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NASA NTRS · 20040112419

Proprioceptor pathway development is dependent on Math1

Bermingham, N. A.·Hassan, B. A.·Wang, V. Y.·Fernandez, M.·Banfi, S.·Bellen, H. J.·Fritzsch, B.·Zoghbi, H. Y.
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Abstract

The proprioceptive system provides continuous positional information on the limbs and body to the thalamus, cortex, pontine nucleus, and cerebellum. We showed previously that the basic helix-loop-helix transcription factor Math1 is essential for the development of certain components of the proprioceptive pathway, including inner-ear hair cells, cerebellar granule neurons, and the pontine nuclei. Here, we demonstrate that Math1 null embryos lack the D1 interneurons and that these interneurons give rise to a subset of proprioceptor interneurons and the spinocerebellar and cuneocerebellar tracts. We also identify three downstream genes of Math1 (Lh2A, Lh2B, and Barhl1) and establish that Math1 governs the development of multiple components of the proprioceptive pathway.

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Non-NASA CenterNASA Discipline Developmental BiologyProprioception/genetics/physiologyTranscription Factors/deficiency/genetics/metabolismInterneurons/physiologySpinal Cord/embryology/physiologyBrain/embryology/physiologyHomeodomain Proteins/geneticsCerebellum/embryology/physiologyGene Expression Regulation, DevelopmentalApoptosisHeterozygoteHelix-Loop-Helix MotifsSkin/innervationAnimalsSupport, U.S. Gov't, P.H.SMice, KnockoutMice, TransgenicEmbryo and Fetal DevelopmentNerve Tissue Proteins/genetics/metabolismBody Patterningbeta-Galactosidase/geneticsMice

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Bermingham, N. A., Hassan, B. A., Wang, V. Y., Fernandez, M., Banfi, S., Bellen, H. J., Fritzsch, B., Zoghbi, H. Y.. 2001-05-01. Proprioceptor pathway development is dependent on Math1. https://ntrs.nasa.gov/citations/20040112419

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