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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 19 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Factors influencing mode choice of adults with travel-limiting disability

Introduction: Despite the plethora of research devoted to analyzing the impact of disability on travel behavior, not enough studies have investigated the varying impact of social and environmental factors on the mode choice of people with disabilities that restrict their ability to use transportation modes efficiently. This research gap can be addressed by investigating the factors influencing the mode choice behavior of people with travel-limiting disabilities, which can inform the development of accessible and sustainable transportation systems. Additionally, such studies can provide insights into the social and economic barriers faced by this population group, which can help policymakers to promote social inclusion and equity. Method: This study utilized a Random Parameters Logit model to identify the individual, trip, and environmental factors that influence mode selection among people with travel-limiting disabilities. Here, using the 2017 National Household Travel Survey data for New York State, which included information on respondents with travel-limiting disabilities, the analysis focused on a sample of 8,016 people. In addition, climate data from the National Oceanic and Atmospheric Administration were integrated as additional explanatory variables in the modeling process. Results: The results revealed that people with disabilities may be inclined to travel longer distances walking in the absence of suitable accommodation facilities for other transportation modes. Furthermore, people were less inclined to walk during summer and winter, indicating a need to consider weather conditions as a significant determinant of mode choice. Moreover, low-income people with disabilities were more likely to rely on public transport or walking. Conclusion: Based on this study’s findings, transportation agencies could design infrastructure and plan for future expansions that is more inclusive and accessible, thus catering to the mobility needs of people with travel-limiting disabilities.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2025

Identifying spatiotemporal patterns in opioid vulnerability: investigating the links between disability, prescription opioids and opioid-related mortality

Background: The opioid crisis remains one of the most daunting and complex public health problems in the United States. This study investigates the national epidemic by analyzing vulnerability profiles of three key factors: opioid-related mortality rates, opioid prescription dispensing rates, and disability rank ordered rates. Methods: This study utilizes county level data, spanning the years 2014 through 2020, on the rates of opioid-related mortality, opioid prescription dispensing, and disability. To successfully estimate and predict trends in these opioid-related factors, we augment the Kalman Filter with a novel spatial component. To define opioid vulnerability profiles, we create heat maps of our filter’s predicted rates across the nation’s counties and identify the hotspots. In this context, hotspots are defined on a year-by-year basis as counties with rates in the top 5% nationally. Results: Our spatial Kalman filter demonstrates strong predictive performance. From 2014 to 2018, these predictions highlight consistent spatiotemporal patterns across all three factors, with Appalachia distinguished as the nation’s most vulnerable region. Starting in 2019 however, the dispensing rate profiles undergo a dramatic and chaotic shift. Conclusions: The initial primary drivers of opioid abuse in the Appalachian region were likely prescription opioids; however, it now appears that abuse is sustained by illegal drugs. Additionally, we find that the disabled subpopulation may be more at risk of opioid-related mortality than the general population. Public health initiatives must extend beyond controlling prescription practices to address the transition to and impact of illicit drug use.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2023

Enabling Success: Enhancing Accessibility in Professional Societies and Programs for Disabled Individuals

For disabled and chronically ill individuals, “extracurriculars” – or pursuit of activities that are additional or adjacent to job success beyond our position descriptions – can sometimes feel out of reach. Here, we encourage leadership of all organizations and institutions to fully engage with disabled individuals to understand some of the ways in which accommodations may fall short, and how we can overcome the issue of accessibility and its impacts on employee achievement and career trajectories.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2019

Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network

Soybean lipoxygenase (SLO) has served as a prototype for understanding the molecular origin of enzymatic rate accelerations. The double mutant (DM) L546A/L754A is considered a dramatic outlier, due to the unprecedented size and near temperature-independence of its primary kinetic isotope effect, low catalytic efficiency, and elevated enthalpy of activation. To uncover the physical basis of these features, we herein apply three structural probes: hydrogen–deuterium exchange mass spectrometry, room-temperature X-ray crystallography and EPR spectroscopy on four SLO variants (wild-type (WT) enzyme, DM, and the two parental single mutants, L546A and L754A). DM is found to incorporate features of each parent, with the perturbation at position 546 predominantly influencing thermally activated motions that connect the active site to a protein–solvent interface, while mutation at position 754 disrupts the ligand field and solvation near the cofactor iron. However, the expanded active site in DM leads to more active site water molecules and their associated hydrogen bond network, and the individual features from L546A and L754A alone cannot explain the aggregate kinetic properties for DM. Lastly, using recently published QM/MM-derived ground-state SLO-substrate complexes for WT and DM, together with the thorough structural analyses presented herein, we propose that the impairment of DM is the combined result of a repositioning of the reactive carbon of linoleic acid substrate with regard to both the iron cofactor and a catalytically linked dynamic region of protein.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Physical Education Teachers’ Representations of Their Training to Promote the Inclusion of Students with Disabilities

School inclusion is based on the need to adopt and implement a holistic view of education, training, and human development embodied in the idea of everyone, for everyone. In the context of Physical Education (PE), there are still several constraints to the realization of this universal desideratum. Among these, teacher training and qualification for the inclusion of students with Specific Health Needs (SHNs) stands out. That is, students with physical and mental health problems whose impact is significantly manifested in the learning process. Thus, the objective of this study was to identify the representations of PE teachers about their training to develop inclusive processes with students with SES. Participants in this study were 151 PE teachers from different regions and districts of Portugal (Algarve, Aveiro, Castelo Branco, Lisbon, Porto, and Viseu) who had 23.6 ± 8.1 years of teaching service. Teachers answered an online questionnaire, on the Google Forms platform, with open and closed questions about their education and training to develop inclusive processes in PE. The results indicate two significant dimensions: (1) initial training for teaching inclusive PE and (2) continuous training for inclusion. Regarding initial training, a large majority of the teachers under study, at the end of their initial training, did not have the essential skills to teach PE to students with SES. It was also identified that a large majority reported not having had any contact with students with SES throughout their training process for teaching. It was also recognized that this training was not adjusted to the development of intervention skills with students with SHN. Regarding continuous training, it was identified that attendance at this training increased their skills to teach PE to students with SHN. Workshops/actions/training courses are the main training models adopted. However, it is recognized that the training provided does not respond concretely to their training needs to intervene with students with SHN, since teachers essentially seek to improve intervention in the context of inclusive physical education. We conclude that teacher training for inclusion is not yet fully adjusted to the reality of the inclusive school paradigm. In this sense, in practical terms, the following are suggested: (1) the need for reinforcement in study plans with specific and long-term curricular units; (2) the introduction of real practice components in context; and (3) supervised pedagogical practice in diverse contexts.

Celestino, Tadeu (ORCID:0000000163087981)↗
DOE OSTI2022

UAE6 - Wind Tunnel Tests Data - UAE6 - Sequence E - Raw Data

Sequence E: Yaw Releases (P) This test sequence used a downwind, rigid turbine with a 3.4° cone angle. The wind speeds ranged from 7 m/s to 17 m/s. Initial yaw angles of ±90° were achieved. The blade tip pitch was 3°. The rotor rotated at 72 RPM. Blade and probe pressure measurements were collected. The teeter dampers were replaced with rigid links, and these two channels were flagged as not applicable by setting the measured values in the data file to –99999.99 Nm. The teeter link load cell was pre-tensioned to 40,000 N. The turbine was positioned at each specified yaw angle. A 30- second data set was collected with the yaw brake engaged. These points used a letter for the last digit beginning with A and proceeding through the alphabet as repeat points were needed. These points were plotted and compared to ascertain the functionality of the instrumentation. The files ending in numbers beginning with 0 and increasing with each repetition represent yaw release points. Once the fixed-position yaw test was complete, the yaw drive was engaged to hold the turbine. The yaw brake was released, and the yaw drive was disabled allowing the turbine to yaw freely. The yaw drive was disabled about 5 seconds into the campaign, and the turbine was allowed to yaw freely for the rest of the 30-second duration. When the yaw drive is disabled, no torque is applied to the motor, and the inertia and yawing force of the nacelle and rotor overcomes the friction and inertia of the yaw gear and motor. The yaw releases were repeated five times at each condition. Four additional campaigns were collected to determine the turbine’s natural yaw error by releasing the brake at 0° yaw error. These file names use the E designation, followed by two digits for wind speed, followed by XXXX, followed by the repetition digit.

17 WIND ENERGY↗
DOE OSTI2023

Community vulnerability is the key determinant of diverse energy burdens in the United States

Low-income households generally experience a high energy burden; however, the factors influencing energy burdens are beyond socio-economics. This study explores the relationships between the multidimensionality of community vulnerability factors and energy burden across multiple geospatial levels in the United States. Our study found the distribution of energy burden in 2020 showed a great deal of variety, ranging from a minimum of 2.93 % to a maximum of 30.45 % across 3142 counties. The results of non-spatial and spatial regressions showed that the vulnerability ranks of socioeconomic, household composition and disability, minority and language, household type and transportation, and COVID mortality rate are significant predictors of energy burdens at the national level. However, at the regional level, only socioeconomic, minority and language significantly influence energy burdens. Minority and language negatively impact energy burdens except for the South East-Central region. Additionally, our analyses highlight the need to consider community vulnerability indicators' spatial homogeneity and heterogeneity. At the national level, only the epidemiological factors index is a spatially homogeneous predictor; on the regional and state level, the spatially homogeneous predictors such as socioeconomic status, household composition and disability, and household type and transportation vary by region. Such a region-sensitive relationship between energy burden and the predictors indicates spatial heterogeneity. Here this study suggests policy recommendations through the lens of the multidimensionality of community vulnerability factors. Implementing flexible national energy policies while making particular energy assistance policies for the vulnerable population at the regional or state levels is essential.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OSTI2021

Investigating the Causes and Impacts of Convective Aggregation in a High Resolution Atmospheric GCM

Abstract A ∼50 km resolution atmospheric general circulation model (GCM) is used to investigate the impact of radiative interactions on spatial organization of convection, the model's mean state, and extreme precipitation events in the presence of realistic boundary conditions. Mechanism‐denial experiments are performed in which synoptic‐scale feedbacks between radiation and dynamics are suppressed by overwriting the model‐generated atmospheric radiative cooling rates with its monthly varying climatological values. When synoptic‐scale radiative interactions are disabled, the annual mean circulation and precipitation remain almost unchanged, however tropical convection becomes less aggregated, with an increase in cloud fraction and relative humidity in the free troposphere but a decrease in both variables in the boundary layer. Changes in cloud fraction and relative humidity in the boundary layer exhibit more sensitivity to the presence of radiative interactions than variations in the degree of aggregation. The less aggregated state is associated with a decrease in the frequency of extreme precipitation events, coincident with a decrease in the dynamical contribution to the magnitude of extreme precipitation. At regional scales, the spatial contrast in radiative cooling between dry and moist regions diminishes when radiative interactions are suppressed, reducing the upgradient transport of energy, degree of aggregation, and frequency of extreme precipitation events. However, the mean width of the tropical rain belt remains almost unaffected when radiative interactions are disabled. These results offer insights into how radiation‐circulation coupling affects the spatial organization of convection, distributions of clouds and humidity, and weather extremes.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2021

Cortical proteins may provide motor resilience in older adults

Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that provide motor resilience. We studied 1226 older decedents with annual motor testing, postmortem brain pathologies and quantified 226 proteotypic peptides in prefrontal cortex. Twenty peptides remained associated with motor decline in models controlling for ten brain pathologies (FDR < 0.05). Higher levels of nine peptides and lower levels of eleven peptides were related to slower decline. A higher motor resilience protein score based on averaging the levels of all 20 peptides was related to slower motor decline, less severe parkinsonism and lower odds of mobility disability before death. Cortical proteins may provide motor resilience. Targeting these proteins in further drug discovery may yield novel interventions to maintain motor function in old age.

Buchman, Aron↗
DOE OSTI2025

Mid-latitude clouds contribute to Arctic amplification via interactions with other climate feedbacks

Abstract Traditional feedback analyses, which assume that individual climate feedback mechanisms act independently and add linearly, suggest that clouds do not contribute to Arctic amplification. However, feedback locking experiments, in which the cloud feedback is disabled, suggest that clouds, particularly outside of the Arctic, do contribute to Arctic amplification. Here, we reconcile these two perspectives by introducing a framework that quantifies the interactions between radiative feedbacks, radiative forcing, ocean heat uptake, and atmospheric heat transport. We show that including the cloud feedback in a comprehensive climate model can result in Arctic amplification because of interactions with other radiative feedbacks. The surface temperature change associated with including the cloud feedback is amplified in the Arctic by the surface-albedo, Planck, and lapse-rate feedbacks. A moist energy balance model with a locked cloud feedback exhibits similar behavior as the comprehensive climate model with a disabled cloud feedback and further indicates that the mid-latitude cloud feedback contributes to Arctic amplification via feedback interactions. Feedback locking in the moist energy balance model also suggests that the mid-latitude cloud feedback contributes substantially to the intermodel spread in Arctic amplification across comprehensive climate models. These results imply that constraining the mid-latitude cloud feedback will greatly reduce the intermodel spread in Arctic amplification. Furthermore, these results highlight a previously unrecognized non-local pathway for Arctic amplification.

58 GEOSCIENCES↗
DOE OSTI2025

Investigating the role of adipose tissue in mobility and aging: design and methods of the Adipose Tissue ancillary to the Study of Muscle, Mobility, and Aging (SOMMA-AT)

Background Age-related changes in adipose tissue affect chronic medical diseases and mobility disability but mechanism remains poorly understood. The goal of this study is to define methods for phenotyping unique characteristics of adipose tissue from older adults. Methods Older adults enrolled in study of muscle, mobility, and aging selected for the adipose tissue ancillary (SOMMA-AT; N = 210, 52.38% women, 76.12 ± 4.37 years) were assessed for regional adiposity by whole-body magnetic resonance (AMRA) and underwent a needle-aspiration biopsy of abdominal subcutaneous adipose tissue (ASAT). ASAT biopsies were flash frozen, fixed, or processed for downstream applications and deposited at the biorepository. Biopsy yields, qualitative features, adipocyte sizes, and concentration of adipokines secreted in ASAT explant conditioned media were measured. Inter-measure Spearman correlations were determined. Results Regional, but not total, adiposity differed by sex: women had greater ASAT mass (8.20 ± 2.73 kg, p < .001) and biopsy yield (3.44 ± 1.81 g, p < .001) than men (ASAT = 5.95 ± 2.30 kg, biopsy = 2.30 ± 1.40 g). ASAT mass correlated with leptin (r = 0.54, p < .001) and not resistin (p = .248) and adiponectin (p = .353). Adipocyte area correlated with ASAT mass (r = 0.34, p < .001), BMI (r = 0.33, p < .001), adiponectin (r = −0.22, p = .005) and leptin (r = 0.18, p = .024) but not with resistin (p = .490). Conclusion In addition to the detailed ASAT biopsy processing in this report, we found that adipocyte area correlated with ASAT mass, and both measures related to some key adipokines in the explant conditioned media. In conclusion, these results, methods, and biological repositories underscore the potential of this unique cohort to impact the understanding of aging adipose biology on disease, disability, and other aging tissues.

60 APPLIED LIFE SCIENCES↗