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At least 19 records

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NASA NTRSDate not supplied

Effect of Carbon Dioxide Exposure on Physical and Cognitive Performance in a Simulated Spaceflight Contingency Scenario

Introduction: Carbon dioxide (CO2) produced by astronauts inside space suits can accumulate to levels that affect health and performance. The human health and performance risks associated with different levels of CO2 exposure in the flight environment remain an area of debate. The purpose of this study is to characterize the limit of acceptable performance (cognitive and physical) decrements and symptom severity for mission operations when subjected to elevated inspired CO2 levels in the spacesuit during contingency EVA scenarios. Methods: This study will create a simulation of a 1-hour contingency EVA walk back to the habitat, incorporating a passive treadmill and a fully immersive virtual reality (VR) simulation of a lunar EVA. Subjects will be asked to walk on a treadmill while breathing partial pressures of CO2 of 0, 5, 10, 15, 20, 25, 30mmHg for 1 hour at a time. Cognitive performance will be quantified using validated cognitive tests and measures of functional task performance embedded within the VR environment. Test subject symptoms and self-assessment of performance will be evaluated via survey. Results: This study currently has approval from NASA’s Institutional Review Board and has completed the Test Readiness Review process. Next steps for this research study include test subject recruitment, data collection, and analysis. Data collection is planned for calendar year 2022 and 2023. Discussion: This study will provide valuable information regarding how various partial pressures of CO2 exposure impact acute health, as well as cognitive and physical performance during simulated lunar EVA. This information will be vital in the assessment of overall risk associated with current hardware (vehicle and suit) design for upcoming exploration missions. It will also be invaluable for informing future standards and requirements.

carbon dioxide↗

NASA NTRSDate not supplied

Effect of Carbon Dioxide Exposure on Physical and Cognitive Performance in A Simulated Spaceflight Contingency Scenario

INTRODUCTION: Carbon dioxide (CO2) produced by astronauts inside space suits can accumulate to levels that may affect health and performance. The human health and performance risks associated with different levels of CO2 exposure in the flight environment remain an area of debate. The purpose of this study is to characterize the limit of acceptable performance (cognitive and physical) decrements and symptom severity for mission operations when subjected to elevated inspired CO2 levels in simulated contingency lunar extravehicular activity (EVA) scenarios. METHODS: This study will create a simulation of a 1-hour, ~2km contingency EVA walk back to a habitat, incorporating a passive treadmill and a fully immersive virtual reality (VR) simulation of a lunar EVA environment. Subjects will be asked to walk on a treadmill while breathing partial pressures of CO2 of 0, 5, 10, 15, 20, 25, 30mmHg for 1 hour at a time. Cognitive performance will be quantified using validated cognitive tests and measures of functional task performance embedded within the VR environment. Test subject symptoms and self-assessment of performance will be evaluated via survey. RESULTS: This study currently has approval from NASA’s Institutional Review Board and has completed the Test Readiness Review process. Next steps for this research study include test subject recruitment, data collection, and analysis. Data collection is planned for calendar year 2023 and 2024. DISCUSSION: This study will provide valuable information regarding how various partial pressures of CO2 exposure impact acute health, as well as cognitive and physical performance during simulated contingency lunar EVA. This information will enable assessment of health and performance risk associated with spacesuit systems and operations concepts for future exploration missions as well as informing definition of future standards and requirements.

carbon dioxide↗

NASA NTRSDate not supplied

Effect of Carbon Dioxide Exposure on Physical and Cognitive Performance in A Simulated Spaceflight Contingency Scenario

D. M. Nusbaum↗

NASA NTRS2005

Cognitive Performance in Operational Environments

Optimal cognition during complex and sustained operations is a critical component for success in current and future military operations. "Cognitive Performance, Judgment, and Decision-making" (CPJD) is a newly organized U.S. Army Medical Research and Materiel Command research program focused on sustaining operational effectiveness of Future Force Warriors by developing paradigms through which militarily-relevant, higher-order cognitive performance, judgment, and decision-making can be assessed and sustained in individuals, small teams, and leaders of network-centric fighting units. CPJD evaluates the impact of stressors intrinsic to military operational environments (e.g., sleep deprivation, workload, fatigue, temperature extremes, altitude, environmental/physiological disruption) on military performance, evaluates noninvasive automated methods for monitoring and predicting cognitive performance, and investigates pharmaceutical strategies (e.g., stimulant countermeasures, hypnotics) to mitigate performance decrements. This manuscript describes the CPJD program, discusses the metrics utilized to relate militarily applied research findings to academic research, and discusses how the simulated combat capabilities of a synthetic battle laboratory may facilitate future cognitive performance research.

Russo, Michael↗

NASA NTRS2024

Cognitive Performance in ISS Astronauts on 6-Month Low Earth Orbit Missions

Introduction: Current and future astronauts will endure prolonged exposure to spaceflight hazards and environmental stressors that could compromise cognitive functioning, yet cognitive performance in current missions to the International Space Station remains critically under-characterized. We systematically assessed cognitive performance across 10 cognitive domains in astronauts on 6-month missions to the ISS. Methods: Twenty-five professional astronauts were administered the Cognition Battery as part of National Aeronautics and Space Administration (NASA) Human Research Program Standard Measures Cross-Cutting Project. Cognitive performance data were collected at five mission phases: pre-flight, early flight, late flight, early post-flight, and late post-flight. We calculated speed and accuracy scores, corrected for practice effects, and derived z-scores to represent deviations in cognitive performance across mission phases from the sample’s mean baseline (i.e., pre-flight) performance. Linear mixed models with random subject intercepts and pairwise comparisons examined the relationships between mission phase and cognitive performance. Results: Cognitive performance was generally stable over time with some differences observed across mission phases for specific subtests. There was slowed performance observed in early flight on tasks of processing speed, visual working memory, and sustained attention. We observed a decrease in risk-taking propensity during late flight and post-flight mission phases. Beyond examining group differences, we inspected scores that represented a significant shift from the sample’s mean baseline score, revealing that 11.8% of all flight and post-flight scores were at or below 1.5 standard deviations below the sample’s baseline mean. Finally, exploratory analyses yielded no clear pattern of associations between cognitive performance and either sleep or ratings of alertness. Conclusions: There was no evidence for a systematic decline in cognitive performance for astronauts on a 6-month missions to the ISS. Some differences were observed for specific subtests at specific mission phases, suggesting that processing speed, visual working memory, sustained attention, and risk-taking propensity may be the cognitive domains most susceptible to change in Low Earth Orbit for high performing, professional astronauts. We provide descriptive statistics of pre-flight cognitive performance from 25 astronauts, the largest published preliminary normative database of its kind to date, to help identify significant performance decrements in future samples.

Data curation↗

NASA NTRSDate not supplied

The Development and Application of Cognitive Performance Assessment for Exploration Class Mission EVAs

The objectives of our research are to: 1) Define cognitive performance requirements for future Lunar and Mars mission EVAs, 2) Characterize cognitive performance in subjects conducting simulated EVAs in analog studies, and 3) Develop and test unobtrusive EVA cognitive performance metrics. Our long-term goal is to develop exploration class cognitive performance monitoring capabilities for EVA and to provide data that can inform EVA planning for Lunar and Mars missions.

S R Anderson↗

NASA NTRSDate not supplied

Ensuring Safe Decision-Making on the Moon and Mars: Cognitive Performance Assessment for Exploration Class Mission EVA

Extravehicular activity (EVA) is one of the most dangerous and cognitively demanding actions that astronauts can execute, and the cognitive demands associated with future partial gravity EVAs on the Moon and Mars are expected to be higher compared to microgravity EVAs currently conducted from the International Space Station. Decrements in cognitive performance present an important risk to crew safety during exploration mission class EVA. Yet there is currently insufficient data to characterize cognitive performance prior to, during, and following EVA. Furthermore, it is still unclear which cognitive domains are most important for conducting mission critical decisions with crew safety implications. To address this gap, we conducted a cognitive task analysis (CTA) of EVA to characterize the procedures, the cognitive demands required, and the critical safety decisions associated with decrements in cognitive performance. We conducted a cognitive task analysis with 15 astronauts and subject matter experts in EVA operations and research. Interviews focused on surface exploration EVA and elicited feedback from experts on the cognitive skills required for specific EVA tasks, including cognitive strategies, critical cues, and decision-making strategies. A cognitive demands table was assembled to consolidate and synthesize the information from all interviews. The information from this cognitive task analysis informs ongoing exploration EVA for Moon to Mars. This work identifies the specific cognitive challenges that astronauts are likely to encounter during surface exploration EVA, and provides the foundation for: (1) prioritized and targeted cognitive performance measurement and functional performance tests, (2) EVA simulation design at varying levels of cognitive workload, and (3) the development of training and other technologies that can improve safe decision-making and inform EVA planning on future spaceflight missions to the Moon and Mars.

Steven R Anderson↗

NASA NTRS2009

Homocysteine and Cognitive Performance in Elders with Self-Neglect

Elevated plasma homocysteine has been associated with altered cognitive performance in older adults. Elders referred to Adult Protective Services (APS) for self-neglect have been reported to have elevated plasma homocysteine levels and to suffer from cognitive impairment. This study assesses the association, if any, between plasma homocysteine and cognitive performance among elders with self-neglect. Methods: Sixty-five community-living adults, 65 years of age and older, reported to Adult Protective Services for self-neglect and 55 matched controls (matched for age, ethnicity, gender and socio-economic status) consented and participated in this study. The research team conducted in-home comprehensive geriatric assessments which included the mini-mental state exam (MMSE), the 15-item geriatric depression scale (GDS), the Wolf-Klein Clock Drawing Tests (CDT) and a comprehensive nutritional biochemistry panel, which included plasma homocysteine. Student s t tests and Pearson correlations were conducted to assess for bivariate associations. Results: Elders with self-neglect had significantly higher plasma homocysteine levels (M=12.68umol/L, sd=4.4) compared to the controls (M=10.40umol/L, sd=3.61;t=3.21, df=127, p=.002). There were no statistically significant associations between cognitive performance and plasma homocysteine in the self-neglect group, however there was a significant correlation between plasma homocysteine and the CDT among the controls (r=-.296, p=.022). Conclusion: Mean plasma homocysteine levels were significantly higher in elders with self-neglect, however, they do not appear to be related to cognitive performance, indicating that cognitive impairment in elder self-neglect involve mechanisms other than hyperhomocysteinemia. These findings warrant further investigation

Burnett, J.↗

NASA NTRS2024

Ensuring Safe Decision-Making on the Moon and Mars: Cognitive Performance Assessment for Exploration Class Mission EVA

Extravehicular activity (EVA) is one of the most dangerous and cognitively demanding actions that astronauts can execute, and the cognitive demands associated with future partial gravity EVA on the Moon and Mars are expected to be higher compared to microgravity EVA currently conducted from the International Space Station (ISS). Decrements in cognitive performance present an important risk to crew safety during exploration mission class EVA. Yet there is currently insufficient data to characterize cognitive performance prior to, during, and following EVA. Furthermore, it is still unclear which cognitive domains are most important for conducting mission critical decisions with crew safety implications. To address this gap, we conducted a cognitive task analysis (CTA) of EVA to characterize the procedures, the cognitive demands required, and the critical safety decisions associated with decrements in cognitive performance. We used the applied cognitive task analysis method as outlined by Militello and Hutton (1998) and conducted interviews with subject matter experts (SMEs) in EVA at NASA Johnson Space Center in summer 2024. Interviews focused on exploration EVA and elicited feedback from SMEs on the cognitive skills required for specific EVA tasks including cognitive strategies, critical cues, and decision-making strategies. A cognitive demands table was assembled to consolidate and synthesize the information from all interviews. The information from this cognitive task analysis will inform ongoing work to identify the key cognitive domains for safe decision-making during exploration mission class EVA on the Moon and Mars. This work will importantly provide a link between cognitive domains identified in the cognitive task analysis and operationally-relevant performance metrics collected during spaceflight and simulation EVA that can be tracked and assessed by NASA mission operations. Ultimately, this work will aid in the development and application of exploration class cognitive performance monitoring capabilities to improve safe decision-making and inform EVA planning on future spaceflight missions to the Moon and Mars.

Steven R Anderson↗

NASA NTRS1999

EEG Analysis of the Effects of Therapeutic Cooling on the Cognitive Performance of Multiple Sclerosis Patients

The objective of this project was to determine whether a controlled period of head and torso cooling would enhance the cognitive performance of multiple sclerosis patients. Nineteen MS patients (11 men and 8 women) participated in the study. Control data were taken from nineteen healthy volunteers (12 men and 7 women). All but six of nineteen MS patients tested improved their cognitive performance, as measured by their scores on the Rao test battery. A second objective was to gain insight into the neurological effects of cooling. Visual evoked potentials (VEPs) stimulated by a reversing checkerboard pattern were recorded before and after cooling. We found that cooling selectively benefited the cognitive performance of those MS patients whose pre-cooling VEPs were abnormally shaped (which is an indication of visual pathway impairment due to demyelinization). Moreover, for female MS patients, the degree of cognitive performance improvement following cooling was correlated with a change in the shape of their VEPs toward a more normal shape following cooling.

Montgomery, Leslie D.↗

NASA NTRS2009

Spatial Cognitive Performance During Adaptation to Conflicting Tilt-Translation Stimuli as a Sensorimotor Spaceflight Analog

The need to resolve new patterns of sensory feedback in altered gravitoinertial environments requires cognitive processes to develop appropriate reference frames for spatial orientation awareness. The purpose of this study was to examine deficits in spatial cognitive performance during adaptation to conflicting tilt-translation stimuli. Fourteen subjects were tilted within a lighted enclosure that simultaneously translated at one of 3 frequencies. Tilt and translation motion was synchronized to maintain the resultant gravitoinertial force aligned with the longitudinal body axis, resulting in a mismatch analogous to spaceflight in which the canals and vision signal tilt while the otoliths do not. Changes in performance on different spatial cognitive tasks were compared 1) without motion, 2) with tilt motion alone (pitch at 0.15, 0.3 and 0.6 Hz or roll at 0.3 Hz), and 3) with conflicting tilt-translation motion. The adaptation paradigm was continued for up to 30 min or until the onset of nausea. The order of the adaptation conditions were counter-balanced across 4 different test sessions. There was a significant effect of stimulus frequency on both motion sickness and spatial cognitive performance. Only 3 of 14 were able to complete the full 30 min protocol at 0.15 Hz, while 7 of 14 completed 0.3 Hz and 13 of 14 completed 0.6 Hz. There were no changes in simple visual-spatial cognitive tests, e.g., mental rotation or match-to-sample. There were significant deficits during 0.15 Hz adaptation in both accuracy and reaction time during a spatial reference task in which subjects are asked to identify a match of a 3D reoriented cube assemblage. Our results are consistent with antidotal reports of cognitive impairment that are common during sensorimotor adaptation with G-transitions. We conclude that these cognitive deficits stem from the ambiguity of spatial reference frames for central processing of inertial motion cues.

Kayanickupuram, A. J.↗

NASA NTRS2012

Review of Human Cognitive Performance in Spaceflight

Human space exploration is inherently hazardous, particularly for lon g duration (LD) missions (22 days or longer). Maintenance of cognitive functioning is essential, but flight environments pose numerous pote ntial risks to the brain and cognitive performance (eg, radiation, to xins, chronic stress, sleep deprivation, hypercarbia, fluid shifts, h ormone imbalances, and injury). There have been persistent anecdotal reports of cognitive deficits during missions, but an up?-to-date rev iew of the evidence for such changes has remained unavailable. Method s: We identified and reviewed English language publications found via electronic searches in PubMed, PsycInfo, Inspec, the NASA Technical Report Server, and the Defense Technical Information Center, plus rec ursive searches of publication bibliographies. Search terms included the word cognition, cognitive, or performance along with spaceflight, flight, mission, or closely related terms. Results: Inter?-study variability precluded meta?-analysis. Some 32 published studies involving cognitive assessment during spaceflight were identified, involving a total of 110 participants (mean: 3.4 participants per study). The lo ngest?-duration study spanned 438 days, with six additional studies i nvolving flight durations of 90 days, and 11 more studies involved fl ight durations exceeding 21 days. The available evidence failed to st rongly support or refute the existence of cognitive deficits in LD sp aceflight, in part due to inadequate power or control conditions. Evi dence of increased variability in cognitive performance during spacef light, both within and between individuals, was common. Discussion: T hese results represent a negative finding based on small numbers of s ubjects for any given cognitive function. The increased variability within and (particularly) between individuals highlights the potential danger of generalizing from case studies. A mismatch therefore remain s between anecdotal reports describing generalized cognitive slowing, attention and memory problems during missions and the experimental e vidence supporting such deficits. Since a major justification for man ned spaceflight rests with the cognitive flexibility of humans, addit ional studies and further analysis of existing operational data appea rs warranted.

Strangman, Gary↗

DOE OSTI2022

Sex comparisons in physiological and cognitive performance during hypoxic challenge

Within the tactical aviation community, human performance research lags in considering potential psychophysiological differences between male and female aviators due to little inclusion of females during the design and development of aircraft systems. A poor understanding of how male and female aviators differ with respect to human performance results in unknown potential sex differences on aeromedically relevant environmental stressors, perchance leading to suboptimal performance, safety, and health guidelines. For example, previous hypoxia studies have excluded female participants or lacked a sizeable sample to examine sex comparisons. As such, progress toward sensor development and improving hypoxia familiarization training are stunted due to limited knowledge of how individual differences, including sex, may or may not underlie hypoxia symptoms and performance impairment. Investigating sex differences bridges the gap between aerospace medicine and operational health, and addressing hypoxia is one of many facets yet to be studied. In the current study, we retrospectively examined N = 6 hypoxia studies with male-female participant samples (total, N = 189; male, n = 118; female, n = 71). We explored sex as a predictor of physiological response, sensory deficits, the severity of cognitive performance declines, and symptom manifestation via linear and binary logistic regression models. We found that the female sex predicted lower peripheral oxygen saturation and the likelihood of headache reporting in response to hypoxic challenge, yet explained little variance when combined with age and body mass index. The sensory and cognitive performance models did not converge, suggesting high intra-individual variability. Together, sex, age, and body mass index were not the most robust predictors in responses to hypoxic challenge; we cannot infer this for sensory deficits and cognitive performance within an experimentally induced hypoxic environment. The findings have implications for improving hypoxia familiarization training, monitoring sensor development, and emergency response and recovery protocols in case of a hypoxia occurrence suitable for all aircrew. We recommend continuing to elucidate the impact of sex and intrapersonal differences in hypoxia and other aeromedically relevant stressors in tactical aviation.

60 APPLIED LIFE SCIENCES↗

NASA NTRSDate not supplied

The Cognition Battery: Developing a Normative Database for Spaceflight and Examining the Impact of Prolonged Isolation and Confinement on Cognitive Performance

INTRODUCTION: Astronauts on future long duration space exploration will be required to execute complex tasks in which even minor errors could have devastating consequences. Intact cognition is critical to maintain exceptional performance standards and it is possible that variability even at the highest ends of the performance spectrum will impact operational tasks. Exposure to spaceflight hazards could compromise cognitive performance, and decrements have been documented under conditions of altered gravity and radiation exposure. The cognitive impacts of prolonged isolation and confinement remain relatively unknown. Traditional neuropsychological assessments cannot support earth independent monitoring, do not have normative comparisons for high functioning individuals, and most are not sensitive enough to detect small performance decrements. The Cognition Battery was developed to address these limitations but currently lacks comprehensive normative data. In this project, we aimed to 1) develop a preliminary normative database for astronauts and astronaut surrogates using the Cognition Battery, and 2) characterize differences in cognitive performance after short and long duration analog missions. PARTICIPANTS & METHODS: We assessed baseline cognitive performance by administering the Cognition Battery to 97 astronaut and astronaut surrogates recruited to approximate astronaut demographics (mean age: 39.38, SD=7.62; 35.1% female; 91.7% advanced degrees). For aim 1, we calculated speed and accuracy outcomes for each subtest and summarized the data with descriptive statistics. We examined the relationship between age and performance with Pearsons’s correlations and the relationship between gender and performance with independent samples t-tests. A subset of individuals on short duration (n=48; mean age: 38.18, SD=7.14; 37.5% female; 91.7% advanced degrees) missions of 45 days and long duration (n=34; mean age: 42.12, SD=8.39; 38.2% female; 94.1% advanced degrees) missions ranging from 4-8 months were administered the Cognition Battery during and after their respective missions. For aim 2, we accounted for practice effects using published corrections, and z-transformed post-mission scores using the full sample’s baseline scores. One-way analysis of covariance tests determined the main effect of analog duration on post-mission performance, after accounting for age and gender. The False Discovery Rate method was applied to adjust for multiple comparisons. RESULTS: In the full normative sample, older age was associated with slower reaction times on a processing speed task (r=.39, p=.02), and men were more accurate on processing speed (t=-2.19, p=.03) and faster on sustained attention (t=2.02, p=.049) and risk-taking tasks (t=2.49, p=.02). We observed a main effect of duration on performance on tasks of visual memory (f(1)=5.62, p=.04), processing speed (f(1)=5.48, p=.03), and sensorimotor functioning (f(1)=39.52, p < .001), such that slower performance was observed after long duration missions relative to short. Only sensorimotor functioning was significant after adjustments for multiple comparisons (adjusted p<.001). DISCUSSION: The full sample represents the largest dataset of cognitive performance assessed by the Cognition Battery available and can be used for further research in spaceflight and high-performance populations. Relationships between performance and key demographic variables suggest future research that include age and gender stratification is needed. Our results also show minimal changes in cognitive performance between longer and shorter periods of isolation and confinement.

S I Dev↗

NASA NTRS1999

Arctic cognition: a study of cognitive performance in summer and winter at 69 degrees N

Evidence has accumulated over the past 15 years that affect in humans is cyclical. In winter there is a tendency to depression, with remission in summer, and this effect is stronger at higher latitudes. In order to determine whether human cognition is similarly rhythmical, this study investigated the cognitive processes of 100 participants living at 69 degrees N. Participants were tested in summer and winter on a range of cognitive tasks, including verbal memory, attention and simple reaction time tasks. The seasonally counterbalanced design and the very northerly latitude of this study provide optimal conditions for detecting impaired cognitive performance in winter, and the conclusion is negative: of five tasks with seasonal effects, four had disadvantages in summer. Like the menstrual cycle, the circannual cycle appears to influence mood but not cognition.

Cognition↗

NASA NTRS1992

Microgravity effects on standardized cognitive performance measures

The purpose of this experiment, selected to fly on the International Microgravity Laboratory (IML-2) Spacelab mission, is to determine the effects of microgravity upon the cognitive skills which are critical to successful performance of many tasks on board the Space Shuttle. Six tests from the Unified Tri-service Cognitive Performance Assessment Battery (UTC-PAB) will be administered to the Mission Specialists to fulfill the goals of this experiment. These tests are based upon current theoretical models of human performance and the hypothesized effects of microgravity. The principle objective is the identification of the effects of microgravity upon specific information processing skills affecting performance from those of fatigue and shifts in work/rest cycles. Multiple measures of both short and long term fatigue will be obtained and used as a major independent variable for the analysis of these performance data. Scientific supporting studies will determine optimum practice and performance testing schedules for the astronauts. The same tests will be used post-flight to collect data on the recovery of any cognitive performance impairment compared with pre-flight, baseline levels.

Schiflett, Samuel G.↗

NASA NTRS1987

Lack of effects of astemizole on vestibular ocular reflex, motion sickness, and cognitive performance in man

Astemizole was orally administered to 20 subjects in a randomized, double-blind design to assess the efficacy of this peripherally active antihistamine as an antimotion sickness drug possessing no central side-effects. Measures of vestibular ocular reflex (VOR) were made to evaluate the agent as a selective vestibular depressant. Following one week of orally administered astemizole (30 mg daily), a Staircase Profile Test, a VOR test, and a variety of tests of cognitive performance were administered. These tests revealed no statistically significant effects of astemizole. This leads to the conclusion that, although the drug probably reaches the peripheral vestibular apparatus in man by crossing the blood-vestibular barrier, a selective peripheral antihistamine (H1) action is inadequate to control motion sickness induced through cross-coupled accelerative semicircular canal stimulation in a rotating chair.

Kohl, Randall L.↗

NASA NTRSDate not supplied

Changes in Cognitive Performance and Behavior Induced by Space-like Environment

Exposure to space radiation is a principal consideration of spaceflight missions as risk is leveraged as time and dose—both expected to increase with future missions to the Moon, Mars, and beyond. Previous mission exposure levels, galactic cosmic radiation (GCR) and solar particle events (SPE), have been characterized as increased compared to those natural to Earth and are predicted to cause robust deficits at higher doses and longer durations. The cognitive health implications of this critical difference are understood as risks to mission and crew operations. We examined potential radiation-induced disruptions on brain health through resting-state in-cage behavior. 23–24-week-old male and female mice were exposed to 0 cGy (Sham), 5 cGy, 15 cGy, and 50 cGy via Five-Ion GCR Simulation (H, Si, He, O, Fe) at the NASA Space Radiation Lab in Brookhaven National Labs. Behavioral and cognitive performance were evaluated via frequency/duration of digging, rearing, and grooming within the 72-hour (acute) and 91-day (delayed) period following irradiation. Additionally, during this time we evaluated nestlet building using a 5-stage Deacon score, rating shredding and shelter assembly of cotton material from untouched (1) to shredded and formed into a crater shape (5). We have observed differences in behavior frequency and duration differences among the 15 cGy subset within the acute observation window. There were no significant differences in behavior frequencies nor duration during the delayed observation period. These experimental design aspects that allot for gender-inclusivity is supportive of the diversification of future space travel mission plans. Investigating gender differences is an element under our main objective of determining radiation dose-response curves. In brief, these studies identified a space-relevant radiation dose of 15 cGy that that can be utilized for future standardized ground studies on the nervous system.

O. Siu↗