Nanofluidic size exclusion chromatograph for in situ macromolecular analyses
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Nano-fabricated size exclusion chromatograph
This paper describes the development of a nano-fabricated size exclusion chromatograph (nSEC) based on the principle that molecules traveling through amicrocolumn containing nano-fabricated features will have characteristic elution times that directly correlate to molecular weight. Compared to conventional size exclusion chromatography, the nSEC offers greater control over the size exclusion process; mass fabrication; integration of the separation column with associated valves, pumps, and detectors; and dramatic reductions in instrument mass and power requirements.
nanofluids lab-on-a-chip chromatograph separation↗