Trapping a non-cognate nucleotide upon initial binding for replication fidelity control in SARS-CoV-2 RNA dependent RNA polymerase
Non-cognate GTP and dATP nucleotides can be stabilized or trapped upon initial binding to be prevented from further insertion into the active site of SARS-CoV-2 RdRp enzyme in viral genome replication fidelity control.
Chemistry↗