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Current Status of Chemical Studies on the Origin of Life
Chemical studies of life origin, discussing chemical and biological evolution, precellular organization and synthesis of various life compounds
Vitality models found useful in modeling tag-failure times in acoustic-tag survival studies
Abstract Acoustic telemetry studies often rely on the assumption that premature tag failure does not affect the validity of inferences. However, in some cases this assumption is possibly or likely invalid and it is necessary to apply a correction to estimation procedures. The question of which approaches and specific models are best suited to modeling acoustic tag failures has received little research attention. In this short communication, we present a meta-analysis of 42 acoustic tag-life studies, originally used to correct survival studies involving outmigrating juvenile salmonids in the Columbia/Snake river basin. We compare the performance of nine alternative parametric models including common failure–time/survival models and the vitality models of Li and Anderson Theor Popul Biol 76:118–131, (2009) and Demogr Res 28:341–372, (2013). The tag-life studies used acoustic tags from three different tag manufacturers, had expected lifetimes between 12 and 61 days, and had dry weights ranging from 0.22 to 1.65 g. In 57% of the cases, the vitality models of Li and Anderson Theor Popul Biol 76:118–131, (2009) and Demogr Res 28:341–372, (2013) fit the tag-failure times best. The vitality models were also the second-best choices in 17% of the cases. Together, the vitality models, log-logistic, (19%), and gamma models (14%) accounted for 90% of the models selected. Unlike more traditional failure–time models (e.g., Weibull, Gompertz, gamma, and log-logistic), the vitality models are capable of characterizing both the early onset of tag failure due to manufacturing errors and the anticipated battery life. We provide further guidance on appropriate sample sizes (50–100 tags) and procedures to be considered when applying precise tag-life corrections in release–recapture survival studies.
Measurement of extremely low fluid permeabilities of rocks significant to studies of the origin of life Final report
Permeater for measuring low fluid permeabilities of rocks used to study origin of life
Chemical studies on the origin of life.
Chemical laboratory experiments on origin, chemical components and structural attributes of life
Ames interactive molecular model building system - A 3-D computer modelling system applied to the study of the origin of life
The investigation of specific interactions among biological molecules must take into consideration the stereochemistry of the structures. Thus, models of the molecules are essential for describing the spatial organization of potentially interacting groups, and estimations of conformation are required for a description of spatial organization. Both the function of visualizing molecules, and that of estimating conformation through calculations of energy, are part of the molecular modeling system described in the present paper. The potential uses of the system in investigating some aspects of the origin of life rest on the assumption that translation of conformation from genetic elements to catalytic elements would have been required for the development of the first replicating systems subject to the process of biological evolution.
Possible Mechanism(s) in the Photo-Magnetic Production of Enantiomer Excesses.
Among the multitude of organic compounds identified in carbonaceous chondrites are sugar acids ((HO-R)xCOOH), i.e., oxidized counterparts of the common aldehyde sugars (e.g., glyceraldehyde, erythrose, ribose, glucose, etc.). In the historical study of extraterrestrial compounds chiral analyses are particularly significant in origins-of-life studies. Chiral compounds are composed of two non-superposable mirror images or "enantiomers", analogous to a left and right hand. Such molecules are important in contemporary life because biological polymers (proteins, nucleic acids, etc.) are homochiral, i.e., their chiral monomers usually consist of only one of the two enantiomers. It has been shown, at least in one lab setting, that abiotic syntheses of significantly sized RNA polymers do not proceed if the monomers are present in racemic (50:50) amounts. The latter results may argue for, at least, significant enantiomer excesses in organic compounds before the origin of nucleic acids and life. Therefore, the finding that amino acids and sugar acids in carbonaceous chondrites possess enantiomeric excesses may aid in understanding one source of precursors to homochirality. Note: Attachment contains full abstract.
A Radical Pathway for Organic Phosphorylation during Schreibersite Corrosion with Implications for the Origin of Life
Phosphorylated compounds (e.g. DNA, RNA, phospholipids, and many coenzymes) are critical to biochemistry. Thus, their origin is of prime interest to origin of life studies. The corrosion of the meteoritic mineral schreibersite ((Fe,Ni)3P) may have significantly contributed to the origin of phosphorylated biomolecules. Corrosion of synthetic schreibersite in a variety of solutions was analyzed by nuclear magnetic resonance spectroscopy, mass spectrometry, and electron paramagnetic resonance spectroscopy. These methods suggest a radical reaction pathway for the corrosion of schreibersite to form phosphite radicals (raised dot PO3 sup 2-)) aqueous solution. These radicals can form activated polyphosphates and can phosphorylate organic compounds such as acetate (3% yield). Phosphonates (O3P-C) are found in the organic P inventory of the carbonaceous meteorite Murchison. While phosphonates are rare in biochemistry, the ubiquity of corroding iron meteorites on the early Earth could have provided an accessible source of organophosphorous for the origin of life allowing the invention of the organophosphates in modern biology as a product of early evolution.
Aerothermodynamics for Dragonfly's Titan Entry
Dragonfly is a proposed spacecraft and mission that would send a mobile robotic rotorcraft lander to Titan, the largest moon of Saturn, in order to study prebiotic chemistry and extraterrestrial habitability at various locations. Titan is unique in having an abundant, complex, and diverse carbon-rich chemistry on the surface of a water-ice-dominated world with an interior water ocean, making it a high priority target for astrobiology and origin of life studies. The mission was initially proposed in April 2017 to NASA's New Frontiers program by the Johns Hopkins Applied Physics Laboratory. In December 2017, it was selected as one of two finalists (out of twelve proposals) to further refine the mission's concept. NASA Ames Research Center and NASA Langley Research Center are partnering as the leads for the Dragonfly's entry system to provide the completed EDL Assembly. The aerothermal analysis for Dragonfly utilizes four simulation tools from NASA Ames Research Center. Traj for calculating the trajectory, DPLR 4.04.0 for calculating the flowfield around the vehicle and convective heating, NEQAIR V15.0 for calculating the radiative heating, and FIAT for calculating the material response and thermal protection system (TPS) sizing for the heatshield. The entry conditions are relatively benign and can readily be accommodated with a tiled PICA heatshield similar to MSL and a number of flight proven materials for the backshell. This work will demonstrate that the aerothermal entry environments can be readily solved using heritage materials and techniques.
A new view of the ''synthesis of life.''
Experimental research concerned with origin of life, studying synthesis of precursor polymers and self assembly into protocells
Publications of the planetary biology program for 1978: A special bibliography
The planetary events which are responsible for, or related to, the origin, evolution, and distribution of life in the universe are investigated. Bibliographies from chemical evolution, organic geochemistry, life detection, biological adaptation, bioinstrumentation, planetary environments, and origin of life studies are presented.
The beginning of comparative planetology
The study of the origin of life question is related to the comparative study of the planets in our solar systems and in fact the universe as a whole. Data relevant to the origin of life is being accumulated from the earth, planets, stars and interstellar space. A variety of spacecraft and earth based techniques are being used to provide this data.
Chemical Evolution and the Origin of Life: Bibliography 1975
This bibliography is the sixth annual supplement to the comprehensive bibliography on the same subject which was published in Space Life Sci.We would like to draw attention to a recently published cumulative bibliography on this same subject: Biochemical Origin of Life: Chemistry and Life. Soil and Water and Its Relationship to Origin of Life. MR - Studies of Prebiotic Polypeptides. Energy, Matter, and Life. Prospects for the Future Orientation of Scientific Research. Photochemical Formation of Self Sustaining Coacervates. Photochemical Formation of Self-Sustaining Coacervates. Comparative Study of Abiogenesis of Cysteine and Other Amino Acids Catalyzed by Various Metal Ions. Protein Structure and the Molecular Evolution of Biological Energy Conversion. Origin of Life. Clues from Relations Between Chemical Compositions of Living Organisms and Natural Environments. Shock Synthesis of Amino Acids II.', Origins of Life 6(1-2). Dynamics of the Chemical Evolution of Earth's Primitive Atmosphere. The Mechanisms of Amino Acids Synthesis by High Temperature Shock-Waves. Theory of Chemical Evolution. Physical Foundations of Probability of Biogenesis.
Life on ice, Antarctica and Mars
The study of the origin of life and the prospects for human exploration of Mars are two themes developed in a new 57-minute film, Life on Ice, Antarctica, and Mars, produced by the InnerSpace Foundation and WHRO Television for broadcast by the Public Broadcasting System (PBS). A brief explanation of the film and how it relates to the future human exploration of space is presented.
Origins of life: a comparison of theories and application to Mars
The field of study that deals with the origins of life does not have a consensus for a theory of life's origin. An analysis of the range of theories offered shows that they share some common features that may be reliable predictors when considering the possible origins of life on another planet. The fundamental datum dealing with the origins of life is that life appeared early in the history of the Earth, probably before 3.5 Ga and possibly before 3.8 Ga. What might be called the standard theory (the Oparin-Haldane theory) posits the production of organic molecules on the early Earth followed by chemical reactions that produced increased organic complexity leading eventually to organic life capable of reproduction, mutation, and selection using organic material as nutrients. A distinct class of other theories (panspermia theories) suggests that life was carried to Earth from elsewhere--these theories receive some support from recent work on planetary impact processes. Other alternatives to the standard model suggest that life arose as an inorganic (clay) form and/or that the initial energy source was not organic material but chemical energy or sunlight. We find that the entire range of current theories suggests that liquid water is the quintessential environmental criterion for both the origin and sustenance of life. It is therefore of interest that during the time that life appeared on Earth we have evidence for liquid water present on the surface of Mars.
Cometary Amino Acids from the STARDUST Mission
NASA's Stardust spacecraft returned samples from comet 81 P/WiId 2 to Earth in January 2006. Examinations of the organic compounds in cometary samples can reveal information about the prebiotic organic inventory present on the early Earth and within the early Solar System, which may have contributed to the origin of life. Preliminary studies of Stardust material revealed the presence of a suite of organic compounds including several amines and amino acids, but the origin of these compounds (cometary vs. terrestrial contamination) could not be identified. We have recently measured the carbon isotopic ratios of these amino acids to determine their origin, leading to the first detection of a cometary amino acid.
Amino Acids from a Comet
NASA's Stardust spacecraft returned samples from comet 81P/Wild 2 to Earth in January 2006. Examinations of the organic compounds in cometary samples can reveal information about the prebiotic organic inventory present on the early Earth and within the early Solar System, which may have contributed to the origin of life. Preliminary studies of Stardust material revealed the presence of a suite of organic compounds including several amines and amino acids, but the origin of these compounds (cometary- vs. terrestrial contamination) could not be identified. We have recently measured the carbon isotopic ratios of these amino acids to determine their origin, leading to the first detection of a coetary amino acid.
Where Synthetic Biology Meets ET
Synthetic biology - the design and construction of new biological parts and systems and the redesign of existing ones for useful purposes - has the potential to transform fields from pharmaceuticals to fuels. Our lab has focused on the potential of synthetic biology to revolutionize all three major parts of astrobiology: Where do we come from? Where are we going? and Are we alone? For the first and third, synthetic biology is allowing us to answer whether the evolutionary narrative that has played out on planet earth is likely to have been unique or universal. For example, in our lab we are re-evolving the biosynthetic pathways of amino acids in order to understand potential capabilities of an early organism with a limited repertoire of amino acids and developing techniques for the recovery of metals from spent electronics on other planetary bodies. And what about the limits for life? Can we create organisms that expand the envelope for life? In the future synthetic biology will play an increasing role in human activities both on earth, in fields as diverse as human health and the industrial production of novel bio-composites. Beyond earth, we will rely increasingly on biologically-provided life support, as we have throughout our evolutionary history. In order to do this, the field will build on two of the great contributions of astrobiology: studies of the origin of life and life in extreme environments.