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DOE OSTI · 2005023

A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile

Rosas-Lemus, Monica·Dey, Supratim·Minasov, George·Tan, Kemin·Anderson, Spencer M.·Brunzelle, Joseph·Nocadello, Salvatore·Shabalin, Ivan·Filippova, Ekaterina·Halavaty, Andrei·Kim, Youngchang·Maltseva, Natalia·Osipiuk, Jerzy·Minor, Wladek·Joachimiak, Andrzej·Savchenko, Alexei·Anderson, Wayne F.·Satchell, Karla J. F.·Newton, ed., Irene L. G.
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Abstract

ABSTRACT Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

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59 BASIC BIOLOGICAL SCIENCESclostridiodesclostridium difficilepipelineprotein structure-functionstructural genomicsx-ray

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Rosas-Lemus, Monica, Dey, Supratim, Minasov, George, Tan, Kemin, Anderson, Spencer M., Brunzelle, Joseph, Nocadello, Salvatore, Shabalin, Ivan, Filippova, Ekaterina, Halavaty, Andrei, Kim, Youngchang, Maltseva, Natalia, Osipiuk, Jerzy, Minor, Wladek, Joachimiak, Andrzej, Savchenko, Alexei, Anderson, Wayne F., Satchell, Karla J. F., Newton, ed., Irene L. G.. 2023-10-19. A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile. https://doi.org/10.1128/mra.00507-23

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