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Robinson, D. M.

Publications and source records attributed to Robinson, D. M..

12 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS2001

NASA/American Cancer Society High-Resolution Flow Cytometry Project-I

BACKGROUND: The NASA/American Cancer Society (ACS) flow cytometer can simultaneously analyze the electronic nuclear volume (ENV) and DNA content of cells. This study describes the schematics, resolution, reproducibility, and sensitivity of biological standards analyzed on this unit. METHODS: Calibrated beads and biological standards (lymphocytes, trout erythrocytes [TRBC], calf thymocytes, and tumor cells) were analyzed for ENV versus DNA content. Parallel data (forward scatter versus DNA) from a conventional flow cytometer were obtained. RESULTS: ENV linearity studies yielded an R value of 0.999. TRBC had a coefficient of variation (CV) of 1.18 +/- 0.13. DNA indexes as low as 1.02 were detectable. DNA content of lymphocytes from 42 females was 1.9% greater than that for 60 males, with a noninstrumental variability in total DNA content of 0.5%. The ENV/DNA ratio was constant in 15 normal human tissue samples, but differed in the four animal species tested. The ENV/DNA ratio for a hypodiploid breast carcinoma was 2.3 times greater than that for normal breast tissue. CONCLUSIONS: The high-resolution ENV versus DNA analyses are highly reliable, sensitive, and can be used for the detection of near-diploid tumor cells that are difficult to identify with conventional cytometers. ENV/DNA ratio may be a useful parameter for detection of aneuploid populations.

NASA Center JSC↗
NASA NTRS1985

Wavelength error analysis in a multiple-beam Fizeau laser wavemeter having a linear diode array readout

An estimate of the wavelength accuracy of a laser wavemeter is performed for a system consisting of a multiple-beam Fizeau interferometer and a linear photosensor array readout. The analysis consists of determining the fringe position errors which result when various noise sources are included in the fringe forming and detection process. Two methods of estimating the fringe centers are considered: (1) maximum pixel current location, and (2) average pixel location for two detectors with nearly equal output currents. Wavelength error results for these two methods are compared for some typical wavemeter parameters.

Robinson, D. M.↗
NASA NTRS1980

Spatial frequency response of an optical heterodyne receiver

The analysis of a passive heterodyne receiver with respect to its imaging performance (transfer function) and its heterodyne efficiency shows departures from the results which are obtained in strictly coherent or incoherent imaging systems. The cascading property of modulation transfer function analysis must be carefully applied, since the coherent transfer function of the optical receiver and that due to the local oscillator-detector combination are not separable but are related by the convolution of their products. Application of these results to a spacelab-type optical heterodyne receiver shows that resolutions of the order of 1.5 to 2.0 km are possible for worst-case type orbital scenarios. In addition to an analysis of the derogatory effects of sampling (aliasing) a comparison of obscured-type receivers (e.g., Cassegrains) with unobscured receivers shows that both resolution and efficiency are severly degraded in an obscured-type receiver and, consequently, should not be used for passive heterodyne detection schemes.

Robinson, D. M.↗
NASA NTRS1980

Spatial frequency response of an optical heterodyne receiver

The principles of transfer function analysis are applied to a passive optical heterodyne receiver to obtain the modulation transfer function (MTF). MTF calculations are performed based on an optical platform which is imaging vertically varying profiles at worst case shuttle orbit altitudes. An analysis of the derogatory effects of sampling (aliasing) and central obscurations on both resolution and heterodyne efficiency is given. It is found that the cascading property of MTF analysis must be carefully applied since the coherent transfer function of the optical receiver and that due to the local oscillator-detector combination are not separable but are related by the convolution of their products. Application of these results to the specific case of a space-lab type optical heterodyne receiver shows that resolutions of the order of 1.5-2.0 Km are possible for worst-case type orbital scenarios. Further, comparison of obscured-type receivers (e.g., Cassegrains) with unobscured receivers shows that both resolution and efficiency are severely degraded in an obscured-type receiver and consequently should not be used for a passive heterodyne detection scheme.

Fales, C. L.↗
NASA NTRS1979

Lens window simplifies TDL housing

Lens window seal in tunable-diode-laser housing replaces plan parallel window. Lens seals housing and acts as optical-output coupler, thus eliminating need for additional reimaging or collimating optics.

Robinson, D. M.↗
NASA NTRS1979

Optically coupling tunable diode lasers

Proposed opticle coupling, using lenses and mirrors that replace complex mechanical systems, can combine separate tunable diode laser outputs and expand wavelength range. Method uses single cooler housing and requires no moving parts within cooler assembly.

Robinson, D. M.↗
NASA NTRS1977

Scattering from a moving spherical particle by two crossed coherent plane waves

The Mie scattering properties of a homogeneous, isotropic spherical particle, moving at a constant velocity and illuminated by two intersecting coherent plane waves having the same polarization direction, have been analyzed based upon an exact solution to Maxwell's equations. The solutions are in a form suitable for the calculation of the time varying scattered signal integrated across a detector aperture of variable size that is centered on either the forward or backward scattering direction. This problem is of importance in defining the scattered signal in a cross beam laser Doppler velocimeter (LDV). Results obtained from calculating the integrated scattered signal indicate a strong dependence upon the following physical parameters: particle size, index of refraction, cross beam angle, and collection solid angle.

Chu, W. P.↗
NASA NTRS1975

Diffraction analysis of Doppler signal characteristics for a cross-beam laser Doppler velocimeter

Based on scalar diffraction theory, single particle scattering characteristics for a cross-beam laser Doppler velocimeter (LDV) have been computed for different particle sizes under varied instrumentation configurations. The modulating component of the scattered signal has been shown to depend upon particle size, shape, and collecting aperture for a given probe volume fringe spacing. Experimental verifications of some of the predictions are presented, and some of the limitations using an LDV as a particle sizing instrument are discussed.

Robinson, D. M.↗
NASA NTRS1974

Removal of spacecraft-surface particulate contaminants by simulated micrometeoroid impacts

A series of hypervelocity impacts has been conducted in an exploding lithium-wire accelerator to examine with a far-field holographic system the removal of particulate contaminants from external spacecraft surfaces subjected to micrometeoroid bombardment. The impacting projectiles used to simulate the micrometeoroids were glass spheres nominally 37 microns in diameter, having velocities between 4 and 17 km/sec. The particulates were glass spheres nominally 25, 50, and 75 microns in diameter which were placed on aluminum targets. For these test, particulates detached had velocities that were log-normally distributed. The significance of the log-normal behavior of the ejected-particulate velocity distribution is that the geometric mean velocity and the geometric standard deviation are the only two parameters needed to model completely the process of particles removed or ejected from a spacecraft surface by a micrometeoroid impact.

Goad, J. H., Jr.↗
NASA NTRS1973

In-flight detection of small hypervelocity particles.

A technique is described in which small (25-micron) hypervelocity (10-km/sec) in-flight particles can be detected in the presence of high background noise. The system is based on a spatial filtering principle whereby spurious noise effects are reduced by use of a beam stop in the entrance aperture of the system and a bandpass filter in the transform plane. A theoretical analysis of the system is presented, and some experimental results are obtained by detecting in-flight hypervelocity particles generated by an exploding lithium wire electrothermal accelerator.

Robinson, D. M.↗
NASA NTRS1972

Holographic nondestructive testing with impact excitation.

Review of some experimental results of bond flaw detection in composite materials by holographic recording of the surface of samples subjected to mechanical impact. The resulting deformation of the samples recorded in a sequence of double exposure holograms at increasingly longer time intervals after impact renders the presence of flaws observable. A proposed deformation enhancement technique increases detection sensitivity and is helpful in visualizing smaller flaws.

Chu, W. P.↗