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NASA NTRS1993

Regional cutaneous microvascular flow responses during gravitational and LBNP stresses

Due to the regional variability of local hydrostatic pressures, microvascular flow responses to gravitational stress probably vary along the length of the body. Although these differences in local autoregulation have been observed previously during whole-body tilting, they have not been investigated during application of artificial gravitational stresses, such as lower body negative pressure or high gravity centrifugation. Although these stresses can create equivalent G-levels at the feet, they result in distinct distributions of vascular transmural pressure along the length of the body, and should consequently elicit different magnitudes and distributions of microvascular response. In the present study, the effects of whole-body tilting and lower body negative pressure on the level and distribution of microvascular flows within skin along the length of the body were compared.

Breit, Gregory A.↗

NASA NTRS1982

Isostatic geoid anomalies on a sphere

Long-wavelength geoid anomalies due to lateral variations in the density or thickness of a thin layer in local isostatic equilibrium on the surface of a sphere depend sensitively on the assumed state of stress within the layer. A number of common intuitive definitions of local isostasy generally believed to be essentially identical are associated with quite different states of isostatic stress, and the corresponding theoretical geoid anomalies can vary by more than a factor of 2. This sensitivity of the theoretical anomaly to the exact definition of local isostasy constitutes an obstacle to any proposed program of interpreting or exploiting observed global isostatic geoid anomalies such as those associated with the aging of the oceanic lithosphere.

Dahlen, F. A.↗

NASA NTRS1994

A dynamic localization model with stochastic backscatter

The modeling of subgrid scales in large-eddy simulation (LES) has been rationalized by the introduction of the dynamic localization procedure. This method allows one to compute rather than prescribe the unknown coefficients in the subgrid-scale model. Formally, the LES equations are supposed to be obtained by applying to the Navier-Stokes equations a 'grid filter' operation. Though the subgrid stress itself is unknown, an identity between subgrid stresses generated by different filters has been derived. Although preliminary tests of the Dynamic Localization Model (DLM) with k-equation have been satisfactory, the use of a negative eddy viscosity to describe backscatter is probably a crude representation of the physics of reverse transfer of energy. Indeed, the model is fully deterministic. Knowing the filtered velocity field and the subgrid-scale energy, the subgrid stress is automatically determined. We know that the LES equations cannot be fully deterministic since the small scales are not resolved. This stems from an important distinction between equilibrium hydrodynamics and turbulence. In equilibrium hydrodynamics, the molecular motions are also not resolved. However, there is a clear separation of scale between these unresolved motions and the relevant hydrodynamic scales. The result of molecular motions can then be separated into an average effect (the molecular viscosity) and some fluctuations. Due to the large number of molecules present in a box with size of the order of the hydrodynamic scale, the ratio between fluctuations and the average effect should be very small (as a result of the 'law of large numbers'). For that reason, the hydrodynamic balance equations are usually purely deterministic. In turbulence, however, there is no clear separation of scale between small and large eddies. In that case, the fluctuations around a deterministic eddy viscosity term could be significant. An eddy noise would then appear through a stochastic term in the subgrid-scale model and could be the source of backscatter.

Carati, Daniele↗

NASA NTRS1982

The 3-D inelastic analysis methods for hot section components: Brief description

Advanced 3-D inelastic structural/stress analysis methods and solution strategies for more accurate yet more cost-effective analysis of components subjected to severe thermal gradients and loads in the presence of mechanical loads, with steep stress and strain gradients are being developed. Anisotropy, time and temperature dependent plasticity and creep effects are also addressed. The approach is to develop four different theories, one linear and three higher order theories (polynomial function, special function, general function). The theories are progressively more complex from linear to general function in order to provide streamlined analysis capability with increasing accuracy for each hot section component and for different parts of the same component according to the severity of the local stress, strain and temperature gradients associated with hot spots, cooling holes and surface coating cracks. To further enhance the computational effectiveness, the higher order theories will have embedded singularities (cooling passages, for example) in the generic modeling region. Each of the four theories consists of three formulation models derivable from independent theoretical formulations. These formulation models are based on: (1) mechanics of materials; (2) special finite elements; and (3) an advanced formulation to be recommended by the contractor.

Chamis, C. C.↗

NASA NTRS2011

Negative Stress Margins - Are They Real?

Advances in modeling and simulation, new finite element software, modeling engines and powerful computers are providing opportunities to interrogate designs in a very different manner and in a more detailed approach than ever before. Margins of safety are also often evaluated using local stresses for various design concepts and design parameters quickly once analysis models are defined and developed. This paper suggests that not all the negative margins of safety evaluated are real. The structural areas where negative margins are frequently encountered are often near stress concentrations, point loads and load discontinuities, near locations of stress singularities, in areas having large gradients but with insufficient mesh density, in areas with modeling issues and modeling errors, and in areas with connections and interfaces, in two-dimensional (2D) and three-dimensional (3D) transitions, bolts and bolt modeling, and boundary conditions. Now, more than ever, structural analysts need to examine and interrogate their analysis results and perform basic sanity checks to determine if these negative margins are real.

Raju, Ivatury S.↗

NASA NTRS2011

Negative stress margins – are they real?

Raju, Ivatury S.↗

NASA NTRS2010

Comparison of Damage Models for Predicting the Non-Linear Response of Laminates Under Matrix Dominated Loading Conditions

Five models for matrix damage in fiber reinforced laminates are evaluated for matrix-dominated loading conditions under plane stress and are compared both qualitatively and quantitatively. The emphasis of this study is on a comparison of the response of embedded plies subjected to a homogeneous stress state. Three of the models are specifically designed for modeling the non-linear response due to distributed matrix cracking under homogeneous loading, and also account for non-linear (shear) behavior prior to the onset of cracking. The remaining two models are localized damage models intended for predicting local failure at stress concentrations. The modeling approaches of distributed vs. localized cracking as well as the different formulations of damage initiation and damage progression are compared and discussed.

Schuecker, Clara↗

NASA NTRS1994

Peripheral Microvascular Responses to Whole-Body Tilting, G(z) Centrifugation, and Lower Body Negative Pressure Stresses in Humans

The response of the cutaneous microcirculation to orthostatic stress varies along the length of the body due to the interaction of central controls with regional responses to local blood pressure. We hypothesize that artificial orthostatic stresses such as Gz centrifugation and LBNP differ from whole-body tilting in terms of the distribution of microvascular blood flow. Cutaneous microvascular flows were measured by laser Doppler flowmetry at the neck, thigh, and leg of 15 normal subjects. Volunteers underwent stepwise head-up tilt (HUT) and short- and long-arm centrifugation protocols from supine control (0 Gz) to 0.2, 0.4, 0.6, 0.8, 1.0, 0.8, 0.6, 0.4, 0.2, and 0 Gz at the feet, for 30-s periods with 10-s transitions between levels. The same subjects underwent a corresponding supine LBNP protocol, up to 100 mmHg (in 20 mmHg increments) and back to zero pressure, which produced transmural pressure across blood vessels in the foot approximately equal to the HUT protocol. In general, application of all orthostatic stresses produced significant flow reductions in the lower body (p less than 0.05) and inconsistent changes in the neck. At low levels of each stress (0.4 Gz, 40 mmHg), LBNP generated the greatest relative reduction in flow in the lower body (-66.9+/-5.7%, thigh; -60.6 +/-5.7%, leg, mean +/- SE). HUT caused a less severe flow reduction than LBNP at the thigh and leg (-39.9 +/- 8.1% and -55.9+/-4.8%), while the effects induced by both forms of centrifugation were the least profound. Higher levels of each stress generally resulted in similar responses. These responses exhibit a consistent relationship to hypothesized changes in local microvascular transmural pressure, suggesting that myogenic and veno-arteriolar reflexes play a significant role in determining microvascular perfusion during orthostatic stress.

Breit, G. A.↗

NASA NTRS1985

A comparison of three algebraic stress closures for combustor flow calculations

A comparison is made of the performance of two locally nonequilibrium and one equilibrium algebraic stress closures in calculating combustor flows. Effects of four different pressure-strain models on these closure models are also analyzed. The results show that the pressure-strain models have a much greater influence on the calculated mean velocity and turbulence field than the algebraic stress closures, and that the best mean strain model for the pressure-strain terms is that proposed by Launder, Reece and Rodi (1975). However, the equilibrium algebraic stress closure with the Rotta return-to-isotropy model (1951) for the pressure-strain terms gives as good a correlation with measurements as when the Launder et al. mean strain model is included in the pressure-strain model. Finally, comparison of the calculations with the standard k-epsilon closure results show that the algebraic stress closures are better suited for simple turbulent flow calculations.

Nikjooy, M.↗

NASA NTRS1992

Three-dimensional co-culture process

The present invention relates to a 3-dimensional co-culture process, more particularly to methods or co-culturing at least two types of cells in a culture environment, either in space or in unit gravity, with minimum shear stress, freedom for 3-dimensional spatial orientation of the suspended particles and localization of particles with differing or similar sedimentation properties in a similar spatial region to form 3-dimensional tissue-like structures. Several examples of multicellular 3-dimensional experiences are included. The protocol and procedure are also set forth. The process allows simultaneous culture of multiple cell types and supporting substrates in a manner which does not disrupt the 3-dimensional spatial orientation of these components. The co-cultured cells cause a mutual induction effect which mimics the natural hormonal signals and cell interactions found in the intact organism. This causes the tissues to differentiate and form higher 3-dimensional structures such as glands, junctional complexes polypoid geometries, and microvilli which represent the corresponding in-vitro structures to a greater degree than when the cell types are cultured individually or by conventional processes. This process was clearly demonstrated for the case of two epithelial derived colon cancer lines, each co-cultured with normal human fibroblasts and with microcarrier bead substrates. The results clearly demonstrate increased 3-dimensional tissue-like structure and biochemical evidence of an increased differentiation state. With the present invention a variety of cells may be co-cultured to produce tissue which has 3-dimensionality and has some of the characteristics of in-vitro tissue. The process provides enhanced 3-dimensional tissue which create a multicellular organoid differentiation model.

Wolf, David A.↗

NASA NTRS1992

Three-dimensional cell to tissue assembly process

The present invention relates a 3-dimensional cell to tissue and maintenance process, more particularly to methods of culturing cells in a culture environment, either in space or in a gravity field, with minimum fluid shear stress, freedom for 3-dimensional spatial orientation of the suspended particles and localization of particles with differing or similar sedimentation properties in a similar spatial region.

Wolf, David A.↗

NASA NTRS2008

Three-dimensional cell to tissue development process

An improved three-dimensional cell to tissue development process using a specific time varying electromagnetic force, pulsed, square wave, with minimum fluid shear stress, freedom for 3-dimensional spatial orientation of the suspended particles and localization of particles with differing or similar sedimentation properties in a similar spatial region.

Goodwin, Thomas J.↗

NASA NTRS1989

Measurements of the stress supported by the crush zone in open hole composite laminates loaded in compression

Measurements of the stress supported by the crush zone in open hole specimens loaded in compression were carried out on two composite laminates, AS4/PEEK and IM6/HST-7, containing circular holes of three different diameters. Compression tests were conducted in a specially designed high-axial-alignment material test system machine. Results indicated that the local stress supported in the crush zone is much less than the stress required to initiate the crush, providing the reason for the finding of Guynn et al. (1987) that the Dugdale model does not accurately predict the load-damage size relationship of open hole composite specimens loaded in compression.

Guynn, E. Gail↗

NASA NTRS1987

Fracture mechanics concepts in reliability analysis of monolithic ceramics

Basic design concepts for high-performance, monolithic ceramic structural components are addressed. The design of brittle ceramics differs from that of ductile metals because of the inability of ceramic materials to redistribute high local stresses caused by inherent flaws. Random flaw size and orientation requires that a probabilistic analysis be performed in order to determine component reliability. The current trend in probabilistic analysis is to combine linear elastic fracture mechanics concepts with the two parameter Weibull distribution function to predict component reliability under multiaxial stress states. Nondestructive evaluation supports this analytical effort by supplying data during verification testing. It can also help to determine statistical parameters which describe the material strength variation, in particular the material threshold strength (the third Weibull parameter), which in the past was often taken as zero for simplicity.

Manderscheid, Jane M.↗

NASA NTRS1978

Shear flow beneath oceanic plates - Local nonsimilarity boundary layers for olivine rheology

The principle of local similarity, which has been used to model the two-dimensional boundary layers in the oceanic upper mantle, permits calculation of the temperature, velocity, and stress fields with essentially analytic techniques. Finite difference numerical methods are hard pressed to resolve the detail required by the large variation of viscosity between the lithosphere and the asthenosphere. In this paper the local similarity approximation has been justified by quantitatively evaluating the effect of nonsimilarity due to viscous heating, nonlinear temperature- and pressure-dependent rheology, buoyancy, adiabatic cooling, etc. Nonsimilar effects produce only small modifications of the locally similar boundary layers; important geophysical observables such as surface heat flux and ocean floor topography are given to better than 10 percent by the locally similar solution. A posteriori evaluations of the terms neglected in the boundary layer simplification of the complete equations have been conducted on the locally similar temperature and velocity profiles close to the spreading ridge. The boundary layer models are valid to depths of 100 km at 3 m.y. and 10 km at 0.3 m.y.

Yuen, D. A.↗

NASA NTRS1979

Development of high-cycle fatigue design curves for a cast aluminum alloy

Life prediction curves for rocket engine pump parts were developed from the results of high-cycle fatigue tests run on cast-aluminum specimens. Notched and smooth specimens were cyclically tested at different mean stress levels at -320 F (78 K). The notch size and mean stress enveloped the design operating conditions. Local stress computed in the groove of the notched specimen was used to represent its fatigue strength. The von Mises criterion was used to determine effective cyclic stresses. The Goodman rule was applied to determine equivalent reversed alternating stresses. The procedure permitted the notched and smooth data sets to each be described by a single curve. High-cycle fatigue life curves were provided for the stress state, mean stress, and stress concentration spanned by the data.

Cooper, R. A.↗

NASA NTRS1990

Growing And Assembling Cells Into Tissues

Laboratory process for growth and assembly of mammalian cells into tissue-like masses demonstrated with hamster and rat cells. New process better able to provide culture environment with reduced fluid shear stress, freedom for three-dimensional spatial orientation of particles suspended in culture medium, and localization of particles of different or similar sedimentation properties in similar spatial region.

Wolf, David A.↗

NASA NTRS1978

Evaluation of a locally homogeneous model of spray evaporation

Measurements were conducted on an evaporating spray in a stagnant environment. The spray was formed using an air-atomizing injector to yield a Sauter mean diameter of the order of 30 microns. The region where evaporation occurred extended approximately 1 m from the injector for the test conditions. Profiles of mean velocity, temperature, composition, and drop size distribution, as well as velocity fluctuations and Reynolds stress, were measured. The results are compared with a locally homogeneous two-phase flow model which implies no velocity difference and thermodynamic equilibrium between the phases. The flow was represented by a k-epsilon-g turbulence model employing a clipped Gaussian probability density function for mixture fraction fluctuations. The model provides a good representation of earlier single-phase jet measurements, but generally overestimates the rate of development of the spray. Using the model predictions to represent conditions along the centerline of the spray, drop life-history calculations were conducted which indicate that these discrepancies are due to slip and loss of thermodynamic equilibrium between the phases.

Shearer, A. J.↗