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At least 19 records

Bridging Resilience Engineering and Human Reliability Analysis

There has been strong interest in the new and emerging field called resilience engineering. This field has been quick to align itself with many existing safety disciplines, but it has also distanced itself from the field of human reliability analysis. To date, the discussion has been somewhat one-sided, with much discussion about the new insights afforded by resilience engineering. This paper presents an attempt to address resilience engineering from the perspective of human reliability analysis (HRA). It is argued that HRA shares much in common with resilience engineering and that, in fact, it can help strengthen nascent ideas in resilience engineering. This paper seeks to clarify and ultimately refute the arguments that have served to divide HRA and resilience engineering.

99 GENERAL AND MISCELLANEOUS↗

Anomaly Detection for Resilient Control Systems Using Fuzzy-Neural Data Fusion Engine

Resilient control systems in critical infrastructures require increased cyber-security and state-awareness. One of the necessary conditions for achieving the desired high level of resiliency is timely reporting and understanding of the status and behavioral trends of the control system. This paper describes the design and development of a neural-network based data-fusion system for increased state-awareness of resilient control systems. The proposed system consists of a dedicated data-fusion engine for each component of the control system. Each data-fusion engine implements three-layered alarm system consisting of: (1) conventional threshold-based alarms, (2) anomalous behavior detector using self-organizing maps, and (3) prediction error based alarms using neural network based signal forecasting. The proposed system was integrated with a model of the Idaho National Laboratory Hytest facility, which is a testing facility for hybrid energy systems. Experimental results demonstrate that the implemented data fusion system provides timely plant performance monitoring and cyber-state reporting.

97 MATHEMATICS AND COMPUTING↗

Resilience: Concepts from Engineering, Ecology, and the Social Sciences

“Resilience” is fast becoming a key word for describing the desired result of the activities we group under the heading of “homeland security.” Department of Homeland Security (DHS) Secretary Napolitano has made resilience a key theme in her speeches, highlighting the efforts of DHS to “strengthen the resilience of ... infrastructure, computer networks, and of ... communities and citizens.” She has talked about resilience as “strengthening the ability for our systems, our cities, our towns, and our country to bounce back quickly from an attack or a natural disaster, and to be even stronger than before. This paper first provides an overview of resilience concepts from U.S. government and academic research sources. It then discusses resilience concepts and metrics from the academic literature in more detail, focusing on three types of resilience: engineering resilience, ecological resilience, and community and regional resilience. Next, it discusses system characteristics that have been associated with increased resilience. Based on this background, we propose a model of the infrastructure resilience analysis process. We then review LANL capabilities for each process element and indicate areas where capability development opportunities exist. Appendices provide additional information on funding sources and key players in infrastructure resilience, and a more detailed technical explanation of ecological resilience.

42 ENGINEERING↗

Engineering in Cyber Resilience with Cyber-Informed Engineering

Engineers have super powers to provide cybersecurity resilience with deterministic engineering solutions and to protect systems from the most catastrophic consequences that a cyber saboteur could cause. Come to this session to learn how to use engineering risk management skills to harden your engineered systems from cyberattacks. Objective 1 Identify what system functions could be digitally induced to cause undesired high-impact consequences. Objective 2 Analyze how loss or instability of digital controls in a subsystem could lead to high-impact consequences. Objective 3 Analyze how loss or instability in the digital connectivity between systems could lead to high-impact consequences. Objective 4 Identify engineering controls which could build resilience by eliminating digital loss or instability pathways or reduce the impact of digital loss or instability. This presentation will introduce Cyber-Informed Engineering, described below, and walk participants through specific engineering use cases to show how engineers can consider the potential for cyber sabotage in their existing system designs and enact deterministic engineering-based controls which eliminate pathways for attack or mitigate specific consequences. A wide variety of application use cases will be considered so that audience members can align the material with familiar engineering applications. CIE is an engineering approach that integrates cyber resilience into the conception, design, build, and operation of any physical system that has digital connectivity, sensors, monitoring, or control. CIE offers the opportunity to use engineering to eliminate or mitigate avenues for cyber attack—starting from the earliest stage of design and continuing throughout the system’s lifecycle. Today, engineers and industrial control system (ICS) technicians build engineered systems with specific goals for safety, reliability, and functionality. While systems engineering includes considerable safety and failure mode analysis, cybersecurity risks are often not specifically addressed—particularly the risks of intentional cyber compromise, exploitation, and misuse. Cyber-Informed Engineering pairs well with traditional cyber defenses and offers an extra designed-in protection to eliminate the most catastrophic consequences which can be realized by an adversary should traditional cyber defenses fail.

42 ENGINEERING↗

Engineering Thermally Resilient and Kinetically Active Reversible Protonic Ceramic Cells via Interfacial Design

Achieving concurrent fast electrode kinetics and long-term thermo-mechanical durability remains a critical challenge for reversible protonic ceramic electrochemical cells (R-PCECs). Herein, we report an interfacial engineering strategy that integrates a perovs.kite-type PrBaRu0.1Co1.9O5+δ (PBRC) nanoparticle layer onto a PrBa0.5Sr0.5Co1.5Fe0.5O5+δ (PBSCF) substrate (PBRC-PBSCF), together with a modified pellet-assisted sintering approach to fabricate dense BaZr0.4Ce0.4Y0.1Yb0.1O3-δ (BZCYYb4411) electrolytes. The in situ reconstructed heterointerface enhances oxygen reduction/evolution reaction (ORR/OER) kinetics, promotes H2O adsorption/dissociation, and improves steam tolerance, as verified by electrochemical measurements and interfacial microstructural analyses. Density functional theory reveals that Ru-induced electronic modulation at the PBRC-PBSCF interface lowers the energy of oxygen vacancy formation and optimizes the position of the O 2p band center, thereby accelerating oxygen redox kinetics and stabilizing the interface. The resulting R-PCECs deliver an excellent peak power density of 1.112 W cm−2 and an electrolysis current density of −1.257 A cm−2 at 1.3 V in 3% H2O wet air at 600°C, with a reasonable faradaic efficiency. Furthermore, the cells demonstrate excellent stability, sustaining 100 h of thermal cycling (400–600°C, 200°C h−1) in both fuel cell and electrolysis modes, with 600 h of stability in electrolysis mode (600°C, −0.5 to −2 A cm−2).

30 DIRECT ENERGY CONVERSION↗

Addressing Human and Organizational Factors in Nuclear Industry Modernization: A Sociotechnically Based Strategic Framework

The modernization of nuclear power plants will require an advanced concept of operations, involving an integrated set of tightly coupled systems in which all stakeholders act in a coordinated manner. For this modernization effort to be enabled, we developed a human and organizational factors approach based on a broad sociotechnical framework. Starting from core human factors principles, we conducted a literature review of the methods and approaches relevant to the modernization problem. These included not only core disciplines such as cognitive systems engineering, systems theoretic accident modeling and processes, human systems integration, resilience engineering, and macroergonomics but also related topics of safety culture and organizational change. From this literature, we developed a conceptual framework centered around the work system with its four interacting components: people, technology, process, and governance. In an effective work system, these four components are jointly optimized according to three systems criteria: efficiency, effectiveness, and safety. System failure may result from excessive emphasis on any one criterion. The actual work of attaining joint optimization in a given work system can be accomplished by utilizing three high-level functions: knowledge elicitation, knowledge representation, and cross-functional integration. Finally, we illustrated the utility of this approach by applying it to practical problems and case studies.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Modeling the Resilience of Nuclear Power Plant for Unexpected Reactor Trip

Resilience can be defined as the intrinsic ability of a system to adjust to its functioning prior to, during, or following changes and disturbances, so that it can sustain required operations under both expected and unexpected conditions. Resilience engineering is a relatively new paradigm for safety management that focuses on how to cope with complexity under pressure or disturbance to achieve success. A resilient system combines inherent human abilities with engineered safety features and organizational features in a controlled and flexible manner both in expected and in unexpected situations. The concept of resilience has been suggested to complement conventional safety analyses. Conventional safety analysis methods such as PSA have several limitations: 1) they primarily focus on technical dimension, 2) the analysis are linear and sequential, 3) they are dominated by static models, 4) they do not take a systemic view into account, and 5) they focus primarily on why accidents happen and not how success is achieved. The concept of resilience provides a more integrated view for the safety analysis in safety-critical systems, e.g., nuclear power plants. The concept of resilience in the organization of NPPs has been highlighted since the Fukushima Daiichi Nuclear Power Plant accident. An IAEA report addresses that a resilient organization is one that quickly realizes deviation from normal operations and has the ability to make even the toughest and least popular decisions and to manage the margins in which it can maneuver. While traditional strategy to safety in NPPs is to identify what could go or has gone wrong, the concept of resilience is focused on what the organization does well and what it does to maintain its successful operation and to capitalize on those processes in the event of an unexpected situation. This study attempts to model the resilience of NPP dynamically, based on the operating experiences in Korean NPPs. First, this study revised the characterization of NPP. Then, a survey on the literature was conducted to identify the influences between the elements in the model of resilience in NPPs. These works provide a qualitative model for the resilience in NPPs. Then, this study reviewed 168 licensee events reports submitted to the Korean regulatory body since 2004 and quantified the relation between the attributes in the model by performing a Pearson correlation analysis. Finally, a few simulations using the System Dynamics were conducted to discuss which factors are most influencing the resilience. (authors)

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Addressing Human and Organizational Factors In Nuclear Industry Modernization: A Sociotechnically-Based Strategic Framework

The modernization of nuclear power plants will require an advanced concept of operations, involving an integrated set of tightly coupled systems in which all stakeholders act in a coordinated manner. For this modernization effort to be enabled, we developed a human and organizational factors approach, based on a broad sociotechnical framework. Starting from core human factors principles, we conducted a literature review of the methods and approaches relevant to the modernization problem. These included core disciplines such as cognitive systems engineering, systems theoretic accident modeling and processes (STAMP), human systems integration, resilience engineering, and macroergonomics but also related topics of safety culture and organizational change. From this literature, we developed a conceptual framework centered around the work system with its four interacting components: people, technology, process, and governance. In an effective work system, these four components are jointly optimized according to three systems criteria: efficiency, effectiveness, and safety. System failure may result from excessive emphasis on any one criterion. The actual work of attaining joint optimization in a given work system can be accomplished by utilizing three high level functions: knowledge elicitation, knowledge representation, and cross-functional integration. We illustrated the utility of this approach by applying it to practical problems and case studies. The complete report is available in [1]; this paper is a description of our approach and report contents.

99 GENERAL AND MISCELLANEOUS↗

Cyber-Informed Engineering (CIE) Guide for States

The Cyber-Informed Engineering (CIE) Guide for States provides state energy offices, public utility commissions, and partner organizations with a structured framework for integrating cyber-resilient engineering practices into energy planning, grantmaking, interconnection processes, and workforce development. As grid digitalization and the adoption of distributed energy resources accelerate, states face expanding cyber-physical risks that traditional cybersecurity measures alone cannot fully address. CIE offers a proactive, consequence-focused engineering methodology that emphasizes eliminating or mitigating high-impact failure modes through design, physical controls, and operational safeguards. The guide outlines the 12 core CIE principles, demonstrates their application through state-focused use cases—including grant evaluation rubrics, interconnection reviews, allow-list development, and training programs—and provides practical tools such as scoring frameworks, impact assessment methods, and implementation checklists. It also highlights pathways for state–utility collaboration and opportunities for technical assistance from national laboratories. By adopting CIE, states can enhance grid reliability, reduce lifecycle costs, strengthen supply-chain assurance, and foster a security-aware engineering culture that aligns with broader resilience and modernization goals. November 2025

29 - ENERGY PLANNING, POLICY AND ECONOMY↗

Cyber-Informed Engineering (CIE) Guide for States

The Cyber-Informed Engineering (CIE) Guide for States provides state energy offices, public utility commissions, and partner organizations with a structured framework for integrating cyber-resilient engineering practices into energy planning, grantmaking, interconnection processes, and workforce development. As grid digitalization and the adoption of distributed energy resources accelerate, states face expanding cyber-physical risks that traditional cybersecurity measures alone cannot fully address. CIE offers a proactive, consequence-focused engineering methodology that emphasizes eliminating or mitigating high-impact failure modes through design, physical controls, and operational safeguards. The guide outlines the 12 core CIE principles, demonstrates their application through state-focused use cases—including grant evaluation rubrics, interconnection reviews, allow-list development, and training programs—and provides practical tools such as scoring frameworks, impact assessment methods, and implementation checklists. It also highlights pathways for state–utility collaboration and opportunities for technical assistance from national laboratories. By adopting CIE, states can enhance grid reliability, reduce lifecycle costs, strengthen supply-chain assurance, and foster a security-aware engineering culture that aligns with broader resilience and modernization goals. November 2025

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Integrating ecological and engineering concepts of resilience in microbial communities

We note that many definitions of resilience have been proffered for natural and engineered ecosystems, but a conceptual consensus on resilience in microbial communities is still lacking. Here, we argue that the disconnect largely results from the wide variance in microbial community complexity, which range from simple synthetic consortia to complex natural communities, and divergence between the typical practical outcomes emphasized by ecologists and engineers. Viewing microbial communities as elasto-plastic systems, we argue that this gap between the engineering and ecological definitions of resilience stems from their respective emphases on elastic and plastic deformation, respectively. We propose that the two concepts may be fundamentally united around the resilience of function rather than state in microbial communities and the regularity in the relationship between environmental variation and a community’s functional response. Furthermore, we posit that functional resilience is an intrinsic property of microbial communities, suggesting that state changes in response to environmental variation may be a key mechanism driving resilience in microbial communities.

59 BASIC BIOLOGICAL SCIENCES↗

Assessing Resilience in Lane Detection Methods: Infrastructure-Based Sensors and Traditional Approaches for Autonomous Vehicles

Traditional autonomous vehicle perception subsystems that use onboard sensors have the drawbacks of high computational load and data duplication. Infrastructure-based sensors, which can provide high quality information without the computational burden and data duplication, are an alternative to traditional autonomous vehicle perception subsystems. However, these technologies are still in the early stages of development and have not been extensively evaluated for lane detection system performance. Therefore, there is a lack of quantitative data on their performance relative to traditional perception methods, especially during hazardous scenarios, such as lane line occlusion, sensor failure, and environmental obstructions. We address this need by evaluating the influence of hazards on the resilience of three different lane detection methods in simulation: (1) traditional camera detection using a U-Net algorithm, (2) radar detections using infrastructure-based radar retro-reflectors (RRs), and (3) direct communication of lane line information using chip-enabled raised pavement markers (CERPMs). The performance of each of these methods is assessed using resilience engineering metrics by simulating the individual methods for each sensor technology’s response to related hazards in the CARLA simulator. Using simulation techniques to replicate these methods and hazards acquires extensive datasets without lengthy time investments. Specifically, the resilience triangle was used to quantitatively measure the resilience of the lane detection system to obtain unique insights into each of the three lane detection methods; notably the infrastructure-based CERPMs and RRs had high resistance to hazards and were not as easily affected as the vision-based U-Net. However, while U-Net was able to recover the fastest from the disruption as compared to the other two methods, it also had the most performance loss. Overall, this study demonstrates that while infrastructure-based lane keeping technologies are still in early development, they have great potential as alternatives to traditional ones.

Patil, Pritesh↗

Integrated Metrics for County-Level Resilience Ranking Using Entropy and TOPSIS

In the face of atypical weather events, power infrastructure failures, and limited resources for resilience investment, energy decision-makers need data-driven metrics to allocate resilience investments and maximize the reduction of power outage impacts. For state-level planning, for instance, ranking the resilience of each county is key to ensuring effective distribution of resources. In such cases, resilience for each spatial unit is multifaceted and is captured by a set of indicators (i.e., metrics) that can be combined into an overall score that reduces the complexity of power outage dynamics to a single decision metric. However, weighting of these indicators is often addressed by simplifying assumptions (i.e., equal weights) or semi-subjective methods that rely on user-defined weights that can introduce biases (e.g., weighted average score). Within the disaster risk reduction and resilience engineering community, a recurring challenge in multicriteria decision-making is the objective weighting of indicators for composite indices. To address this issue, we have leveraged a Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) combined with an entropy-based weighting approach to calculated the integrated scores. This method objectively determines the importance of each metric, better discerns between spatial units (i.e., counties), and offers a more reliable ranking of counties according to their relative resilience attributes. By improving methods for integrating resilience indicators, our approach helps planners and decision-makers prioritize resources more effectively for more efficient resilience investments.

Bhusal, Narayan [Oak Ridge National Laboratory (OR↗

Asparagine synthetase gene regulatory network and plant nitrogen metabolism

This DOE project concerns the molecular mechanisms by which plants coordinate carbon (C) and nitrogen (N) metabolism. Specifically, it focuses on a histone methyltransferase protein that targets C/N-metabolism genes for chromatin modifications. How the dynamic changes of chromatin regulate energy metabolism in response to developmental and environmental cues is a new area of study. We have filled this knowledge-gap with our studies of SDG8, a histone methyltransferase, that targets light, C and N metabolism genes. We aimed to understand how plants allocate C resources to assimilate inorganic N onto C-skeletons -- the most energy-intensive pathway in plants – in order to balance energy production and consumption in a changing environment. In order to achieve more C-efficient N-storage under low energy conditions, plants convert assimilated N from “reactive” Gln (C5:N2) into “inert” Asn (C4:N2) through the enzyme ASN1. To identify regulatory factors in this pathway, we used the ASN1 promoter in a genetic selection and discovered SDG8, a histone methyltransferase. We discovered that histone modification by SDG8 coordinates the expression of genes involved in energy generation (light-harvesting and C fixation) with energy consumption (N assimilation and sulfur metabolism). We used this opportunity to explore how histone modifications control energy metabolism genome-wide. Our aims focus on various levels of the regulation of energy related genes at the level of: 1) Chromatin; 2) Transcription; and 3) Metabolites of the C/N regulatory network. Specifically, we asked: 1) How does histone methylation regulate energy metabolism during the N response? 2) How does histone methylation control transcription of the energy metabolism genes? And 3) how does the histone methyltransferase SDG8 and other TF regulators affect C/N metabolism and N use efficiency? Our study indicates that N supply triggers genome-wide changes in chromatin modification via the histone methyltransferase SDG8 which impacts on gene expression, RNA processing, chlorophyll synthesis, N uptake and metabolism. Our study thus revealed a previously overlooked layer of chromatin regulation during nutrient signaling. In broad terms, our study provides a framework to understand how chromatin modifications influence responses to environmental changes and provides unique opportunities for breeding and engineering resilient crops with better performance in the current climate model. Accomplishments AIM 1 CHROMATIN: Role of histone methylation in the ASN1 energy metabolism network. This aim focuses on understanding the role of chromatin modification in response to the environment. We studied the targeting mechanism of histone methylation by SDG8, in particular the role of the CW domain in reading histone methylation status. We also began to study the effect of nitrogen-treatment on genome-wide chromatin modifications in WT and sdg8 mutant plants. AIM 2 TRANSCRIPTION: Transcription control of the ASN1 energy metabolism network. This aim investigated whether SDG8 and the histone modification it mediates affects mRNA processing. We performed genome-wide profiling that uncovered that histone methylation by SDG8 affects the co-transcriptional RNA processing of downstream genes involved in energy and photosynthesis. AIM 3 METABOLISM: A gene regulatory network controlling energy, C/N metabolism and N use efficiency. In Aim 3A, we showed that SDG8 affects the chromatin modification and expression of a transcription factor, CCT, which in turn affects the regulation of carbon responsive genes. In Aim 3B we showed that C and N metabolism is perturbed in the sdg8 mutant through differences in the chlorophyll content, free amino acids, and N uptake. Project activities In Aim 1, we uncovered that the histone methyltransferase SDG8 affects chromatin modification in response to N treatments. The N treatments causes changes in the H3K36me3 distribution off ~200 genes in WT plants, while the N-triggered changes in H3K36me3 of these genes is abrogated in the sdg8-5 mutant. The functional annotation of these 200 genes shows significant enrichment of N-related pathways. Overall, our study suggests that SDG8 mediates chromatin-level adaption of functionally relevant genes in response to changes in N. In Aim 2, we tested if SDG8 plays a role in transcriptional elongation and/or RNA processing. We detected more N-triggered isoform shifting events in the sdg8-5 mutant than in WT, which provides supports for SDG8 being required for proper RNA processing in response to N signaling. In Aim 3, we identified the gene network controlled by a CCT transcription factor under the epigenetic control of SDG8. Isoform abundance of the CCT protein is regulated by SDG8, which leads to an altered response of energy related genes to N level changes. Using physiological, metabolic and genetic approaches, we found that responses to N, including chlorophyll accumulation, N uptake and free amino acids, are altered in sdg8 mutants. Finally, this project provided training to a high school student who performed experiments on the complex interaction of photosynthesis and N availability. The student was named a semi-finalist in both the Regeneron and Siemens National Science competitions for her work.

59 BASIC BIOLOGICAL SCIENCES↗

Meta-Level Design Guidance and Operator Performance Measures for Hybrid Control Rooms

The purpose of this grant was to refine and test methods to evaluate digital human system interfaces (HSI) for existing largely analog nuclear power plant (NPP) control rooms (CRs). We hypothesized that CR operator performance (CROP) in hybrid NPP CRs will be improved if future digital HSI is designed based on: 1) more robust design guidelines for operator situation awareness (SA) and decision-making (DM); 2) enhanced CROP metrics during HSI evaluation; 3) an ontology for selecting simulation scenarios to evaluate digital HSI; and 4) a model to predict optimal HSI design attributes given CROP objectives. The team conducted numerous nuclear power plant site visits (e.g., to Brown’s Ferry, Palo Verde, Sequoyah and Vogtle) to study control room operations and crisis management and 3 visits to the NRC Chattanooga Training Center. We observed research studies at DC Cook and NRC Chattanooga in collaboration with the Halden Reactor Project. We collected operator performance and workload data in one NPP simulator. A comprehensive human (i.e., CROP) performance literature review was published in Applied Ergonomics. We obtained operator team performance data from CAER to produce our data fusion model and a paper delineating the results have been accepted (revision submitted) in Resilience Engineering and System Safety. We analyzed interview data related to scenario ontology development; a manuscript is still in preparation.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

6 th International Conference on Plant Synthetic Biology, Bioengineering and Biotechnology (Workshop Report)

The objective of the project is to hold a Conference to bring together scientists and engineers from universities, industry and government working in all aspects of plant synthetic biology, plant bioengineering and plant biotechnology. To meet this objective, AIChE will host the 6th International Conference on Plant Synthetic Biology, Bioengineering and Biotechnology on December 9-11, 2022 in Fort Lauderdale, Florida. The conference will feature five technical sessions: (1) Genome and Epigenome Editing, (2) Specialized Metabolism, (3) Engineering Plant Resilience, (4) Engineering more efficient plants, and (5) New tools and Technologies. The conference will allow leading scientists and engineers from universities, industry and government to discuss new tools and technologies being developed as well as their applications, and gaps in the field. The conference will allow students to learn about these new technologies, engage in a discussion with professionals in their field of interest, and showcase their work. The scope, theme, and aims of the Conference on Plant Synthetic Biology, Bioengineering, and Biotechnology fall squarely within the mission of DOE which includes securing US leadership in energy technology and to maintaining a vibrant US effort in science and engineering as a cornerstone for our economic prosperity.

59 BASIC BIOLOGICAL SCIENCES↗