DOE OSTI · 2581931
Trapping a non-cognate nucleotide upon initial binding for replication fidelity control in SARS-CoV-2 RNA dependent RNA polymerase
Abstract
Non-cognate GTP and dATP nucleotides can be stabilized or trapped upon initial binding to be prevented from further insertion into the active site of SARS-CoV-2 RdRp enzyme in viral genome replication fidelity control.
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Romero, Moises, McElhenney, Shannon (ORCID:0000000312484543), Yu, Jin (ORCID:0000000182241374). 2024-01-01. Trapping a non-cognate nucleotide upon initial binding for replication fidelity control in SARS-CoV-2 RNA dependent RNA polymerase. https://doi.org/10.1039/d3cp04410f
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