Search NASA⌕ Search

SEARCH · Search NASA

Results for “systematic literature review”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS2025

Assessing the Added Value of Miniature X-Ray in the Setting of Portable Ultrasound in Spaceflight

INTRODUCTION: Point-of-care ultrasound (POCUS) has become the standard of care for imaging diagnosis and management in low-Earth Orbit (LEO) spaceflight and it has long been hypothesized that POCUS will also be the standard of care for exploration spaceflight. However, like the trajectory for which ultrasound became more portable and user-friendly, the mass, volume, and power requirements of radiography devices for both diagnostic and therapeutic applications have also been dramatically reduced. This study seeks to determine the clinical utility and added value of miniature x-ray (XR) for the diagnosis and management of each of the 119 conditions within NASA Exploration Medical Capability’s IMPACT Condition List (ICL) given that the medical system is presumed to already be carrying a handheld portable POCUS device. METHODS: For each condition, a team of reviewers performed a rapid systematic literature review seeking sensitivity and specificity data for both handheld portable ultrasound and miniature XR. When there was a paucity of data, subject matter expertise and clinical experience was added to semi-quantitatively score the added value of miniature XR, given an US was already available for both diagnosis and management. Diagnostic utility of a modality for a condition was evaluated in the setting of both the best- and worst-case scenario definitions included and defined by the ICL. Evidence tracing and quality of evidence scores were also recorded. RESULTS/DISCUSSION: Conditions for which it was determined that miniature XR added diagnostic or therapeutic value are provided in this presentation. Previously presented work by our team has demonstrated that XR provides diagnostic and management capabilities that are hypothesized to complement or surpass ultrasound for over one-third of medical conditions that may arise during exploration spaceflight (i.e., diagnosis of injuries to the axial skeleton, teeth, and lungs as well as management of orthopedic reductions, endotracheal tube placement, and drain placement confirmation). In the setting of known inclusion of a handheld portable POCUS device, there remains significant added value of portable miniature XR. Whether or not this added clinical benefit is worth the mass, volume, and power requirements of the radiography system remains yet unknown and is the focus of future work. LEARNING OBJECTIVES: 1) Understand the value of ultrasound and radiography in the diagnosis and management of medical comorbidities that may arise in exploration spaceflight; 2) Understand the medical conditions of highest concern on exploration class missions for which miniature x-ray may provide added value to portable ultrasound.

J G Steller↗
NASA NTRSDate not supplied

Assessing the Added Value of Miniature X-Ray in the Setting of US in Spaceflight

INTRODUCTION: Point-of-care ultrasound (POCUS) has become the standard of care for imaging diagnosis and management in lowEarth Orbit (LEO) spaceflight and it has long been hypothesized that POCUS will also be the standard of care for exploration spaceflight. However, like the trajectory for which ultrasound became more portable and user-friendly, the mass, volume, and power requirements of radiography devices for both diagnostic and therapeutic applications have also been dramatically reduced. This study seeks to determine the clinical utility and added value of miniature x-ray (XR) for the diagnosis and management of each of the 119 conditions within NASA Exploration Medical Capability’s IMPACT Condition List (ICL) given that the medical system is presumed to already be carrying a handheld portable POCUS device. METHODS: For each condition, a team of reviewers performed a rapid systematic literature review seeking sensitivity and specificity data for both handheld portable ultrasound and miniature XR. When there was a paucity of data, subject matter expertise and clinical experience was added to semi-quantitatively score the added value of miniature XR, given an US was already available for both diagnosis and management. Diagnostic utility of a modality for a condition was evaluated in the setting of both the best- and worst-case scenario definitions included and defined by the ICL. Evidence tracing and quality of evidence scores were also recorded. RESULTS/DISCUSSION: Conditions for which it was determined that miniature XR added diagnostic or therapeutic value are provided in this presentation. Previously presented work by our team has demonstrated that XR provides diagnostic and management capabilities that are hypothesized to complement or surpass ultrasound for over one-third of medical conditions that may arise during exploration spaceflight (i.e., diagnosis of injuries to the axial skeleton, teeth, and lungs as well as management of orthopedic reductions, endotracheal tube placement, and drain placement confirmation). In the setting of known inclusion of a handheld portable POCUS device, there remains significant added value of portable miniature XR. Whether or not this added clinical benefit is worth the mass, volume, and power requirements of the radiography system remains yet unknown and is the focus of future work. LEARNING OBJECTIVES: 1) Understand the value of ultrasound and radiography in the diagnosis and management of medical comorbidities that may arise in exploration spaceflight; 2) Understand the medical conditions of highest concern on exploration class missions for which miniature x-ray may provide added value to portable ultrasound.

Jon Steller↗
NASA NTRSDate not supplied

Intraocular Pressure Dynamics in Microgravity and Terrestrial Analogues: A Systematic Review and Qualitative Analysis

Spaceflight-Associated Neuro-ocular Syndrome (SANS) presents risk to expeditionary spaceflight. Related ocular findings carry poorly understood pathophysiology, including relationship to intraocular pressure (IOP) dynamics in microgravity. The study objectives were to conduct a systematic literature review and pool available IOP data from terrestrial microgravity analogs plus published spaceflight measures for comparison and qualitative analysis.

Elkhatib, Wiaam↗
NASA NTRS2012

Anaphylaxis, Intra-Abdominal Infections, Skin Lacerations, and Behavioral Emergencies: A Literature Review of Austere Analogs for a near Earth Asteroid Mission

As space exploration is directed towards destinations beyond low-Earth orbit, the consequent new set of medical risks will drive requirements for new capabilities and more resources to ensure crew health. The Space Medicine Exploration Medical Conditions List (SMEMCL), developed by the Exploration Medical Capability element of the Human Research Program, addresses the risk of "unacceptable health and mission outcomes due to limitations of in-flight medical capabilities". It itemizes 85 evidence-based clinical requirements for eight different mission profiles and identifies conditions warranting further research and technology development. Each condition is given a clinical priority for each mission profile. Four conditions -- intra-abdominal infections, skin lacerations, anaphylaxis, and behavioral emergencies -- were selected as a starting point for analysis. A systematic literature review was performed to understand how these conditions are treated in austere, limited-resource, space-analog environments (i.e., high-altitude and mountain environments, submarines, military deployments, Antarctica, isolated wilderness environments, in-flight environments, and remote, resource-poor, rural environments). These environments serve as analogs to spaceflight because of their shared characteristics (limited medical resources, delay in communication, confined living quarters, difficulty with resupply, variable time to evacuation). Treatment of these four medical conditions in austere environments provides insight into medical equipment and training requirements for exploration-class missions.

Chough, Natacha G.↗
NASA NTRSDate not supplied

Cardiovascular Disease Spaceflight Equivalent Stressor Risk Modeling Project

The risk of cardiovascular disease (CVD) may be exacerbated by spaceflight hazards including radiation, isolation, distance from the Earth, gravity fields, and closed or confined environments. This project aims to use epidemiologic, scientific research evidence of surrogate spaceflight stressors on analog populations in terrestrial cohorts to model CVD risk for spaceflight conditions. To date, Dr. Butler and the multi-disciplinary CVD Spaceflight Equivalent Stressors (SES) team have conducted a formal systematic literature review on the risk of sleep loss as it relates to cardiovascular disease outcomes and are currently working on a meta-analysis for the data gathered from nearly 100 studies and their various CVD outcomes. The research will continue to examine other surrogate stressors in depth, such as altered gravity, radiation exposure, noise, etc. with cardiovascular outcomes to determine an overall combined spaceflight risk for long term future missions such as Artemis Lunar and Mars missions.

Jennifer Butler↗
NASA NTRSDate not supplied

State of the Art and Practice for Equity in Urban Air Mobility

Traditionally, new modes of transportation in the United States have benefited upper social classes at the expense of underrepresented and lower socioeconomic classes. Several recent studies in transportation have explored this disparity, and research has highlighted factors that contribute to transportation equity. In this effort, we will examine this previous work as it applies to the broader, current transportation system. We will use our literature search to highlight and educate the current emerging aviation stakeholders on equity strategies that are directly applicable to these novel operations. We will also use our literature research to make informed recommendations for experiments and data collection that will increase our understanding about how these new aviation concepts can be encouraged to provide equity as an emergent property.

transportation equity↗
NASA NTRSDate not supplied

Microgravity Effect on Bacterial Growth: Further Clarification of the Underlying Mechanism

Gravity interacts with other physical environmental factors to impact the formation of today’s Earth and contribute to biological variations between water and land species. With their simple structures and small sizes, microbes are expected to be less gravity-sensitive than larger species. However, microgravity can significantly impact the mass transfer and interface behavior in the extracellular environment, and various effects of spaceflight on bacterial growth have been observed. Our earlier literature review summarizes the systematic efforts to understand the spaceflight effect on microbial growth through the extracellular mass transfer mechanism. It provides an in-depth literature review to address some discrepancies observed in the literature. This paper analyzes the effects of microgravity on the extracellular environment and their potential impact on bacterial growth to further clarify the underlying mechanism of the microgravity effect on bacterial growth.

Wenyan Li↗
NASA NTRS2015

Menstrual Cycle Control in Female Astronauts and the Associated Risk of Venous Thromboembolism

Venous thromboembolism (VTE) is a common and serious condition affecting approximately 1‐2 per 1000 people in the USA every year. There have been no documented case reports of VTE in female astronauts during spaceflight in the published literature. Some female astronauts use hormonal contraception to control their menstrual cycles and it is currently unknown how this affects their risk of VTE. Current terrestrial risk prediction models do not account for the spaceflight environment and the physiological changes associated with it. We therefore aim to estimate a specific risk score for female astronauts who are taking hormonal contraception for menstrual cycle control, to deduce whether they are at an elevated risk of VTE. A systematic review of the literature was conducted in order to identify and quantify known terrestrial risk factors for VTE. Studies involving analogues for the female astronaut population were also reviewed, for example, military personnel who use the oral contraceptive pill for menstrual suppression. Well known terrestrial risk factors, for example, obesity or smoking would not be applicable to our study population as these candidates would have been excluded during astronaut selection processes. Other risk factors for VTE include hormonal therapy, lower limb paralysis, physical inactivity, hyperhomocysteinemia, low methylfolate levels and minor injuries, all of which potentially apply to crew members LSAH data will be assessed to identify which of these risk factors are applicable to our astronaut population. Using known terrestrial risk data, an overall estimated risk of VTE for female astronauts using menstrual cycle control methods will therefore be calculated. We predict this will be higher than the general population but not significantly higher requiring thromboprophylaxis. This study attempts to delineate what is assumed to be true of our astronaut population, for example, they are known to be a healthy fit cohort of individuals, and combine physiological impacts of spaceflight (cephalic fluid shifts, lower limb inactivity) to understand specific risks associated with hormonal contraception.

Jain, Varsha↗
NASA NTRSDate not supplied

The Impact of Delayed Communication on NASA’s Human-Systems Operations: Preliminary Results of a Systematic Review

Throughout the history of human spaceflight, NASA has relied on a team of ground-based experts on Earth to manage its missions, vehicles, and crews to ensure crew safety and mission success. However, as missions progress beyond low-Earth orbit (LEO), this paradigm of dependence on ground must evolve. Beyond LEO, in missions to the moon and Mars, crews will confront new challenges: limited evacuation options, reduced resupply capabilities, and significant communication delays that impede real-time support from experts on the ground. This reduction in ground support amplifies the likelihood that crews will be unable to adequately respond to unanticipated, safety-critical events. Understanding the scope of these risks and identifying effective countermeasures hinges on understanding the impact of communication delays on complex operations, especially in urgent, unforeseen events. Real-time communication currently provides the crew with continuous access to a large, extensively resourced ground team skilled in anomaly resolution. However, as communication delays grow, the need to transfer some responsibilities from ground experts to onboard crew becomes evident. NASA has been exploring this shift in operational responsibilities and its effectiveness in managing complex operations for decades. Nevertheless, a comprehensive understanding of the specific challenges posed by communication delays and the necessary countermeasures to mitigate them remains a gap. In this paper, we present an update on our systematic review of the literature on communication delays, the first in-depth review since 2013 (Rader et al.). We introduce a coding taxonomy to capture key constructs from papers of interest and discuss preliminary findings. These preliminary results suggest two significant research gaps: limited studies have been conducted 1) with lunar-like latencies and 2) on problem-solving strategies for the maximum latencies expected in Mars missions. We outline plans and propose recommendations to address these gaps through ongoing and future research.

human-systems integration↗
NASA NTRSDate not supplied

The Impact of Delayed Communications on NASA's Human-Systems Operations: Preliminary Results of a Systematic Review

Throughout the history of human spaceflight, NASA has relied on a team of ground-based experts on Earth to manage its missions, vehicles, and crews to ensure crew safety and mission success. However, as missions progress beyond low-Earth orbit (LEO), this paradigm of dependence on ground must evolve. Beyond LEO, in missions to the moon and Mars, crews will confront new challenges: limited evacuation options, reduced resupply capabilities, and significant communication delays that impede real-time support from experts on the ground. This reduction in ground support amplifies the likelihood that crews will be unable to adequately respond to unanticipated, safety-critical events. Understanding the scope of these risks and identifying effective countermeasures hinges on understanding the impact of communication delays on complex operations, especially in urgent, unforeseen events. Real-time communication currently provides the crew with continuous access to a large, extensively resourced ground team skilled in anomaly resolution. However, as communication delays grow, the need to transfer some responsibilities from ground experts to onboard crew becomes evident. NASA has been exploring this shift in operational responsibilities and its effectiveness in managing complex operations for decades. Nevertheless, a comprehensive understanding of the specific challenges posed by communication delays and the necessary countermeasures to mitigate them remains a gap. In this paper, we present an update on our systematic review of the literature on communication delays, the first in-depth review since 2013 (Rader et al.). We introduce a coding taxonomy to capture key constructs from papers of interest and discuss preliminary findings. These preliminary results suggest two significant research gaps: limited studies have been conducted 1) with lunar-like latencies and 2) on problem-solving strategies for the maximum latencies expected in Mars missions. We outline plans and propose recommendations to address these gaps through ongoing and future research.

earth-independence↗
NASA NTRS2021

A Systematic Review and Meta-analysis of the Potential Non-human Animal Reservoirs and Arthropod Vectors of the Mayaro Virus

Improving our understanding of Mayaro virus (MAYV) ecology is critical to guide surveillance and risk assessment. We conducted a PRISMA-adherent systematic review of the published and grey literature to identify potential arthropod vectors and non-human animal reservoirs of MAYV. We searched PubMed/MEDLINE, Embase, Web of Science, SciELO and grey-literature sources including PAHO databases and dissertation repositories. Studies were included if they assessed MAYV virological/immunological measured occurrence in field-caught, domestic, or sentinel animals or in field-caught arthropods. We conducted an animal seroprevalence meta-analysis using a random effects model. We compiled granular georeferenced maps of non-human MAYV occurrence and graded the quality of the studies using a customized framework. Overall, 57 studies were eligible out of 1523 screened, published between the years 1961 and 2020. Seventeen studies reported MAYV positivity in wild mammals, birds, or reptiles and five studies reported MAYV positivity in domestic animals. MAYV positivity was reported in 12 orders of wild-caught vertebrates, most frequently in the orders Charadriiformes and Primate. Sixteen studies detected MAYV in wild-caught mosquito genera including Haemagogus, Aedes, Culex, Psorophora, Coquillettidia, and Sabethes. Vertebrate animals or arthropods with MAYV were detected in Brazil, Panama, Peru, French Guiana, Colombia, Trinidad, Venezuela, Argentina, and Paraguay. Among non-human vertebrates, the Primate order had the highest pooled seroprevalence

Mayaro virus↗
NASA NTRSDate not supplied

Assessment of the State of Communication Delay Research in Preparation for Missions Beyond Low Earth Orbit

NASA’s mission-operations paradigm, established during Project Mercury and minimally evolving through the Apollo Program, Space Shuttle Program, and ISS missions, has primarily depended on real-time support from a ground team of experts. This ground team has served as the safety net for crewed spaceflight missions over the past 60 years, managing the combined state of the mission, vehicle, and crew. However, this operational paradigm, which has seen little change in its Human-Systems Integration Architecture (HSIA), will face challenges during long-duration exploration missions beyond low Earth orbit. Lunar missions may experience one-way communication latencies ranging from 3 to 14 seconds, while Mars missions will encounter up to a 44-minute round-trip latency at a maximum distance from Earth. Communication delays negatively impact the behavioral health and performance of individuals and crews operating across the multi-team space-to-ground system. Previous research indicates that increased isolation and the challenges posed by delayed communication lead to heightened stress, frustration, adverse behavioral symptoms, and reduced individual performance. NASA has investigated the nature and effectiveness of managing this shift in complex operations since early 2000, but additional research is necessary to assess the issues associated with communication latencies and identify effective countermeasures. This work aimed to examine the evidence from 20 years of research on comm delays. We systematically reviewed the past 20 years of communication delay literature, focusing on how this research aligns with relevant, high-priority needs in the HSIA, Team, and BMed Risks. This type of panoramic review has not been done since 2013; a current, aggregated picture of what has been studied and how is needed to inform additional studies and mitigation development. Additional perspectives were gained from interviews with the research participants, operations experts, and communication delay researchers. Results from this effort will help characterize the risk posed by communication latency for upcoming Artemis missions and point toward potential mitigations. The final results will be presented. For the literature review, we formed a search term seed set drawing from languages used in two papers representative of the previous state of knowledge and supplemented it with additional search terms. We conducted literature searches on Google Scholar, PubMed, and Web of Science and searched NASA project archives for output from NASA-sponsored research. This search yielded 150 papers, of which 48 were relevant. SME interviews provided perspective on key communication delay issues and concerns and what is being worked on to mitigate those issues. Preliminary results of the literature review have been presented. Final results to be presented include the results of the literature review and findings from the interviews.

literature review↗
NASA NTRS2020

A Systematic Review of Local to Regional Yield Forecasting Approaches and Frequently Used Data Resources

Forecasting crop yields, or providing an expectation of ex-ante harvest amounts, is highly relevant to the whole agricultural production chain. Farmers can adapt their management, traders or insurers their pricing schemes, suppliers their stocks, logistic companies their routes, national authorities their food balance sheets to guide import or export and, finally, international aid organizations can mobilize reliefs. Evidence has grown in the literature that such forecasts with a meaningful lead time are possible on various geographic scales and for a broad range of crops. Here, we present a systematic review of the methods applied in end-of-season yield forecasting and three frequently used data sources: weather data, satellite data and crop masks. Our literature database comprises 362 studies (2004–2019) which were evaluated regarding methods, crops, regions, data sources, lead time and performance. Moreover, we present 24 sources of real-time and predictive weather data, 21 sources of remote sensing data and 16 crop masks. Yield forecasting in our literature sample has been performed for 44 crops in 71 countries, also including many non-staple crops, but with an apparent bias in regions and crops. Forecasting performance depends on various factors, including crop, region, method, lead time to harvest and input diversity. Our systematic review supports a broader application of locally successful approaches at larger scales by providing a comprehensive, accessible compendium of necessary information for yield forecasting. We discuss improvement potentials with respect to methodological approaches and available data sources. We additionally suggest standardization procedures for future forecasting studies and encourage studying additional crops and geographic regions. Implications of forecasts for different target groups on different scales and the adaptation towards climate change are also discussed.

Seasonal crop yield forecasting↗
NASA NTRSDate not supplied

Microgravity Effect on Bacterial Growth: A Literature Review

Gravity is a well-known, but little understood, physical force. It interacts with other physical environmental factors to impact the formation of today’s Earth, and to contribute to biological variations between water and land species. It is also involved with cell differentiation process, and is responsible for setting the boundaries for life and keeping cells small. With their simple structures and small sizes, microbes are expected to be less gravity sensitive than larger species. Nevertheless, various effects of spaceflight on bacterial growth have been reported, but the reports have been sometime inconsistent, and the underlying mechanism remains unclear to many. This paper summarizes the systematic efforts to evaluate the spaceflight effect on microbial growth, highlighting the extracellular mass transfer mechanism. It also provides a critical literature review on the topic to resolve the discrepancy in experimental observations and to further clarify the underlying mechanisms.

Wenyan Li↗
NASA NTRS1984

Kinetics of the reaction O + ClO yields Cl + O2

The kinetics of the reaction O + ClO yields Cl + O2 (k1) were studied by using resonance fluorescence to monitor the decay of O atoms which had been generated from the laser photolysis of ClO. A discharge flow system was used to generate the ClO and its concentration was measured directly by multipass absorption spectrometry. The results are k1(298) = (4.2 + or -0.8) x 10 to the -11th cu cm/s (including systematic errors) with E/R determined to lie in the range + or - 200 K. The literature data are reviewed and a composite value of k1(T) = 6.0 x 10 to the -11th exp-(100/T) is recommended for stratospheric modeling calculations. The atmospheric implications of the revised rate constant are discussed briefly.

Margitan, J. J.↗
NASA NTRS2023

A Review on the Coalescence of Confined Drops with a Focus on Scaling Laws for the Growth of the Liquid Bridge

The surface–tension-driven coalescence of drops has been extensively studied because of the omnipresence of the phenomenon and its significance in various natural and engineering systems. When two drops come into contact, a liquid bridge is formed between them and then grows in its lateral dimensions. As a result, the two drops merge to become a bigger drop. The growth dynamics of the bridge are governed by a balance between the driving force and the viscous and inertial resistances of involved liquids, and it is usually represented by power–law scaling relations on the temporal evolution of the bridge dimension. Such scaling laws have been well-characterized for the coalescence of unconfined or freely suspended drops. However, drops are often confined by solid or liquid surfaces and thus are a different shape from spheres, which affects their coalescence dynamics. As such, the coalescence of confined drops poses more complicated interfacial fluid dynamics challenges compared to that of unconfined drops. Although there have been several studies on the coalescence of confined drops, they have not been systematically reviewed in terms of the properties and geometry of the confining surface. Thus, we aim to review the current literature on the coalescence of confined drops in three categories: drop coalescence on a solid surface, drop coalescence on a deformable surface, and drop coalescence between two parallel surfaces with a small gap (i.e., Hele-Shaw cell), with a focus on power–law scaling relations, and to suggest challenges and outlooks for future research on the phenomena.

Sangjin Ryu↗
NASA NTRSDate not supplied

A Survey Protocol to Assess Meaningfulness and Usefulness of Automated Topic Finding in the NASA Aviation Safety Reporting System

Context: The NASA Aviation Safety Reporting System (ASRS) is a voluntary confidential aviation safety reporting system. The ASRS receives reports from pilots, air traffic controllers, flight attendants and other involved in aviation operations. The reports are de-identified and coded by ASRS expert safety analysts and a short descriptive synopsis is written to describe the safety issue. The de-identified reports are then disseminated to the aviation community in a number of ways including entry into an online database, Safety Alert Bulletins and For Your Information Notices, and the CALLBACK newsletter. Key to these publications are the timely processing (de-identification, coding and summarization) of new reports, which is currently done by ASRS expert safety analysts. Thus, we believe topic modelling could decrease effort in ASRS, if topics are comprehensible. Aim: We propose a methodology to evaluate whether automated topic finding using topic modelling provides meaningful and useful topics. Method: We extend the total error survey methodology to evaluate user topic comprehension of machine learning outputs. To accomplish this we performed a literature review to identify existing methods and define a construct for topic comprehension, utilizing existing ASRS synopsis writing practices to more precisely define meaningfulness and usefulness. Results: A survey protocol was created that addresses the limitations of other survey protocols found in the literature review, which we found lacking in rationale and clear protocol definition. Conclusion: The surveying of user understanding in machine learning outputs presents challenges due to the explosion of parameters to control for and the lack of systematic approach presented in the literature. More reproducible work and survey protocols are needed in the literature and our work is one step towards that direction.

topic finding↗
NASA NTRS2016

Process for Upgrading Cognitive Assessment Capabilities Onboard the International Space Station

MOTIVATION: Spaceflight poses varied and unique risks to the brain and cognitive functioning including radiation exposure, sleep disturbance, fatigue, fluid shifts (increased intracranial pressure), toxin exposure, elevated carbon dioxide, and traumatic brain injury, among others. These potential threats to cognitive functioning are capable of degrading performance and compromising mission success. Furthermore, the threats may increase in severity, and new types of threats may emerge for longer duration exploration missions. This presentation will describe the process used to identify gaps in our current approach, evaluate best practices in cognitive assessment, and transition new cognitive assessment tools to operational use. OVERVIEW: Risks to brain health and performance posed by spaceflight missions require sensitive tools to assess cognitive functioning of astronauts in flight. The Spaceflight Cognitive Assessment Tool for Windows (WinSCAT) is the automated cognitive assessment tool currently deployed onboard the International Space Station (ISS). WinSCAT provides astronauts and flight surgeons with objective data to monitor neurocognitive functioning. WinSCAT assesses 5 discrete cognitive domains, is sensitive to changes in cognitive functioning, and was designed to be completed in less than 15 minutes. However, WinSCAT does not probe other areas of cognitive functioning that might be important to mission success. Researchers recently have developed batteries that may expand current capabilities, such as increased sensitivity to subtle fluctuations in cognitive functioning. Therefore, we engaged in a systematic process review in order to improve upon our current capabilities and incorporate new advances in cognitive assessment. This process included a literature review on newer measures of neurocognitive assessment, surveys of operational flight surgeons at NASA regarding needs and gaps in our capabilities, and expert panel review of candidate cognitive measures and assessment issues and procedures. SIGNIFICANCE: Our process and the results that flowed from it may be helpful to aeromedical professionals charged with transitioning research findings to operational use. Our specific findings regarding cognitive assessment tools are of significance to professionals who must assess readiness to perform in mission critical situations in environments involving threats to cognition and performance

Picano, J. J.↗