Draft findings releated to 'Special Regions'
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planetary protection↗
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Regional specialization in prefrontal cortex manifests in the reliability of task progression codes
The brain has the remarkable ability to guide the performance of complex tasks. Distinct prefrontal cortical areas make specific contributions to this ability, with the orbitofrontal cortex (OFC) critical for processing information related to trial outcomes and the dorsomedial prefrontal cortex (dmPFC) critical for sustained effort and selecting the right action at the right time. Yet, in both areas, neural activity represents both outcome- and action-related quantities. How similar neural representations support different functions remains unclear. Here, we compared OFC and dmPFC activity in rats performing a spatial alternation task. We show that, in contrast to other task-related variables, task progression is represented in both areas, but with distinct patterns of across-trial reliability that match each area’s previously documented functional specialization. Our results indicate that the engagement of reliable, task-phase-specific activity patterns differs across prefrontal regions in a manner well suited to engage different computations at different times.
Biological and medical sciences↗
Mars Soil-Based Resource Processing and Planetary Protection
The ability to extract and process resources at the site of exploration into products and services, commonly referred to as In Situ Resource Utilization (ISRU), can have significant benefits for robotic and human exploration missions. In particular, the ability to use in situ resources to make propellants, fuel cell reactants, and life support consumables has been shown in studies to significantly reduce mission mass, cost, and risk, while enhancing or enabling missions not possible without the incorporation of ISRU. In December 2007, NASA completed the Mars Human Design Reference Architecture (DRA) 5.0 study. For the first time in a large scale Mars architecture study, water from Mars soil was considered as a potential resource. At the time of the study, knowledge of water resources (their form, concentration, and distribution) was extremely limited. Also, due to lack of understanding of how to apply planetary protection rules and requirements to ISRU soil-based excavation and processing, an extremely conservative approach was incorporated where only the top several centimeters of ultraviolet (UV) radiated soil could be processed (assumed to be 3% water by mass). While results of the Mars DRA 5.0 study showed that combining atmosphere processing to make oxygen and methane with soil processing to extract water provided the lowest mission mass, atmosphere processing to convert carbon dioxide (CO2) into oxygen was baselined for the mission since it was the lowest power and risk option. With increased knowledge and further clarification of Mars planetary protection rules, and the recent release of the Mars Exploration Program Analysis Group (MEPAG) report on "Special Regions and the Human Exploration of Mars", it is time to reexamine potential water resources on Mars, options for soil processing to extract water, and the implications with respect to planetary protection and Special Regions on Mars.
Sanders, G. B.↗
Magnetospheric particle populations.
Significant results of magnetospheric charged particle measurements conducted within the past two years are reviewed in an attempt to provide a general description of relationships among particle populations in the magnetosheath, plasma sheet, extraterrestrial ring current region, electron trough, pseudotrapping region, and stable-trapping region. Special attention is given to the characteristics of protons, electrons, alpha particles, and particles with charge greater than three in the stable trapping region.
Vette, J. I.↗
Singlet-doublet dark matter revisited
The singlet-doublet model is an economical model of weakly interacting dark matter. We revisit it in light of improved dark matter direct detection limits. We characterize the now well-defined regions of remaining parameter space with suppressed direct detection cross sections and discuss features of the spectrum accessible at the Large Hadron Collider. We discuss when and how parameters in these special regions might be realized as the result of renormalization group evolution when starting with generic ultraviolet initial conditions.
Particle dark matter↗
Neurochemical, morphologic, and laminar characterization of cortical projection neurons in the cingulate motor areas of the macaque monkey
The primate cingulate gyrus contains multiple cortical areas that can be distinguished by several neurochemical features, including the distribution of neurofilament protein-enriched pyramidal neurons. In addition, connectivity and functional properties indicate that there are multiple motor areas in the cortex lining the cingulate sulcus. These motor areas were targeted for analysis of potential interactions among regional specialization, connectivity, and cellular characteristics such as neurochemical profile and morphology. Specifically, intracortical injections of retrogradely transported dyes and intracellular injection were combined with immunocytochemistry to investigate neurons projecting from the cingulate motor areas to the putative forelimb region of the primary motor cortex, area M1. Two separate groups of neurons projecting to area M1 emanated from the cingulate sulcus, one anterior and one posterior, both of which furnished commissural and ipsilateral connections with area M1. The primary difference between the two populations was laminar origin, with the anterior projection originating largely in deep layers, and the posterior projection taking origin equally in superficial and deep layers. With regard to cellular morphology, the anterior projection exhibited more morphologic diversity than the posterior projection. Commissural projections from both anterior and posterior fields originated largely in layer VI. Neurofilament protein distribution was a reliable tool for localizing the two projections and for discriminating between them. Comparable proportions of the two sets of projection neurons contained neurofilament protein, although the density and distribution of the total population of neurofilament protein-enriched neurons was very different in the two subareas of origin. Within a projection, the participating neurons exhibited a high degree of morphologic heterogeneity, and no correlation was observed between somatodendritic morphology and neurofilament protein content. Thus, although the neurons that provide the anterior and posterior cingulate motor projections to area M1 differ morphologically and in laminar origin, their neurochemical profiles are similar with respect to neurofilament protein. This suggests that neurochemical phenotype may be a more important unifying feature for corticocortical projections than morphology.
NASA Discipline Neuroscience↗
Railroad safety program, volume 1
Since 1981, the Federal Railroad Administration (FRA) has annually prepared a National Inspection Plan (NIP) whose purpose is to summarize regional efforts to improve railroad transportation safety. The research concluded on the following tasks including the problems, conclusions and recommendations associated with these tasks is summarized: (1) the preparation of the 1983 NIP, with recommended procedures for improving future NIPs; (2) the development of an outline for the 1984 NIP, including a methodology for the allocation of inspection resources and other specialized regional activities; (3) the management and development of the 1984 NIP; and (4) the development of an instruction manual to be used in the preparation of future NIPs.
Source record↗
The Contaminant Footprint of Landed Spacecraft: Toward an Inventory and Modelling Framework
All spacecraft generate and carry contaminants, i.e., unwanted and potentially harmful material. When a spacecraft lands and operates in near-vacuum, as onto Earth’s Moon, it introduces contaminants into its environment that may compromise mission science objectives and engineering performance. Contamination of solar system bodies may irrevocably degrade targets of unique value to planetary scientists, for instance, as lunar landed spacecraft introduce propellant effluents into the otherwise pristine ice of the Moon’s permanently shadowed regions. NASA’s planetary protection discipline seeks to ensure that solar system bodies are not contaminated, for scientific purposes, by terrestrial material (i.e., forward contamination). This interest aligns with planetary science interest in mitigating the transport of terrestrial contaminants onto solar system bodies and in controlling types of contamination that could compromise the scientific value of samples or measurements. NASA, and other entities that practice planetary science, have compelling and multidisciplinary interests in the preservation of special regions and sampling sites of high scientific value – including lunar permanently shadowed regions (PSRs) – from inadvertent contamination by any spacecraft, and in understanding the contamination of such regions by all spacecraft. Organic molecular contamination here represents a primary threat. Organic molecules will be introduced to solar system bodies by nominal landed spacecraft and crew processes – including by the action of descent and ascent engines; natural materials outgassing; and crew environmental and life support system sources. Molecular contaminants can also travel in the free-molecular sense at global scale across near-vacuum bodies, including into regions where they may be permanently trapped. This presentation will address a high-level study to identify sources of contaminants – in particular, organic material – generated by landed spacecraft along with the transport vectors by which these contaminants can reach sites of scientific interest on bodies like the Moon. A vision for an integrated modeling framework for the organic contamination footprint of spacecraft missions, individually and collectively, will also be described and presented along with initial conclusions related to organic molecular transport.
Gas Dynamics↗
Engineering handbook on the atmospheric environmental guidelines for use in wind turbine generator development
The guidelines are given in the form of design criteria relative to wind speed, wind shear, turbulence, wind direction, ice and snow loading, and other climatological parameters which include rain, hail, thermal effects, abrasive and corrosive effects, and humidity. This report is a presentation of design criteria in an engineering format which can be directly input to wind turbine generator design computations. Guidelines are also provided for developing specialized wind turbine generators or for designing wind turbine generators which are to be used in a special region of the United States.
Frost, W.↗
Cometary comae
The basis of our knowledge about the structure and composition of a comet nucleus is examined. Such knowledge is inferred from observations of the cometary atmosphere (coma). However, photodissociation, photoionization, and chemistry destroy the mother molecules evaporating from the nucleus. To extract the primary information, the chemical kinetics and the physics of the coma are modeled with a computer and the results are compared with coma observations. The physics and chemistry for a dust free coma are described taking into account energy balance, multi-fluid flow for fast atomic and molecular hydrogen and the bulk fluid, and the transition from a collision dominated inner region to the free molecular flow outer region. Special attention is paid to the molecular data requirements for the current modeld and for extended models which will include solar wind interaction and dust. Such models are an important tool in support of the Giotto mission to Halley's comet, in the analysis and interpretation of coma observations, and in the understanding of the earliest history of the solar system.
Huebner, W. F.↗
Magnetospheric electric fields and currents
The progress made in the years 1983-1986 in understanding the character and operation of magnetospheric electric fields and electric currents is discussed, with emphasis placed on the connection with the interior regions. Special attention is given to determinations of global electric-field configurations, measurements of the response of magnetospheric particle populations to the electric-field configurations, and observations of the magnetospheric currents at high altitude and during northward IMF. Global simulations of current distributions are discussed, and the sources of global electric fields and currents are examined. The topics discussed in the area of impulsive and small-scale phenomena include substorm current systems, impulsive electric fields and associated currents, and field-aligned electrodynamics. A key finding of these studies is that the electric fields and currents are interrelated and cannot be viewed as separate entities.
Mauk, B. H.↗
Emission Line Galaxies in the STIS Parallel Survey: Observations and Data Analysis - 1
In the first three years of operation STIS obtained slitless spectra of approximately 2500 fields in parallel to prime HST observations as part of the STIS Parallel Survey (SPS). The archive contains approximately 300 fields at high galactic latitude (|b| greater than 30) with spectroscopic exposure times greater than 3000 seconds. This sample contains 220 fields (excluding special regions and requiring a consistent grating angle) observed between 6 June 1997 and 21 September 2000, with a total survey area of approximately 160 square arcminutes. At this depth, the SPS detects an average of one emission line galaxy per three fields. We present the analysis of these data, and the identification of 131 low to intermediate redshift galaxies detected by optical emission lines. The sample contains 78 objects with emission lines that we infer to be redshifted [OII]3727 emission at 0.43 < z < 1.7. The comoving number density of these objects is comparable to that of Halpha-emitting galaxies in the NICMOS parallel observations. One quasar and three probable Seyfert galaxies are detected. Many of the emission-line objects show morphologies suggestive of mergers or interactions. The reduced data are available upon request from the authors.
Teplitz, Harry I.↗
Neural substrates linking balance control and anxiety
This communication provides an update of our understanding of the neurological bases for the close association between balance control and anxiety. New data suggest that a vestibulo-recipient region of the parabrachial nucleus (PBN) contains cells that respond to body rotation and position relative to gravity. The PBN, with its reciprocal relationships with the extended central amygdaloid nucleus, infralimbic cortex, and hypothalamus, appears to be an important node in a primary network that processes convergent vestibular, somatic, and visceral information processing to mediate avoidance conditioning, anxiety, and conditioned fear responses. Noradrenergic and serotonergic projections to the vestibular nuclei also have parallel connections with anxiety pathways. The coeruleo-vestibular pathway originates in caudal locus coeruleus (LC) and provides regionally specialized noradrenergic input to the vestibular nuclei, which likely mediate effects of alerting and vigilance on the sensitivity of vestibulo-motor circuits. Both serotonergic and nonserotonergic pathways from the dorsal raphe nucleus and the nucleus raphe obscurus also project differentially to the vestibular nuclei, and 5-HT(2A) receptors are expressed in amygdaloid and cortical targets of the PBN. It is proposed that the dorsal raphe nucleus pathway contributes to both (a) a tradeoff between motor and sensory (information gathering) aspects of responses to self-motion and (b) a calibration of the sensitivity of affective responses to aversive aspects of motion. This updated neurologic model continues to be a synthetic schema for investigating the neurological and neurochemical bases for comorbidity of balance disorders and anxiety disorders.
Review↗
AmphiFoxE4, an amphioxus winged helix/forkhead gene encoding a protein closely related to vertebrate thyroid transcription factor-2: expression during pharyngeal development
The full-length sequence and developmental expression of amphioxus AmphiFoxE4 are described. Transcripts of the gene are first detected in the pharyngeal endoderm, where the club-shaped gland is forming and subsequently in the definitive gland itself. AmphiFoxE4 is closely related to vertebrate genes encoding the thyroid-specific transcription factor-2 (TTF2), which plays an early developmental role in the morphogenesis of the thyroid gland and a later role in hormone-mediated control of thyroid function. In amphioxus, AmphiFoxE4 expression is not thyroid specific because the club-shaped gland, the only structure expressing the gene, is not homologous to the vertebrate thyroid; instead, the thyroid homologue of amphioxus is a specialized region of the pharyngeal endoderm called the endostyle. We propose that (a) the pharynx of an amphioxus-like ancestor of the vertebrates included a club-shaped gland that expressed FoxE4 as well as an endostyle that did not, and (b) the club-shaped gland soon disappeared in the vertebrate line of descent but (c) not before there was a homeogenetic transfer of FoxE4 expression from the club-shaped gland to the nearby endostyle. Such a transfer could have provided part of the genetic program enabling the endostyle to separate from the pharyngeal endoderm and migrate away as the rudiment of the thyroid gland.
Non-NASA Center↗
Gravity-stimulated changes in auxin and invertase gene expression in maize pulvinal cells
Maize (Zea mays) stem gravitropism involves differential elongation of cells within a highly specialized region, the stem internodal pulvinus. In the present study, we investigated factors that control gravitropic responses in this system. In the graviresponding pulvinus, hexose sugars (D-Glc and D-Fru) accumulated asymmetrically across the pulvinus. This correlated well with an asymmetric increase in acid invertase activity across the pulvinus. Northern analyses revealed asymmetric induction of one maize acid invertase gene, Ivr2, consistent with transcriptional regulation by gravistimulation. Several lines of evidence indicated that auxin redistribution, as a result of polar auxin transport, is necessary for gravity-stimulated Ivr2 transcript accumulation and differential cell elongation across the maize pulvinus. First, the auxin transport inhibitor, N-1-naphthylphthalamic acid, inhibited gravistimulated curvature and Ivr2 transcript accumulation. Second, a transient gradient of free indole-3-acetic acid (IAA) across the pulvinus was apparent shortly after initiation of gravistimulation. This temporarily free IAA gradient appears to be important for differential cell elongation and Ivr2 transcript accumulation. This is based on the observation that N-1-naphthylphthalamic acid will not inhibit gravitropic responses when applied to pulvinus tissue after the free IAA gradient peak has occurred. Third, IAA alone can stimulate Ivr2 transcript accumulation in non-gravistimulated pulvini. The gravity- and IAA-stimulated increase in Ivr2 transcripts was sensitive to the protein synthesis inhibitor, cycloheximide. Based on these results, a two-phase model describing possible relationships between gravitropic curvature, IAA redistribution, and Ivr2 expression is presented.
NASA Discipline Plant Biology↗
Functional and structural mapping of human cerebral cortex: solutions are in the surfaces
The human cerebral cortex is notorious for the depth and irregularity of its convolutions and for its variability from one individual to the next. These complexities of cortical geography have been a chronic impediment to studies of functional specialization in the cortex. In this report, we discuss ways to compensate for the convolutions by using a combination of strategies whose common denominator involves explicit reconstructions of the cortical surface. Surface-based visualization involves reconstructing cortical surfaces and displaying them, along with associated experimental data, in various complementary formats (including three-dimensional native configurations, two-dimensional slices, extensively smoothed surfaces, ellipsoidal representations, and cortical flat maps). Generating these representations for the cortex of the Visible Man leads to a surface-based atlas that has important advantages over conventional stereotaxic atlases as a substrate for displaying and analyzing large amounts of experimental data. We illustrate this by showing the relationship between functionally specialized regions and topographically organized areas in human visual cortex. Surface-based warping allows data to be mapped from individual hemispheres to a surface-based atlas while respecting surface topology, improving registration of identifiable landmarks, and minimizing unwanted distortions. Surface-based warping also can aid in comparisons between species, which we illustrate by warping a macaque flat map to match the shape of a human flat map. Collectively, these approaches will allow more refined analyses of commonalities as well as individual differences in the functional organization of primate cerebral cortex.
Review↗
Coronal Holes
This paper reviews measurements of the plasma properties in coronal holes and how these measurements are used to reveal details about the physical processes that heat the solar corona and accelerate the solar wind. Evidence is presented for both heating and acceleration of the solar wind by open flux tubes energized by footpoint-driven wave-like fluctuations, and for intermittent energy deposition from closed loops into the open-field regions. Special emphasis is given to spectroscopic and coronagraphic measurements that allow the highly dynamic nonequilibrium evolution of the plasma to be followed as the asymptotic conditions in interplanetary space are established in the extended corona. For example, the importance of kinetic plasma physics and turbulence in coronal holes has been affirmed by surprising measurements from the UVCS instrument on SOHO that heavy ions are heated to hundreds of times the temperatures of protons and electrons. These observations point to specific kinds of collisionless Alfven wave damping (i.e., ion cyclotron resonance). Despite our incomplete knowledge of the complex multi-scale plasma physics, much progress has been made toward the goal of understanding the physical processes ultimately responsible for producing the observed properties of coronal holes.
Cranmer, Steven R.↗