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Following the first Nuclear Thermal Propulsion (NTP) system test, also known as DRACO, the next NTP system to be developed would be the 1st Generation NTP system. An analysis was conducted to determine the performance of different vehicle configurations utilizing hydrogen (H-NTP), ammonia (A-NTP), and methane (M-NTP) as propellants launched onboard commercial launch vehicles. This was enabled by a quasi-steady-state power balance engine model and vehicle component physics that sized the vehicle system using Master Equipment List (MEL) parameters. The analysis considered configuration cases outlined by a matrix of different mission classes and vehicle configurations that covered the design space of the 1st Generation NTP system to explore various propellant options, engine architectures, and mission scopes. Four mission classes were evaluated which included single burn missions performing maneuvers having a ΔV of 1 km/s and 2.5 km/s followed by 2-burn and 4-burn missions that aimed to exhaust the launch vehicles volume or mass limitations. In all cases, the NTP systems with the lowest thrust class had the longest burn time of which A-NTP and M-NTP systems provided the longest and shortest burn times depending on the launch vehicle used while H-NTP systems tended to cluster together in the middle. Longer burn times could be useful as a testing platform to increase the time for data accumulation. Across the multi-burn cases, H-NTP systems were found to be volume limited while A-NTP and M-NTP systems were mass limited. Both single burn missions showed that A-NTP configurations provided the lowest dry mass given that ammonia had the highest density with comparable performance to M-NTP systems and no requirement for cryocoolers. The results showed that beyond the propellant selection type, the launch vehicle selection, which included Starship, New Glenn, Vulcan, Falcon 9 (recoverable), and Falcon Heavy (recoverable), was a primary driving factor in the test vehicle’s capabilities. Trends were determined based on a set of dimensionless parameters that included the mass ratio of inert mass to initial wetted mass, ratio of specific impulse to burn time, and a dimensionless engine parameter (ratio of impulse to engine momentum). These relationships found the “knees-in-the-curves” that could be a significant point of reference for the designer as they indicate a change in the trend which is located at a specific impulse to burn time ratio of 1, a mass ratio of 0.6, and an engine performance parameter of 4. This study did not attempt to make a recommendation rather provide the tools for the reader to select their own configuration based on their needs.