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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 19 records

Using Temporal Information from Human Mobility Data to Detect Anchor Points

Spatiotemporal mobility data are available in massive quantities, but large quantities of data typically include fewer variables or data fields. Often, the only available fields are User ID, Longitude, Latitude, Timestamp (ULLT). This raises an important question: how much can we infer about human mobility patterns using only these four fields? With ULLT data, we do not know individuals' socioeconomic status information or when they are visiting their anchor points (AP) or locations (such as homes, places of employment, or schools), and it is a modern challenge to use this data to infer these characteristics. When detecting anchor locations with limited input information, verification and validation (VV) are significant challenges. This paper addresses the problem of identifying individuals' anchor locations using only temporal information from spatiotemporal datasets with limited attributes. Our approach does not explicitly use latitude and longitude during analysis. Locationbased information is only employed in the preprocessing stage to identify periods of movement (trips) and stops (dwelling). Beyond this step, all analysis is based on temporal patterns. In theory, if stops and dwell times could be detected through alternative means, our method could function entirely without location-based input. We demonstrate this methodology on the 2017 National Household Travel Survey (NHTS) data, because it includes a carefully designed and collected time use survey with representative sampling and labeled ground truth. The high-quality survey data allows us to test the accuracy of our methods because NHTS contains intended place labels and agent/user characteristics. We have also applied our validated AP identification algorithm on very large-scale GPS based trajectory data for Patterns-of-Life (PoL) assessment and other applications, but due to space limit that could not be presented here.

McBride, Liz [ORNL] (ORCID:0000000286925869)↗

Concentration-response gene expression analysis in zebrafish reveals phenotypically-anchored transcriptional responses to retene

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants and are associated with human disease. Canonically, many PAHs induce toxicity via activation of the aryl hydrocarbon receptor (AHR) pathway. While the interaction between PAHs and the AHR is well-established, understanding which AHR-regulated transcriptional effects directly result in observable phenotypes and which are adaptive or benign is important to better understand PAH toxicity. Retene is a frequently detected PAH in environmental sampling and has been associated with AHR2-dependent developmental toxicity in zebrafish, though its mechanism of toxicity has not been fully elucidated. To interrogate transcriptional changes causally associated with retene toxicity, we conducted whole-animal RNA sequencing at 48 hours post-fertilization after exposure to eight retene concentrations. The concentrations were selected to produce effects ranging from no phenotype to mortality and malformations in 100% of animals at 5 days post-fertilization. We identified a concentration-response relationship between retene teratogenicity and differential gene expression in both number of DEGs and magnitude of expression change. Elevated expression of cyp1a at retene concentrations below the threshold for teratogenicity suggested that while cyp1a expression is a sensitive biomarker of AHR activation, it may be too sensitive to serve as a biomarker of AHR-dependent teratogenicity. Genes differentially expressed at only non-teratogenic concentrations were enriched for transforming growth factor-ß (TGF-ß) signaling pathway disruption while DEGs identified at only teratogenic concentrations were significantly enriched for response to xenobiotic stimulus and reduction-oxidation reaction activity. DEGs which spanned both non-teratogenic and teratogenic concentrations showed similar disrupted biological processes to those unique to teratogenic concentrations, indicating these processes were disrupted at low exposure concentrations. Gene co-expression network analysis identified several gene modules, including those associated with PAHs and AHR2 activation. One, Module 7, was strongly enriched for AHR2-associated genes and contained the strongest responses to retene. Benchmark concentration (BMC) of Module 7 genes identified a median BMC of 7.5 µM, nearly the highest retene concentration with no associated teratogenicity, supporting the hypothesis that Module 7 genes are largely responsible for retene toxicity.

Toxin, Zebrafish, Retene, Transcriptomics, network↗

AOI [1] Advanced Manufacturing of Ceramic Anchors with Embedded Sensors for Process and Health Monitoring of Coal Boilers

Researchers at West Virginia University (WVU) developed methods to fabricate and test ceramic anchors with an embedded sensor technology for monitoring the health and processing conditions within pulverized coal (PC) and fluidized-bed combustion (FBC) boiler systems. The technology included the development of advanced manufacturing processes for 2D/3D printing electroceramic (conductive ceramic) sensor designs within the ceramic anchor microstructure during the manufacturing process. This advanced manufacturing process would allow for the precise control of local microstructure and composition in order to engineer layer-by-layer any protective and electrically active materials within the refractory anchor. This 3D printing technology would permit the rapid and controlled design of the refractory microstructure and embedded sensor design throughout the volume of the ceramic anchor. The work also included a method to interconnect the sensors to boiler shell through the anchor clamp, where the sensor signals will be processed by low-power electronics and transmitted wirelessly to a central processing hub. The end-goal of the program was to produce a ceramic anchor sensor system which would be ready for implementation within a coal boiler, and/or other similar refractory liner systems (such as that in the glass and metal manufacturing areas). The project objectives were to: 1) Define the chemical and microstructural stability, in addition to the electrical properties, of oxide and non-oxide ceramic composites to be embedded within the ceramic anchor compositions that may operate up to 1400ºC; 2) Develop and implement the 2D/3D printing technology to pattern and control the microstructure of the ceramic anchor and embedded sensor circuits; 3) Develop an interconnect technology which will permit easy installation of the ceramic anchors and signal collection at the boiler shell; 4) Develop low power analog electronics and wireless communication hardware to efficiently collect the sensor signal at each processing unit and transmit data to a central hub for data analysis; 5) Demonstrate the smart ceramic anchor system for temperature and liner fracture within a high-temperature processing unit, such as a boiler furnace or glass melting furnace floor/wall liner.

20 FOSSIL-FUELED POWER PLANTS↗

Electrochemically Mediated Au–C(sp 2 ) Anchors for Molecular Electronics

Terminal anchor groups play a key role in the stability and electronic properties of molecular junctions. Single molecule junctions typically consist of two preinstalled terminal anchors linking organic molecules to metal electrodes. Here, in this work, we show that p -terphenyl derivatives containing only a single terminal anchor show conductance features similar to junctions with two preinstalled terminal anchors. A set of p -terphenyl derivatives with one terminal anchor was prepared using automated chemical synthesis and characterized using single molecule electronics experiments, molecular dynamics (MD) simulations, bulk electrochemistry and spectroscopy, and nonequilibrium Green’s function-density functional theory (NEGF-DFT) calculations. Our results show that 4-amino- p -terphenyl (PPP) and related analogs exhibit a well-defined high conductance state that is diminished or absent in other p-terphenyl derivatives lacking a preinstalled amine terminal anchor or fluorine or methyl substitutions at the terminal para position. However, a low conductance state is observed in all amino- p -terphenyl derivatives with one preinstalled anchor due to molecular junctions formed by noncovalent dimeric π–π stacking interactions. The observed high conductance state diminishes upon the addition of reducing agents and is restored upon the addition of an oxidizing agent. Our results suggest that the high conductance state arises due to Au–C(sp 2 ) bond formation facilitated by a single electron oxidation event at the electrode surface. A series of control experiments with different anchor groups shows that primary amines play a key role in forming Au–C bonds for molecular junctions. Overall, these results suggest that Au–C bond formation gives rise to high conductance pathways in organic molecules containing only one preinstalled terminal anchor. Insights from this work can be leveraged in the design of molecular electronic devices, particularly in understanding the mechanisms of molecular binding and junction formation.

charge transport↗

Vehicle for installing anchors in an underwater substrate

A method of installing one or more anchors in an underwater substrate in a body of water including installing an anchor into the underwater substrate by rotating an anchor installation vehicle about a central axis Y to drive the anchor coupled to the anchor installation vehicle into the underwater substrate. The anchor installation vehicle includes a vehicle frame having a top end and bottom end, a plurality of arms extending outward from the vehicle frame, one or more rotational thrusters disposed at distal ends of the respective arms, and an anchor system that holds the anchor extending from the bottom end of the vehicle frame with the anchor aligned with a central axis Y.

42 ENGINEERING↗

Assessing the impacts of wakes on floating wind farms with shared anchors

This paper examines wake effects for floating wind farms with shared anchors. Three 20-turbine farms are examined: a grid-formation baseline with no shared anchors, a farm based on 3-line anchors, and a farm based on 6-line anchors, governed by a wind turbine spacing of 8 rotor diameters. The IEA 15 MW reference turbine on the UMaine semisubmersible platform was used with a taut mooring system in deep- water depths representative of U.S. west coast lease areas. A steady-state wake model showed that, when evaluating a sweep of wind headings, the baseline design had the lowest wake losses, with a value of 11.7 %, followed by the 6-line at 12.9% and the 3-line at 13.8%. Dynamic simulations were run in FAST.Farm to analyse the effects of wakes on mean anchor loads for wind headings that showed significant wake losses. The baseline farm showed the largest anchor load reductions due to wake effects (up to 16%), followed by the 3-line farm (up to 8%), and the 6-line farm, which showed relatively consistent load magnitudes on the 6-line anchors across all headings.

17 WIND ENERGY↗

Intramedullary Unicortical Button and All-Suture Anchors Provide Similar Maximum Strength for Onlay Distal Biceps Tendon Repair

To evaluate the biomechanical profile of onlay distal biceps repair with an intramedullary unicortical button versus all-suture anchors under cyclic loading and maximal load to failure. Twenty paired fresh-frozen human cadaveric elbows were randomized to onlay distal biceps repair with either a single intramedullary button or with two 1.35-mm all-suture anchors. A 1.3-mm high tensile strength tape was used in a Krackow stitch to suture the tendons in both groups. Specimens and repair constructs were loaded for 3,000 cycles and then loaded to failure. Maximum load to failure, mode of failure, and construct elongation were recorded. Mean (± standard deviation) maximum load to failure for the unicortical intramedullary button and all-suture anchor repairs were 503.23 ± 141.77 N and 537.33 ± 262.13 N (P = .696), respectively. Mean maximum displacement after 3,000 cycles (± standard deviation) was 4.17 ± 2.05 mm in the button group and 2.06 ± 1.05 mm in the suture anchor group (P = .014). Mode of failure in the button group was suture tape rupture in 7 specimens, failure at the tendon–suture interface in 2 specimens, and button pullout in 1 specimen. Anchor pullout was the mode of failure in all suture anchor specimens. There were no tendon ruptures or radial tuberosity fractures in either group. In conclusion, this study demonstrates that onlay distal biceps repair with 2 all-suture anchors has similar maximum strength to repair with an intramedullary button and that both are viable options for fixation.

60 APPLIED LIFE SCIENCES↗

Investigation of Anchor Link Magnetohydrodynamic Effects in the Toroidally Symmetric Lead-Lithium (TSLL) Blanket Concept

This paper presents a comprehensive study on the magnetohydrodynamic (MHD) flow in a slotted channel with a cylindrical anchor link, which is an imperative component of the toroidally symmetric lead-lithium (TSLL) blanket concept. Following the validation of the MHD solver implemented in COMSOL and a proposed subtraction approach to compute the anchor link pressure drop, the effects of computational domain size on the pressure drop and velocity distribution are examined. The results show that the pressure drop associated with the anchor link and the maximum flow velocity follow an asymptotic trend as the domain width increases, with wall-induced pressure drop being more dominant than that of the anchor link. The velocity distribution analysis revealed the formation of an internal boundary layer extending along the magnetic field direction, which is a unique feature of the investigated MHD flow. An estimation of the total MHD pressure drop associated with the array of anchor links under the TSLL blanket conditions suggests ~0.3 MPa, which is significantly lower than the recommended maximum allowable blanket pressure drop of 2 MPa. In conclusion, this work offers valuable insights into the anchor link–associated MHD phenomena and serves as a foundation for further development of the TSLL blanket concept for future fusion reactors.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Fatigue performance of the Deeply Embedded Ring Anchor

Existing anchor solutions are limited in their applicability to the floating offshore wind industry, which demands prolonged load endurance in extreme weather conditions and varied seabed soils. This limitation restricts project feasibility and increases costs. In order to address these challenges, the Deeply Embedded Ring Anchor (DERA) is proposed to achieve substantial reductions in anchor costs through efficiency enhancements. Ensuring the long-term safety and reliability of the DERA, especially considering a minimum operational period of 25 years, necessitates a comprehensive understanding of fatigue damage. Induced by repetitive loading below material yield strength, fatigue poses a significant threat to structures exposed to waves and currents. Anchors, vital for station keeping, are susceptible to fatigue damage, particularly in the padeye area. This paper conducts a fatigue analysis, focusing on factors such as the wall thickness of the ring anchor, inner stiffeners, and stiffener thickness, to evaluate the performance of DERA in this context. The results showed that the stiffener significantly affects the elongation of the total life of the anchor. In conclusion, this paper focuses on advancing innovations like DERA, enabling the efficient utilization of offshore wind resources, and addressing safety concerns through meticulous fatigue analysis.

17 WIND ENERGY↗

Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner

Presentation of peptides by class I MHC proteins underlies T cell immune responses to pathogens and cancer. The association between peptide binding affinity and immunogenicity has led to the engineering of modified peptides with improved MHC binding, with the hope that these peptides would be useful for eliciting cross-reactive immune responses directed toward their weak binding, unmodified counterparts. Increasing evidence, however, indicates that T cell receptors (TCRs) can perceive such anchor-modified peptides differently than wild-type (WT) peptides, although the scope of discrimination is unclear. We show here that even modifications at primary anchors that have no discernible structural impact can lead to substantially stronger or weaker T cell recognition depending on the TCR. Surprisingly, the effect of peptide anchor modification can be sensed by a TCR at regions distant from the site of modification, indicating a through-protein mechanism in which the anchor residue serves as an allosteric modulator for TCR binding. Our findings emphasize caution in the use and interpretation of results from anchor-modified peptides and have implications for how anchor modifications are accounted for in other circumstances, such as predicting the immunogenicity of tumor neoantigens. Our data also highlight an important need to better understand the highly tunable dynamic nature of class I MHC proteins and the impact this has on various forms of immune recognition.

60 APPLIED LIFE SCIENCES↗

Engineering microalgal cell wall-anchored proteins using GP1 PPSPX motifs and releasing with intein-mediated fusion

AbstractHarnessing and controlling the localization of recombinant proteins is critical for advancing applications in synthetic biology, industrial biotechnology, and drug delivery. This study explores protein anchoring and controlled release inChlamydomonas reinhardtii, providing innovative tools for these fields. Using truncated variants of the GP1 glycoprotein fused to the plastic-degrading enzyme PHL7, we identified the PPSPX motif as essential for anchoring proteins to the cell wall. Constructs with increased PPSPX content exhibited reduced secretion but improved anchoring, pinpointing the potential anchor-signal sites of GP1 and highlighting the distinct roles of these motifs in protein localization. Building on the anchoring capabilities established with these glycomodules, we also demonstrated a controlled release system using a pH-sensitive intein derived from RecA fromMycobacterium tuberculosis. This intein efficiently cleaved and released PHL7 and mCherry that was fused to GP1 under acidic conditions, enabling precise temporal and environmental control. At pH 5.5, fluorescence kinetics demonstrated significant mCherry release from the pJPW4mCherry construct within 4 hours. In contrast, release was minimal under pH 8.0 conditions and negligible for the pJPW2mCherry (W2) control, irrespective of the pH. Additionally, bands on the Western blot at the expected size of mCherry also showed its efficient release from the mCherry::intein::GP1 fusion protein at pH 5.5. Conversely, at pH 8.0, no bands were detected. This anchor-release approach offers significant potential for drug delivery, biocatalysis, and environmental monitoring applications. By integrating glycomodules and pH-sensitive inteins, this study establishes a versatile framework for optimizing protein localization and release inC. reinhardtii, with broad implications for proteomics, biofilm engineering, and scalable therapeutic delivery systems.Graphical Abstract

Kang, Kalisa (ORCID:0009000619398129)↗

Opacity on NIF: Anchor 2 Iron (Level 2 Milestone 7118 Report)

In FY2020 we fulfilled the exit criteria of milestone 7118. We fielded iron opacity experiments at higher densities and temperatures approaching anchor 2 conditions and made good progress on overcoming the problems that we found. This report describes in detail the progress that has been made. We presented the results in a LANL seminar on August 10 and we gave two talks on our results to the National Opacity Workshop Series, one on July 9 and the other on September 14. Before discussing the anchor 2 measurements, we present an update of the NIF anchor 1 data. We did a new analysis of the anchor 1 data and compared the results to a series of calculations using the LANL ATOMIC code. Figures 1 and 2 compare the data with the best-fit to calculations. This result is significantly improved over the result published in Atoms. The differences are small for the iron quasi-continuum between 8-9.5 Å and for the Mg Heα and Lyα lines. The opacities near the centers of the iron bound-bound features also match fairly well in the 9.5-12.5 Å range. However, the opacity windows between the large iron bound-bound features are deeper in the Atomic predictions than the measurement. Furthermore, large discrepancies exist for the Mg He β, γ, and δ lines and for the short-wavelength quasicontinuum. The experiment and analysis refinements described below have set the stage for unraveling these discrepancies. Specifically, we can repeat the Anchor 1 experiments using improved backlighter, hohlraum, and spectrometers to obtain reduced backgrounds and better spectral resolution. Exploiting the AlMg calibration experiments and repeating the Anchor 1 measurements multiple times will enable formal and rigorous uncertainty determination. This well-defined path gives us confidence that high quality opacity data can be obtained on NIF.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Comparison of Coupled and Uncoupled Modeling of Floating Wind Farms with Shared Anchors

As design options for floating wind farms continue to be explored, shared (or multiline) anchors that secure mooring lines from multiple turbines remain a promising technology that can potentially reduce the number of anchors and overall mooring costs. This study evaluates two methods for analyzing the loads on shared anchors: one in which floating offshore wind turbines are simulated individually (using the software OpenFAST), and one in which an entire floating wind farm is simulated collectively (using the software FAST.Farm). A three-line shared anchor is evaluated for multiple loading scenarios in deep water, using the International Energy Agency 15 MW turbine on the VolturnUS-S semisubmersible platform. While the two methods produce broadly comparable results, the coupled wave loading on platforms within the farm results in wave force cancellations and amplifications that decrease multiline force directional ranges and increase multiline force extreme values (up to 7%) and standard deviations (up to 11%) for wave-driven load cases. The inclusion of wakes in FAST.Farm also reduces the net load on the shared anchor due to the velocity deficit, leading to larger differences between OpenFAST and FAST.Farm (up to 3% difference in mean loads) for load cases with operational turbines.

17 WIND ENERGY↗

Single-Molecule Charge Transport through Positively Charged Electrostatic Anchors

The charge transport in single-molecule junctions depends critically on the chemical identity of the anchor groups that are used to connect the molecular wires to the electrodes. In this research, we report a new anchoring strategy — called the electrostatic anchor here — formed through the efficient Coulombic interaction between the gold electrodes and the positively charged pyridinium terminal groups. Our results show that these pyridinium groups serve as efficient electrostatic anchors forming robust gold–molecule–gold junctions. Here, we have also observed binary switching in dicationic viologen molecular junctions, demonstrating an electron injection-induced redox switching in single-molecule junctions. We attribute the difference in low- and high conductance states to a dicationic ground state and a radical cationic metastable state, respectively. Overall, this anchoring strategy and redox switching mechanism could constitute the basis for a new class of redox-activated single-molecule switches.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Critical role of oxide anchoring groups in organic electron transport layers for perovskite solar cell stability

Charge transport layers (CTLs) play a critical role in the performance and long-term stability of perovskite solar cells (PSCs) by facilitating efficient charge extraction and providing interfacial stabilization. For organic CTLs, different functional groups have been designed to modulate the interactions with the substrate. Anchoring groups are used to establish strong adhesion to transparent conductive oxides (TCOs) but are not routinely incorporated in organic CTL design. In this study, we investigate the influence of anchoring groups in organic electron transport layers (ETLs) on PSC performance and stability by synthesizing and evaluating two naphthalene diimide (NDI)-based ETLs: NDI-(PhPA) 2 , functionalized with polar phenyl phosphonic acid (PhPA) groups, and NDI-(PhBr) 2 , modified with nonpolar bromophenyl (PhBr) groups. X-ray photoelectron spectroscopy confirms that PhPA functionalization leads to NDIs anchored onto fluorine-doped tin oxide (FTO) following chemical bath deposition, while NDI-(PhBr) 2 shows no detectable surface presence after deposition. We show that NDI-(PhPA) 2 deposits as a thin film on FTO, exhibiting strong adhesion, high solvent resistance, and enhanced light and thermal stability, achieving a maximum device efficiency of 14.3%. Stability assessments conducted under continuous illumination at 25 °C for 200 hours and at 65 °C for 100 hours demonstrate performance on par with TiO 2 -based ETLs. In contrast, NDI-(PhBr) 2 , which lacks strong anchoring interactions, fails to adhere to the FTO surface, resulting in a rapid decrease in efficiency over a few hours, comparable to devices without an ETL. These findings highlight the importance of anchoring groups in organic CTLs for achieving long-term PSC stability under operational conditions.

Kim, Sanggyun [Georgia Institute of Technology, At↗