Interdiffusion, Segregation, Ensemble Interactions, and Radiation Induced Effects in InGaAs/GaAs Quantum Dots
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New multi-roll coronagraphic images of the HD181327 debris disk obtained using the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope reveal the debris ring in its entirety at high signal-to-noise ratio and unprecedented spatial resolution. We present and apply a new multi-roll image processing routine to identify and further remove quasi-static point-spread function-subtraction residuals and quantify systematic uncertainties. We also use a new iterative image deprojection technique to constrain the true disk geometry and aggressively remove any surface brightness asymmetries that can be explained without invoking dust density enhancements/ deficits. The measured empirical scattering phase function for the disk is more forward scattering than previously thought and is not well-fit by a Henyey-Greenstein function. The empirical scattering phase function varies with stellocentric distance, consistent with the expected radiation pressured-induced size segregation exterior to the belt. Within the belt, the empirical scattering phase function contradicts unperturbed debris ring models, suggesting the presence of an unseen planet. The radial profile of the flux density is degenerate with a radially varying scattering phase function; therefore estimates of the ring's true width and edge slope may be highly uncertain.We detect large scale asymmetries in the disk, consistent with either the recent catastrophic disruption of a body with mass greater than 1% the mass of Pluto, or disk warping due to strong interactions with the interstellar medium.
Genetic effects in yeast induced by heavy ion radiation, studying lethality, mitotic segregation, allelic recombination and reverse mutation
The study of combustible particle clouds is of fundamental scientific interest as well as a practical concern. The principal scientific interests are the characteristic combustion properties, especially flame structure, propagation rates, stability limits, and the effects of stoichiometry, particle type, transport phenomena, and nonadiabatic processes on these properties. The feasibility tests for the particle cloud combustion experiment (PCCE) were performed in reduced gravity in the following stages: (1) fuel particles were mixed into cloud form inside a flammability tube; (2) when the concentration of particles in the cloud was sufficiently uniform, the particle motion was allowed to decay toward quiescence; (3) an igniter was energized which both opened one end of the tube and ignited the suspended particle cloud; and (4) the flame proceeded down the tube length, with its position and characteristic features being photographed by high-speed cameras. Gravitational settling and buoyancy effects were minimized because of the reduced gravity enviroment in the NASA Lewis drop towers and aircraft. Feasibility was shown as quasi-steady flame propagation which was observed for fuel-rich mixtures. Of greatest scientific interest is the finding that for near-stoichiometric mixtures, a new mode of flame propagation was observed, now called a chattering flame. These flames did not propagate steadily through the tube. Chattering modes of flame propagation are not expected to display extinction limits that are the same as those for acoustically undisturbed, uniform, quiescent clouds. A low concentration of fuel particles, uniformly distributed in a volume, may not be flammable but may be made flammable, as was observed, through induced segregation processes. A theory was developed which showed that chattering flame propagation was controlled by radiation from combustion products which heated the successive discrete laminae sufficiently to cause autoignition.
The Radiat experiment was one of 17 investigations which used the ESA Biorack on IML-1 (International Microgravity Laboratory) and it had two objectives. The first objective was to isolate and characterize mutations induced by cosmic rays; the second was to assess the fidelity of development in 0-gravity over two consecutive generations. Two strategies were used to isolate mutations in a set of essential genes or a specific gene and to correlate the genetic events with the passage of charged particles. The results were isolation of 60 lethal mutations whose phenotypes are related to the local pattern of energy deposition. 12 mutations in the unc-22 gene include large deletions as characterized by DNA hybridization studies. Development of nematodes proceeded through two consecutive generations with no obvious defects. Cytoplasmic determinants in embryos, nuclear location and symmetry of cellular anatomy were normal as were Mendelian segregation and recombination of genetic markers.
The impact of spaceflight on immune function is undoubtedly a critical focus in the area of space biology and human health research. Heat shock proteins (Hsp) are an evolutionarily conserved family of proteins that are expressed in response to cellular and physiological stressors, experienced during radiation exposure, confinement, circadian rhythm disruption, and altered gravity (hypergravity experienced at launch/landing and microgravity experienced in-flight). In particular, Hsp70 aids in the folding of proteins, facilitates the movement of proteins across the membranes during signal transductions and can stimulate innate immunity. Since Hsp70 is induced during cellular stress, and can act as a stimulator for innate immunity, we sought to address how a loss of Hsp70 affects immunity, under the stress-inducing model of acute and chronic hypergravity. Moreover, the effects of gravity as a continuum on the induction of Hsps and key immune genes were also assessed to determine if increased cellular stress, via increased gravity (g)-force, contributes to immune dysfunctions. For this, wildtype (W1118) and Hsp70 deficient (Hsp70null) Drosophila melanogaster were subjected to simulated hypergravity at increasing levels of g-force (1.2g, 3g, and 5g) for acute (1hr) and chronic (7-day) timepoints and were compared to 0g 'non-hypergravity' controls. Following simulation, whole bodies were sex-segregated, RNA was isolated and quantitative (q)PCR was performed to determine differential immune gene expression profiles. Further, functional output of hemocytes were assessed by a phagocytosis assay. Collectively, these studies evaluated the effects of Hsp70 in the context of immunity during acute and chronic hypergravity. Indeed, relevance for this work can directly translate to acute effects of launch/landing gravitational forces upon liftoff (~1.7g) and entry (~3.4g) that astronauts experience. In addition, the effects of chronic cellular stress is directly relevant to the immune health of astronauts on long duration missions, as well. Thus, as we approach the goal of returning to the Moon and landing the first humans on Mars, an evaluation of gravity as a continuum and the stress-inducing effects of altered gravity experienced during spaceflight on astronaut immunity and health are necessary.