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At least 19 records

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NASA NTRS2017

Investigation of Tear Biomarkers as an Indicator of Human Health

Scientific literature suggests that tear biomarkers can be used as a guide towards clinical diagnosis of human health (Hagan et al., 2016). This study will investigate whether tear biomarkers represents a research and clinical opportunity to assess human health prior to, during, and after exposure to the spaceflight environment. The focus of this study is to compare biomarkers previously identified as potentially relevant to both ocular and brain health against unique physiological outcomes of exposure to the space flight environment. Study subjects suffering from terrestrial conditions thought to be similar to Spaceflight Associated Neuro-ocular Syndrome (SANS: formerly VIIP), e.g. patients with idiopathic intracranial hypertension (IIH) and optic neuritis may be relevant to conditions associated with spaceflight. This study will review methodologies, tear biomarkers related to state of ocular and brain health, the strengths and weakness of using tear fluid biomarkers versus other body fluid samples, and will survey current tear fluid biomarker knowledge in research and clinical practice. A strength of using tear biomarkers is that sampling is non-invasive and used as a guide in understanding pathologies, including ocular and systemic inflammatory conditions (Cocho et al., 2016)., Salvisberg et al., 2014). Moreover, tear biomarkers may reflect diseases affecting the central nervous system (CNS) (Salvisberg et al., 2014). For example, in multiple sclerosis (MS), the concordance rate between tear biomarkers versus cerebrospinal fluid (CSF) is approximately 83%, indicating that, in the majority of cases, tears are at least as effective as CSF in potentially identifying novel MS biomarkers (Devos et al., 2001).

Morton, Stephen↗

NASA NTRS2018

Pilot Study on the Investigation of Tear Fluid Biomarkers as an Indicator of Ocular, Neurological, and Immunological Health in Astronauts

The purpose of this pilot study is to investigate the collection, preparation, and analysis of tear biomarkers as a means of assessing ocular, neurological, and immunological health. At present, no published data exists on the cytokine profiles of tears from astronauts exposed to long periods of microgravity and space irradiations. In addition, no published data exist on cytokine (biomarker) profiles of tears that have been collected from irradiated non-human biological systems (primates and other animal models). A goal for the proposed pilot study is to discover novel tear biomarkers which can help inform researchers, clinicians, epidemiologist and healthcare providers about the health status of a living biological system, as well as informing them when a disease state is triggered. This would be done via analysis of the onset of expression of pro-inflammatory cytokines, leading up to the full progression of a disease (i.e. cancer, loss of vision, radiation-induced oxidative stress, cardiovascular disorders, fibrosis in major organs, bone loss). Another goal of this pilot study is to investigate the state of disease against proposed medical countermeasures, in order to determine whether the countermeasures are efficacious in preventing or mitigating these injuries. An example of an up and coming tear biomarker technology, Ascendant Dx, a clinical stage diagnostic company, is developing a screening test to detect breast cancer using proteins from tears. The team utilized Liquid Chromatography -Mass Spectrometry with Mass analysis (LC MS/MS) as a discovery platform followed by validation with ELISA to come up with a panel of protein biomarkers that can differentiate breast cancer samples from control ("cancer free") samples with results far surpassing the results of imaging techniques in use today. Continued research into additional proteins is underway to increase the sensitivity and specificity of the test and development efforts are on the way to transfer the test onto a fast, accurate and inexpensive point of care platform. In conclusion, the expected results from this proposed pilot study are to: a) establish an SOP for retrieving/storing/transporting tear fluid samples from multicentre sites b) establish a normal range for relevant biomarkers in tears; and c) establish a database (biobank) of tears of space naïve versus veteran astronauts, to establish a personal baseline for long-term ocular health monitoring

Morton, Stephen↗

NASA NTRS1981

Tearing modes at the magnetopause

This paper examines the possible occurrence of tearing modes in the dayside magnetopause. First, the expected magnetic signature of tearing, as obtained from existing theory, is reviewed. Magnetometer data from one terrestrial magnetopause crossing of Jupiter's magnetopause are then examined in detail. Magnetic field oscillations are found in three subsegments of the terrestrial crossing at a frequency of 0.1-0.2 Hz and with peak amplitudes of 5-10 nanotesla (nT), and in one segment of the Jovian crossing, at 0.05-0.1 Hz and with 2-nT amplitude. The frequency range, as well as the orientation of the magnetic field perturbation vectors, agrees with a model in which tearing-produced magnetic islands are convected past the satellite with the plasma flow in the current layer. In both cases the magnetopause structure was of the rotational discontinuity type with a nonvanishing normal magnetic field component. Hence, if the tearing structures were active, i.e., growing, at the observation site, ion tearing (or perhaps resistive tearing, with the resistivity provided by microturbulence) must be invoked. But it is also possible that the structures were passive, consisting of 'debris' from active tearing elswhere on the magnetopause surface, this debris being convected along the magnetopause past the observation site.

Greenly, J. B.↗

NASA NTRS1985

Streaming tearing mode

The magnetohydrodynamic stability of streaming tearing mode is investigated numerically. A bulk plasma flow parallel to the antiparallel magnetic field lines and localized in the neutral sheet excites a streaming tearing mode more strongly than the usual tearing mode, particularly for the wavelength of the order of the neutral sheet width (or smaller), which is stable for the usual tearing mode. Interestingly, examination of the eigenfunctions of the velocity perturbation and the magnetic field perturbation indicates that the streaming tearing mode carries more energy in terms of the kinetic energy rather than the magnetic energy. This suggests that the streaming tearing mode instability can be a more feasible mechanism of plasma acceleration than the usual tearing mode instability.

Shigeta, M.↗

NASA NTRS2009

Use of DSC and DMA to Study Rubber Crystallization as a Possible Cause for a Tear in a Neoprene Glove Used in a Space Shuttle Pressurized Astronaut Suit

The Advanced Crew Escape Suit (ACES) is a pressurized suit normally worn by astronauts during launch and landing phases of Space Shuttle operations. In 2008, a large tear (0.5 -1 in. long, between the pinky and ring finger) in the ACES left-hand glove made of neoprene latex rubber was found during training for Shuttle flight STS-124. An investigation to help determine the cause(s) of the glove tear was headed by the NASA Johnson Space Center (JSC) in Houston, Texas. Efforts at JSC to reproduce the actual glove tear pattern by cutting/tearing or rupturing were unsuccessful. Chemical and material property data from JSC such as GC-MS, FTIR, DSC and TGA mostly showed little differences between samples from the torn and control gloves. One possible cause for the glove tear could be a wedding ring/band worn by a male astronaut. Even with a smooth edge, such a ring could scratch the material and initiate the tear observed in the left-hand glove. A decision was later made by JSC to not allow the wearing of such a ring during training or actual flight. Another possible cause for the ACES glove tear is crystallinity induced by strain in the neoprene rubber over a long period of time and use. Neoprene is one several elastomeric materials known to be susceptible to crystallization, and such a process is accelerated with exposure of the material to cold temperatures plus strain. When the temperature is lowered below room temperature, researchers have shown that neoprene crystallization may be maintained at temperatures as high as 45-50 F, with a maximum crystallization rate near 20-25 F (1). A convenient conditioning temperature for inducing neoprene crystallization is a typical freezer that is held near 0 F. For work at the NASA Marshall Space Flight Center (MSFC), samples were cut from several areas/locations (pinky/ring finger crotch, index finger and palm) on each of two pairs of unstrained ACES gloves for DSC and DMA thermal analysis testing. The samples were conditioned in a freezer for various times up to about 14 days. Some rectangular conditioned samples were unstrained, while most were subjected to strains up to 250% with the aid of two slotted aluminum blocks and two aluminum clamps per sample. Trends were observed to correlate DSC data (heat of fusion) and DMA data (linear CTE and stress for iso-strain testing) with: (a) sample location on each glove; and (b) level of strain during conditioning. Control samples cut as is from each glove location were also tested by DSC and DMA.

Wingard, Doug↗

NASA NTRS1974

Effect degree of crosslinking on the tearing energy

Much recent work has been carried out on the tear behavior of elastomers, both filled and unfilled. By use of a criterion for tearing involving the concept of the tearing energy, the effects of variables such as test temperature, test rate, specimen geometry, and chemical nature of the elastomer have been investigated. The one variable which has not yet been studied is the specific effect of changes in the degree of crosslinking on tear behavior. By use of data published in the literature on the smooth tear behavior of unfilled vulcanizates, it is shown that these data can all be superposed onto a common response curve when the proper normalizations are applied.

Fedors, R. F.↗

NASA NTRS1995

A new approach to the linear theory of single-species tearing in two-dimensional quasi-neutral sheets

We have developed the linear theory of collisionless ion tearing in a two-dimensional magnetotail equilibrium for a single resonant species. We have solved the normal mode problem for tearing instability by an algorithm that employs particle-in-cell simulation to calculate the orbit integrals in the Maxwell-Vlasov eigenmode equation. The results of our single-species tearing analysis can be applied to ion tearing where electron effects are not included. We have calculated the tearing growth rate as a function of the magnetic field component B(sub n) normal to the current sheet for thick and thin current sheets, and we show that marginal stability occurs when the normal gyrofrequency Omega(sub n) is comparable to the Harris neutral sheet growth rate. A cross-tail B(sub y) component has little effect on the growth rate for B(sub y) approximately = B(sub n). Even in the limit B(sub y) much greater than B(sub n), the mode is strongly stabilized by B(sub n). We report than random pitch angle scattering can overcome the stabilizing effect of B(sub n) and drive the growth rate up toward the Harris neutral sheet (B(sub n) = 0) value when the pitch angle diffusion rate is comparable to Omega(sub n).

Brittnacher, M.↗

NASA NTRS1982

Magnetotail dynamics excited by the streaming tearing mode

Magnetotail reconnection in the presence of plasma streaming parallel to the neutral sheet is modeled. The tearing mode is excited much more violently in the case with parallel plasma flow in the plasma sheet than in the case with no flow. The flow patterns for the nonlinear resistive tearing mode and the streaming tearing mode are much more complex than those for the linear tearing mode. Flow vortices are observed in both cases.

Sato, T.↗

NASA NTRS1987

The electrostatic effect for the collisionless tearing mode

Electron dynamics has not been self-consistently considered in collisionless tearing mode theories to date because of the mathematical complexity of the Vlasov-Maxwell equations. It has been found, using computer simulations, that electrostatic fields play an important role in the tearing mode. Vlasov theory, including the electrostatic field, is investigated for topologies with both antiparallel and nonantiparallel magnetic field lines. The electrostatic field influences the resonant current in the neutral sheet which is a non-MHD effect, and modifies the linear growth rate. At the magnetopause, where the field lines are not antiparallel, the electrostatic effect acts to raise the linear growth rate of the tearing mode. On the other hand, in the magnetotail, where magnetic field lines are antiparallel, the electrostatic effect reduces the tearing mode growth rate.

Hoshino, Masahiro↗

NASA NTRS1990

Linear tearing modes of a forced current-sheet equilibrium

Linear tearing modes are studied in a nearly singular forced current-sheet equilibrium, such as could result from global magnetic forces in the solar corona. Growth rates for the tearing modes, determined by solving the linearized reduced MHD (Strauss) equations numerically, were found to scale as (gamma)tau(d) = about S exp 4/5 k(y) exp 4/5, where S is the Lundquist number, k(y) is the wavenumber, and tau(d) is the classical resistive diffusion time. This scaling is in agreement with predictions from analytical theory. Because of the faster S scaling of these modes compared to the tearing modes of a diffuse current-sheet equilibrium, the modes have much higher growth rates (by a factor of about 10,000) for coronal values of S (about 10 to the 12th). For coronal parameters, the growth times of these new modes are estimated to be on the order of several hours to days, as compared to growth times of months to years for the tearing modes in a diffuse current-shear equilibrium. The growth times are comparable to reconnection times scales required in models of coronal heating by magnetic field dissipation.

Liewer, Paulett C.↗

NASA NTRS1995

Localized tearing modes in the magnetotail driven by curvature effects

The stability of collisionless tearing modes is examined in the presence of curvature drift resonances and the trapped particle effects. A kinetic description for both electrons and ions is employed to investigate the stability of a two-dimensional equilibrium model. The main features of the study are to treat the ion dynamics properly by incorporating effects associated with particle trajectories in the tail fields and to include the linear coupling of trapped particle modes. Generalized dispersion relations are derived in several parameter regimes by considering two important sublayers of the reconnecting region. For a typical choice of parameters appropriate to the current sheet region, we demonstrate that localized tearing modes driven by ion curvature drift resonance effects are excited in the current sheet region with growth time of the order of a few seconds. Also, we examine nonlocal characteristics of tearing modes driven by curvature effects and show that modes growing in a fraction of a second arise when mode widths are larger than the current sheet width. Further, we show that trapped particle effects, in an interesting frequency regime, significantly enhance the growth rate of the tearing mode. The relevance of this theory for substorm onset phase and other features of the substorms is briefly discussed.

Sundaram, A. K.↗

NASA NTRS1994

On the energy principle and ion tearing in the magnetotail

We re-examine the use of the energy principle as applied to the tearing instability in the magnetotail. We demonstrate that when a magnetic field component normal to the current sheet is present, electron pitch-angle diffusion (PAD) either by micro-turbulence or by chaotic orbits cannot remove the strong stabilization of the tearing mode caused by electron compressibility. We find that our conclusions are in agreement with those of Pellat et al. (1991), who argued on the basis of canonical P(sub y) conservation that the stabilization of the ion tearing mode cannot be removed by the introduction of PAD. Our results are at variance with those of Kuznetsova and Zelenyi (1991), who argued that the application of the energy principle used by Pellat et al. (1991) is incorrect, and that tearing is in fact unstable in the limit of strong PAD. We show that the disagreement between these two studies can be traced to an incorrect orbit evaluation first introduced by Coroniti (1980) and subnsequently used by Kuznetsova and Zelenyi (1991).

Brittnacher, M.↗

NASA NTRS1998

Analyses of Buckling and Stable Tearing in Thin-Sheet Materials

This paper was to verify the STAGS (general shell, geometric and material nonlinear) code and the critical crack tip opening angle (CTOA) fracture criterion for predicting stable tearing in cracked panels that fail with severe out of plane buckling. Materials considered ranged from brittle to ductile behavior. Test data used in this study are reported elsewhere. The STAGS code was used to model stable tearing using a critical CTOA value that was determined from a cracked panel that was 'restrained' from buckling. ne analysis methodology was then used to predict the influence of buckling on stable tearing and failure loads. Parameters like crack length to specimen width ratio, crack configuration, thickness, and material tensile properties had a significant influence on the buckling behavior of cracked thin sheet materials. Experimental and predicted results showed a varied buckling response for different crack length to sheet thickness ratios because different buckling modes were activated. Effects of material tensile properties and fracture toughness on buckling response were presented. The STAGS code and the CTOA fracture criterion were able to predict the influence of buckling on stable tearing behavior and failure loads on a variety of materials and crack configurations.

Seshadri, B. R.↗

NASA NTRS1978

Explosive tearing mode reconnection in the magnetospheric tail

A speculative model for the nonlinear phase of the collisionless tearing instability is developed for the case of a single long wavelength tearing mode. Using an energy principle formalism, we find that the nonlinear growth rate is linearly proportional to the mode amplitude. Hence in the nonlinear phase, the tearing mode grows explosively in time, and saturates when the width of the magnetic islands become comparable to the thickness of the current sheet. For typical plasma sheet parameters, the explosive phase lasts 5-10 minutes, and develops cross-tail emf's of several 100 KV.

Galeev, A. A.↗

NASA NTRS1979

The energetics of resistive magnetic tearing

A new treatment of the energetics of resistive magnetic tearing is presented. This instability is the only known field-reconnection mechanism which develops in time, and is thus a primary candidate for a number of astrophysical 'flare' processes occurring in stressed magnetic fields. The tearing process is elucidated by a subdivision into magnetic regions of different characteristics: first, as dominated by resistive or highly conductive dynamics, and then by function as a source or sink of the energy flux. Matching conditions between these zones provide a determination of the growth rate and its physical-parameter dependence. The observable plasma energy outputs, due mainly to two distinct magnetically driven acceleration mechanisms, are estimated and their directive spatial properties shown. Finally, the generality of resistive tearing is demonstrated by an application of the previous considerations to realistic sheared-field configurations, including the case of a solar coronal loop, for which flare-instability thresholds and energy-deposition sites are described.

Van Hoven, G.↗

NASA NTRS1980

On the tearing mode in quasi-neutral sheets

The paper examines the stability of the tearing mode in a quasi-neutral sheet which contains electron pitch angle scattering wave turbulence (or collisions). It is found that the pitch angle scattering dissipation destabilizes the tearing mode and that the tearing growth rate is proportional to the pitch angle diffusion coefficient. The results are discussed with reference to theories of the plasma sheet.

Coroniti, F. V.↗

NASA NTRS1983

The effects of Ohmic heating and stable radiation on magnetic tearing

A study is made of the effect of a temperature-dependent Coulomb-like resistivity on the planar tearing mode. The local evolution of the temperature is described by an energy equation which includes Joule heating and optically thin radiation. The resulting system of coupled linear magnetohydrodynamic equations is solved numerically, and eigenfunctions and growth rates are obtained. In the absence of radiation, there are two distinct solutions above a critical value of the magnetic Reynolds number S, a tearing-like mode and a Joule-heating mode. Below this point, the growth rates coalesce into a conjugate-complex pair. When stable radiation (dR/dT greater than 0) is added, the heating mode disappears and a modified tearing excitation exists to much lower values of S before its growth is cut off by Ohmic heating. Examples are given for solar coronal parameters, and for those characteristic of fusion-research devices. The introduction of an effective value for the resistivity, in the presence of energy transport, allows a simple qualitative discussion of the different modes.

Tachi, T.↗

NASA NTRS1984

Nonlinear evolution of magnetopause tearing modes

Since the magnetosheath plasma is highly turbulent, reconnection at the dayside magnetopause is likely to be temporally unsteady. The tearing mode can be viewed as a model for the unsteady development of a reconnecting magnetic topology. Magnetopause tearing occurs in the guide-field limit and has a wave packet spatial structure in the east-west direction. This paper solves for the nonlinear evolution of a single wavelength guide-field tearing mode including the effects of finite transit time on the Landau resonant electrons. Short wavelength modes evolve algebraically in time with perturbation amplitudes proportional to t-squared. Long wavelength modes are fully nonlinear, and the amplitude grows linearly in time.

Coroniti, F. V.↗