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At least 19 records

Functional Imaging of Human Vestibular Cortex Activity Elicited by Skull Tap and Auditory Tone Burst

The aim of the current study was to characterize the brain activation in response to two modes of vestibular stimulation: skull tap and auditory tone burst. The auditory tone burst has been used in previous studies to elicit saccular Vestibular Evoked Myogenic Potentials (VEMP) (Colebatch & Halmagyi 1992; Colebatch et al. 1994). Some researchers have reported that airconducted skull tap elicits both saccular and utricle VEMPs, while being faster and less irritating for the subjects (Curthoys et al. 2009, Wackym et al., 2012). However, it is not clear whether the skull tap and auditory tone burst elicit the same pattern of cortical activity. Both forms of stimulation target the otolith response, which provides a measurement of vestibular function independent from semicircular canals. This is of high importance for studying the vestibular disorders related to otolith deficits. Previous imaging studies have documented activity in the anterior and posterior insula, superior temporal gyrus, inferior parietal lobule, pre and post central gyri, inferior frontal gyrus, and the anterior cingulate cortex in response to different modes of vestibular stimulation (Bottini et al., 1994; Dieterich et al., 2003; Emri et al., 2003; Schlindwein et al., 2008; Janzen et al., 2008). Here we hypothesized that the skull tap elicits the similar pattern of cortical activity as the auditory tone burst. Subjects put on a set of MR compatible skull tappers and headphones inside the 3T GE scanner, while lying in supine position, with eyes closed. All subjects received both forms of the stimulation, however, the order of stimulation with auditory tone burst and air-conducted skull tap was counterbalanced across subjects. Pneumatically powered skull tappers were placed bilaterally on the cheekbones. The vibration of the cheekbone was transmitted to the vestibular cortex, resulting in vestibular response (Halmagyi et al., 1995). Auditory tone bursts were also delivered for comparison. To validate our stimulation method, we measured the ocular VEMP outside of the scanner. This measurement showed that both skull tap and auditory tone burst elicited vestibular evoked activation, indicated by eye muscle response. Our preliminary analyses showed that the skull tap elicited activation in medial frontal gyrus, superior temporal gyrus, postcentral gyrus, transverse temporal gyrus, anterior cingulate, and putamen. The auditory tone bursts elicited activation in medial frontal gyrus, superior temporal gyrus, superior frontal gyrus, precentral gyrus, inferior and superior parietal lobules. In line with our hypothesis, skull taps elicited a pattern of cortical activity closely similar to one elicited by auditory tone bursts. Further analysis will determine the extent to which the skull taps can replace the auditory tone stimulation in clinical and basic science vestibular assessments.

Noohi, Fatemeh↗

Functional Imaging of Human Vestibular Cortex Activity Elicited by Skull Tap and Auditory Tone Burst

The current study characterizes brain activation in response to two modes of vestibular stimulation: skull tap and auditory tone burst. The auditory tone burst has been used in previous studies to elicit either the vestibulo-spinal reflex (saccular-mediated colic Vestibular Evoked Myogenic Potentials (cVEMP)), or the ocular muscle response (utricle-mediated ocular VEMP (oVEMP)). Some researchers have reported that air-conducted skull tap elicits both saccular and utricle-mediated VEMPs, while being faster and less irritating for the subjects. However, it is not clear whether the skull tap and auditory tone burst elicit the same pattern of cortical activity. Both forms of stimulation target the otolith response, which provides a measurement of vestibular function independent from semicircular canals. This is of high importance for studying otolith-specific deficits, including gait and balance problems that astronauts experience upon returning to earth. Previous imaging studies have documented activity in the anterior and posterior insula, superior temporal gyrus, inferior parietal lobule, inferior frontal gyrus, and the anterior cingulate cortex in response to different modes of vestibular stimulation. Here we hypothesized that skull taps elicit similar patterns of cortical activity as the auditory tone bursts, and previous vestibular imaging studies. Subjects wore bilateral MR compatible skull tappers and headphones inside the 3T GE scanner, while lying in the supine position, with eyes closed. Subjects received both forms of the stimulation in a counterbalanced fashion. Pneumatically powered skull tappers were placed bilaterally on the cheekbones. The vibration of the cheekbone was transmitted to the vestibular system, resulting in the vestibular cortical response. Auditory tone bursts were also delivered for comparison. To validate our stimulation method, we measured the ocular VEMP outside of the scanner. This measurement showed that both skull tap and auditory tone burst elicited vestibular evoked myogenic potentials, indicated by eye muscle responses. We further assessed subjects' postural control and its correlation with vestibular cortical activity. Our results provide the first evidence of using skull taps to elicit vestibular activity inside the MRI scanner. By conducting conjunction analyses we showed that skull taps elicit the same activation pattern as auditory tone bursts (superior temporal gyrus), and both modes of stimulation activate previously identified vestibular cortical regions. Additionally, we found that skull taps elicit more robust vestibular activity compared to auditory tone bursts, with less reported aversive effects. This further supports that the skull tap could replace auditory tone burst stimulation in clinical interventions and basic science research. Moreover, we observed that greater vestibular activation is associated with better balance control. We showed that not only the quality of balance (indicated by the amount of body sway) but also the ability to maintain balance for a longer time (indicated by the balance time) was associated with individuals' vestibular cortical excitability. Our findings support an association between vestibular cortical activity and individual differences in balance. In sum, we found that the skull tap stimulation results in activation of canonical vestibular cortex, suggesting an equally valid, but more tolerable stimulation method compared to auditory tone bursts. This is of high importance in longitudinal vestibular assessments, in which minimizing aversive effects may contribute to higher protocol adherence.

Noohi, F.↗

Subband/transform functions for image processing

Functions for image data processing written for use with the MATLAB(TM) software package are presented. These functions provide the capability to transform image data with block transformations (such as the Walsh Hadamard) and to produce spatial frequency subbands of the transformed data. Block transforms are equivalent to simple subband systems. The transform coefficients are reordered using a simple permutation to give subbands. The low frequency subband is a low resolution version of the original image, while the higher frequency subbands contain edge information. The transform functions can be cascaded to provide further decomposition into more subbands. If the cascade is applied to all four of the first stage subbands (in the case of a four band decomposition), then a uniform structure of sixteen bands is obtained. If the cascade is applied only to the low frequency subband, an octave structure of seven bands results. Functions for the inverse transforms are also given. These functions can be used for image data compression systems. The transforms do not in themselves produce data compression, but prepare the data for quantization and compression. Sample quantization functions for subbands are also given. A typical compression approach is to subband the image data, quantize it, then use statistical coding (e.g., run-length coding followed by Huffman coding) for compression. Contour plots of image data and subbanded data are shown.

Glover, Daniel↗

Assessing Vegetation Function with Imaging Spectroscopy

Healthy vegetation function supports diverse biological communities and ecosystem processes, and provides crops, forest products, forage, and countless other benefits. Vegetation function can be assessed by examining dynamic processes and by evaluating plant traits, which themselves are dynamic. Using both trait-based and process-based approaches, spectroscopy can assess vegetation function at multiple scales using a variety of sensors and platforms ranging from proximal to airborne and satellite measurements. Since spectroscopic data are defined by the instruments and platforms available, along with their corresponding spatial, temporal and spectral scales, and since these scales may not always match those of the function of interest, consideration of scale is a necessary focus. For a full understanding of vegetation processes, combined (multi-scale) sampling methodsusing empirical and theoretical approaches are required, along with improved informatics.

Gamon, J. A.↗

Functional brain imaging of a complex navigation task following one night of total sleep deprivation

Study Objectives: To assess the cerebral effects associated with sleep deprivation in a simulation of a complex, real-world, high-risk task. Design and Interventions: A two-week, repeated measures, cross-over experimental protocol, with counterbalanced orders of normal sleep (NS) and total sleep deprivation (TSD). Setting: Each subject underwent functional magnetic resonance imaging (fMRI) while performing a dual-joystick, 3D sensorimotor navigation task (simulated orbital docking). Scanning was performed twice per subject, once following a night of normal sleep (NS), and once following a single night of total sleep deprivation (TSD). Five runs (eight 24s docking trials each) were performed during each scanning session. Participants: Six healthy, young, right-handed volunteers (2 women; mean age 20) participated. Measurements and Results: Behavioral performance on multiple measures was comparable in the two sleep conditions. Neuroimaging results within sleep conditions revealed similar locations of peak activity for NS and TSD, including left sensorimotor cortex, left precuneus (BA 7), and right visual areas (BA 18/19). However, cerebral activation following TSD was substantially larger and exhibited higher amplitude modulations from baseline. When directly comparing NS and TSD, most regions exhibited TSD>NS activity, including multiple prefrontal cortical areas (BA 8/9,44/45,47), lateral parieto-occipital areas (BA 19/39, 40), superior temporal cortex (BA 22), and bilateral thalamus and amygdala. Only left parietal cortex (BA 7) demonstrated NS>TSD activity. Conclusions: The large network of cerebral differences between the two conditions, even with comparable behavioral performance, suggests the possibility of detecting TSD-induced stress via functional brain imaging techniques on complex tasks before stress-induced failures.

Strangman, Gary↗

Point spread functions in imaging a Lambert surface from zenith through a thin scattering layer

Analytical techniques for good spatial resolution in remotely sensed images of renewable resources, such as crops, are discussed for satellite multispectral radiometry. A model is developed for an optically and geometrically thin scattering layer to account for atmospheric scattering above the object pixel of fluxes reflected from adjacent areas. The cross radiance is explored as a spread function of a point source and as a spurious component of measured radiance, and an integration over large source areas is formulated. The Henyey-Greenstein (HG) phase function is defined for an integral over a sphere and point-spread functions are presented for HG scattering. Cross radiance limited spatial resolution is also determined for the HG phase function and boundaries between reflecting and black half-planes are considered in terms of the cross radiance.

Otterman, J.↗

Texture functions in image analysis: A computationally efficient solution

A computationally efficient means for calculating texture measurements from digital images by use of the co-occurrence technique is presented. The calculation of the statistical descriptors of image texture and a solution that circumvents the need for calculating and storing a co-occurrence matrix are discussed. The results show that existing efficient algorithms for calculating sums, sums of squares, and cross products can be used to compute complex co-occurrence relationships directly from the digital image input.

Cox, S. C.↗

Subband/Transform MATLAB Functions For Processing Images

SUBTRANS software is package of routines implementing image-data-processing functions for use with MATLAB*(TM) software. Provides capability to transform image data with block transforms and to produce spatial-frequency subbands of transformed data. Functions cascaded to provide further decomposition into more subbands. Also used in image-data-compression systems. For example, transforms used to prepare data for lossy compression. Written for use in MATLAB mathematical-analysis environment.

Glover, D.↗

Multifunction Imaging and Spectroscopic Instrument

A proposed optoelectronic instrument would perform several different spectroscopic and imaging functions that, heretofore, have been performed by separate instruments. The functions would be reflectance, fluorescence, and Raman spectroscopies; variable-color confocal imaging at two different resolutions; and wide-field color imaging. The instrument was conceived for use in examination of minerals on remote planets. It could also be used on Earth to characterize material specimens. The conceptual design of the instrument emphasizes compactness and economy, to be achieved largely through sharing of components among subsystems that perform different imaging and spectrometric functions. The input optics for the various functions would be mounted in a single optical head. With the exception of a targeting lens, the input optics would all be aimed at the same spot on a specimen, thereby both (1) eliminating the need to reposition the specimen to perform different imaging and/or spectroscopic observations and (2) ensuring that data from such observations can be correlated with respect to known positions on the specimen. The figure schematically depicts the principal components and subsystems of the instrument. The targeting lens would collect light into a multimode optical fiber, which would guide the light through a fiber-selection switch to a reflection/ fluorescence spectrometer. The switch would have four positions, enabling selection of spectrometer input from the targeting lens, from either of one or two multimode optical fibers coming from a reflectance/fluorescence- microspectrometer optical head, or from a dark calibration position (no fiber). The switch would be the only moving part within the instrument.

Mouroulis, Pantazis↗

Function Generator for Image Processor

Basic elements of function generator are memory chips and interpolator chip, which incorporates multipliers and adders. Memory includes CMOS static random-access devices. 120 ns cycle time of devices allows real-time processing of image data.

Gennery, D. B.↗

A technique for increasing the accuracy of the numerical inversion of the Laplace transform with applications

A technique is introduced which extends the range of useful approximation of numerical inversion techniques to many cycles of an oscillatory function without requiring either the evaluation of the image function for many values of s or the computation of higher-order terms. The technique consists in reducing a given initial value problem defined over some interval into a sequence of initial value problems defined over a set of subintervals. Several numerical examples demonstrate the utility of the method.

Berger, B. S.↗

Spectrometer integrated with a facsimile camera

This invention integrates a spectrometer capability with the basic imagery function of facsimile cameras without significantly increasing mechanical or optical complexity, or interfering with the imaging function. The invention consists of a group of photodetectors arranged in a linear array in the focal plane of the facsimile camera with a separate narrow band interference filter centered over each photodetector. The interference filter photodetector array is on a line in the focal plane of the facsimile camera along the direction of image motion due to the rotation of the facsimile camera's vertical mirror. As the image of the picture element of interest travels down the interference filter photodetector array, the photodetector outputs are synchronously selected and sampled to provide spectral information on the single picture element.

Burcher, E. E.↗

Multimodal Neurodiagnostic Tool for Exploration Missions

Linea Research Corporation has developed a neurodiagnostic tool that detects behavioral stress markers for astronauts on long-duration space missions. Lightweight and compact, the device is unobtrusive and requires minimal time and effort for the crew to use. The system provides a real-time functional imaging of cortical activity during normal activities. In Phase I of the project, Linea Research successfully monitored cortical activity using multiparameter sensor modules. Using electroencephalography (EEG) and functional near-infrared spectroscopy signals, the company obtained photoplethysmography and electrooculography signals to compute the heart rate and frequency of eye movement. The company also demonstrated the functionality of an algorithm that automatically classifies the varying degrees of cognitive loading based on physiological parameters. In Phase II, Linea Research developed the flight-capable neurodiagnostic device. Worn unobtrusively on the head, the device detects and classifies neurophysiological markers associated with decrements in behavior state and cognition. An automated algorithm identifies key decrements and provides meaningful and actionable feedback to the crew and ground-based medical staff.

Lee, Yong Jin↗

Hubble Space Telescope: Optical telescope assembly handbook. Version 1.0

The Hubble Space Telescope is described along with how its design affects the images produced at the Science Instruments. An overview is presented of the hardware. Details are presented of the focal plane, throughput of the telescope, and the point spread function (image of an unresolved point source). Some detailed simulations are available of this, which might be useful to observers in planning their observations and in reducing their data.

Burrows, Chris↗