Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site
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99 GENERAL AND MISCELLANEOUS↗
SEARCH · Search NASA
Results for “highlights”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Display format, highlight validity, and highlight method: Their effects on search performance
Display format and highlight validity were shown to affect visual display search performance; however, these studies were conducted on small, artificial displays of alphanumeric stimuli. A study manipulating these variables was conducted using realistic, complex Space Shuttle information displays. A 2x2x3 within-subjects analysis of variance found that search times were faster for items in reformatted displays than for current displays. Responses to valid applications of highlight were significantly faster than responses to non or invalidly highlighted applications. The significant format by highlight validity interaction showed that there was little difference in response time to both current and reformatted displays when the highlight validity was applied; however, under the non or invalid highlight conditions, search times were faster with reformatted displays. A separate within-subject analysis of variance of display format, highlight validity, and several highlight methods did not reveal a main effect of highlight method. In addition, observed display search times were compared to search time predicted by Tullis' Display Analysis Program. Benefits of highlighting and reformatting displays to enhance search and the necessity to consider highlight validity and format characteristics in tandem for predicting search performance are discussed.
Donner, Kimberly A.↗
DCS - A high flux beamline for time resolved dynamic compression science – Design highlights
The Dynamic Compression Sector (DCS) beamline, a national user facility for time resolved dynamic compression science supported by the National Nuclear Security Administration (NNSA) of the Department of Energy (DOE), has recently completed construction and is being commissioned at Sector 35 of the Advanced Photon Source (APS) at Argonne National Laboratory (ANL). The beamline consists of a First Optics Enclosure (FOE) and four experimental enclosures. A Kirkpatrick–Baez focusing mirror system with 2.2 mrad incident angles in the FOE delivers pink beam to the experimental stations. A refocusing Kirkpatrick–Baez mirror system is situated in each of the two most downstream enclosures. Experiments can be conducted in either white, monochromatic, pink or monochromatic-reflected beam mode in any of the experimental stations by changing the position of two interlocked components in the FOE. The beamline Radiation Safety System (RSS) components have been designed to handle the continuous beam provided by two in-line revolver undulators with periods of 27 and 30 mm, at closed gap, 150 mA beam current, and passing through a power limiting aperture of 1.5 x 1.0 mm{sup 2}. A novel pink beam end station stop [1] is used to stop the continuous and focused pink beam which can achieve a peak heat flux of 105 kW/mm{sup 2}. A new millisecond shutter design [2] is used to deliver a quick pulse of beam to the sample, synchronized with the dynamic event, the microsecond shutter, and the storage ring clock.
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
Highlighting the Impact of Yaw Control by Parsing Atmospheric Conditions Based on Total Variation: Preprint
Identification of atmospheric conditions within a multivariate atmospheric dataset is a necessary step in the validation of wind plant control strategies. Most often, operating conditions are characterized in terms of aggregated observations and assume that the atmosphere is 'quasi-steady'. Aggregation of observations without regard to covariance between time series discounts the dynamical nature of the atmosphere and is not sufficiently representative of wind plant operating conditions. Identification and characterization of continuous time periods with atmospheric conditions that have a high value for analysis or simulation sets the stage for more advanced model validation and the development of real-time control and operation strategies. Controlling observational data for statistical stationarity highlights significant enhancements to the power production of waked turbines under wake steering wind plant control. Considering the combined energy ratio of the turbine to which yaw offsets are prescribed as well as the waked turbine show only moderate improvements when filtering for total validation. The same quality control that highlights wake steering also serves to underpin the off-nominal operation of the controlled turbine.
17 WIND ENERGY↗
Target highlights in CASP14: Analysis of models by structure providers
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Alexander, Leila T.↗
Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states
MTAN (5'-methylthioadenosine nucleosidase) catalyzes the hydrolysis of the N-ribosidic bond of a variety of adenosine-containing metabolites. The Helicobacter pylori MTAN (HpMTAN) hydrolyzes 6-amino-6-deoxyfutalosine in the second step of the alternative menaquinone biosynthetic pathway. Substrate binding of the adenine moiety is mediated almost exclusively by hydrogen bonds, and the proposed catalytic mechanism requires multiple proton-transfer events. Of particular interest is the protonation state of residue D198, which possesses a pKa above 8 and functions as a general acid to initiate the enzymatic reaction. In this study we present three corefined neutron/X-ray crystal structures of wild-type HpMTAN cocrystallized with S-adenosylhomocysteine (SAH), Formycin A (FMA), and (3R,4S)-4-(4-Chlorophenylthiomethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine (p-ClPh-Thio-DADMe-ImmA) as well as one neutron/X-ray crystal structure of an inactive variant (HpMTAN-D198N) cocrystallized with SAH. These results support a mechanism of D198 pKa elevation through the unexpected sharing of a proton with atom N7 of the adenine moiety possessing unconventional hydrogen-bond geometry. Additionally, the neutron structures also highlight active site features that promote the stabilization of the transition state and slight variations in these interactions that result in 100-fold difference in binding affinities between the DADMe-ImmA and ImmA analogs.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
STAR Highlights
In this overview talk, I have represented STAR to highlight the results of 19 parallels talks and 38 posters at this Quark Matter Conference. Overall, the contents have 8 major categories: 1. experimental measurements related to the BreitWheeler process and vacuum birefringence; 2. probes of initial states of heavy-ion collisions (parton distribution function and azimuthal correlations in small systems); 3. constraints on temperature-dependent viscosity (η/s(T)) with multiple flow harmonics and rapidity correlations; 4. hard probes using jet structures and heavy flavors; 5. exploration of the origin of global polarization and vorticity; 6. chiral and thermal properties of the QGP; 7. Beam Energy Scan (BES) and the critical point search; 8. upgrades and summary.
73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
State of practice and emerging application of analytical techniques of nuclear forensic analysis: highlights from the 4th Collaborative Materials Exercise of the Nuclear Forensics International Technical Working Group (ITWG)
Founded in 1996 upon the initiative of the “Group of 8” governments (G8), the Nuclear Forensics International Technical Working Group (ITWG) is an ad hoc organization of official nuclear forensics practitioners (scientists, law enforcement, and regulators) that can be called upon to provide technical assistance to the global community in the event of a seizure of nuclear or radiological materials. The ITWG is supported by and is affiliated with roughly 40 countries and international partner organizations including the International Atomic Energy Agency (IAEA), EURATOM, INTERPOL, EUROPOL, and the United Nations Interregional Crime and Justice Research Institute (UNICRI). Besides providing a network of nuclear forensics laboratories that are able to assist law enforcement during a nuclear smuggling event, the ITWG is also committed to the advancement of the science of nuclear forensic analysis, largely through participation in periodic table top and Collaborative Materials Exercises (CMXs). Exercise scenarios use “real world” samples with realistic forensics investigation time constraints and reporting requirements. These exercises are designed to promote best practices in the field and test, evaluate, and improve new technical capabilities, methods and techniques in order to advance the science of nuclear forensics. The ITWG recently completed its fourth CMX in the 20 year history of the organization. This was also the largest materials exercise to date, with participating laboratories from 16 countries or organizations. Three samples of low enriched uranium were shipped to these laboratories as part of an illicit trafficking scenario, for which each laboratory was asked to conduct nuclear forensic analyses in support of a fictitious criminal investigation. An objective review of the State Of Practice and Art of international nuclear forensic analysis based upon the outcome of this most recent exercise is provided.
ITWG CMX-4↗
Searching for the nano effect in Cu-HCF (II) particles to improve Cs sorption efficiency: Highlighting the use of intrinsic magnetism
Not provided.
nuclear, materials and chemistry by design, synthe↗
Highlights from the ATLAS experiment
This report provides an overview of the new results obtained by the ATLAS Collaboration at the LHC, which were presented at the Quark Matter 2018 conference. Furthermore these measurements were covered in 12 parallel talks, one flash talk and 11 posters. In this document, a discussion of results is grouped into four areas: electromagnetic interactions, jet quenching, quarkonia and heavy-flavour production, and collectivity in small and larger systems. Measurements from the xenon-xenon collisions based on a short run collected in October 2017 are reported for the first time.
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
Highlights from the STAR experiment
The STAR experiment at the Relativistic Heavy Ion Collider (RHIC) studies properties and phase transitions of nuclear matter in various nucleus-nucleus collisions at center-of-mass energies per nucleon collision $\sqrt{s}$$_ {NN}$ = 7.07-200 GeV. With a fixed target made of gold foils installed inside the beam pipe, STAR also starts to explore high baryon density regime ($\mu_B$ ≈ 420-720 MeV) at $\sqrt{s}$$_ {NN}$ = 3.0-7.7 GeV. A few selected results reported by the STAR collaboration at the Quark Matter 2018 (QM2018) conference are described in these proceedings.
73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
Impacts of oxo interactions within actinyl metal organic materials: highlight on thermal expansion behaviour
Physical properties of actinyl materials are influenced by the presence of oxo functional groups. Herein, we report large thermal expansion coefficients for a uranyl metal organic nanotube that switch from positive to negative upon dehydration. Finally, different behaviour is observed in the neptunyl system due to variations in the oxo interactions.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
The EIC accelerator: design highlights and project status
The design of the electron-ion collider (EIC) at Brookhaven National Laboratory is well underway, aiming at a peak electron-proton luminosity of 10e+34 cm^-1·sec^-1. This high luminosity, the wide center-of-mass energy range from 29 to 141 GeV (e-p) and the high level of polarization require innovative solutions to maximize the performance of the machine, which makes the EIC one of the most challenging accelerator projects to date. The complexity of the EIC will be discussed, and the project status and plans will be presented.
43 PARTICLE ACCELERATORS↗
Aeronautics and Space Highlights [1979 Highlights]
The videotape includes footage of the following: Voyagers to Jupiter, Pioneer to Saturn, High Energy Astronomy Observatory, space telescope, space shuttle, astronauts Young and Crippen, 10th anniversary of Apollo 11, Skylab reentry, Landsat, satellite freeze warning, Fire Fighting Module, SAGE, wind generators, Solar Energy Project, electric car research, XV-15, HiMAT, and crash worthiness tests.
Source record↗
Display format and highlight validity effects on search performance using complex visual displays
Display format and highlight validity were shown to affect visual display search performance; however, these studies were conducted on small, artificial displays of alphanumeric stimuli. A study manipulating these variables was conducted using realistic, complex Space Shuttle information displays. A 2x2x3 within-subjects analysis of variance found that search times were faster for items in reformatted displays than for current displays. The significant format by highlight validity interaction showed that there was little difference in response time to both current and reformatted displays when the highlight validity was applied; however, under the non or invalid highlight conditions, search times were faster with reformatted displays. Benefits of highlighting and reformatting displays to enhance search and the necessity to consider highlight validity and format characteristics in tandem for predicting search performance are discussed.
Donner, Kimberly A.↗
STS-102 Mission Highlight Resource Tape, Tape 2 of 4
A continuation of 'STS-102 Mission Highlight Resource Tape, Part 1 of 2, Tape 1 of 2' (internal ID 2001096942), this video shows highlights from flight day five of STS-102, including the deployment of the Space Shuttle's Robotic Arm and the opening of the hatch between the Unity Module and Leonard Multipurpose Logistics Module by Expedition 1 Commander Bill Shepherd. The activities of flight days 6-14 can be seen on 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 1 of 2' (internal ID 2001096943) and 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 2 of 2' (internal ID 2001096940).
Source record↗
STS 110 Mission Highlights Resource Tape
A continuation of 'STS 110 Mission Highlights Resource Tape'. This video, Part 3 of 4, shows footage from flight days 6 through 9 of STS-110. The spacecrew includes Michael J. Bloomfield, Commander Stephen N. Frick, Pilot; Jerry L. Ross, Mission Specialist; Steven L. Smith, Mission Specialist; Ellen Ochoa, Mission Specialist; Lee M.E. Morin, Mission Specialist; Rex J. Walheim, Mission Specialist. On flight day 6, Ross and Morin conduct an EVA (extravehicular activity) to secure a tripod like strut to the S0 Truss of the International Space Station (ISS). They also move the drag link and keel pins from one face of the Truss to the other to free the rail on the truss for a railcar to move. Smith installs a camera onto the CANADARM robotic arm on flight day 7, and on flight day 8 the restraints are removed from the railcar connected to the S0 Truss in preparation for checkout. The checkout of the railcar is shown, including its inaugural run. Ross and Morin conduct another EVA on flight day 9 to complete the outfitting of the S0 Truss Structure. Notable footage includes views of Ross and Morin at work from the helmet-mounted camera on Ross' EVA suit, including close-ups of the pistol grip tool, CANADARM 2 onboard the ISS lit at sunrise, a 'diamond ring' effect formed by the Sun between the Earth's limb and the ISS, a brief shot of the Yucatan peninsula, and a end-to-end pan down the length of the ISS. The activities from other flights days can be seen on "STS 110 Mission Highlights Resource Tape" Part 1 of 4 (internal ID 2002137575), "STS 110 Mission Highlights Resource Tape" Part 2 of 4 (internal ID 2002137573), and "STS 110 Mission Highlights Resource Tape" Part 4 of 4 (internal ID 2002137517).
Source record↗