Engineering topics

Brunzelle, Joseph

Publications and source records attributed to Brunzelle, Joseph.

3 records

All sources NASA NTRS DOE OSTI

DOE OSTI2024

Biochemical and Structural Analysis of the Bacterial Enzyme Succinyl-Diaminopimelate Desuccinylase (DapE) from Acinetobacter baumannii

Not provided.

Chemistry↗

DOE OSTI2023

A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile

ABSTRACT Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2020

High-resolution structures of the SARS-CoV-2 2′- O -methyltransferase reveal strategies for structure-based inhibitor design

Crystal structures of an mRNA-capping enzyme from SARS-CoV-2 in complex with its substrates suggest targets for drug design.

60 APPLIED LIFE SCIENCES↗