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By introducing variable section silencers in divergent and convergent sections or elbows of ventilation plants, the length of classical silencers can be reduced. Presented is an original calculation method for active noise silencers with a continuously variable section, as well as calculation relations worked out by this method for eight common practical cases.
The Schneebeli silencer is made entirely of soft sheet steel. It is connected with the engine for receiving the exhaust gases, and consists of two parts: the silencer proper and a conical exit. The Birger silencer, made by the Ad Astra Company in Switzerland, is based on the principle of rapid cooling of the exhaust gases.
Ceruloplasmin (Cp) is an acute-phase protein with ferroxidase, amine oxidase, and pro- and antioxidant activities. The primary site of Cp synthesis in human adults is the liver, but it is also synthesized by cells of monocytic origin. We have shown that gamma interferon (IFN-gamma) induces the synthesis of Cp mRNA and protein in monocytic cells. We now report that the induced synthesis of Cp is terminated by a mechanism involving transcript-specific translational repression. Cp protein synthesis in U937 cells ceased after 16 h even in the presence of abundant Cp mRNA. RNA isolated from cells treated with IFN-gamma for 24 h exhibited a high in vitro translation rate, suggesting that the transcript was not defective. Ribosomal association of Cp mRNA was examined by sucrose centrifugation. When Cp synthesis was high, i.e., after 8 h of IFN-gamma treatment, Cp mRNA was primarily associated with polyribosomes. However, after 24 h, when Cp synthesis was low, Cp mRNA was primarily in the nonpolyribosomal fraction. Cytosolic extracts from cells treated with IFN-gamma for 24 h, but not for 8 h, contained a factor which blocked in vitro Cp translation. Inhibitor expression was cell type specific and present in extracts of human cells of myeloid origin, but not in several nonmyeloid cells. The inhibitory factor bound to the 3' untranslated region (3'-UTR) of Cp mRNA, as shown by restoration of in vitro translation by synthetic 3'-UTR added as a "decoy" and detection of a binding complex by RNA gel shift analysis. Deletion mapping of the Cp 3'-UTR indicated an internal 100-nucleotide region of the Cp 3'-UTR that was required for complex formation as well as for silencing of translation. Although transcript-specific translational control is common during development and differentiation and global translational control occurs during responses to cytokines and stress, to our knowledge, this is the first report of translational silencing of a specific transcript following cytokine activation.
Acoustical performance and pressure drop were measured for two types of splitters designed to attenuate sound propagating in ducts - resonant-cavity baffles and fiberglass-filled baffles. Arrays of four baffles were evaluated in the 7- by 10-foot wind tunnel number 1 at Ames Research Center at flow speeds from 0 to 41 m/sec. The baffles were 2.1 m high, 305 to 406 mm thick, and 3.1 to 4.4 m long. Emphasis was on measurements of silencer insertion loss as affected by variations of such parameters as baffle length, baffle thickness, perforated skin geometry, cavity size and shape, cavity damping, wind speed, and acoustic field directivity. An analytical method for predicting silencer performance is described and compared with measurements. With the addition of cavity damping in the form of 25-mm foam linings, the insertion loss above 250 Hz of the resonant-cavity baffles was improved 2 to 7 db compared with the undamped baffles; the loss became equal to or greater than the insertion loss of comparable size fiberglass baffles at frequencies above 250 Hz. Variations of cavity size and shape showed that a series of cavities with triangular cross-sections (i.e., variable depth) were superior to cavities with rectangular cross sections (i.e., constant depth). In wind, the undamped, resonant-cavity baffles generated loud cavity-resonance tones; the tones could be eliminated by cavity damping.
Presented is a description of the design construction and performance of the exhaust silencer for the NAL high Reynolds number two-dimensional transonic blow down wind tunnel, which was completed in October 1979. The silencer is a two-storied construction made of reinforced concrete, 40 m. long, 10 m. wide and 19 m. high and entirely enclosed by thick concrete walls. The upstream part of the first story, particularly, is covered with double walls, the thickness of the two walls being 0.3 m. (inner wall) and 0.2 m. (outer wall), respectively. A noise reduction system using three kinds of parallel baffles and two kinds of lined bends is adopted for the wind tunnel exhaust noise.
Targeted gene silencing in mammalian cells by RNA interference (RNAi) using small interfering RNAs (siRNAs) was recently described by Elbashir et al. (S. M. Elbashir et al., Nature (Lond.), 411: 494-498, 2001). We have used this methodology in several human cell strains to reduce expression of the Prkdc (DNA-PKcs) gene coding for the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) that is involved in the nonhomologous end joining of DNA double-strand breaks. We have also demonstrated a radiosensitization for several phenotypic endpoints of radiation damage. In low-passage normal human fibroblasts, siRNA knock-down of DNA-PKcs resulted in a reduced capacity for restitution of radiation-induced interphase chromosome breaks as measured by premature chromosome condensation, an increased yield of acentric chromosome fragments at the first postirradiation mitosis, and an increased radiosensitivity for cell killing. For three strains of related human lymphoblasts, DNA-PKcs-targeted siRNA transfection resulted in little or no increase in radiosensitivity with respect to cell killing, a 1.5-fold decrease in induced mutant yield in TK6- and p53-null NH32 cells, but about a 2-fold increase in induced mutant yield in p53-mutant WTK1 cells at both the hypoxanthine quanine phosphoribosyl transferase (hprt) and the thymidine kinase loci.
Radiated sound power conducted with cold model jets applied to acoustical problems and design of ground runup silencers for use with jet aircraft
Resonant-cavity parallel baffles, either empty or with a thin absorbent lining, have been investigated as an alternative to fiberglass-filled baffles commonly used to control noise emission from large ducts. A method for predicting silencer attenuation is described, and it is shown that the new type of baffle is characterized by an acoustic performance similar to that of fibrous baffles, while being virtually immune to such problems as clogging, erosion, or settling. The emphasis of the study is on insertion loss measurements in a 7 by 10 ft wind tunnel.
Conventional models of sound propagation between porous walls (Scott, 1946) are adapted in order to calculate design curves for the lined circular and annular-duct silencers used in HVAC systems. The derivation of the governing equations is outlined, and results for two typical cases are presented graphically. Good agreement with published experimental data is demonstrated.
A boundary layer control device includes a porous cover plate, an acoustic absorber disposed under the porous cover plate, and a porous flow resistive membrane interposed between the porous cover plate and the acoustic absorber. The porous flow resistive membrane has a flow resistance low enough to permit sound to enter the acoustic absorber and high enough to damp unsteady flow oscillations.
Sounds are an integral and sometimes annoying part of our daily life. Virtual worlds which imitate natural environments gain a lot of authenticity from fast, high quality visualization combined with sound effects. Sounds help to increase the degree of immersion for human dwellers in imaginary worlds significantly. The virtual reality toolkit of IGD (Institute for Computer Graphics) features a broad range of standard visual and advanced real-time audio components which interpret an object-oriented definition of the scene. The virtual reality system 'Virtual Design' realized with the toolkit enables the designer of virtual worlds to create a true audiovisual environment. Several examples on video demonstrate the usage of the audio features in Virtual Design.
A stacked-disc structure is comprised of a stack of annular discs (13) scalloped along the outer edge to provide lobes (13a) and etched on one side to provide lands (13a). A web (13d) is retained in the lobes to strengthen the discs so that they will not collapse due to high fluid pressure. The stack of discs is retained by a housing (10) having a fluted interior wall to retain the ends of the lobes. End plates (11 and 12) secure the stack of discs with a spacer (14) at one end having lands (14a) on lobes which match the lobes of the stacked discs to allow fluid to flow into, or out of, the spaces between the lobes of the stacked discs. The spaces between the lands on the etched discs provide passages for fluid flow into or out of the hollow core of the stack. The height of the lands (i.e., depth of the etch) determines the size of the smallest particle that will be permitted to flow through. The stacked-disc structure may be connected to the inlet of a valve, or be incorporated into the valve housing on the inlet side of the valve seat to assure substantially constant fluid velocity, and thereby reduce valve noise when the valve is operated.
This report has been developed by the National Aeronautics and Space Administration (NASA) ESMD Risk and Knowledge Management team. This document provides a point-in-time, cumulative, summary of key lessons learned derived from the official Columbia Accident Investigation Board (CAIB). Lessons learned invariably address challenges and risks and the way in which these areas have been addressed. Accordingly the risk management thread is woven throughout the document. This report is accompanied by a video that will be sent at request
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Fan silencers with low-pressure drop have been designed and installed in the NASA Ames 7- by 10-Foot Wind Tunnel No. 1. The silencers are composed of an absorbent lining flush with the wind-tunnel walls upstream of the fan and an absorbent splitter in the duct downstream of the fan. An acoustical insertion loss of 4 to 12 dB was measured between 100 and 1000 Hz. High-frequency performance of the silencers was reduced by test-section noise and by corner vanes which turned the sound waves so they followed the duct axis. Sound below 1.2 kHz diffracted around the 305-mm-long vanes and impinged on acoustically absorbent corner walls. Wind-tunnel flow losses are discussed.
An important noise source in a drilling plant is Diesel engine exhaust. In order to reduce this noise, a reactive silencer of the derivative resonator type was proposed, calculated from the acoustic and design point of view and applied. As a result of applying such a silencer on the exhaust conduit of a Diesel engine the noise level dropped down to 18 db.
A family of acoustic finite elements was developed based on C continuity (acoustic pressure being the nodal variable) and the no-flow condition. The family include triangular, quadrilateral and hexahedral isoparametric elements with linear quadratic and cubic variation in modelling and distortion. Of greatest use in problems with irregular boundaries are the cubic isoparametric elements: the 32 node hexahedral element for three-dimensional systems; and the twelve node quadrilateral and ten node triangular elements for two-dimensional/axisymmetric applications. These elements were applied to problems involving cavity resonances, transmission loss in silencers and the study of end effects, using a Floating Point Systems 164 attached array processor accessed through an Amdahl 5860 mainframe. The elements are presently being used to study the end effects associated with duct terminations within finite enclosures. The transmission losses with various silencers and sidebranches in ducts is also being studied using the same elements.
The sound field produced by a supersonic propeller operating in a uniform flow is investigated. The main interest is the effect of the finite forward flight speed on the directivity of the sound field as seen by an observer on the aircraft. It is found that there are cones of silence on the axis of the propeller. The semiapex angles on these cones are equal fore and aft of the propeller plane, and depend on the tip Mach number only. The Fourier coefficients of the acoustic pressure contain the Doppler amplification factor. The sound field weakens in the upstream direction and strengthen downstream. Kinematic considerations of the emitted Mach waves not only confirm these results, but also provide physical insight into the sound generation mechanism. The predicted zone of silence and the Doppler amplification factor are compared to the theoretical prediction of shock wave formation and the flight test of the SR3 propeller.