interpret BMP signaling within the cNCCs to cooperatively coordinate OFT morphogenesis.
Syntgen: a system to generate temporal networks with user-specified topology
Abstract In the last few years, the study of temporal networks has progressed markedly. The evolution of clusters of nodes (or communities) is one of the major focus of these studies. However, the time dimension increases complexity, introducing new constructs and requiring novel and enhanced algorithms. In spite of recent improvements, the relative scarcity of timestamped representations of empiric networks, with known ground truth, hinders algorithm validation. A few approaches have been proposed to generate synthetic temporal networks that conform to static topological specifications while in general adopting an ad hoc approach to temporal evolution. We believe there is still a need for a principled synthetic network generator that conforms to problem domain topological specifications from a static as well as temporal perspective. Here, we present such a system. The unique attributes of our system include accepting arbitrary node degree and cluster size distributions and temporal evolution under user control, while supporting tunable joint distribution and temporal correlation of node degrees. Theoretical contributions include the analysis of conditions for graphic sequences of inter- and intracluster node degrees and cluster sizes and the development of a heuristic to search for the cluster membership of nodes that minimizes the shared information distance between clusterings. Our work shows that this system is capable of generating networks under user controlled topology with up to thousands of nodes and hundreds of clusters with strong topology adherence. Much larger networks are possible with relaxed requirements. The generated networks support algorithm validation as well as problem domain analysis.
A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specifi
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Tissue-Specifi c Oncogenic Activity of KRAS[superscript A146T]
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Specifying Calibration of Energy-Measuring Equipment
Instruments and standards need to be calibrated periodically to ensure that their use yields accurate measurements. Calibration needs, however, vary in sophistication, based on user expectations. This white paper reviews calibration terminology and standards, and describes best practices that have been developed for a) calibrating measurement equipment to ensure some known level of accuracy, and b) accrediting calibration service providers. Calibration is discussed in the context of metrological traceability, and excerpts from laboratory scopes of accreditation are shared to reveal the diversity of terminology and format among them. In an effort to aid those who currently calibrate measuring equipment or who have new or changing needs for calibrating measuring equipment, rationale is provided for why a specification might be used to request calibration services that meet specific test needs. Given the growing interest in using data to manage the energy consumption of systems, and the increasing number and variety of systems (e.g., building, computing) that can report such information, use cases requiring energy data are used to facilitate further discussion and provide examples. Commercially available service providers who are accredited for energy-measuring equipment calibration are compared and contrasted, and a specification template that might be used for requesting this calibration is presented. The specification template should be tailored to meet each user’s needs. To illustrate, an example set of energy-measuring-equipment test conditions (reflecting the planned usage of the device to be calibrated) is used to develop a customized calibration specification, and commercially available service providers are assessed in terms of their qualifications for calibration to that particular implementation of the specification template.
Specifying Calibration of Energy-Measuring Equipment
A report on calibrating energy-measuring equipment to maximize energy efficiency of lighting and other systems. The report describes best practices for accrediting calibration laboratories and for calibrating measuring equipment, compares and contrasts service providers accredited for energy-measuring equipment calibration, presents a tailorable specification template for requesting such calibration, and offers recommendations to a range of stakeholders.
Specifying Calibration of Environmental Sensors
The emergence of the Internet of Things is resulting in an increased ability of devices and systems to share data and is generating increasing interest in integrating sensors into a variety of devices deployed in the built environment. The value of such data is a function of how the data can be used. Data-producing devices and systems that enable valuable use-cases in turn can be seen as more valuable. Lighting systems are particularly interesting platforms for integrated sensors. Both indoor and outdoor lighting devices are becoming more connected, and their location is often ideally suited for hosting environmental sensors that can characterize the properties of indoor or outdoor spaces in ways that support a wide variety of use cases, from improving air quality to supporting fault diagnostics and prediction. The value of environmental-sensor-driven use-cases and the lighting systems that house them is dependent to some degree on sensor accuracy. Environmental sensors utilize a wide variety of sensing techniques or technologies and have varying accuracy. More-accurate, laboratory-grade products or reference standards are often used to characterize, refine, calibrate, adjust, and monitor devices that are deployed, or are intended to be deployed, in physical spaces of interest. Sensors or reference standards need to be calibrated periodically to ensure that their use yields accurate measurements. Calibration needs, however, vary in sophistication, based on user and use-case requirements. This paper provides guidance for evaluating the performance of environmental sensors so as to ensure that they meet user or use-case needs. It describes best practices that have been developed for a) calibrating sensors to ensure some known level of accuracy, and b) determining whether calibration-laboratory accreditation meets user or use-case needs. Excerpts from laboratory scopes of accreditation are shared to reveal the diversity of terminology and format among them. In an effort to aid those who currently have sensors calibrated or who have new or changing needs for sensor calibration, rationale is provided for why a specification might be used to request calibration services that meet specific needs. Commercially available calibration-service providers that are accredited for environmental-sensor calibration are compared and contrasted, and a specification template that might be used for requesting this calibration is presented. The specification template should be tailored to meet each user’s needs. To illustrate, an example set of environmental-sensor test conditions (reflecting the planned usage of the device to be calibrated) is used to develop a customized calibration specification, and commercially available service providers are assessed in terms of their qualifications for calibration to that particular implementation of the specification template.