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At least 19 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS1993

Photometric and spectroscopic monitoring of AA Tau, DN Tau, UX Tau A, T Tau, RY Tau, Lk Ca 4, and Lk Ca 7

We report the results of a UBVRI photometric monitoring campaign for three classical T Tauri stars (AA Tau, DN Tau, and UX Tau A) and two weak emission line T Tauri stars (Lk Ca 4 and Lk Ca 7). Observations were obtained at three sites during a core observing period spanning UT 1985 October 14 through UT 1985 December 25, with additional observations continuing until UT 1986 April 6. Concurrent spectrophotometric observations were obtained for all main program stars except Lk Ca 7 and additionally for T Tau, RW Aur, and RY Tau. Periodic photometric variability, assumed to be the stars' rotation periods, were found for AA Tau, DN Tau, Lk Ca 4, and Lk Ca 7, respectively, as 8.2, 6.3, 3.4, and 5.7 days. Several U-filter flares were observed for Lk Ca 4 and Lk Ca 7, which are strongly concentrated toward phases of minimum light. Correlations are found between H-alpha line strengths and V magnitudes for AA Tau and RY Tau. An analysis of absolute color variations of classical T Tauri stars confirms that hot spots are the predominant cause of these stars' variability. Our overall results are consistent with earlier findings that long-lived cool spots are responsible for most of the variability found for weak-emission T Tauri stars, while temporal hot spots are primarily responsible for the observed variability found in classical T Tauri stars.

Vrba, F. J.↗
DOE OSTI2026

Tau-Jet Matching and Tag-and-Probe Tau Tagging Efficiencies for HH→bbτ+τ− Searches Using Run 3 CMS Scouting Data

We are studying tau-jet matching efficiency and tau tagging efficiency for the search for Higgs boson pair production in the HH→bbτ+τ− decay channel using Run 3 CMS scouting data. Collision events in the CMS detector produce many particle candidates, so jets are clustered using the anti-kT algorithm to identify possible tau signatures. In Monte Carlo simulation, tau-jet matching efficiency can be measured by comparing generated taus to reconstructed jets. In actual collision data, however, generated taus are not available, so we use a tag-and-probe method with Z→τ+τ− candidate events. In this method, one tau candidate is used as the tag and the other as the probe. The invariant mass of the tau-pair candidates is plotted and fitted with signal and background functions to estimate the number of real tau events and determine the tagging efficiency. By comparing efficiencies in data and Monte Carlo simulation, this work helps evaluate the performance of scouting-based tau reconstruction and tau tagging for future HH→bbτ+τ− searches.

Bellot, Annella [North Central Coll.; Fermilab]↗
DOE OSTI2026

Tau-Jet Matching and Tag-and-Probe Tau Tagging Efficiencies for HH→bbτ+τ− Searches Using Run 3 CMS Scouting Data

We are studying tau-jet matching efficiency and tau tagging efficiency for the search for Higgs boson pair production in the HH→bbτ+τ− decay channel using Run 3 CMS scouting data. Collision events in the CMS detector produce many particle candidates, so jets are clustered using the anti-kT algorithm to identify possible tau signatures. In Monte Carlo simulation, tau-jet matching efficiency can be measured by comparing generated taus to reconstructed jets. In actual collision data, however, generated taus are not available, so we use a tag-and-probe method with Z→τ+τ− candidate events. In this method, one tau candidate is used as the tag and the other as the probe. The invariant mass of the tau-pair candidates is plotted and fitted with signal and background functions to estimate the number of real tau events and determine the tagging efficiency. By comparing efficiencies in data and Monte Carlo simulation, this work helps evaluate the performance of scouting-based tau reconstruction and tau tagging for future HH→bbτ+τ− searches.

Bellot, Annella [North Central Coll.; Fermilab]↗
DOE OSTI2026

Search for heavy resonances decaying into two Higgs bosons in the $\text {b}{\bar{\text {b}}} \tau ^{+} \tau ^{-}$ final state in proton–proton collisions at $\sqrt{s} = 13\,\text {Te}\hspace{-.08em}\text {V}$

A search is presented for massive narrow-width resonances in the mass range of 1–4.5 TeV , decaying into pairs of Higgs bosons (HH). The search uses proton–proton collision data at a center-of-mass energy of 13 TeV collected with the CMS detector at the CERN LHC during 2016–2018, corresponding to an integrated luminosity of 138 fb -1 . The analysis targets final states where one Higgs boson decays into a pair of bottom quarks and the other into a pair of tau leptons, ${\text {X}} \rightarrow {\text {HH}} \rightarrow \text {b}{\bar{\text {b}}}\,\tau ^{+}\tau ^{-}$. It uses a single large radius jet to reconstruct the ${\text {H}} \rightarrow \text {b}{\bar{\text {b}}}$ decay, while the ${\text {H}} \rightarrow \tau ^{+}\tau ^{-}$ decay products can either be contained within a single large radius jet or appear as two isolated tau leptons. The observed data are consistent with standard model background expectations. Upper limits at 95% confidence level are set on the production cross section for resonant HH production for masses between 1 and 4.5 TeV. This analysis sets the most sensitive limits to date on ${\text {X}} \rightarrow {\text {HH}} \rightarrow \text {b}\bar{\hbox {b}}\, \tau ^{+}\tau ^{-}$ decays in the mass range of 1.4–4.5 TeV.

Hayrapetyan, A. [Yerevan Physics Institute]↗
DOE OSTI2024

Observation of $\gamma\gamma\to\tau\tau$ in proton-proton collisions and limits on the anomalous electromagnetic moments of the $\tau$ lepton

The production of a pair of τ leptons via photon–photon fusion, ${{\unicode{x03B3}\unicode{x03B3}\to\unicode{x03C4}\unicode{x03C4}}}$, is observed for the first time in proton–proton collisions, with a significance of 5.3 standard deviations. This observation is based on a data set recorded with the CMS detector at the LHC at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138 fb$^{−1}$. Events with a pair of τ leptons produced via photon–photon fusion are selected by requiring them to be back-to-back in the azimuthal direction and to have a minimum number of charged hadrons associated with their production vertex. The τ leptons are reconstructed in their leptonic and hadronic decay modes. The measured fiducial cross section of ${{\unicode{x03B3}\unicode{x03B3}\to\unicode{x03C4}\unicode{x03C4}}}$ is $\sigma^\text{fid}_\text{obs} = 12.4 ^{+3.8}_{-3.1}\,\textrm{fb}$. Constraints are set on the contributions to the anomalous magnetic moment (${a_{\unicode{x03C4}}}$) and electric dipole moments (${d_{\unicode{x03C4}}}$) of the τ lepton originating from potential effects of new physics on the $\unicode{x03B3}\unicode{x03C4}\unicode{x03C4}$ vertex: ${a_{\unicode{x03C4}}} = 0.0009_{-0.0031}^{+0.0032}$ and $|{d_{\unicode{x03C4}}}| \lt 2.9\times 10^{-17}\,{e}\,\textrm{cm}$ (95% confidence level), consistent with the standard model.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2022

Measurement of the energy response of the ATLAS calorimeter to charged pions from $W^{\pm }\rightarrow \tau ^{\pm }(\rightarrow \pi ^{\pm }\nu _{\tau })\nu _{\tau }$ events in Run 2 data

The energy response of the ATLAS calorimeter is measured for single charged pions with transverse momentum in the range 10 < p T < 300 GeV. The measurement is performed using 139 fb –1 of LHC proton–proton collision data at √s = 13 TeV taken in Run 2 by the ATLAS detector. Charged pions originating from τ-lepton decays are used to provide a sample of high-p T isolated particles, where the composition is known, to test an energy regime that has not previously been probed by in situ single-particle measurements. The calorimeter response to single-pions is observed to be overestimated by ~2% across a large part of the p T spectrum in the central region and underestimated by ~4% in the endcaps in the ATLAS simulation. The uncertainties in the measurements are ≲1% for 15 < p T < 185 GeV in the central region. To investigate the source of the discrepancies, the width of the distribution of the ratio of calorimeter energy to track momentum, the energies per layer and response in the hadronic calorimeter are also compared between data and simulation.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2025

Contributions of major tau kinase activation and phospho-tau accumulation to cortical and hippocampal tangle formation and cognition in older adults

Aberrant activation of tau kinases (tauK) has been proposed as a major step in tau hyperphosphorylation and misfolding, and subsequent formation of neurofibrillary tangles (NFT) in Alzheimer's disease (AD). However, evidence of tauK hyperactivation in actual AD brains is scarce and inconsistent, and their role in age-related cognitive decline remains undocumented. We evaluated activated/inhibited species of CDK5/p35/p25, GSK3a/ß, and ERK1/2 as well as ten tau/phospho-tau (ptau) peptides (mapping Ser 202 , Thr 217 , Ser 262 , Ser 305 , and Ser 404 phospho-residues) by Western blot or selected reaction monitoring proteomics, respectively, in postmortem dorsolateral prefrontal cortex (DLPFC) and hippocampal samples of 150 participants from the Rush Memory and Aging Project (MAP). Regression models and mediation analyses assessed the contributions of these variables to tau phosphorylation, NFT deposition and antemortem cognitive status of MAP participants. Surprisingly, greater p25 and p35 (indices for CDK5 activation) and lower pSer 21/9 -GSK3a/ß (inhibited species) immunodensities were associated with lower ptau peptide amounts. Individuals with higher p25 cortical densities displayed better cognitive outcomes, particularly working memory. Statistical mediation analyses indicated that the beneficial effect of CDK5/p25 on cognition was mediated by lower densities of phospho-Thr 217 -tau and NFT deposition in DLPFC, and also identified Thr 217 and Ser 262 as the ptau sites with greatest influence in both NFT accumulation and cognitive impairment. The present data suggest that tau hyperphosphorylation, tangle deposition, and the subsequent cognitive impairment do not rely on aberrant activation of major tauKs. Additionally, novel evidence was provided for the beneficial contribution of cortical CDK5/p25 to the maintenance of working memory.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2024

Search for decays of the Higgs boson into a pair of pseudoscalar particles decaying into $b\overline{b}$$\tau$ + $\tau$ - using pp collisions at √s = 13 TeV with the ATLAS detector

This paper presents a search for exotic decays of the Higgs boson into a pair of new pseudoscalar particles, H → aa, where one pseudoscalar decays into a b-quark pair and the other decays into a $\tau$-lepton pair, in the mass range 12 ≤ m a ≤ 60 GeV. The analysis uses pp collision data at $\sqrt{s}$ = 13 TeV collected with the ATLAS detector at the LHC, corresponding to an integrated luminosity of 140 fb -1 . No significant excess above the Standard Model (SM) prediction is observed. Assuming the SM Higgs boson production cross section, the search sets upper limits at 95% confidence level on the branching ratio of Higgs bosons decaying into $b\overline{b}$$\tau$ + $\tau$ - , $\mathcal{B}$(H → aa → $b\overline{b}$$\tau$ + $\tau$ - ), between 2.2% and 3.9% depending on the pseudoscalar mass.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
NASA NTRS2002

Circumstellar jets and disk of DL Tau and CW Tau observed with HST/STIS and the GSFC Fabry-Perot imager

The pre-main sequence T Tauri stars DL Tau and CW Tau were observed with Hubble Space Telescope/Space Telescope Imaging Spectrograph (HST/STIS) and the Goddard Fabry-Perot Imager at the Apache Point 3.5-m telescope in their coronagraphic modes. The STIS observation of DL Tau shows a circumstellar disk with a dark ring, and the jet with structure along the length, and a faint counter-jet. On CW Tau, STIS shows a jet with a bright blob about 4 arcsec away, and the Fabry-Perot shows the jet extended in both directions in [SII] to 60 and 90 arcsec from the star.

Grady, Carol↗
DOE OSTI2023

Search for resonant and non-resonant Higgs boson pair production in the $b\overline{b}{\tau}^{+}{\tau}^{-}$ decay channel using 13 TeV $pp$ collision data from the ATLAS detector

A search for Higgs boson pair production in events with two $b$-jets and two $τ$-leptons is presented, using a proton–proton collision dataset with an integrated luminosity of 139 fb -1 collected at $\sqrt{s}$ = 13 TeV by the ATLAS experiment at the LHC. Higgs boson pairs produced non-resonantly or in the decay of a narrow scalar resonance in the mass range from 251 to 1600 GeV are targeted. Events in which at least one $τ$-lepton decays hadronically are considered, and multivariate discriminants are used to reject the backgrounds. No significant excess of events above the expected background is observed in the non-resonant search. The largest excess in the resonant search is observed at a resonance mass of 1 TeV, with a local (global) significance of 3.1$σ$ (2.0$σ$). Observed (expected) 95% confidence-level upper limits are set on the non-resonant Higgs boson pair-production cross-section at 4.7 (3.9) times the Standard Model prediction, assuming Standard Model kinematics, and on the resonant Higgs boson pair-production cross-section at between 21 and 900 fb (12 and 840 fb), depending on the mass of the narrow scalar resonance.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2020

Search for a light pseudoscalar Higgs boson in the boosted $\mu\mu\tau\tau$ final state in proton-proton collisions at $\sqrt{s}=$ 13 TeV

A search for a light pseudoscalar Higgs boson (a) decaying from the 125 GeV (or a heavier) scalar Higgs boson (H) is performed using the 2016 LHC proton-proton collision data at $ \sqrt{s} $ = 13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{−1}$, collected by the CMS experiment. The analysis considers gluon fusion and vector boson fusion production of the H, followed by the decay H → aa → μμττ, and considers pseudoscalar masses in the range 3.6 < m$_{a}$< 21 GeV. Because of the large mass difference between the H and the a bosons and the small masses of the a boson decay products, both the μμ and the ττ pairs have high Lorentz boost and are collimated. The ττ reconstruction efficiency is increased by modifying the standard technique for hadronic τ lepton decay reconstruction to account for a nearby muon. No significant signal is observed. Model-independent limits are set at 95% confidence level, as a function of m$_{a}$, on the branching fraction (ℬ) for H → aa → μμττ, down to 1.5 (2.0) × 10$^{−4}$ for m$_{H}$ = 125 (300) GeV. Model-dependent limits on ℬ(H → aa) are set within the context of two Higgs doublets plus singlet models, with the most stringent results obtained for Type-III models. These results extend current LHC searches for heavier a bosons that decay to resolved lepton pairs and provide the first such bounds for an H boson with a mass above 125 GeV.[graphic not available: see fulltext]

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2025

A measurement of the high-mass $\tau \overline{\tau}$ production cross-section at $\sqrt{s}=13$ TeV with the ATLAS detector and constraints on new particles and couplings

The production cross-section of high-mass τ-lepton pairs is measured as a function of the dilepton visible invariant mass, using 140 fb −1 of $\sqrt{s}=13$ TeV proton-proton collision data recorded with the ATLAS detector at the Large Hadron Collider. The measurement agrees with the predictions of the Standard Model. A fit to the invariant mass distribution is performed as a function of b-jet multiplicity, to constrain the non-resonant production of new particles described by an effective field theory or in models containing leptoquarks or Z′ bosons that couple preferentially to third-generation fermions. The constraints on new particles improve on previous results, and the constraints on effective operators include those affecting the anomalous magnetic moment of the τ-lepton.

beyond Standard Model↗
DOE OSTI2021

Three-repeat and four-repeat tau isoforms form different oligomers

Different tauopathies are characterized by the isoform-specific composition of the aggregates found in the brain and by structurally distinct tau strains. Although tau oligomers have been implicated as important neurotoxic species, little is known about how the primary structures of the six human tau isoforms affect tau oligomerization because the oligomers are metastable and difficult to analyze. To address this knowledge gap, here, we analyzed the initial oligomers formed by the six tau isoforms in the absence of posttranslational modifications or other manipulations using dot blots probed by an oligomer-specific antibody, native-PAGE/western blots, photo-induced cross-linking of unmodified proteins, mass-spectrometry, and ion-mobility spectroscopy. We found that under these conditions, three-repeat (3R) isoforms are more prone than four-repeat (4R) isoforms to form oligomers. In this study, we also tested whether known inhibitors of tau aggregation affect its oligomerization using three small molecules representing different classes of tau aggregation inhibitors, Methylene Blue (MB), the molecular tweezer CLR01, and the all-D peptide TLKIVW, for their ability to inhibit or modulate the oligomerization of the six tau isoforms. Unlike their reported inhibitory effect on tau fibrillation, the inhibitors had little or no effect on the initial oligomerization. Our study provides novel insight into the primary–quaternary structure relationship of human tau and suggests that 3R-tau oligomers may be an important target for future development of compounds targeting pathological tau assemblies.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Baseline [ 18 F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer’s disease

Background: The role and implementation of tau PET imaging for predicting subsequent cognitive decline in Alzheimer’s disease (AD) remains uncertain. This study was designed to evaluate the relationship between baseline [ 18 F]GTP1 tau PET and subsequent longitudinal change across multiple cognitive measures over 18 months. Methods: Our analyses incorporated data from 67 participants, including cognitively normal controls (n = 10) and β-amyloid (Aβ)-positive individuals ([ 18 F] florbetapir Aβ PET) with prodromal (n = 26), mild (n = 16), or moderate (n = 15) AD. Baseline measurements included cortical volume (MRI), tau burden ([ 18 F]GTP1 tau PET), and cognitive assessments [Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), 13-item version of the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog13), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)]. Cognitive assessments were repeated at 6-month intervals over an 18-month period. Associations between baseline [ 18 F]GTP1 tau PET indices and longitudinal cognitive performance were assessed via univariate (Spearman correlations) and multivariate (linear mixed effects models) approaches. The utility of potential prognostic tau PET cut points was assessed with ROC curves. Results: Univariate analyses indicated that greater baseline [ 18 F]GTP1 tau PET signal was associated with faster rates of subsequent decline on the MMSE, CDR, and ADAS-Cog13 across regions of interest (ROIs). In multivariate analyses adjusted for baseline age, cognitive performance, cortical volume, and Aβ PET SUVR, the prognostic performance of [ 18 F]GTP1 SUVR was most robust in the whole cortical gray ROI. When AD participants were dichotomized into low versus high tau subgroups based on baseline [ 18 F]GTP1 PET standardized uptake value ratios (SUVR) in the temporal (cutoff = 1.325) or whole cortical gray (cutoff = 1.245) ROIs, high tau subgroups demonstrated significantly more decline on the MMSE, CDR, and ADAS-Cog13. Conclusions: Our results suggest that [ 18 F]GTP1 tau PET represents a prognostic biomarker in AD and are consistent with data from other tau PET tracers. Tau PET imaging may have utility for identifying AD patients at risk for more rapid cognitive decline and for stratification and/or enrichment of participant selection in AD clinical trials.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2020

Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults

Studies suggest that tau deposition starts in the anterolateral entorhinal cortex (EC) with normal aging, and that the presence of β-amyloid (Aβ) facilitates its spread to neocortex, which may reflect the beginning of Alzheimer's disease (AD). Functional connectivity between the anterolateral EC and the anterior-temporal (AT) memory network appears to drive higher tau deposition in AT than in the posterior-medial (PM) memory network. Here, we investigated whether this differential vulnerability to tau deposition may predict different cognitive consequences of EC, AT, and PM tau. Using 18 F-flortaucipir (FTP) and 11 C-Pittsburgh compound-B (PiB) positron emission tomography (PET) imaging, we measured tau and Aβ in 124 cognitively normal human older adults (74 females, 50 males) followed for an average of 2.8 years for prospective cognition. We found that higher FTP in all three regions was individually related to faster memory decline, and that the effects of AT and PM FTP, but not EC, were driven by Aβ+ individuals. Moreover, when we included all three FTP measures competitively in the same model, only AT FTP significantly predicted memory decline. Our data support a model whereby tau, facilitated by Aβ, transits from EC to cortical regions that are most closely associated with the anterolateral EC, which specifically affects memory in the initial stage of AD. Memory also appears to be affected by EC tau in the absence of Aβ, which may be less clinically consequential. These findings may provide clarification of differences between normal aging and AD, and elucidate the transition between the two stages. SIGNIFICANCE STATEMENT Tau and β-amyloid (Aβ) are hallmarks of Alzheimer's disease (AD) but are also found in cognitively normal people. It is unclear whether, and how, this early deposition of tau and Aβ may affect cognition in normal aging and the asymptomatic stage of AD. We show that tau deposition in the entorhinal cortex (EC), which is common in advanced age, predicts memory decline in older adults independent of Aβ, likely reflecting normal, age-related memory loss. In contrast, tau in anterior-temporal (AT) regions is most predictive of memory decline in Aβ+ individuals. These data support the idea that tau preferentially spreads to specific cortical regions, likely through functional connections, which plays a primary role in memory decline in the early stage of AD.

60 APPLIED LIFE SCIENCES↗