The immune system in space and microgravity

Sonnenfeld, Gerald

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NASA NTRS · 20040087945

The immune system in space and microgravity

Sonnenfeld, Gerald

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Abstract

Space flight and models that created conditions similar to those that occur during space flight have been shown to affect a variety of immunological responses. These have primarily been cell-mediated immune responses including leukocyte proliferation, cytokine production, and leukocyte subset distribution. The mechanisms and biomedical consequences of these changes remain to be established. Among the possible causes of space flight-induced alterations in immune responses are exposure to microgravity, exposure to stress, exposure to radiation, and many more as yet undetermined causes. This review chronicles the known effects of space flight on the immune system and explores the possible role of stress in contributing to these changes.

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unmanned Cosmos Project NASA Discipline Regulatory Physiology manned short duration Review STS Shuttle Project Review, Tutorial Non-NASA Center Flight Experiment Immune System/physiology Weightlessness Space Flight Animals Human Support, U.S. Gov't, Non-P.H.S

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Sonnenfeld, Gerald. 2002-12-01. The immune system in space and microgravity. https://ntrs.nasa.gov/citations/20040087945

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