Low energy charged particle detection using the continuous channel electron multiplier
Low energy charged particle detection with continuous channel electron multiplier
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Low energy charged particle detection with continuous channel electron multiplier
Windowless continuous-channel electron multiplier detecting low energy charged particles in space
Continuous channel electron multiplier with saturated pulse independent of excitation for low energy charged particle detection
Design and performance of curved photomultiplier tube - effects of structural configuration on dead time and gain stability
Simulation of charged particle penetration in solid state detectors by stimulating them with IR light pulses, examining program generator and switching logic
A transistorized spectrometric amplifier with a shaper is reported that selects the shape of the frequency characteristic of the amplifying channel for which the primary frequency spectrum of the signal will pass, but where the noise spectrum is limited to the maximum. A procedure is presented for selecting the shaping circuits and their inclusion principles.
Mathematical models of certain systematic telemetry signal errors arising during the passage of the signal through the recording and transmitting blocks of the physical instruments aboard the spacecraft are classified and constructed. Statistical analysis methods are used to determine the background function and relative sensitivity coefficients of the channels of a charged particle detector. Results are presented. A block diagram for a method taking into account the effect of distortions is given.
A gamma-ray spectrometer has been flown on the Apollo 15 and 16 spacecraft to determine the lunar-surface composition and measure the cosmic gamma-ray flux. The instrument included a NaI(Tl) scintillation crystal coupled to a 7.6-cm photomultiplier tube, a plastic mantle for anti-coincidence rejection of charged particles, and 511 channels of analysis. Boom-mounted operation permitted a significant reduction in the background. The data were transmitted on an event-by-event basis. About 22% of the lunar surface was mapped and spectra of the cosmic gamma-ray flux over an energy range of 0.065-27.5 MeV have been obtained.
The X-ray sensitivity of the low energy proton channels in the Low Energy Charged Particle (LECP) experiment and its directional measurements determined whether X-rays from Jupiter can be recognized as additional flux above background as Voyager 1 approached the planet. Between about 230 and about 100 R(J), a statistically significant count rate was detected interpreted as X-rays and/or neutral particles. Such an X-ray flux leads to estimates of precipitating electrons over the Jovian polar caps which are 200 times larger than over observed electron fluxes in the Io plasma torus.
An inexpensive and simple data acquisition system has been developed for balloon borne experiments and has been tested with a gamma ray detector in a balloon flight launched from Palestine, Texas. The detector used for the test consisted of an NaI(T1) scintillation crystal encased in a 1/8 in. plastic scintillator-charged particle shield. The combination was viewed by a single photomultiplier and charged particle gating was accomplished by a conventional phoswich discriminator. The pulse height analysis of the NaI events, not associated with prompt charged particle interactions, is accomplished by converting to a time spectrum using an airborne height to time converter. A range of pulse widths from 5 microseconds to 250 microseconds corresponds to energy losses in NaI from 100 to 1000 keV. The time spectrum information, along with charged particle events and barometric pressure, is fed to a mixer which modulates a 252.4 Mc FM transmitter. The original scintillator spectrum is recovered on the ground utilizing conversion circuitry at the receiver video output and a 128 channel commercial pulse height analyzer. The charged particle events of standard time width are stored with the spectrum at a fixed channel position and are therefore represented by a sharp line riding on the lower part of the NaI energy loss spectrum. An energy loss greater than 1000 keV is presented by the maximum pulse width of the converter and stored in the last analyzer channel. Barometric pressure data is transmitted by low frequency modulation of the sme FM carrier. In flight operation, the receiver video output can be recorded on a wide band tape recorder and simultaneously analyzed by the 128 channel analyzer, or the telemetered data can be analyzed later. The flight system features high pulse resolution, essentially instantaneous time response, high data rate, and flexibility; and is of modest cost. A detailed description of the system and operating performance is discussed.
An apparatus for measuring particle size distribution includes a charging device and a precipitator. The charging device includes a corona that generates charged ions in response to a first applied voltage, and a charger body that generates a low energy electrical field in response to a second applied voltage in order to channel the charged ions out of the charging device. The corona tip and the charger body are arranged relative to each other to direct a flow of particles through the low energy electrical field in a direction parallel to a direction in which the charged ions are channeled out of the charging device. The precipitator receives the plurality of particles from the charging device, and includes a disk having a top surface and an opposite bottom surface, wherein a predetermined voltage is applied to the top surface and the bottom surface to precipitate the plurality of particles.
The central dogma of molecular biology states that information is stored in DNA, transcribed to messenger RNA (mRNA) and then translated into proteins. This picture is significantly augmentated when we consider the action of certain proteins in regulating transcription. These transcription factors provide a feedback pathway by which genes can regulate one another's expression as mRNA and then as protein. To review: DNA, RNA and proteins have different functions. DNA is the molecular storehouse of genetic information. When cells divide, the DNA is replicated, so that each daughter cell maintains the same genetic information as the mother cell. RNA acts as a go-between from DNA to proteins. Only a single copy of DNA is present, but multiple copies of the same piece of RNA may be present, allowing cells to make huge amounts of protein. In eukaryotes (organisms with a nucleus), DNA is found in the nucleus only. RNA is copied in the nucleus then translocates(moves) outside the nucleus, where it is transcribed into proteins. Along the way, the RNA may be spliced, i.e., may have pieces cut out. RNA then attaches to ribosomes and is translated to proteins. Proteins are the machinery of the cell other than DNA and RNA, all the complex molecules of the cell are proteins. Proteins are specialized machines, each of which fulfills its own task, which may be transporting oxygen, catalyzing reactions, or responding to extracellular signals, just to name a few. One of the more interesting functions a protein may have is binding directly or indirectly to DNA to perform transcriptional regulation, thus forming a closed feedback loop of gene regulation. The structure of DNA and the central dogma were understood in the 50s; in the early 80s it became possible to make arbitrary modifications to DNA and use cellular machinery to transcribe and translate the resulting genes; more recently, genomes (i.e., the complete DNA sequence) of many organisms have been sequenced. This large-scale sequencing began with simple organisms, viruses and bacteria, progressed to eukaryotes such as yeast, and more recently (1998) progressed to a multi-cellular animal, the nematode Caenorhabditis elegans. Sequencers have now moved on to the fruit fly Drosophila melanogaster, whose sequence is slated for completion by the end of 1999. The human genome project is expected to determine the complete sequence of all 3 billion bases of human DNA within the next five years. In the wake of genome-scale sequencing, further instrumentation is being developed to assay gene expression and function on a comparably large scale. Much of the work in computational biology focuses on computational tools used in sequencing, finding genes that are related to a particular gene, finding which parts of the DNA code for proteins and which do not, understanding what proteins will be formed from a given length of DNA, predicting how the proteins will fold from a one-dimensional structure into a three dimensional structure, and so on. Much less computational work has been done regarding the function of proteins. One reason for this is that different proteins function very differently, and so work on protein function is very specific to certain classes of proteins. There are, for example, proteins such enzymes that catalyze various intracellular reactions, receptors that respond to extracellular signals and ion channels that regulate the flow of charged particles into and out of the cell. In this chapter, we will consider a particular class of proteins called transcription factors(TFs), which are responsible for regulating when a certain gene is expressed in a certain cell, which cells it is express in, and how much is expressed. Understanding these processes will involve developing a deeper understanding of transcription, translation, and the cellular processes that control those processes. All of these elements fall under the aegis of gene regulation or more narrowly transcriptional regulation. Some of the key questions in gene regulation are: What genes are expressed in a certain cell at a certain time? How does gene expression differ from cell to cell in a multicellular organism? Which proteins act as transcription factors, i.e., are important in regulating gene expression? From questions like these, we hope to understand which genes are important for various macroscopic processes. Nearly all of the cells of a multicellular organism contain the same DNA. Yet this same genetic information yields a large number of different cell types. The fundamental difference between a neuron and a liver cell, for example, is which genes are expressed. Thus understanding gene regulation is an important step in understanding development. Furthermore, understanding the usual genes that are expressed in cells may give important clues about various diseases. Some diseases, such as sickle cell anemia and cystic fibrosis, are caused by defects in single, non-regulatory genes; others, such as certain cancers, are caused when the cellular control circuitry malfunctions - an understanding of these diseases will involve pathways of multiple interacting gene products. There are numerous challenges in the area of understanding and modeling gene regulation. First and foremost, biologists would like to develop a deeper understanding of the processes involved, including which genes and families of genes are important, how they interact, etc. From a computation point of view, there has been embarrassingly little work done. In this chapter there are many areas in which we can phrase meaningful, non-trivial computational questions, but questions that have not been addressed. Some of these are purely computational (what is a good algorithm for dealing with a model of type X) and others are more mathematical (given a system with certain characteristics, what sort of model can one use? How does one find biochemical parameters from system-level behavior using as few experiments as possible?). In addition to biological and algorithmic problems, there is also the ever-present issue of theoretical biology - what general principles can be derived from these systems, what can one do with models other than just simulate time-courses, what can be deduced about a class of systems without knowing all the details? The fundamental challenge to computationalists and theorists is to add value to the biology - to use models, modeling techniques and algorithms to understand the biology in new ways.
The effect of the induced charge was found on particles less than 1 eV as they passed through simulated parallel, grounded channels that are comparable in dimension to those that are presently in space plasma instruments which measure the flux of low-energy ions. Applications were made to both conducting and semiconducting channels that ranged in length from 0.1 to 50 mm and in aspect ratio from 1 to 100. The effect of the induced charge on particle trajectories from simple straight lines. Several configurations of channel aspect ratio and detector locations are considered. The effect is important only at very low energies with small dimensions.
A radiation or charged particle detector is described which incorporates a channel multiplier structure to amplify the detected rays or particles. The channel multiplier structure has a support multiplying element with a longitudinal slot along one side. The element supports a pair of plates positioned contiguous with the slot. The plates funnel the particles or rays to be detected into the slotted aperture and the element, thus creating an effectively wide aperture detector of the windowless type.
Notch charge-coupled devices are imaging arrays of photodetectors designed to exhibit high charge-transfer efficiencies necessary for operation in ultra-large array, and less vulnerable to degradation by energetic protons, neutrons, and electrons. Main channel of horizontal register includes deep narrow inner channel (notch). Small packets of charge remain confined to notch. Larger packets spill into rest of channel; transferred in usual way. Degradation of charge-transfer efficiency by energetic particles reduced.
By combining a toroidal electrostatic analyzer with a novel cylindrically symmetric isochronous time-of-flight mass spectrometer, an instrument was developed that simultaneously determines the three-dimensional distribution function of ions and differentiates species. The ion mass is determined to high resolution (M/Delta-M greater than 50) from the time of flight within a harmonic field configuration defined by hyperboloid equipotential surfaces. A second conventional time-of-flight channel makes use of particles leaving the thin entrance foil as neutrals. An additional solid state detector in which the neutrals are stopped allows the total energy and thereby the ionic charge of the incident ions to be determined as well. Information from the neutral and the ion channels can be combined to determine the total mass of an incident molecular ion and the mass of one atomic fragment.
An instrument for rapidly measuring the electric charges and sizes (from approximately 1 to approximately 100 micrometers) of airborne particles is undergoing development. Conceived for monitoring atmospheric dust particles on Mars, instruments like this one could also be used on Earth to monitor natural and artificial aerosols in diverse indoor and outdoor settings for example, volcanic regions, clean rooms, powder-processing machinery, and spray-coating facilities. The instrument incorporates a commercially available, low-noise, ultrasensitive charge-sensing preamplifier circuit. The input terminal of this circuit--the gate of a field-effect transistor--is connected to a Faraday-cage cylindrical electrode. The charged particles of interest are suspended in air or other suitable gas that is made to flow along the axis of the cylindrical electrode without touching the electrode. The flow can be channeled and generated by any of several alternative means; in the prototype of this instrument, the gas is drawn along a glass capillary tube (see upper part of figure) coaxial with the electrode. The size of a particle affects its rate of acceleration in the flow and thus affects the timing and shape of the corresponding signal peak generated by the charge-sensing amplifier. The charge affects the magnitude (and thus also the shape) of the signal peak. Thus, the signal peak (see figure) conveys information on both the size and electric charge of a sensed particle. In experiments thus far, the instrument has been found to be capable of measuring individual aerosol particle charges of magnitude greater than 350 e (where e is the fundamental unit of electric charge) with a precision of +/- 150 e. The instrument can sample particles at a rate as high as several thousand per second.
ATIC (Advanced Thin Ionization Calorimeter) is a balloon borne experiment designed to measure the cosmic ray composition for elements from hydrogen to iron and their energy spectra from approx.50 GeV to near 100 TeV. It consists of a Si-matrix detector to determine the charge of a CRT particle, a scintillator hodoscope for tracking, carbon interaction targets and a fully active BGO calorimeter. ATIC had its first flight from McMurdo, Antarctica from 28/12/2000 to 13/01/2001. The ATIC flight collected approximately 25 million events. The silicon matrix of the ATIC spectrometer is designed to resolve individual elements from proton to iron. To provide this resolution careful calibration of each pixel of the silicon matrix is required. Firstly, for each electronic channel of the matrix the pedestal value was subtracted taking into account its drift during the flight. The muon calibration made before the flight was used then to convert electric signals (in ADC channel number) to energy deposits in each pixel. However, the preflight muon calibration was not accurate enough for the purpose, because of lack of statistics in each pixel. To improve charge resolution the correction was done for the position of Helium peak in each pixel during the flight . The other way to set electric signals in electronics channels of the Si-matrix to one scale was correction for electric channel gains accurately measured in laboratory. In these measurements it was found that small different nonlinearities for different channels are present in the region of charge Z > 20. The correction for these non-linearities was not done yet. In linear approximation the method provides practically the same resolution as muon calibration plus He-peak correction. For searching a pixel with the signal of primary particle an indication from the cascade in the calorimeter was used. For this purpose a trajectory was reconstructed using weight centers of energy deposits in BGO layers. The point of intersection of this trajectory with Si-matrix and its RMS was determined. The pixel with maximal signal in 3sigma region was taken as sought. The signal in this pixel was corrected by trajectory zenith angle. The preliminary results on charge resolution of the Si-matrix in the range from protons to iron are presented.